Hypoxia, a key factor in the immune microenvironment DOI Open Access
Jingyao Hu, Xinyu Li, Liang Yang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 151, P. 113068 - 113068

Published: May 27, 2022

The physical and chemical pressures in the tumor microenvironment (TME) play an important role development by regulating stromal elements, including immune cells. Hypoxia can induce a cascade of events initiation via regulation. As dangerous factor, hypoxia activates multiple signaling pathways to reshape microenvironment, leading immunosuppression. Consequently, targeting TME is potential strategy prevent escape inhibit malignant progression. In this review, we summarized hypoxia-induced factors process provide novel pathway restrain progression development.

Language: Английский

Nanotechnology Reprogramming Metabolism for Enhanced Tumor Immunotherapy DOI

Yangkai Zhou,

Jing Yuan, Ke Xu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 1846 - 1864

Published: Jan. 5, 2024

Mutation burden, hypoxia, and immunoediting contribute to altered metabolic profiles in tumor cells, resulting a microenvironment (TME) characterized by accumulation of toxic metabolites depletion various nutrients, which significantly hinder the antitumor immunity via multiple mechanisms, hindering efficacy immunotherapies. In-depth investigation mechanisms underlying these phenomena are vital for developing effective drugs therapies, while therapeutic effects metabolism-targeting restricted off-target toxicity toward effector immune cells high dosage-mediated side effects. Nanotechnologies, exhibit versatility plasticity targeted delivery metabolism modulation, have been widely applied boost immunometabolic therapies strategies, including targeting pathways. In this review, recent advances understanding roles cell both immunoevasion immunosuppression reviewed, nanotechnology-based reprogramming strategies enhanced immunotherapies discussed.

Language: Английский

Citations

22
Metabolic reprogramming and immune evasion: the interplay in the tumor microenvironment DOI Creative Commons
Haixia Zhang, Shizhen Li, Dan Wang

et al.

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 3, 2024

Abstract Tumor cells possess complex immune evasion mechanisms to evade system attacks, primarily through metabolic reprogramming, which significantly alters the tumor microenvironment (TME) modulate cell functions. When a is sufficiently immunogenic, it can activate cytotoxic T-cells target and destroy it. However, tumors adapt by manipulating their pathways, particularly glucose, amino acid, lipid metabolism, create an immunosuppressive TME that promotes escape. These alterations impact function differentiation of non-tumor within TME, such as inhibiting effector T-cell activity while expanding regulatory myeloid-derived suppressor cells. Additionally, these changes lead imbalance in cytokine chemokine secretion, further enhancing landscape. Emerging research increasingly focusing on roles evaluating how reprogrammed metabolism influence functional ultimately aid evasion. Despite our incomplete understanding intricate interactions between cells, connection elements presents significant challenges for cancer immunotherapy. This review highlights altered providing new insights could facilitate development novel immunotherapies.

Language: Английский

Citations

19
Tumor microenvironment: recent advances in understanding and its role in modulating cancer therapies DOI
Disha D. Shah, Mehul R. Chorawala, Neha R. Raghani

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 18, 2025

Language: Английский

Citations

3
Dendritic cell maturation in cancer DOI
Chang Moon, Meriem Belabed, Matthew D. Park

et al.

Nature reviews. Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

Citations

2
2′-FL in Dairy Matrices Attenuates Allergic Symptoms in Mice by Reducing BLG Hypersensitivity and Modulating Gut Microecology DOI

Xintong Chen,

Fan Yang,

Tianliang Bai

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

2'-Fucosyllactose (2'-FL), an industrial breast milk oligosaccharide, is approved for use in infant formula and may reduce cow's protein allergenicity. To investigate whether glycosylation products of 2'-FL dairy (2'-FL-β-LG) increase its sensitization, we cross-linked β-LG with used it to sensitize Balb/c mice, comparing nonglycosylated β-LG. Both 2'-FL-β-LG sensitization oral intervention reduced allergic symptoms, specific antibodies (IgE, IgG, IgG2a), inflammatory cytokine levels, intestinal damage. also shifted T-cell differentiation, cell surface expression DC receptors, enhanced gut microbial diversity. Oral showed the greatest efficacy, suggesting potential lowering allergenicity formula.

