Research in Pharmaceutical Sciences,
Journal Year:
2025,
Volume and Issue:
20(1), P. 1 - 24
Published: Jan. 1, 2025
Individuals
with
inflammatory
bowel
disease
(IBD)
are
at
a
higher
risk
of
developing
mental
disorders,
such
as
anxiety
and
depression.
The
imbalance
between
the
intestinal
microbiota
its
host,
known
dysbiosis,
is
one
factors,
disrupting
balance
metabolite
production
their
signaling
pathways,
leading
to
progression.
A
metabolomics
approach
can
help
identify
role
gut
in
disorders
associated
IBD
by
evaluating
metabolites
comprehensively.
This
narrative
review
focuses
on
studies
that
have
comprehensively
elucidated
altered
microbial
pathways
underlying
patients.
information
was
compiled
searching
PubMed,
Web
Science,
Scopus,
Google
Scholar
from
2005
2023.
findings
indicated
dysbiosis
patients
leads
depression
through
disturbances
metabolism
carbohydrates,
sphingolipids,
bile
acids,
neurotransmitters,
neuroprotective,
amino
acids.
Furthermore,
reduction
neuroprotective
factors
increase
inflammation
observed
these
also
contribute
worsening
psychological
symptoms.
Analyzing
profile
comparing
it
healthy
individuals
using
advanced
technologies
like
metabolomics,
aids
early
diagnosis
prevention
disorders.
allows
for
more
precise
identification
microbes
responsible
production,
enabling
development
tailored
dietary
pharmaceutical
interventions
or
targeted
manipulation
microbiota.
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: June 19, 2023
Cognitive
function
in
humans
depends
on
the
complex
and
interplay
between
multiple
body
systems,
including
hypothalamic-pituitary-adrenal
(HPA)
axis.
The
gut
microbiota,
which
vastly
outnumbers
human
cells
has
a
genetic
potential
that
exceeds
of
genome,
plays
crucial
role
this
interplay.
microbiota-gut-brain
(MGB)
axis
is
bidirectional
signalling
pathway
operates
through
neural,
endocrine,
immune,
metabolic
pathways.
One
major
neuroendocrine
systems
responding
to
stress
HPA
produces
glucocorticoids
such
as
cortisol
corticosterone
rodents.
Appropriate
concentrations
are
essential
for
normal
neurodevelopment
function,
well
cognitive
processes
learning
memory,
studies
have
shown
microbes
modulate
throughout
life.
Stress
can
significantly
impact
MGB
via
other
Animal
research
advanced
our
understanding
these
mechanisms
pathways,
leading
paradigm
shift
conceptual
thinking
about
influence
microbiota
health
disease.
Preclinical
trials
currently
underway
determine
how
animal
models
translate
humans.
In
review
article,
we
summarize
current
knowledge
relationship
axis,
cognition,
provide
an
overview
main
findings
conclusions
broad
field.
BMC Complementary Medicine and Therapies,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 13, 2025
The
human
microbiome
plays
a
vital
role
in
health,
mediated
by
the
gut–brain
axis,
with
large
diversity
of
functions
and
physiological
benefits.
dynamics
mechanisms
meditations
on
oral
gut
modulations
are
not
well
understood.
This
study
investigates
short-term
during
an
Arhatic
Yoga
meditation
retreat
as
improving
well-being
through
possible
gut-brain
axis.
A
single-arm
pilot
clinical
trial
was
conducted
controlled
environment
9-day
intensive
practices
vegetarian
diet.
Oral
fecal
samples
24
practitioners
were
collected
at
start
(Day0:
T1),
middle
(Day3:
T2),
end
(Day9:T3)
retreat.
Targeted
16S
rRNA
gene
amplicon
sequencing
performed
for
both
samples.
Functional
pathway
predictions
identified
using
phylogenetic
investigation
communities
reconstruction
unobserved
states
(PICRUSt2).
DESeq2
used
to
identify
differential
abundant
taxa.
Various
statistical
analyses
assess
significant
changes
data.
Our
findings
revealed
that
together
diet
led
profiles
within
profile
showed
(p
<
0.05)
difference
species
richness
evenness
study,
while
non-metric
multidimensional
scaling
(NMDS)
confirmed
shift
T2
timepoint,
which
further
supported
PERMANOVA
analysis
0.05).
Health-benefiting
microbes
known
improve
gastrointestinal
gut-barrier
functions,
immune
modulation,
axis
enriched.
