Metabolic reprogramming in skin wound healing

Burns & Trauma, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 1, 2024

Abstract Metabolic reprogramming refers to the ability of a cell alter its metabolism in response different stimuli and forms pressure. It helps cells resist external stress provides them with new functions. Skin wound healing involves metabolic nutrients, such as glucose, lipids, amino acids, which play vital roles proliferation, differentiation, migration multiple types. During glucose process wounds, transporters key enzymes cause elevated metabolite levels. Glucose-mediated oxidative drives proinflammatory promotes healing. Reprogramming lipid increases number fibroblasts decreases macrophages. enhances local neovascularization improves fibrin stability promote extracellular matrix remodelling, accelerates healing, reduces scar formation. acid affects re-epithelialization, collagen deposition, angiogenesis. However, comprehensive reviews on role skin are lacking. Therefore, we have systematically reviewed acids during Notably, identified their targets potential therapeutic value elucidated mechanisms action.

Language: Английский

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Glycolipid Metabolic Disorders, Metainflammation, Oxidative Stress, and Cardiovascular Diseases: Unraveling Pathways

Biology, Journal Year: 2024, Volume and Issue: 13(7), P. 519 - 519

Published: July 12, 2024

Glycolipid metabolic disorders (GLMDs) are various resulting from dysregulation in glycolipid levels, consequently leading to an increased risk of obesity, diabetes, liver dysfunction, neuromuscular complications, and cardiorenal vascular diseases (CRVDs). In patients with GLMDs, excess caloric intake a lack physical activity may contribute oxidative stress (OxS) systemic inflammation. This study aimed review the connection between GLMD, OxS, metainflammation, onset CRVD. GLMD is due causing dysfunction synthesis, breakdown, absorption glucose lipids body, excessive ectopic accumulation these molecules. mainly neuroendocrine dysregulation, insulin resistance, metainflammation. many inflammatory markers defense cells play vital role related tissues organs, such as blood vessels, pancreatic islets, liver, muscle, kidneys, adipocytes, promoting lesions that affect interconnected organs through their signaling pathways. Advanced glycation end products, ATP-binding cassette transporter 1, Glucagon-like peptide-1, Toll-like receptor-4, sphingosine-1-phosphate (S1P) crucial since they glucolipid metabolism. The consequences this system organ damage morbidity mortality.

Language: Английский

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Monocytes and macrophages: Origin, homing, differentiation, and functionality during inflammation

Heliyon, Journal Year: 2024, Volume and Issue: 10(8), P. e29686 - e29686

Published: April 1, 2024

Monocytes and macrophages are essential components of innate immune system have versatile roles in homeostasis immunity. These phenotypically distinguishable mononuclear phagocytes play distinct different stages, contributing to the pathophysiology various forms making them a potentially attractive therapeutic target inflammatory conditions. Several pieces evidence supported role cell surface receptors expressed on these cells their downstream signaling molecules initiating perpetuating response. In this review, we discuss current understanding monocyte macrophage biology inflammation, highlighting chemoattractants, inflammasomes, integrins function monocytes during events inflammation. This review also covers recent interventions targeting at cellular molecular levels.

Language: Английский

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Association between the C-reactive protein–albumin–lymphocyte index and metabolic syndrome: evidence from the 2003–2010 national health and nutrition examination survey

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 31, 2025

Metabolic syndrome (MetS) is a global public health problem that significantly impacts human and quality of life. The relationship between MetS the C-reactive protein-albumin-lymphocyte (CALLY) index uncertain. This study analyzed data 7,534 individuals from National Health Nutrition Examination Survey cycles (2003-2010 cycles). Weighted logistic regression weighted restricted cubic spline (RCS) curve analyses were used to identify relationships CALLY MetS, as well its components. Of participants, 2,086 diagnosed with MetS. estimated prevalence decreased an increase in (P < 0.001). Multivariable analysis showed odds ratio was 0.25 (95% confidence interval 0.20-0.32, P 0.001) highest quartile compared lowest after adjusting for confounding variables. RCS revealed non-linear or inverse risk. might be valuable identifying who are at high risk Not applicable.

