Long-Term Implicit Epigenetic Stress Information in the Enteric Nervous System and its Contribution to Developing and Perpetuating IBS DOI Creative Commons
Noémi Császár-Nagy, Petr Bob, István Bókkon

et al.

Current Neuropharmacology, Journal Year: 2024, Volume and Issue: 22(13), P. 2100 - 2112

Published: May 10, 2024

: Psychiatric and mood disorders may play an important role in the development persistence of irritable bowel syndrome (IBS). Previously, we hypothesized that stress-induced implicit memories persist throughout life via epigenetic processes enteric nervous system (ENS), independent central (CNS). These ENS contribute to developing perpetuating IBS. Here, further elaborate on our earlier hypothesis. That is, during pregnancy, maternal prenatal stresses perturb HPA axis increase circulating cortisol levels, which can affect gut microbiota. Maternal cross placental barrier cortisol-circulating levels fetus. This leads dysregulation axis, affecting microbiota, microbial metabolites, intestinal permeability Microbial such as short-chain fatty acids (which also regulate fetal ENS), modulate a range diseases by inducing changes. mentioned suggest stress-related, implicit, long-term be programmed into pregnancy. Subsequently, this stress information from could conveyed CNS through bidirectional microbiota-gut-brain (MGBA), leading perturbed functional connectivity among various brain networks affective pain processes.

Language: Английский

Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis DOI Creative Commons
Jody Rusch, Brian T. Layden, Lara R. Dugas

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: June 19, 2023

Cognitive function in humans depends on the complex and interplay between multiple body systems, including hypothalamic-pituitary-adrenal (HPA) axis. The gut microbiota, which vastly outnumbers human cells has a genetic potential that exceeds of genome, plays crucial role this interplay. microbiota-gut-brain (MGB) axis is bidirectional signalling pathway operates through neural, endocrine, immune, metabolic pathways. One major neuroendocrine systems responding to stress HPA produces glucocorticoids such as cortisol corticosterone rodents. Appropriate concentrations are essential for normal neurodevelopment function, well cognitive processes learning memory, studies have shown microbes modulate throughout life. Stress can significantly impact MGB via other Animal research advanced our understanding these mechanisms pathways, leading paradigm shift conceptual thinking about influence microbiota health disease. Preclinical trials currently underway determine how animal models translate humans. In review article, we summarize current knowledge relationship axis, cognition, provide an overview main findings conclusions broad field.

Language: Английский

Citations

134
Microbiota–neuroepithelial signalling across the gut–brain axis DOI
Takahiro E. Ohara, Elaine Y. Hsiao

Nature Reviews Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

Citations

3
Advances in dietary polyphenols: Regulation of inflammatory bowel disease (IBD) via bile acid metabolism and the gut-brain axis DOI
Kexin Jiang,

Yun-Qing Bai,

Ruyan Hou

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 472, P. 142932 - 142932

Published: Jan. 21, 2025

Language: Английский

Citations

3
Blockade of PI3K/AKT signaling pathway by Astragaloside IV attenuates ulcerative colitis via improving the intestinal epithelial barrier DOI Creative Commons

Xinhui Zhang,

Fan Zhang, Yan Li

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 30, 2024

The specific pathogenesis of UC is still unclear, but it has been clear that defects in intestinal barrier function play an important role it. There a temporary lack drugs for clinical treatment. Astragaloside IV (AS-IV) one the main active ingredients extracted from Astragalus root and common Chinese herbal medicine treatment gastrointestinal diseases. This study aimed to determine whether AS-IV therapeutic value DSS or LPS-induced epithelial dysfunction vivo vitro its potential molecular mechanisms.

Language: Английский

Citations

16
Gut microbiome promotes mice recovery from stress-induced depression by rescuing hippocampal neurogenesis DOI Creative Commons

