The significance of reactive oxygen species in the formation of calcium oxalate stones and the protective effects of antioxidants on the kidneys DOI Creative Commons
Ying Xu, Chen Yang, Zongyao Hao

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 21, 2025

Exposure of renal tubular epithelial cells (RTCs) to kidney stones or calcium oxide crystals triggers the production reactive oxygen species (ROS), leading oxidative stress. This milieu incites cellular injury and elicits an inflammatory cascade within RTCs. Notably, membranes compromised facilitate adherence subsequent retention crystals, which is instrumental in pathogenesis stones. The pathways ROS are diverse, involving numerous signaling cascades. Recent researchers’ endeavors have elucidated that selective antioxidants can attenuate intracellular concentrations by modulating these intricate reduction levels has been empirically demonstrated significantly curtail accumulation oxalate tissues animal models, heralding a novel therapeutic paradigm for amelioration nephrolithiasis. In this review, we endeavor elucidate contributory role stone explore protective mechanisms certain safeguard function.

Language: Английский

Signaling pathways in macrophages: molecular mechanisms and therapeutic targets DOI Creative Commons
Ming Li, Mengjie Wang, Yuanjia Wen

et al.

MedComm, Journal Year: 2023, Volume and Issue: 4(5)

Published: Sept. 11, 2023

Abstract Macrophages play diverse roles in development, homeostasis, and immunity. Accordingly, the dysfunction of macrophages is involved occurrence progression various diseases, such as coronavirus disease 2019 atherosclerosis. The protective or pathogenic effect that exert different conditions largely depends on their functional plasticity, which regulated via signal transduction Janus kinase–signal transducer activator transcription, Wnt Notch pathways, stimulated by environmental cues. Over past few decades, molecular mechanisms signaling pathways have been gradually elucidated, providing more alternative therapeutic targets for diseases treatment. Here, we provide an overview basic physiology expound regulatory within them. We also address crucial role pathogenesis including autoimmune, neurodegenerative, metabolic, infectious cancer, with a focus advances macrophage‐targeted strategies exploring modulation components regulators pathways. Last, discuss challenges possible solutions therapy clinical applications. hope this comprehensive review will directions further research targeting macrophage are promising to improve efficacy

Language: Английский

Citations

49
Pathophysiology and Main Molecular Mechanisms of Urinary Stone Formation and Recurrence DOI Open Access

Flavia Tamborino,

Rossella Cicchetti,

Marco Mascitti

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 3075 - 3075

Published: March 6, 2024

Kidney stone disease (KSD) is one of the most common urological diseases. The incidence kidney stones has increased dramatically in last few decades. are mineral deposits calyces or pelvis, free attached to renal papillae. They contain crystals and organic components, they made when urine supersaturated with minerals. Calcium-containing common, calcium oxalate as main component stones. However, many these form on a phosphate matrix called Randall’s plaque, which found surface papilla. etiology multifactorial, recurrence rate high 50% within 5 years after first onset. There great need for prevention that requires better understanding mechanisms involved formation facilitate development more effective drugs. This review aims understand pathophysiology molecular known date prevent recurrences, behavioral nutritional interventions, well pharmacological treatments specific type stone.

Language: Английский

Citations

26
Oxalate homeostasis DOI
Theresa Ermer, Lama Nazzal, Maria Clarissa Tio

et al.

Nature Reviews Nephrology, Journal Year: 2022, Volume and Issue: 19(2), P. 123 - 138

Published: Nov. 3, 2022

Language: Английский

Citations

65
Metabolic changes in kidney stone disease DOI Creative Commons
Zhenzhen Xu, Xiangyang Yao, Chen Duan

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 9, 2023

Kidney stone disease (KSD) is one of the earliest medical diseases known, but mechanism its formation and metabolic changes remain unclear. The kidney stones a extensive complicated process, which regulated by in various substances. In this manuscript, we summarized progress research on discuss valuable role some new potential targets. We reviewed influence metabolism common substances formation, such as regulation oxalate, release reactive oxygen species (ROS), macrophage polarization, levels hormones, alternation other New insights into substance disease, well emerging techniques, will provide directions treatment stones. Reviewing great that has been made field help to improve understanding urologists, nephrologists, health care providers contribute explore targets for clinical therapy.