Language: Английский

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Sex hormones, the anticancer immune response, and therapeutic opportunities

Cancer Cell, Journal Year: 2025, Volume and Issue: 43(3), P. 343 - 360

Published: March 1, 2025

SummarySex-based differences have been observed in the incidence and prognosis of various cancers, as well response to immune check point inhibitors (ICIs). These disparities are partially attributed sex-based molecular characteristics anticancer response, which largely influenced by sex hormones. Here, we provide a comprehensive overview on how hormones affect innate adaptive immunity contribute shaping features tumor microenvironment immunotherapy. We also discuss promising potential challenges combining hormone manipulation with immunotherapy new therapeutic strategy. surmise that perspective should be part precision medicine approaches, provides opportunities for innovative approaches.

Language: Английский

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Novel Insight into the Mechanisms of the Bidirectional Relationship between Diabetes and Periodontitis

Biomedicines, Journal Year: 2022, Volume and Issue: 10(1), P. 178 - 178

Published: Jan. 16, 2022

Periodontitis and diabetes are two major global health problems despite their prevalence being significantly underreported underestimated. Both epidemiological intervention studies show a bidirectional relationship between periodontitis diabetes. The hypothesis of potential causal link the diseases is corroborated by recent in experimental animals that identified mechanisms whereby can adversely affect each other. Herein, we will review clinical data on existence two-way discuss possible mechanistic interactions both directions, focusing particular new highlighting importance host response. Moreover, address trained immunity may represent unifying mechanism explaining intertwined association periodontitis. Achieving better insight clustering infectious, inflammatory, metabolic provide therapeutic options to reduce risk diabetes-associated comorbidities.

Language: Английский

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How inflammation dictates diabetic peripheral neuropathy: An enlightening review

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(4)

Published: Oct. 5, 2023

Diabetic peripheral neuropathy (DPN) constitutes a debilitating complication associated with diabetes. Although, the past decade has seen rapid developments in understanding complex etiology of DPN, there are no approved therapies that can halt development or target damaged nerve. Therefore, clarifying pathogenesis DPN and finding effective treatment crucial issues for clinical management DPN.

Language: Английский

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Association between periodontitis and inflammatory comorbidities: The common role of innate immune cells, underlying mechanisms and therapeutic targets

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 128, P. 111558 - 111558

Published: Jan. 23, 2024

Language: Английский

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The cGAS-STING pathway: a therapeutic target in diabetes and its complications

Burns & Trauma, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 1, 2024

Diabetic wound healing (DWH) represents a major complication of diabetes where inflammation is key impediment to proper healing. The cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) signaling pathway has emerged as central mediator inflammatory responses cell stress and damage. However, the contribution cGAS-STING activation impaired in DWH remains understudied. In this review, we examine evidence that cGAS-STING-driven critical factor underlying defective DWH. We summarize studies revealing upregulation diabetic wounds discuss how exacerbates senescence disrupts cellular metabolism block Partial pharmaceutical inhibition shown promise damping improving preclinical models. highlight knowledge gaps regarding DWH, including its relationships with endoplasmic reticulum metal-ion signaling. Elucidating these mechanisms may unveil new therapeutic targets within improve outcomes This review synthesizes current understanding contributes pathology proposes future research directions exploit modulation for benefit.

Language: Английский

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Health Benefits of Vegetarian Diets: An Insight into the Main Topics

Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2398 - 2398

Published: July 29, 2024

Vegetarian diets are plant-based including all the edible foods from Plant Kingdom, such as grains, legumes, vegetables, fruits, nuts, and seeds. Dairy eggs can be added in small amounts lacto-ovo-vegetarian subtype, or not at vegan subtype. The abundance of non-processed plant foods-typical well-planned diets, vegetarian ones-can provide body with numerous protective factors (fiber, phytocompounds), while limiting intake harmful nutrients like saturated fats, heme-iron, cholesterol. beneficial effects on health this balance have been reported for many main chronic diseases, both observational intervention studies. scientific literature indicates that vegetarians a lower risk certain types cancer, overall overweight-obesity, type 2 diabetes, dyslipidemia, hypertension, vascular diseases. Since trend following diet is increasing among citizens developed countries, knowledge field will benefit further studies confirming consistency these findings clarifying other controversial topics.

Language: Английский

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