Estrogen deficiency‐mediated osteoimmunity in postmenopausal osteoporosis

Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Postmenopausal osteoporosis (PMO) is a common disease associated with aging, and estrogen deficiency considered to be the main cause of PMO. Recently, however, osteoimmunology has been revealed closely related On one hand, directly affects activity bone cells (osteoblasts, osteoclasts, osteocytes). other deficiency‐mediated osteoimmunity also plays crucial role in loss In this review, we systematically describe progress mechanisms PMO, osteoimmunity, differences between PMO patients postmenopausal populations without osteoporosis, immune (T cells, B macrophages, neutrophils, dendritic mast cells) activity. The comprehensive summary paper provides clear knowledge context for future research on mechanism loss.

Language: Английский

---

Exon junction complexes regulate osteoclast‐induced bone resorption by influencing the NFATc1 m6A distribution through the “shield effect”

Clinical and Translational Medicine, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 1, 2025

The distribution of the m6A methylation modification on transcriptome is highly regionally selective and mainly concentrated in abnormally long exons stop codons. However, in-depth research mechanism still lacking. In this research, meRIP sequencing, mRNA meRIP, luciferase reporter assays CRISPR/Cas9 conditional knockout mice were used to elucidate characteristics NFATc1 m6A. METTL14 controls osteoclast-mediated bone resorption by means (4249 A) gene during osteoclast differentiation. Exon junction complexes (EJCs) selectively protect sites gene. When are located within short exon fragments (50-200 nt), EJCs prevent their hypermethylation degradation through "shield effect"; when 3' UTR region or (greater than 300 effect" disappears. Downstream, YTHDF2 induced transcripts without site restriction. act as "shields" regulate selectivity gene, thereby determining Importantly, can raise level degrade its mRNA, inhibiting differentiation preserving mass. These results will be helpful for identifying potential molecular targets osteoporosis treatment. remaining (located inner fragment 50-200 nt) from degradation. disappears extended nt.

Language: Английский

---

Targeting chronic inflammation as a potential adjuvant therapy for osteoporosis

Life Sciences, Journal Year: 2022, Volume and Issue: 306, P. 120847 - 120847

Published: July 28, 2022

Language: Английский

---

Changes in the composition of gut and vaginal microbiota in patients with postmenopausal osteoporosis

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 12, 2022

Postmenopausal osteoporosis (PMO) is influenced by estrogen metabolism and immune response, which are modulated several factors including the microbiome inflammation. Therefore, there increasing interest in understanding role of microbiota PMO.To investigate variations gut (GM) vaginal (VM) postmenopausal women with osteoporosis.A total 132 were recruited for study divided into (n = 34), osteopenia 47), control 51) groups based on their T score. The serum levels interleukin (IL)-10, tumor necrosis factor (TNF)-α, lipopolysaccharide-binding protein determined via enzyme-linked immunosorbent assay. Additionally, 16S rRNA gene V3-V4 region sequencing was performed to GM VM participants.Significant differences observed microbial compositions fecal samples between (p < 0.05). It noted that GM, Romboutsia, unclassified_Mollicutes, Weissella spp. enriched group, whereas abundances Fusicatenibacter, Lachnoclostridium, Megamonas higher group than other groups. VM, Lactobacillus Peptoniphilus, Propionimicrobium, Gallicola predicted functional capacities different various We also found level IL-10 significantly lower while TNF-α 0.05).The results show changes BMD associated VM; however, more closely correlated PMO VM.

Language: Английский

---

Overview on postmenopausal osteoporosis and periodontitis: The therapeutic potential of phytoestrogens against alveolar bone loss

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 23, 2023

Osteoporosis and periodontitis are two major chronic diseases of postmenopausal women. The association between these evident through systemic bone loss alveolar loss. Both osteoporosis impose a considerable personal socioeconomic burden. Biphosphonate hormone replacement therapy effective in preventing periodontitis, but they coupled with severe adverse effects. Phytoestrogens plant-based estrogen-like compounds, which have been used for the treatment menopause-related symptoms. In last decades, numerous preclinical clinical studies carried out to evaluate therapeutic effects phytoestrogens including health. aim this article is give an overview bidirectional interrelationship summarize skeletal report most studied promising protective effect model, without experimental periodontitis. To date, there limited on osteoporosis. may exerted their by inhibiting resorption enhancing formation. With reported findings bone, well-designed trials needed better investigate compilation outcomes presented review provide recent research field direct further vivo future.