Language: Английский

Citations

32
Protective effect of carbon dots as antioxidants on intestinal inflammation by regulating oxidative stress and gut microbiota in nematodes and mouse models DOI

Nannan Peng,

Jingmin Wang, Haimei Zhu

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 131, P. 111871 - 111871

Published: March 16, 2024

Language: Английский

Citations

11
New insight into oxidative stress and inflammatory responses to kidney stones: Potential therapeutic strategies with natural active ingredients DOI Open Access
Yue Sun,

Hongmei Sun,

Zhengze Zhang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117333 - 117333

Published: Sept. 8, 2024

Language: Английский

Citations

11
Characterizing Chemokine Signaling Pathways and Hub Genes in Calcium Oxalate-Induced Kidney Stone Formation: Insights from Rodent Models DOI Creative Commons
Biao Wang, Zhibo Tan,

Wusheng She

et al.

Biochemical Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

The predominant component of kidney stone is calcium oxalate monohydrate (COM), a fact widely acknowledged. Although rodent models are frequently used to induce (CaOx) crystallization, further exploration Randall's plaques (RPs) in these still needed. We first selected the GSE89028 and GSE75542 datasets from Gene Expression Omnibus (GEO) database identify commonly differentially expressed genes (co-DEGs). Based on co-DEGs, we conducted Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses significantly enriched pathways. Additionally, performed Set Enrichment Analysis (GSEA) validate In order hub genes, established network protein–protein interactions (PPI). Finally, real-time PCR Western blot findings bioinformatics analysis. 28 co-DEGs two datasets. enrichment analysis using GO, KEGG, GSEA revealed significant chemokine-related signaling histogram showed that three chemokine factor-related were involved multiple Cytohubba confirm presence genes. Subsequently, external quantitative polymerase chain reaction (qRT-PCR) demonstrated upregulation CCL2, CXCL1, CXCL2 HK-2 cells following CaOx treatment compared control group (p < 0.05). Our study upon stimulation by CaOx, renal tubular epithelial release chemokines, including CXCL2. This chemokines accompanied activation pathways such as TNF IL-17. These may provide new directions for future research Kidney Stone Disease.

Language: Английский

Citations

1
Engineered Macrophage Membrane-Coated Nanoparticles Attenuate Calcium Oxalate Nephrocalcinosis-Induced Kidney Injury by Reducing Oxidative Stress and Pyroptosis DOI

Xiaozhuo Ba,

Tao Ye,

Yu He

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Breaking the Feedback Loop of β-Cell Failure: Insight into the Pancreatic β-Cell’s ER-Mitochondria Redox Balance DOI Creative Commons
Amira Zaher, Samuel B. Stephens

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 399 - 399

Published: March 8, 2025

Pancreatic β-cells rely on a delicate balance between the endoplasmic reticulum (ER) and mitochondria to maintain sufficient insulin stores for regulation of whole animal glucose homeostasis. The ER supports proinsulin maturation through oxidative protein folding, while supply energy redox buffering that proteostasis. In development Type 2 diabetes (T2D), progressive decline β-cell function is closely linked disruptions in ER-mitochondrial communication. Mitochondrial dysfunction well-established driver failure, whereas downstream consequences homeostasis have only recently emerged. This interdependence functions suggests an imbalance both cause consequence metabolic dysfunction. this review, we discuss regulatory mechanisms control requirements mitochondrial function. addition, describe how imbalances may trigger vicious feed forward cycle accelerates T2D onset.

Language: Английский

Citations

1
Inhibitory effect of Incarvillea diffusa Royle extract in the formation of calcium oxalate nephrolithiasis by regulating ROS-induced Nrf2/HO-1 pathway in rats DOI
Ming Gao,

Tengteng Meng,

Faju Chen

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 325, P. 117619 - 117619

Published: Jan. 23, 2024

Language: Английский

Citations

7