Haili He,

Zhihuang Zhao,

Chenghong Xiao

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 191, P. 106396 - 106396

Published: Jan. 2, 2024

Studies from rodents to primates and humans indicate that individuals vary in how resilient they are stress, understanding the basis of these variations may help improve treatments for depression. Here we explored potential contribution gut microbiome such variation. Mice were exposed chronic unpredictable mild stress (CUMS) 4 weeks then allowed recover 3 weeks, after which subjected behavioral tests categorized as showing low or high resilience. The two types mouse compared terms hippocampal gene expression using RNA sequencing, fecal microbiomes 16S extent neurogenesis hippocampus immunostaining brain sections. Fecal microbiota transplanted either type into previously stress-exposed stress-naïve animals, effects transplantation on stress-induced behaviors examined. Finally, blocked temozolomide explore role promoted by enhancing resilience stress. Results showed highly stress-resilient mice, but not those with resilience, improved significantly measures anhedonia, despair, anxiety 3-week recovery CUMS. Their feces greater abundance Lactobacillus, Bifidobacterium Romboutsia than mice well lower Staphylococcus, Psychrobacter Corynebacterium. Similarly, animals Transplanting CUMS-exposed recipients rescued hippocampus, facilitating depression cognitive decline. Blockade abolished CUMS-induced decline In conclusion, our results suggested remodeling reverse impairment thereby promote

Language: Английский

Citations

14
Profiling the patient with inflammatory bowel disease in the relationship between physical activity and partner/social network status: A post hoc patient-tailored analysis of the “BE-FIT-IBD” study DOI
Antonietta Gerarda Gravina, Raffaele Pellegrino, Giovanna Palladino

et al.

Gastroenterología y Hepatología, Journal Year: 2024, Volume and Issue: unknown, P. 502203 - 502203

Published: May 1, 2024

Citations

12
Gut microbiota regulate stress resistance by influencing microglia-neuron interactions in the hippocampus DOI Creative Commons

Haili He,

Hui He, Li Mo

et al.

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 36, P. 100729 - 100729

Published: Jan. 23, 2024

Communication among the brain, gut and microbiota in is known to affect susceptibility stress, but mechanisms involved are unclear. Here we demonstrated that stress resistance mice was associated with more abundant

Language: Английский

Citations

11
Neurobiological Implications of Chronic Stress and Metabolic Dysregulation in Inflammatory Bowel Diseases DOI Creative Commons

Aleksandar Sič,

Kiana Cvetkovic,

Eshanika Manchanda

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(9), P. 220 - 220

Published: Sept. 18, 2024

Chronic stress is a significant factor affecting modern society, with profound implications for both physical and mental health. Central to the response cortisol, glucocorticoid hormone produced by adrenal glands. While cortisol release adaptive in acute stress, prolonged exposure elevated levels can result adverse effects. This manuscript explores neurobiological of chronic its impact on metabolic dysregulation, particularly context inflammatory bowel diseases (IBDs). The hypothalamic-pituitary-adrenal (HPA) axis regulates production, which influences metabolism, immune response, neurobiology. Elevated are associated development exacerbation disorders like IBD contribute neurodegenerative processes, including cognitive impairments increased susceptibility psychiatric conditions. interaction between receptors, underscores complexity these review aims elucidate mechanisms through dysregulation health function, providing insights into potential therapeutic strategies mitigating

Language: Английский

Citations

11
Psychological impairment in inflammatory bowel diseases: the key role of coping and defense mechanisms DOI Creative Commons
Gabriella Martino, Anna Viola, Carmelo M. Vicario

et al.

Research in Psychotherapy Psychopathology Process and Outcome, Journal Year: 2024, Volume and Issue: 26(3)

Published: Jan. 15, 2024

A comprehensive investigation of psychological features in chronic patients is very important for tailoring effective treatments. In this study we tested anxiety, depression, health related quality life (HR-QoL), alexithymia, coping styles, and defense mechanisms, eighty-four with Crohn disease (CD) ulcerative colitis (UC). Participants reported low to moderate HRQoL apart from alexithymia. Women experienced lower QoL higher levels anxiety depressive symptoms. Coping strategies were distress symptoms QoL. Positive attitude principalization, showed negative associations alexithymia also found be associated mental health. CD used significantly more turning against objects (p=0.02) projections (p=0.01) UC reversal (p=0.04). Elderly women perceived Multiple regression analysis revealed depression independently Significant differences emerged styles among UC. participants maladaptive which distress, together level Findings suggest that aspects play a key role suffering inflammatory bowel diseases. multi-integrated clinical strategy including psychotherapeutic interventions should considered treating

Language: Английский

Citations

10
The influence of stress, coping mechanisms and psychological symptoms on inflammatory bowel disease activity: A retrospective case-control analysis DOI

Javad Shirvani,

Seyed Taher Hashemi Petrodi,

Hoda Shirafkan

et al.

Indian Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

2