Interplay among Vaginal Microbiome, Immune Response and Sexually Transmitted Viral Infections

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(2), P. 266 - 266

Published: Jan. 11, 2019

The vaginal ecosystem is important for women’s health and a successful reproductive life, an optimal host-microbial interaction required the maintenance of eubiosis. microbiota dominated by Lactobacillus species in majority women. Loss dominance promotes colonization anaerobic bacterial with increase microbial diversity. Vaginal dysbiosis very frequent condition which affects immune homeostasis, inducing rupture epithelial barrier favoring infection sexually transmitted pathogens. In this review, we describe known interactions among cells commensals govern or disease status. Particular attention given to compositions which, through interplay cells, facilitate establishment viral infections, such as Human Immunodeficiency Virus (HIV), Papilloma (HPV), Herpes Simplex 2 (HSV2).

Language: Английский

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A review of the pathophysiology of recurrent implantation failure

Fertility and Sterility, Journal Year: 2021, Volume and Issue: 116(6), P. 1436 - 1448

Published: Oct. 20, 2021

Language: Английский

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Clinical Relevance of Vaginal and Endometrial Microbiome Investigation in Women with Repeated Implantation Failure and Recurrent Pregnancy Loss

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(1), P. 622 - 622

Published: Jan. 3, 2024

Recent studies have investigated if and how the vaginal endometrial microbiome might affect receptivity reproductive health. Although there is no consensus on existence of a core uterine yet, evidence shows that dominance Lactobacillus spp. in female tract generally associated with eubiosis improved chances successful implantation an ongoing pregnancy. Conversely, dysbiosis can cause local inflammation increase pro-inflammatory cytokines, compromising integrity mucosa potentially hampering embryonic implantation. This review provides critical appraisal influence as parts fertility outcomes, focusing repeated failure (RIF) recurrent pregnancy loss (RPL). It seems RIF well RPL are both diversity lower system.

Language: Английский

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Endometrial Receptivity–Lessons from “Omics”

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 106 - 106

Published: Jan. 11, 2025

The window of implantation (WOI) is a critical phase the menstrual cycle during which endometrial lining becomes receptive and facilitates embryo implantation. Drawing on findings from various branches “omics”, including genomics, epigenomics, transcriptomics, proteomics, lipidomics, metabolomics, microbiomics, this narrative review aims to (1) discuss mechanistic insights receptivity its implication in infertility; (2) highlight advances investigations for receptivity; (3) novel diagnostic therapeutic strategies that may improve reproductive outcomes.

Language: Английский

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Recent Insights on the Maternal Microbiota: Impact on Pregnancy Outcomes

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: Oct. 23, 2020

Hormonal changes during and after pregnancy are linked with modifications in the maternal microbiota. In our manuscript, we describe importance of microbiota examine whether microbial composition at different body sites may have an association complications. We also analyze likely interactions between immune system. Gastrointestinal (Gut) Microbiota. During pregnancy, undergoes profound changes, leading to increase lactic acid-producing bacteria a reduction butyrate-producing bacteria. The meaning such still remains be clarified. Additionally, various studies indicated possible involvement gut autoimmune life-long diseases. Vaginal human vagina has its own microbiota; vaginal seem related number Recent shown reduced Lactobacilli, increased bacterial diversity, low levels β-defensin-2 patients preterm birth (PTB). contrast, early healthy pregnancies characterized by diversity numbers communities dominated Lactobacillus. These observations suggest that cultures, show absence Lactobacillus polymicrobial colonization, risk factors for PTB. Endometrial Endometrium is not sterile site: it only been recent years resident endometrial defined. Questions remain however around what main components their impact on reproductive tract, terms both fertility outcomes. A classification based patterns would help develop microbiota-based diagnosis, personalized therapies prevention obstetrical complications treatments through nutritional, microbial, or pharmaceutical interventions.

Language: Английский

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Interaction Between Chronic Endometritis Caused Endometrial Microbiota Disorder and Endometrial Immune Environment Change in Recurrent Implantation Failure

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 4, 2021

Objective To investigate the Interaction between chronic endometritis (CE) caused endometrial microbiota disorder and immune environment change in recurrent implantation failure (RIF). Method Transcriptome sequencing analysis of 112 patients was preform by using High-Throughput Sequencing. The 43 analyzed 16s rRNA technology. Result In host endometrium, CD4 T cell macrophage exhibited significant differences abundance CE non-CE patients. enrichment indicated differentially expressed genes mainly enriched immune-related functional terms. Phyllobacterium Sphingomonas were significantly high infiltration patients, active pathways related to carbohydrate metabolism and/or fat metabolism. increased synthesis lipopolysaccharide, an important immunomodulator, result microbial disorders endometrium. Conclusion composition microorganisms different. regulated cells interfering with process might regulate Th17 response ratio Th1 through lipopolysaccharide (LPS).

