Baicalin and Kaempferol Alleviates Cuprizone-Induced Demyelination and Microglial Activation by Inhibiting the Stat3 and Nf-Κb Signaling Pathways DOI
Liming Liu, Yufang Zhao,

Jingjing Bu

et al.

Published: Jan. 1, 2025

Language: Английский

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection DOI Creative Commons
Md. Rezaul Islam,

Md Al-Imran,

Mehrukh Zehravi

et al.

Animal Models and Experimental Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Neurodegenerative diseases (NDs), including Alzheimer's disease, Parkinson's and Huntington's are complex challenging due to their intricate pathophysiology limited treatment options. This review systematically sourced articles related neurodegenerative diseases, neurodegeneration, quercetin, clinical studies from primary medical databases, Scopus, PubMed, Web of Science. Recent have included quercetin impact the cellular molecular pathways involved in neurodegeneration. Quercetin, a flavonoid abundant vegetables fruits, is gaining attention for its antioxidant, anti-inflammatory, antiapoptotic properties. It regulates signaling such as nuclear factor-κB (NF-κB), sirtuins, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt). These essential survival, inflammation regulation, apoptosis. Preclinical shown that improves symptoms pathology models, indicating promising outcomes. The study explores potential incorporating laboratory research into practical treatment, focusing on quercetin's neuroprotective effects NDs optimal dosage.

Language: Английский

Citations

1

Natural drug delivery systems for the treatment of neurodegenerative diseases DOI
Greta Kaspute, Arūnas Ramanavičius,

Urtė Prentice

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 10, 2025

Language: Английский

Citations

1

SIRT1 activation by 2,3,5,6-tetramethylpyrazine alleviates neuroinflammation via inhibiting M1 microglia polarization DOI Creative Commons
Yu Chen,

Fu Peng,

Chao Yang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 4, 2023

Background Neuroinflammation has been reported as a potential contributing factor to brain diseases, and is characterized by activated microglia with release of multiple inflammatory mediators. 2,3,5,6-Tetramethylpyrazine (TMP) an active alkaloid in Ligusticum chuanxiong Hort. various biological activities, including anti-inflammatory neuroprotection properties. However, the anti-neuroinflammatory activity TMP less studied its molecular mechanisms this field remain unclear. This study aimed investigate effects underlying neuroinflammation. Methods In vitro , lipopolysaccharide (LPS)-stimulated BV2 were used assess on cytokines well components SIRT1/NF-κB signaling pathway, which measured using ELISA, western blotting, qRT-qPCR immunofluorescence. Moreover, LPS-induced acute neuroinflammation model mice was performed detect whether could exert vivo EX527, SIRT1 inhibitor, given intraperitoneally every two days prior treatment. Serums spinal trigeminal nucleus (Sp5) tissues collected for ELISA assay, Sp5 HE staining, Nissl immunofluorescence, qRT-PCR blotting. Results treatment significantly reduced secretion pro-inflammatory cytokines, TNF-α IL-6, promoted protein expression inactivated NF-κB pathway Interestingly, pretreatment EX527 blocked therapeutic . Furthermore, levels chemokines, prevented from polarizing towards state through activating inhibiting activation mice. And reversed beneficial against LPS exposure Conclusion summary, unravels that mitigate via pathway.

Language: Английский

Citations

17

Bupleurum in Treatment of Depression Disorder: A Comprehensive Review DOI Creative Commons
Shuzhen Ran, Rui Peng,

Qingwan Guo

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 512 - 512

Published: April 16, 2024

The incidence of depression has been steadily rising in recent years, making it one the most prevalent mental illnesses. As pursuit novel antidepressant drugs captivates pharmaceutical field, therapeutic efficacy Traditional Chinese Medicine (TCM) widely explored. Chaihu (

Language: Английский

Citations

8

Autophagy in Neuroinflammation: A Focus on Epigenetic Regulation DOI Creative Commons
Yu Chen, Junren Chen, Ziwei Xing

et al.