Gut
beginner
advanced
similar
trends
convergence
study.
implies
strong
selection
pressure
beneficial
microbiome.
demonstrates
combined
short
resulted
enrichment
health-promoting
microbes.
Such
microbial
consortia
may
be
developed
potential
health
benefits
probiotics
systems,
Study
submitted
https://clinicaltrials.gov/on28-02-2024
.
Retrospective
registered.
Neurobiology of Disease,
Journal Year:
2024,
Volume and Issue:
191, P. 106396 - 106396
Published: Jan. 2, 2024
Studies
from
rodents
to
primates
and
humans
indicate
that
individuals
vary
in
how
resilient
they
are
stress,
understanding
the
basis
of
these
variations
may
help
improve
treatments
for
depression.
Here
we
explored
potential
contribution
gut
microbiome
such
variation.
Mice
were
exposed
chronic
unpredictable
mild
stress
(CUMS)
4
weeks
then
allowed
recover
3
weeks,
after
which
subjected
behavioral
tests
categorized
as
showing
low
or
high
resilience.
The
two
types
mouse
compared
terms
hippocampal
gene
expression
using
RNA
sequencing,
fecal
microbiomes
16S
extent
neurogenesis
hippocampus
immunostaining
brain
sections.
Fecal
microbiota
transplanted
either
type
into
previously
stress-exposed
stress-naïve
animals,
effects
transplantation
on
stress-induced
behaviors
examined.
Finally,
blocked
temozolomide
explore
role
promoted
by
enhancing
resilience
stress.
Results
showed
highly
stress-resilient
mice,
but
not
those
with
resilience,
improved
significantly
measures
anhedonia,
despair,
anxiety
3-week
recovery
CUMS.
Their
feces
greater
abundance
Lactobacillus,
Bifidobacterium
Romboutsia
than
mice
well
lower
Staphylococcus,
Psychrobacter
Corynebacterium.
Similarly,
animals
Transplanting
CUMS-exposed
recipients
rescued
hippocampus,
facilitating
depression
cognitive
decline.
Blockade
abolished
CUMS-induced
decline
In
conclusion,
our
results
suggested
remodeling
reverse
impairment
thereby
promote
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 30, 2024
The
specific
pathogenesis
of
UC
is
still
unclear,
but
it
has
been
clear
that
defects
in
intestinal
barrier
function
play
an
important
role
it.
There
a
temporary
lack
drugs
for
clinical
treatment.
Astragaloside
IV
(AS-IV)
one
the
main
active
ingredients
extracted
from
Astragalus
root
and
common
Chinese
herbal
medicine
treatment
gastrointestinal
diseases.
This
study
aimed
to
determine
whether
AS-IV
therapeutic
value
DSS
or
LPS-induced
epithelial
dysfunction
vivo
vitro
its
potential
molecular
mechanisms.
Brain Behavior & Immunity - Health,
Journal Year:
2024,
Volume and Issue:
36, P. 100729 - 100729
Published: Jan. 23, 2024
Communication
among
the
brain,
gut
and
microbiota
in
is
known
to
affect
susceptibility
stress,
but
mechanisms
involved
are
unclear.
Here
we
demonstrated
that
stress
resistance
mice
was
associated
with
more
abundant
Diseases,
Journal Year:
2024,
Volume and Issue:
12(9), P. 220 - 220
Published: Sept. 18, 2024
Chronic
stress
is
a
significant
factor
affecting
modern
society,
with
profound
implications
for
both
physical
and
mental
health.
Central
to
the
response
cortisol,
glucocorticoid
hormone
produced
by
adrenal
glands.
While
cortisol
release
adaptive
in
acute
stress,
prolonged
exposure
elevated
levels
can
result
adverse
effects.
This
manuscript
explores
neurobiological
of
chronic
its
impact
on
metabolic
dysregulation,
particularly
context
inflammatory
bowel
diseases
(IBDs).
The
hypothalamic-pituitary-adrenal
(HPA)
axis
regulates
production,
which
influences
metabolism,
immune
response,
neurobiology.
Elevated
are
associated
development
exacerbation
disorders
like
IBD
contribute
neurodegenerative
processes,
including
cognitive
impairments
increased
susceptibility
psychiatric
conditions.
interaction
between
receptors,
underscores
complexity
these
review
aims
elucidate
mechanisms
through
dysregulation
health
function,
providing
insights
into
potential
therapeutic
strategies
mitigating
