International Journal of Science for Global Sustainability,
Journal Year:
2023,
Volume and Issue:
9(3), P. 70 - 78
Published: Oct. 31, 2023
Snake
bites
are
a
common,
serious
medical
issue
often
neglected
in
developing
countries.
This
study
aims
to
investigate
the
effectiveness
of
methanolic
extract
from
root
bark
Annona
senegalensis
neutralizing
biological
activities
Naja
nigricollis
envenomation
vivo.
The
was
fractionated
using
liquid-liquid
fractionating
method.
inhibition
venom-induced
edematogenic
and
hemorrhagic
effects
evaluated
albino
rats
pre-incubation
protocol.
aqueous-methanol
fraction
(AM)
A.
AM
significantly
inhibited
edema-inducing
venom.
derived
has
exhibited
promising
potential
as
an
effective
anti-snake
venom
agent.
Journal of Biomolecular Structure and Dynamics,
Journal Year:
2023,
Volume and Issue:
42(10), P. 5238 - 5252
Published: June 28, 2023
Myotoxicity
caused
by
snakebite
envenoming
emerges
as
one
of
the
main
problems
ophidic
accidents
it
is
not
well
neutralized
current
serum
therapy.
A
promising
alternative
to
search
for
efficient
small
molecule
inhibitors
that
can
act
against
multiple
venom
components.
Phospholipase
A2
(PLA2)
frequently
found
in
snake
and
usually
associated
with
myotoxicity.
Thus
represents
an
excellent
target
new
treatments.
This
work
reports
effect
temperature
inhibition
catalytic
properties
PLA2
from
Bothrops
brazili
Rosmarinic
(RSM)
Chlorogenic
(CHL)
acids
through
experimental
computational
approaches.
Three
temperatures
were
evaluated
(25,
37
50
°C).
In
section,
enzymatic
assays
showed
RSM
a
better
inhibitor
all
three
temperatures.
At
°C,
efficiency
decayed
significantly
both
acids.
Docking
studies
revealed
ligands
bind
hydrophobic
channel
protein
dimer
where
phospholipid
binds
process,
interacting
several
functional
residues.
this
context,
presents
interaction
energies
due
stronger
interactions
chain
B
dimer.
Molecular
dynamics
simulations
establish
selective
ARG112B
PLA2,
which
located
next
residues
putative
Membrane
Disruption
Site
PLA2-like
structures.
The
affinity
CHL
towards
mainly
driven
electrostatic
interactions,
especially
salt
bridge
established
ARG33B
(for
CHL)
hydrogen
bonds
residue
ASP89A.
inability
stable
was
identified
reason
its
lower
compared
at
Furthermore,
extensive
structural
analysis
performed
explain
°C
ligands.
provides
important
information
future
design
inhibitors.Communicated
Ramaswamy
H.
Sarma.
Toxins,
Journal Year:
2022,
Volume and Issue:
14(8), P. 565 - 565
Published: Aug. 18, 2022
Snake
envenomation
is
a
medical
emergency
capable
of
causing
local
and
systemic
complications.
However,
information
on
venomous
snakebite
in
dogs
South
Korea
scarce.
In
this
study,
fifty-nine
treated
at
private
veterinary
clinic
from
2004
to
2021
were
retrospectively
studied.
The
aim
was
characterize
the
demographics,
elapsed
time
between
presentation,
laboratory
findings,
clinical
signs,
treatments,
adverse
reactions
antivenom,
prognosis
snakebite.
Snakebite
mostly
observed
12
p.m.
5
April
October.
On
days
envenomation,
weather
conditions
cloudy,
followed
by
rain/precipitation,
least
frequently
fair
weather.
Grassland
most
common
incident
location,
leashed
dog
walking
frequent
activity
when
occurred.
main
symptoms
edema,
hemorrhagic
discharge,
cutaneous
erythema,
ulceration,
necrosis.
Major
signs
tachypnea,
tachycardia,
altered
mentation,
ptyalism,
hypotension.
Based
interval
presentation
clinic,
two
groups
defined:
<4
h
(Group
1,
49.2%)
≥4
2,
50.8%).
Systemic
inflammation
more
Group
2.
level
C-reactive
protein
(p
=
0.036)
highest-level
during
hospitalization
0.023)
significantly
elevated
2
(≥4
h).
displayed
muscle
damage
(increased
creatine
kinase)
than
higher
kinase
associated
with
delayed
h)
after
0.003).
All
symptomatically,
34
(58%)
received
antivenom.
Treatment
antivenom
showed
no
study.
recovered.
One
euthanized
without
any
treatment
due
respiratory
distress,
hypotension,
cost
constraints.
conclusion,
study
provides
baseline
Korea.
excellent,
especially
within
4
h.
International Journal of Science for Global Sustainability,
Journal Year:
2023,
Volume and Issue:
9(3), P. 70 - 78
Published: Oct. 31, 2023
Snake
bites
are
a
common,
serious
medical
issue
often
neglected
in
developing
countries.
This
study
aims
to
investigate
the
effectiveness
of
methanolic
extract
from
root
bark
Annona
senegalensis
neutralizing
biological
activities
Naja
nigricollis
envenomation
vivo.
The
was
fractionated
using
liquid-liquid
fractionating
method.
inhibition
venom-induced
edematogenic
and
hemorrhagic
effects
evaluated
albino
rats
pre-incubation
protocol.
aqueous-methanol
fraction
(AM)
A.
AM
significantly
inhibited
edema-inducing
venom.
derived
has
exhibited
promising
potential
as
an
effective
anti-snake
venom
agent.