Aging and Disease, Journal Year: 2023, Volume and Issue: 15(2), P. 739 - 739

Published: Aug. 2, 2023

Neuroinflammation, characterized by the secretion of abundant inflammatory mediators, pro-inflammatory polarization microglia, and recruitment infiltrating myeloid cells to foci inflammation, drives or exacerbates pathological processes central nervous system disorders, especially in neurodegenerative diseases. Autophagy plays an essential role neuroinflammatory processes, underlaying physiological mechanisms are closely correlated with neuroinflammation-related signals. Inhibition mTOR activation AMPK FOXO1 enhance autophagy thereby suppress NLRP3 inflammasome activity apoptosis, leading relief response. And mitigates neuroinflammation mainly manifested promoting microglia from a anti-inflammatory state, reducing production up-regulating levels factors. Notably, epigenetic modifications intimately associated onset progression various brain Non-coding RNAs, including microRNAs, circular RNAs long noncoding histone acetylation have been reported adjust autophagy-related gene protein expression alleviate inflammation neurological The present review primarily focuses on responses, as well reveal potential therapeutic targets

Language: Английский

Citations

16

Flavonoids as Aglycones in Retaining Glycosidase-Catalyzed Reactions: Prospects for Green Chemistry DOI Creative Commons
Michael Kotik, Natalia Kulik, Kateřina Valentová

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(41), P. 14890 - 14910

Published: Oct. 6, 2023

Flavonoids and their glycosides are abundant in many plant-based foods. The (de)glycosylation of flavonoids by retaining glycoside hydrolases has recently attracted much interest basic applied research, including the possibility altering glycosylation pattern flavonoids. Research this area is driven significant differences physicochemical, organoleptic, bioactive properties between flavonoid aglycones glycosylated counterparts. While present nature at low levels, some occur substantial quantities, making them readily available low-cost glycosyl donors for transglycosylations. Retaining glycosidases can be used to synthesize natural novel glycosides, which serve as standards bioactivity experiments analyses, using donors. Engineered also prove valuable synthesis chemically synthesized activated This review outlines bioactivities highlights applications context acting substrates, products, or deglycosylation transglycosylation reactions.

Language: Английский

Citations

16

Targeting STAT3 signaling pathway in the treatment of Alzheimer’s disease with compounds from natural products DOI

Xiyue Wen,

Jinyue Hu

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112936 - 112936

Published: Aug. 19, 2024

Language: Английский

Citations

5

SIRT1 activation by Ligustrazine ameliorates migraine via the paracrine interaction of microglia and neurons DOI
Yu Chen, Ziwei Xing, Junren Chen

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156069 - 156069

Published: Sept. 17, 2024

Language: Английский

Citations

5

Flavonoids and the gut microbiome: a powerful duo for brain health DOI

Soroush Taherkhani,

Parisa Ahmadi, Leila Roozbeh Nasiraie

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16

Published: Dec. 4, 2024

Flavonoids, a class of polyphenolic compounds, are widely distributed in plant-based foods and have been recognized for their potential to promote overall health well-being. Flavonoids fruits vegetables offer various beneficial effects such as anti-aging, anticancer, anti-inflammatory properties. extensively studied neuroprotective properties, which attributed ability cross the blood-brain barrier interact with neural cells. Factors like gut microbiota composition, age, genetics, diet can impact how well flavonoids absorbed gut. The enhance absorption through enzymatic processes, making composition key factor influenced by diet. modulate prebiotic antimicrobial effects, affecting production microbial metabolites short-chain fatty acids (SCFAs) butyrate, play role brain function health. microbiome also modulates immune system, is critical preventing neuroinflammation. Additionally, benefit mental psychological influencing signaling pathways cells increasing tyrosine tryptophan, precursors neurotransmitters serotonin, dopamine, norepinephrine, adrenaline, gamma-aminobutyric acid (GABA). flavonoid-gut axis complex multifaceted relationship that has significant implications neurological This review will explore genetic environmental factors flavonoid positive on network.

Language: Английский

Citations

5

The role of astrocyte in neuroinflammation in traumatic brain injury DOI Creative Commons
Liang He, Ruqiang Zhang,

Maiqiao Yang

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2023, Volume and Issue: 1870(3), P. 166992 - 166992

Published: Dec. 19, 2023

Language: Английский

Citations

13