Language: Английский

---

Systemic immune-inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal women

Endocrine Connections, Journal Year: 2023, Volume and Issue: 12(2)

Published: Jan. 4, 2023

This study aims to investigate the associations of systemic immune-inflammation index (SII) with bone mineral density (BMD) and osteoporosis in adult females from a nationally representative sample.A cross-sectional was performed among 4092 aged ≥20 years National Health Nutrition Examination Survey 2007-2010. Linear logistic regressions were applied explore relationships SII BMD risk osteoporosis, respectively.Linear regression analyses found that doubling levels significantly correlated 1.39% (95% CI: 0.57%, 2.20%) decrease total femur BMD, 1.16% 0.31%, 2.00%) neck 1.73% 0.78%, 2.66%) trochanter 1.35% 0.50%, intertrochanteric postmenopausal women, after adjusting for covariates. Logistic showed compared women lowest quartile, those highest quartile had higher risks (odds ratio (OR) = 1.70, 95% 1.04, 2.76), (OR 1.86, 1.07, 3.38), intertrochanter 2.01, 1.05, 4.04) as well overall 1.57, 2.37). In contrast, there no significant association between premenopausal women.SII negatively associated but not women. Elevated could be potential factor

Language: Английский

---

Associations Between Inflammatory Mediators and Bone Outcomes in Postmenopausal Women: A Cross-Sectional Analysis of Baseline Data from the Prune Study

Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 639 - 663

Published: Feb. 1, 2023

Hypoestrogenism triggers increased production of inflammatory mediators, which contribute to bone loss during postmenopausal osteoporosis. This study aimed investigate the association between circulating markers and outcomes in women.We conducted a cross-sectional, secondary analysis baseline data from participants who completed 12-month randomized controlled trial, The Prune Study (NCT02822378), included healthy women (n=183, 55-75 years old) with mineral density (BMD) T-score 0.0 -3.0 at any site. BMD was measured using dual-energy X-ray absorptiometry, geometry strength were peripheral quantitative computed tomography. Blood collected measure (1) serum biomarkers turnover, including procollagen type 1 N-terminal propeptide (P1NP) C-terminal telopeptide (2) markers, high-sensitivity C-reactive protein (hs-CRP) plasma pro-inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-8, monocyte chemoattractant (MCP)-1, enzyme-linked immunosorbent assay. associations analyzed correlation regression analyses.Serum hs-CRP negatively correlated P1NP (r=-0.197, p=0.042). Plasma IL-1β, TNF-α trabecular score lumbar spine (all p<0.05). In normal-weight women, IL-8 (p<0.05) cortical area, content, various sites tibia radius. Serum positively predicted (β=0.078, p=0.028). IL-6 total body (β=-0.131, p=0.027) (β=-0.151, p=0.036), whereas hip (β=-0.114, p=0.028).At baseline, inversely associated estimates density, geometry, women. These findings suggest that may be an important mediator for loss.

Language: Английский

---

Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis

Journal of Bone and Mineral Metabolism, Journal Year: 2023, Volume and Issue: 41(2), P. 145 - 162

Published: March 1, 2023

Language: Английский

---

Estrogen plays an important role by influencing the NLRP3 inflammasome

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 167, P. 115554 - 115554

Published: Sept. 20, 2023

The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is an important part of the natural immune system that plays role in many diseases. Estrogen a sex hormone controlling reproduction and regulates physiological pathological processes. Recent studies have indicated estrogen associated with disease progression. can ameliorate some diseases (e. g, sepsis, mood disturbances, cerebral ischemia, hepatopathy, Parkinson's disease, amyotrophic lateral sclerosis, inflammatory bowel spinal cord injury, multiple myocardial ischemia/reperfusion osteoarthritis, renal fibrosis) by inhibiting NLRP3 inflammasome. also promote development (e.g., ovarian endometriosis, dry eye systemic lupus erythematosus) upregulating In addition, has dual effect on cancers asthma. However, mechanism these effects not summarized. This article reviewed progress understanding its mechanisms recent years to provide theoretical basis for in-depth study.

Language: Английский

---

KLF transcription factors in bone diseases

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(8)

Published: March 28, 2024

Abstract Krüppel‐like factors (KLFs) are crucial in the development of bone disease. They a family zinc finger transcription that unusual containing three highly conserved structural domains interacting with DNA. It has been discovered it engages various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, is for human tissues. In recent years, role KLFs physiology pathology received adequate attention. addition to regulating normal growth musculoskeletal system, participate pathological process bones joints intimately linked several skeletal illnesses, such as osteoarthritis (OA), rheumatoid arthritis (RA), osteoporosis (OP) osteosarcoma (OS). Consequently, targeting emerged promising therapeutic approach an array disorders. this review, we summarize current literature on importance emergence regulation particular emphasis pertinent mechanisms by which regulate diseases. We also discuss need KLFs‐based medication‐targeted treatment. These endeavours offer new perspectives use disorders provide prognostic biomarkers, targets possible drug candidates

Language: Английский

---