Language: Английский

Citations

2
The impact of hypoxia on immune state in cancer DOI
Keywan Mortezaee, Jamal Majidpoor

Life Sciences, Journal Year: 2021, Volume and Issue: 286, P. 120057 - 120057

Published: Oct. 18, 2021

Language: Английский

Citations

73
Metabolic reprogramming of immune cells in pancreatic cancer progression DOI Open Access
Hong Xiang,

Runjuan Yang,

Jiaxin Tu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 157, P. 113992 - 113992

Published: Nov. 14, 2022

Abnormal intracellular metabolism not only provides nutrition for tumor occurrence and development, but also sensitizes the function of various immune cells in microenvironment to promote escape. This review discusses emerging role progress pancreatic cancer, acrossing metabolic reprogramming key pathways present different cell types. At present, hotspots cancer progression mainly focuses on glucose metabolism, lipid tricarboxylic acid cycle amino which affect anti-tumor immunosuppressive microenvironment, such as macrophages, dendritic cells, T myeloid-derived suppressor neutrophils B by a series signaling pathways, PI3K/AKT, mTOR, AMPK, HIF-1α, c-Myc p53. Drugs that target clinical treatment are systematically elaborated, may constitute food others' projects involved anti-cancer research.

Language: Английский

Citations

43
Strategies to overcome DC dysregulation in the tumor microenvironment DOI Creative Commons
Guillaume Mestrallet,

Kazuki Sone,

Nina Bhardwaj

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 6, 2022

Dendritic cells (DCs) play a key role to modulate anti-cancer immunity in the tumor microenvironment (TME). They link innate adaptive by processing and presenting antigens T thereby initiating an anti-tumor response. However, subsets of DCs also induce immune-tolerance, leading immune escape. In this regard, TME plays major adversely affecting DC function. Better understanding impairment mechanisms will lead more efficient DC-targeting immunotherapy. Here, we review different subtypes functions TME, including conventional DCs, plasmacytoid newly proposed subset, mregDC. We further focus on how cancer escape from host’s immune-surveillance. Immune checkpoint expression, small molecule mediators, metabolites, deprivation pro-immunogenic release pro-tumorigenic cytokine secretion tumors tumor-attracted immuno-suppressive inhibit differentiation Finally, discuss impact established therapies such as blockade. Creative DC-targeted therapeutic strategies be highlighted, vaccines cell-based therapies.

Language: Английский

Citations

40
The tumor microenvironment: shaping cancer progression and treatment response DOI
Sharav Desai, Vipul P. Patel, Kunal Bhosle

et al.

Journal of Chemotherapy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 30

Published: Jan. 5, 2024

The tumor microenvironment (TME) plays a crucial role in cancer progression and treatment response. It comprises complex network of stromal cells, immune extracellular matrix, blood vessels, all which interact with cells influence behaviour. This review article provides an in-depth examination the TME, focusing on signaling molecules, ECM, along commonly available therapeutic compounds that target these components. Moreover, we explore TME as novel strategy for discovering new anti-tumor drugs. dynamic adaptive nature offers opportunities targeting specific cellular interactions pathways. We discuss emerging approaches, such combination therapies simultaneously modulate TME. Finally, address challenges future prospects Overcoming drug resistance, improving delivery, identifying targets within are among discussed. also highlight potential personalized medicine integration technologies, immunotherapy nanotechnology, TME-targeted therapies. comprehensive insights into its implications. Understanding TME's complexity components offer promising avenues development improved patient outcomes.

Language: Английский

Citations

16
Reprogramming Dysfunctional Dendritic Cells by a Versatile Catalytic Dual Oxide Antigen-Captured Nanosponge for Remotely Enhancing Lung Metastasis Immunotherapy DOI Creative Commons

Min‐Ren Chiang,

Chin-Wei Hsu,

Wulin Pan

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Dendritic cells (DCs) play a crucial role in initiating antitumor immune responses. However, the tumor environment, dendritic often exhibit impaired antigen presentation and adopt an immunosuppressive phenotype, which hinders their function reduces ability to efficiently present antigens. Here, dual catalytic oxide nanosponge (DON) doubling as remotely boosted catalyst inducer of programming DCs program therapy is reported. Intravenous delivery DON enhances accumulation via marginated target. At site, incorporates cerium nanozyme (CeO

Language: Английский

Citations

10