Longitudinal associations between adolescents’ individualised risk for depression and inflammation in a UK cohort study DOI Creative Commons
Rachel M. Latham, Christian Kieling, Louise Arseneault

et al.

Brain Behavior and Immunity, Journal Year: 2022, Volume and Issue: 101, P. 78 - 83

Published: Jan. 3, 2022

Inflammation is associated with poor physical and mental health including major depressive disorder (MDD). Moreover, there evidence that childhood adversity – a risk factor for MDD becomes biologically embedded via elevated inflammation. However, the of developing arises from multiple sources yet has been little investigation links between individuals' constellation subsequent We therefore examined associations individual calculated in early adolescence levels inflammation six years later. use data Environmental Risk (E-Risk) Longitudinal Twin Study, nationally representative UK birth cohort 2,232 children followed to age 18 93% retention. Participants' future was at 12 using recently developed prediction model comprising psychosocial factors. Plasma three biomarkers were measured 18: C-reactive protein (CRP), interleukin-6 (IL-6), newer biomarker, soluble urokinase plasminogen activator receptor (suPAR), which thought reflect level systemic chronic scores positively suPAR (but not CRP or IL-6) after adjusting key covariates (b = 1.70, 95% CI 0.46 2.95, p 0.007). Adolescents high (risk ≥ 90th centile) had significantly higher mean later than adolescents who identified as low ≤ 10th 0.41, 0.18 0.64, < 0.001). Findings support notion leads increased low-grade If replicated studies repeated assessments throughout adolescence, these findings would targeted interventions reduce inflammation, by suPAR, potentially prevent development depression problems related

Language: Английский

Early suPAR levels as a predictor of COVID-19 severity: A new tool for efficient patient triage DOI Creative Commons

Pauline Nègre,

Didier Tayac,

Thibaut Jamme

et al.

Infectious Diseases Now, Journal Year: 2025, Volume and Issue: 55(4), P. 105058 - 105058

Published: March 16, 2025

Language: Английский

Citations

2
Metal‐Based Nanozymes with Multienzyme‐Like Activities as Therapeutic Candidates: Applications, Mechanisms, and Optimization Strategy DOI
Dan Li, Danni Dai,

Gege Xiong

et al.

Small, Journal Year: 2022, Volume and Issue: 19(7)

Published: Dec. 13, 2022

Most nanozymes in development for medical applications only exhibit single-enzyme-like activity, and are thus limited by insufficient catalytic activity dysfunctionality complex pathological microenvironments. To overcome the impediments of substrate availabilities concentrations, some metal-based may mimic two or more activities natural enzymes to catalyze cascade reactions multiple substrates simultaneously, thereby amplifying catalysis. Metal-based with multienzyme-like (MNMs) adapt dissimilar conditions exert different enzyme-like effects. These can synergize realize "self-provision substrate," which upstream catalysts produce downstream limitation microenvironment. Consequently, MNMs potent antitumor, antibacterial, anti-inflammatory effects preclinical models. This review summarizes cellular underlying mechanisms MNMs. Their potential utility optimization strategy from perspective clinical requirements also discussed, aim provide a theoretical reference design, development, therapeutic application their

Language: Английский

Citations

57
Monocyte-to-lymphocyte ratio predicts mortality and cardiovascular mortality in the general population DOI
Hua Yang,

Jin-Yu Sun,

Yu-Xuan Lou

et al.

International Journal of Cardiology, Journal Year: 2023, Volume and Issue: 379, P. 118 - 126

Published: March 9, 2023

Language: Английский

Citations

36
Endotheliopathy in Acute COVID-19 and Long COVID DOI Open Access
Alice G. Vassiliou, Charikleia S. Vrettou, Chrysi Keskinidou

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8237 - 8237

Published: May 4, 2023

The pulmonary endothelium is a highly regulated organ that performs wide range of functions under physiological and pathological conditions. Since endothelial dysfunction has been demonstrated to play direct role in sepsis acute respiratory distress syndrome, its COVID-19 also extensively investigated. Indeed, apart from the COVID-19-associated coagulopathy biomarkers, new biomarkers were recognised early during pandemic, including markers cell activation or injury. We systematically searched literature up 10 March 2023 for studies examining association between long severity outcomes biomarkers.

Language: Английский

Citations

33
The uPA/uPAR System Orchestrates the Inflammatory Response, Vascular Homeostasis, and Immune System in Fibrosis Progression DOI Open Access
Yosuke Kanno

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1796 - 1796

Published: Jan. 16, 2023

Fibrotic diseases, such as systemic sclerosis (SSc), idiopathic pulmonary fibrosis, renal fibrosis and liver cirrhosis are characterized by tissue overgrowth due to excessive extracellular matrix (ECM) deposition. Fibrosis progression is caused ECM overproduction the inhibition of degradation several events, including inflammation, vascular endothelial dysfunction, immune abnormalities. Recently, it has been reported that urokinase plasminogen activator (uPA) its receptor (uPAR), known be fibrinolytic factors, orchestrate inflammatory response, homeostasis, homeostasis system. The uPA/uPAR system may show promise a potential therapeutic target for fibrotic diseases. This review considers role in

Language: Английский

Citations

31
The General Factor of Psychopathology (p): Choosing Among Competing Models and Interpreting p DOI Creative Commons
Avshalom Caspi, Renate Houts, Helen L. Fisher

et al.

