A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs DOI Creative Commons

Mirja Thomsen,

Axel Künstner, Inken Wohlers

et al.

Microbiome, Journal Year: 2023, Volume and Issue: 11(1)

Published: Oct. 21, 2023

Like its human counterpart, canine atopic dermatitis (cAD) is a chronic relapsing condition; thus, most cAD-affected dogs will require lifelong treatment to maintain an acceptable quality of life. A potential intervention modulation the composition gut microbiota, and in fact, probiotic has been proposed tried (AD) patients. Since are currently receiving intensive medical care, this be same option for dogs, while evidence dysbiosis cAD still missing, although skin microbial profiling conducted several studies. Therefore, we comprehensive analysis both microbiota one specific cAD-predisposed breed, Shiba Inu. Additionally, evaluated impact commonly used management on (Janus kinase; JAK inhibitor, oclacitinib) microbiota. Furthermore, genotyped Inu according mitochondrial DNA haplogroup assessed association with microbiota.Staphylococcus was predominant bacterial genus observed skin; Escherichia/Shigella Clostridium sensu stricto were highly abundant dogs. In Fusobacteria Megamonas healthy but significantly reduced The abundance these taxa positively correlated effect state disease. Oclacitinib shifted towards that latter brought it much closer particularly gut. even within dog mtDNA varied, there between skin.Dysbiosis Our findings provide basis by manipulating as well Video Abstract.

Language: Английский

Role of gut microbiota in infectious and inflammatory diseases DOI Creative Commons
Miriãn Ferrão Maciel-Fiuza,

Guilherme Cerutti Müller,

Daniel Marques Stuart Campos

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: March 27, 2023

Thousands of microorganisms compose the human gut microbiota, fighting pathogens in infectious diseases and inhibiting or inducing inflammation different immunological contexts. The microbiome is a dynamic complex ecosystem that helps proliferation, growth, differentiation epithelial immune cells to maintain intestinal homeostasis. Disorders cause alteration this microbiota lead an imbalance host's regulation. Growing evidence supports microbial community associated with development progression inflammatory diseases. Therefore, understanding interaction between modulation system fundamental mechanisms involved pathologies, as well for search new treatments. Here we review main bacteria capable impacting response pathologies discuss by which can alter disease outcomes.

Language: Английский

Citations

90
Neuroimmune communication regulating pruritus in atopic dermatitis DOI Creative Commons
Martin Steinhoff, Fareed Ahmad, Atul Kumar Pandey

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2022, Volume and Issue: 149(6), P. 1875 - 1898

Published: March 23, 2022

Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with significant burden. Genetic and environmental trigger factors contribute to AD, activating 2 of our largest organs, the nervous system immune system. Dysregulation neuroimmune circuits plays key role in pathophysiology causing inflammation, pruritus, pain, barrier dysfunction. Sensory nerves can be activated by or endogenous factors, transmitting itch stimuli brain. On stimulation, sensory nerve endings also release neuromediators into skin, contributing again dysfunction, itch. In addition, dysfunctional peripheral central neuronal structures neuroinflammation, sensitization, elongation, neuropathic itch, thus chronification therapy resistance. Consequently, may targets treat pruritus AD. Cytokines, chemokines, proteases, lipids, opioids, ions excite/sensitize endings, which not only induces but further aggravates/perpetuates disruption, as well. Thus, targeted therapies for well pathway inhibitors (eg, kinase inhibitors) beneficial control AD either systemic and/or topical form. Understanding signaling will optimize approach all pathological mechanisms pruritus.

Language: Английский

Citations

89
Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony DOI Creative Commons

Pengjun Zhou,

Chunlan Chen,

Sandip Patil

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 8, 2024

The gut microbiota and immune system interaction play a crucial role in maintaining overall health. Probiotics, prebiotics, postbiotics have emerged as promising therapeutic approaches to positively influence this complex axis enhance health outcomes. live bacteria, promote the growth of cells, shape responses, maintain barrier integrity. They modify by fostering beneficial bacteria while suppressing harmful ones. Additionally, probiotics interact with system, increasing cell activity anti-inflammatory cytokine production. Prebiotics, indigestible fibers, selectively nourish microorganisms gut, enhancing microbial diversity activity. This, turn, improves boosts responses controlling inflammation through its immunomodulatory properties. Postbiotics, produced during probiotic fermentation, such short-chain fatty acids antimicrobial peptides, impact modulate responses. Ensuring quality control standardization will be essential for successful clinical implementation these interventions. Overall, understanding harnessing microbiota-immune interplay offer avenues improving digestive immunological

Language: Английский

Citations

62
Microbiome: Role in Inflammatory Skin Diseases DOI Creative Commons

Xue-Er Zhang,

Pai Zheng,

S Ye

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 1057 - 1082

Published: Feb. 1, 2024

Abstract: As the body's largest organ, skin harbors a highly diverse microbiota, playing crucial role in resisting foreign pathogens, nurturing immune system, and metabolizing natural products. The dysregulation of human microbiota is implicated inflammatory responses. This review delineates microbial alterations features common Inflammatory Skin Diseases (ISDs) such as psoriasis, rosacea, atopic dermatitis(AD), seborrheic dermatitis(SD), diaper dermatitis(DD), Malassezia folliculitis (MF).The complex evolving community, undergoes changes composition function that can compromise barrier. These induce water loss abnormal lipid metabolism, contributing to onset ISDs. Additionally, microorganisms release toxins, like Staphylococcus aureus secreted α toxins proteases, which may dissolve stratum corneum, impairing barrier allowing entry into bloodstream. Microbes entering bloodstream activate molecular signals, leading disorders subsequent For instance, stimulates dendritic cells(DCs) IL-12 IL-23, differentiating Th17 cell population producing proinflammatory mediators IL-17, IL-22, TNF-α, IFN-α.This offers new insights ISDs, paving way for future microbiome-specific targeted therapies. Keywords: diseases, dermatitis, acne,