Language: Английский

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Microbiome and Cervical Cancer

Pathobiology, Journal Year: 2020, Volume and Issue: 88(2), P. 187 - 197

Published: Nov. 23, 2020

Persistent infection with some types of mucosal human papillomavirus (HPV) is the etiological factor for development cervical cancer and its precursor lesions. Besides, several cofactors are known to play a role in disease onset progression either by favoring or preventing HPV persistence. The microbiome healthy female genital tract characterized presence 1 few varieties lactobacilli. However, high-throughput studies addressing bacterial diversity abundance have shown that factors, including hormonal levels, hygiene habits, sexually transmitted diseases may disrupt natural balance, outgrowth groups bacteria, which turn favor pathological states. Recently, vaginal has emerged as new variable could greatly influence history infections their clinical impact. In this context, changes been detected women infected HPV-associated lesions cancer. specific bacteria development/progression prevention/regression pathologies not well understood. review we summarize current knowledge concerning disease. We discuss potential functional interplay between outcomes.

Language: Английский

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The early life education of the immune system: Moms, microbes and (missed) opportunities

Gut Microbes, Journal Year: 2020, Volume and Issue: 12(1), P. 1824564 - 1824564

Published: Oct. 12, 2020

The early life immune system is characterized by unique developmental milestones. Functionally diverse cells arise from distinct waves of hematopoietic stem cells, a phenomenon referred to as 'layered' immunity. This stratified development extends lineages both innate and adaptive cells. defined time window for the these lends itself influence specific exposures typical period. perinatal develops in relatively sterile fetal environment but emerges into one filled with multitude antigenic encounters. A major burden this comes form microbiota that being newly established at mucosal surfaces newborn. Accumulating evidence suggests microbial exposures, including those arising utero, can imprint long-lasting changes offspring's determine disease risk throughout life. In review, I highlight features immunity explore role intestinal bacteria educating developing system.

Language: Английский

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The female reproductive tract microbiotas, inflammation, and gynecological conditions

Frontiers in Reproductive Health, Journal Year: 2022, Volume and Issue: 4

Published: Aug. 9, 2022

The intricate interactions between the host cells, bacteria, and immune components that reside in female reproductive tract (FRT) are essential maintaining homeostasis. Much of our current knowledge surrounding FRT microbiota relates to vaginal microbiota, where ‘health’ has long been associated with low bacterial diversity Lactobacillus dominance. This concept recently challenged as women can have a diverse microbial composition absence symptomatic disease. structures upper (the endocervix, uterus, Fallopian tubes, ovaries) distinct, lower biomass microbiotas than vagina; however, existence permanent at these sites is disputed. During homeostasis, balance exists bacteria system maintains quiescence. Alterations system, or local environment may result perturbances defined dysbiosis. inflammatory signature perturbed “dysbiotic” characterized by elevated concentrations pro-inflammatory cytokines cervical fluid. It appears homeostasis be disrupted two different mechanisms: first, shift toward increased trigger inflammation, second, immunity altered some manner, which disrupts response an environmental change. dysbiosis negative effects on health. review will examine increasing evidence for involvement inflammation gynecologic conditions such endometriosis, infertility, endometrial ovarian cancer; precise mechanisms involved remains speculative present. While only their infancy, use antibiotics probiotics therapeutically alter being studied discussed herein. Our understanding intimate relationship its early days, more research needed deepen mechanistic this assess how present harnessed assist diagnosis treatment conditions.

Language: Английский

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Female reproductive tract microbiota and recurrent pregnancy loss: a nested case-control study

Reproductive BioMedicine Online, Journal Year: 2022, Volume and Issue: 45(5), P. 1021 - 1031

Published: June 17, 2022

Is the composition of endometrial or vaginal microbiota associated with recurrent pregnancy loss (RPL)?Endometrial and samples were collected from 47 women two more consecutive losses 39 healthy control without a history loss, between March 2018 December 2020 at Helsinki University Hospital, Helsinki, Finland. The compositions microbiota, analysed using 16S rRNA gene amplicon sequencing, compared RPL women, individual samples. mycobiota was internal transcribed spacer 1 sequencing for descriptive summary. models adjusted body mass index, age parity. False discovery rate-corrected P-values (q-values) used to define nominal statistical significance q < 0.05.Lactobacillus crispatus less abundant in controls (mean relative abundance 17.2% versus 45.6%, = 0.04). Gardnerella vaginalis group than both (12.4% 5.8%, 0.001) (8.7% 5.7%, 0.002) microbial correlated strongly (R 0.85, P 0.001). Fungi detected 22% 36% samples.Dysbiosis reproductive tract is may represent novel risk factor losses.

Language: Английский

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