Clinical Psychological Science, Journal Year: 2023, Volume and Issue: 12(1), P. 53 - 82

Published: May 3, 2023

Over the past 10 years, general factor of psychopathology, p, has attracted interest and scrutiny. We review history idea that all mental disorders share something in common, p; how we arrived at this idea; it became conflated with a statistical representation, Bi-Factor Model. then leverage Environmental Risk (E-Risk) longitudinal twin study to examine properties nomological network different representations p. find p performed similarly regardless was modelled, suggesting if sample content are same resulting will be similar. suggest meaning is not found by dueling over models but conducting well-specified criterion-validation studies developing new measurement approaches. outline directions refresh research efforts uncover what have common.

Language: Английский

Citations

28
Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood DOI Creative Commons
Timothy Matthews, Line Jee Hartmann Rasmussen, Antony Ambler

et al.

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 115, P. 727 - 736

Published: Nov. 21, 2023

Social isolation and loneliness have been associated with poor health increased risk for mortality, inflammation might explain this link. We used data from the Danish TRIAGE Study of acutely admitted medical patients (N = 6,144, mean age 60 years), two population-representative birth cohorts: New Zealand Dunedin Longitudinal 881, 45) UK Environmental Risk (E-Risk) Twin 1448, 18), to investigate associations social three markers systemic inflammation: C-reactive protein (CRP), interleukin-6 (IL-6), a newer marker, soluble urokinase plasminogen activator receptor (suPAR), which is thought index chronic inflammation. In Study, socially isolated (those living alone) had significantly higher median levels suPAR (but not CRP or IL-6) compared by themselves. prospectively measured in childhood was longitudinally CRP, IL-6, adulthood (at 45 18 E-Risk Study), but only remained after controlling covariates. participants who reported at 38 elevated 45. contrast, reporting did show any conclusion, robustly adulthood, both general population. It particular inflammation, evident consistently stronger than other biomarkers.

Language: Английский

Citations

27
suPAR links a dysregulated immune response to tissue inflammation and sepsis-induced acute kidney injury DOI Creative Commons
Christian Nußhag, Changli Wei, Eunsil Hahm

et al.

JCI Insight, Journal Year: 2023, Volume and Issue: 8(7)

Published: April 9, 2023

Acute kidney injury (AKI) secondary to sepsis results in poor outcomes and conventional function indicators lack diagnostic value. Soluble urokinase plasminogen activator receptor (suPAR) is an innate immune-derived molecule implicated inflammatory organ damage. We characterized the ability of longitudinal serum suPAR levels discriminate severity course sepsis-induced AKI (SI-AKI) 200 critically ill patients meeting Sepsis-3 criteria. The pathophysiologic relevance varying SI-AKI was explored a polymicrobial model WT, (s)uPAR-knockout, transgenic suPAR-overexpressing mice. At all time points studied, provided robust classification disease severity, with improved prediction renal replacement therapy (RRT) mortality compared established biomarkers. Patients greater than 12.7 ng/mL were at highest risk for RRT or death, adjusted odds ratio 7.48 (95% CI, 3.00-18.63). deficiency protected mice against SI-AKI. exhibited damage poorer survival through inflamed kidneys, accompanied by local upregulation potent chemoattractants pronounced T cell infiltration. Hence, allows function-independent staging offers stratification. promotes cell-based inflammation, while improves

Language: Английский

Citations

25
Urokinase-Type Plasminogen Activator Receptor (uPAR) in Inflammation and Disease: A Unique Inflammatory Pathway Activator DOI Creative Commons

Mostafa Hamada,

Kyle Varkoly,

Omer Riyadh

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1167 - 1167

Published: May 24, 2024

The urokinase-type plasminogen activator receptor (uPAR) is a unique protease binding receptor, now recognized as key regulator of inflammation. Initially, uPA/uPAR was considered thrombolytic (clot-dissolving); however, recent studies have demonstrated its predominant immunomodulatory functions in inflammation and cancer. complex has multifaceted central role both normal physiological also pathological responses. uPAR expressed glycophosphatidylinositol (GPI)-linked interacting with vitronectin, integrins, G protein-coupled receptors, growth factor receptors within large lipid raft. Through protein-to-protein interactions, cell surface modulates intracellular signaling, altering cellular adhesion migration. modifies extracellular activity, activating to form plasmin, which breaks down fibrin, dissolving clots matrix metalloproteinases that lyse connective tissue, allowing immune cancer invasion releasing factors. biomarker for inflammatory diseases cancer; soluble fragments (suPAR) are increased viral sepsis (COVID-19), bowel disease, metastasis. Here, we provide comprehensive overview the structure, function, current examining suPAR diagnostic markers therapeutic targets. Understanding developing ongoing development antibody, small-molecule, nanogel, virus-derived immune-modulating treatments target uPAR.

Language: Английский

Citations

12
Mechanisms Underlying Vascular Inflammaging: Current Insights and Potential Treatment Approaches DOI Creative Commons
Ying Zeng, Francesco Buonfiglio, Jingyan Li

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Inflammaging refers to chronic, low-grade inflammation that becomes more common with age and plays a central role in the pathophysiology of various vascular diseases. Key inflammatory mediators involved inflammaging contribute endothelial dysfunction accelerate progression atherosclerosis. In addition, specific pathological mechanisms inflammasomes have emerged as critical drivers immune responses within vasculature. A comprehensive understanding these processes may lead innovative treatment strategies could significantly improve management age-related Emerging therapeutic approaches, including cytokine inhibitors, senolytics, specialized pro-resolving mediators, aim counteract restore health. This review seeks provide an in-depth exploration molecular pathways underlying highlight potential interventions.

Language: Английский

Citations

1