Language: Английский

Citations

26
Atopic dermatitis: Pathophysiology, microbiota, and metabolome – A comprehensive review DOI
Shahnawaz Mohammad, Md Rezaul Karim, Safia Iqbal

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 281, P. 127595 - 127595

Published: Jan. 3, 2024

Language: Английский

Citations

19
Probiotic Incorporation into Yogurt and Various Novel Yogurt-Based Products DOI Creative Commons

Douglas W. Olson,

Kayanush J. Aryana

Applied Sciences, Journal Year: 2022, Volume and Issue: 12(24), P. 12607 - 12607

Published: Dec. 8, 2022

Probiotics are commonly added to yogurt provide many health benefits for the consumer. A description is provided some used probiotics in yogurt. GRAS (generally recognized as safe) list of probiotic bacteria that can be or similar types products provided. Additionally, prebiotics, synbiotics (combination prebiotics and probiotics), postbiotics, paraprobiotics, psychobiotics Probiotic come various forms addition spoonable yogurt, an ingredient other food products. Many useful functional ingredients applied The safety must addressed, especially critically ill patients susceptible populations. survive within throughout its entire shelf-life gastrointestinal tract after consumption by consumer benefits, techniques maintain survival Furthermore, Greek acid whey. opportunities exist adding a wide variety yogurt-based

Language: Английский

Citations

42
Fecal microbiota transplantation affects the recovery of AD-skin lesions and enhances gut microbiota homeostasis DOI Creative Commons
Xinyu Jiang, Zhifang Liu,

Yizhao Ma

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 118, P. 110005 - 110005

Published: March 14, 2023

Accumulating evidence has shown that gut microbiota plays a key role in the progression of atopic dermatitis (AD). Fecal transplantation (FMT), as an effective method to restore homeostasis, been successfully applied for treating many inflammatory diseases. However, therapeutic effect FMT on AD remains unclear. The following study examined and mechanism AD-skin lesions mouse model. In this study, we exposed shaved back skin BALB/c mice calcipotriol (MC903) induce Mice were then treated with FMT, which was performed from healthy mice. tracked by 16S rRNA gene sequencing. tissues histopathology cytokines change serum ELISA. had faster trend reversion increases epidermal layer thicknesses suppressed some representative cytokines. microbial community natural recovery process varied significantly group at day 7 (ANOSIM P = 0.0229, r 0.2593). Notably, long-lasting beneficial impact compositions increasing ratio Firmicutes Bacteroidetes amount butyric-producing bacteria (BPB), including Erysipelotrichaceae, Lactobacillaceae, Eubacteriacea. Furthermore, relative abundances microbiota-mediated functional pathways involved cell growth death, amino acid, energy, lipid, carbohydrate metabolisms, immune system increased after treatment. modulated homeostasis affected AD-related inflammations, suggesting it could be used treatment strategy patients clinic.

Language: Английский

Citations

24
The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases DOI Open Access
Izabella Ryguła, Wojciech Pikiewicz, Beniamin Oskar Grabarek

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 1984 - 1984

Published: Feb. 6, 2024

Dermatoses are an increasingly common problem, particularly in developed countries. The causes of this phenomenon include genetic factors and environmental elements. More more scientific reports suggest that the gut microbiome, specifically its dysbiosis, also plays important role induction progression diseases, including dermatological diseases. microbiome is recognised as largest endocrine organ, has a key function maintaining human homeostasis. In review, authors will take close look at link between gut-skin axis pathogenesis dermatoses such atopic dermatitis, psoriasis, alopecia areata, acne. focus on probiotics remodelling alleviation dermatoses.

Language: Английский

Citations

15
The Role of the Microbiota in the Pathogenesis and Treatment of Atopic Dermatitis—A Literature Review DOI Open Access
Martyna Wrześniewska,

Julia Wołoszczak,

Gabriela Świrkosz

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6539 - 6539

Published: June 13, 2024

Atopic dermatitis (AD) is a chronic inflammatory skin condition with high prevalence worldwide. AD pathogenesis complex and consists of immune system dysregulation impaired barrier, influenced by genetic environmental factors. The purpose the review to show interplay between atopic microbiota. Human microbiota plays an important role in course disease. Dysbiosis factor contributing development diseases, including dermatitis. gut can influence composition microbiota, strengthening barrier regulating response via involvement bacterial metabolites, particularly short-chain fatty acids, signaling pathways gut–skin axis. be modulated antibiotic intake, dietary adjustments, hygiene, living conditions. One promising strategies for modulating probiotics. This offers summary how influences treatment AD, highlighting aspects that warrant additional investigation.

Language: Английский

Citations

14
Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics study DOI Creative Commons
Bin Du,

Aga Shama,

Yi Zhang

et al.

World Allergy Organization Journal, Journal Year: 2025, Volume and Issue: 18(1), P. 101017 - 101017

Published: Jan. 1, 2025

Language: Английский

Citations

1