Natural Product Communications,
Journal Year:
2023,
Volume and Issue:
18(7)
Published: July 1, 2023
Macrophages
are
the
primary
immune
cells
in
tumor
microenvironment,
where
they
exhibit
immunosuppressive
M2
phenotype
to
support
development.
Reshaping
tumor-associated
macrophages
(TAMs)
into
antitumor
M1
is
a
promising
approach
immunotherapy.
We
had
previously
demonstrated
that
high-purity
homogeneous
Sambucus
adnata
wall
polysaccharide
SPS-1
isolated
from
S.
exerted
good
immunoregulatory
effect.
In
present
study,
we
explored
whether
can
remodel
TAMs
and
inhibit
development
of
lung
cancer.
mouse
model
transplanted
with
Lewis
cancer,
promoted
apoptosis
inhibited
angiogenesis
tissues
by
remodeling
microenvironment
macrophages,
which
effective
effects.
Therefore,
may
be
used
as
novel
immunostimulator
immunotherapy,
our
study
also
provides
pathway
material
for
reshaping
defense
prevent
treat
tumors.
Phytomedicine,
Journal Year:
2024,
Volume and Issue:
129, P. 155564 - 155564
Published: March 23, 2024
The
incidence
of
ulcerative
colitis
(UC)
is
on
the
rise
globally
and
development
drugs
targeting
UC
urgent.
Finding
target
action
natural
products
important
for
drug
discovery,
elucidation
mechanism,
disease
mechanism.
San-Ye-Qing
(SYQ),
an
ancient
herbal
medicine,
but
whether
powder
its
rhizome
has
pharmacological
effects
against
mechanism
are
not
clear.
Journal of Functional Foods,
Journal Year:
2024,
Volume and Issue:
114, P. 106065 - 106065
Published: Feb. 12, 2024
The
aim
of
this
study
was
to
investigate
the
effects
Phyllanthus
Emblica
polysaccharide
(PEP)
on
immunomodulation
and
intestinal
flora
in
cyclophosphamide
(CTX)-treated
female
mice.
results
showed
that
PEP
could
directly
modulate
immune
activity
(CTX)
mice
by
attenuating
its
damage
spleen,
thymus
tissues.
Meanwhile,
our
revealed
activate
TLR4-mediated
MAPK
NF-κB
pathways
promote
expression
cytokines
such
as
IL-2
TNF-α,
thus
modulating
function
immunosuppressed
In
addition,
positively
correlated
with
properties,
strongest
correlation
spleen
index,
also
regulate
flora,
increasing
content
Lactobacillus
Bifidobacterium.
Therefore,
may
be
a
potential
novel
immunomodulator
ameliorate
CTX-induced
immunosuppression
dysregulation.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 21, 2024
Polysaccharides
are
generally
considered
to
have
immune
enhancing
functions,
and
mulberry
leaf
polysaccharide
is
the
main
active
substance
in
leaves,
while
there
few
studies
on
whether
(MLP)
has
an
effect
immunosuppression
intestinal
damage
caused
by
cyclophosphamide
(CTX),
we
investigated
MLP
ameliorative
CTX.
A
total
of
210
1-day-old
Mahuang
cocks
were
selected
for
this
experiment.
Were
equally
divided
into
six
groups
used
evaluate
MLP.
Our
results
showed
that
significantly
enhanced
growth
performance
chicks
elevated
secretion
cytokines
(IL-1β,
IL-10,
IL-6,
TNF-α,
IFN-γ),
immunoglobulins
antioxidant
enzymes
serum
immunosuppressed
chicks.
It
attenuated
jejunal
expression
tight
junction
proteins
Claudin1,
Zo-1
MUC2,
which
protected
health.
activated
TLR4-MyD88-NF-κB
pathway
TLR4,
MyD88
NF-κB,
served
protect
intestine.
16S
rDNA
gene
high-throughput
sequencing
increased
species
richness,
restored
CTX-induced
gut
microbiome
imbalance,
abundance
probiotic
bacteria
gut.
improves
cyclophosphamide-induced
inhibition
modulating
flora
regulation
capacity.
In
conclusion,
study
provides
a
scientific
basis
as
enhancer
regulate
chick
mucosal
damage.
