Published: Jan. 1, 2025
Language: Английский
Animal Models and Experimental Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
Neurodegenerative diseases (NDs), including Alzheimer's disease, Parkinson's and Huntington's are complex challenging due to their intricate pathophysiology limited treatment options. This review systematically sourced articles related neurodegenerative diseases, neurodegeneration, quercetin, clinical studies from primary medical databases, Scopus, PubMed, Web of Science. Recent have included quercetin impact the cellular molecular pathways involved in neurodegeneration. Quercetin, a flavonoid abundant vegetables fruits, is gaining attention for its antioxidant, anti-inflammatory, antiapoptotic properties. It regulates signaling such as nuclear factor-κB (NF-κB), sirtuins, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt). These essential survival, inflammation regulation, apoptosis. Preclinical shown that improves symptoms pathology models, indicating promising outcomes. The study explores potential incorporating laboratory research into practical treatment, focusing on quercetin's neuroprotective effects NDs optimal dosage.
Language: Английский
Citations
1
Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: Feb. 10, 2025
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Aug. 4, 2023
Background Neuroinflammation has been reported as a potential contributing factor to brain diseases, and is characterized by activated microglia with release of multiple inflammatory mediators. 2,3,5,6-Tetramethylpyrazine (TMP) an active alkaloid in Ligusticum chuanxiong Hort. various biological activities, including anti-inflammatory neuroprotection properties. However, the anti-neuroinflammatory activity TMP less studied its molecular mechanisms this field remain unclear. This study aimed investigate effects underlying neuroinflammation. Methods In vitro , lipopolysaccharide (LPS)-stimulated BV2 were used assess on cytokines well components SIRT1/NF-κB signaling pathway, which measured using ELISA, western blotting, qRT-qPCR immunofluorescence. Moreover, LPS-induced acute neuroinflammation model mice was performed detect whether could exert vivo EX527, SIRT1 inhibitor, given intraperitoneally every two days prior treatment. Serums spinal trigeminal nucleus (Sp5) tissues collected for ELISA assay, Sp5 HE staining, Nissl immunofluorescence, qRT-PCR blotting. Results treatment significantly reduced secretion pro-inflammatory cytokines, TNF-α IL-6, promoted protein expression inactivated NF-κB pathway Interestingly, pretreatment EX527 blocked therapeutic . Furthermore, levels chemokines, prevented from polarizing towards state through activating inhibiting activation mice. And reversed beneficial against LPS exposure Conclusion summary, unravels that mitigate via pathway.
Language: Английский
Citations
17
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 512 - 512
Published: April 16, 2024
The incidence of depression has been steadily rising in recent years, making it one the most prevalent mental illnesses. As pursuit novel antidepressant drugs captivates pharmaceutical field, therapeutic efficacy Traditional Chinese Medicine (TCM) widely explored. Chaihu (
Language: Английский
Citations
8
Aging and Disease, Journal Year: 2023, Volume and Issue: 15(2), P. 739 - 739
Published: Aug. 2, 2023
Neuroinflammation, characterized by the secretion of abundant inflammatory mediators, pro-inflammatory polarization microglia, and recruitment infiltrating myeloid cells to foci inflammation, drives or exacerbates pathological processes central nervous system disorders, especially in neurodegenerative diseases. Autophagy plays an essential role neuroinflammatory processes, underlaying physiological mechanisms are closely correlated with neuroinflammation-related signals. Inhibition mTOR activation AMPK FOXO1 enhance autophagy thereby suppress NLRP3 inflammasome activity apoptosis, leading relief response. And mitigates neuroinflammation mainly manifested promoting microglia from a anti-inflammatory state, reducing production up-regulating levels factors. Notably, epigenetic modifications intimately associated onset progression various brain Non-coding RNAs, including microRNAs, circular RNAs long noncoding histone acetylation have been reported adjust autophagy-related gene protein expression alleviate inflammation neurological The present review primarily focuses on responses, as well reveal potential therapeutic targets
Language: Английский
Citations
16
Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(41), P. 14890 - 14910
Published: Oct. 6, 2023
Flavonoids and their glycosides are abundant in many plant-based foods. The (de)glycosylation of flavonoids by retaining glycoside hydrolases has recently attracted much interest basic applied research, including the possibility altering glycosylation pattern flavonoids. Research this area is driven significant differences physicochemical, organoleptic, bioactive properties between flavonoid aglycones glycosylated counterparts. While present nature at low levels, some occur substantial quantities, making them readily available low-cost glycosyl donors for transglycosylations. Retaining glycosidases can be used to synthesize natural novel glycosides, which serve as standards bioactivity experiments analyses, using donors. Engineered also prove valuable synthesis chemically synthesized activated This review outlines bioactivities highlights applications context acting substrates, products, or deglycosylation transglycosylation reactions.
Language: Английский
Citations
16
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112936 - 112936
Published: Aug. 19, 2024
Language: Английский
Citations
5
Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156069 - 156069
Published: Sept. 17, 2024
Language: Английский
Citations
5
Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16
Published: Dec. 4, 2024
Flavonoids, a class of polyphenolic compounds, are widely distributed in plant-based foods and have been recognized for their potential to promote overall health well-being. Flavonoids fruits vegetables offer various beneficial effects such as anti-aging, anticancer, anti-inflammatory properties. extensively studied neuroprotective properties, which attributed ability cross the blood-brain barrier interact with neural cells. Factors like gut microbiota composition, age, genetics, diet can impact how well flavonoids absorbed gut. The enhance absorption through enzymatic processes, making composition key factor influenced by diet. modulate prebiotic antimicrobial effects, affecting production microbial metabolites short-chain fatty acids (SCFAs) butyrate, play role brain function health. microbiome also modulates immune system, is critical preventing neuroinflammation. Additionally, benefit mental psychological influencing signaling pathways cells increasing tyrosine tryptophan, precursors neurotransmitters serotonin, dopamine, norepinephrine, adrenaline, gamma-aminobutyric acid (GABA). flavonoid-gut axis complex multifaceted relationship that has significant implications neurological This review will explore genetic environmental factors flavonoid positive on network.
Language: Английский
Citations
5
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2023, Volume and Issue: 1870(3), P. 166992 - 166992
Published: Dec. 19, 2023
Language: Английский
Citations
13