Potential targets of natural medicines: preventing lung cancer pre-metastatic niche formation by regulating exosomes DOI Creative Commons
Xiaoyu Zhu, Jie Li

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Aug. 28, 2023

Lung cancer is one of the most devastating diseases worldwide with high incidence and mortality, continues to rise. Metastasis leading cause death in lung patients, yet molecular effectors underlying tumor dissemination remain poorly defined. Research findings recent years confirmed primed microenvironment future metastatic sites, called pre‐metastatic niche, a prerequisite for overt metastasis. Exosomes have recently emerged as important players niche formation. Natural medicines traditionally been rich sources drug discovery. Some them exhibit favorable anti-lung activity. The review focused on latest advances regulation formation by contents exosomes representative natural medicines. Additionally, mechanism was summarized detail, which would provide new insights anti-cancer development.

Language: Английский

NK cell-derived exosomes enhance the anti-tumor effects against ovarian cancer by delivering cisplatin and reactivating NK cell functions DOI Creative Commons

Heyong Luo,

Yanhua Zhou, Jing Zhang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 19, 2023

Exosomes are membranous vesicles actively secreted by almost all cells and they deliver certain intracellular molecules, including nucleic acids, proteins, lipids, to target cells. They also considered be good carriers for drug delivery due their biocompatibility, high permeability, low immunogenicity, toxicity. from immune were reported have immunomodulatory activities. Herein we evaluated the application of exosomes derived expanded natural killer (eNK-EXO) treatment ovarian cancer (OC). We demonstrate that eNK-EXO express typical protein markers (NK) cells, can preferentially uptaken SKOV3 display cytotoxicity against OC Furthermore, loaded with cisplatin could sensitize drug-resistant anti-proliferation effect cisplatin. In addition, show activate NK immunosuppressive tumor microenvironment, mechanism which is explored transcriptional analysis. summary, exhibit anti-tumor activity on its own, used enhance cytotoxic reverse immunosuppression may lead great prospect using in clinic. Our work builds a strong foundation further evaluation other solid therapies.

Language: Английский

Citations

53
Potential Pathophysiological Pathways in the Complex Relationships between OSA and Cancer DOI Open Access
Manuel Sánchez‐de‐la‐Torre, Carolina Cubillos‐Zapata, Olivia J. Veatch

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(4), P. 1061 - 1061

Published: Feb. 7, 2023

Several epidemiological and clinical studies have suggested a relationship between obstructive sleep apnea (OSA) higher incidence or severity of cancer. This appears to be dependent on myriad factors. These include non-modifiable factors, such as age gender; modifiable preventable specific comorbidities (especially obesity), the use particular treatments, and, above all, histological type location Heterogeneity in OSA cancer is also related influences intermittent hypoxemia (a hallmark feature OSA), among others, metabolism microenvironment different types tumoral cells. The hypoxia inducible transcription factor (HIF-1α), molecule activated expressed situations hypoxemia, seems key enabling variety pathophysiological mechanisms that are becoming increasingly better recognized. appear operationally involved via alterations cellular functions (mainly involving immune system) molecular functions, by inducing modifications microbiome. This, turn, may individually collectively increase risk cancer, which then, further modulated genetic susceptibility individual. Here, we provide an updated brief review pathways been identified could explain We identify future challenges need overcome this intriguing field research.

Language: Английский

Citations

26
Exosome-like systems: Nanotechnology to overcome challenges for targeted cancer therapies DOI
Jenifer García-Fernández, María de la Fuente

Cancer Letters, Journal Year: 2023, Volume and Issue: 561, P. 216151 - 216151

Published: March 29, 2023

Language: Английский

Citations

23
Exploring the clinical transition of engineered exosomes designed for intracellular delivery of therapeutic proteins DOI Creative Commons
Minseong Kim, Hojun Choi, Deok-Jin Jang

et al.

Stem Cells Translational Medicine, Journal Year: 2024, Volume and Issue: 13(7), P. 637 - 647

Published: June 5, 2024

Abstract Extracellular vesicles, particularly exosomes, have emerged as promising drug delivery systems owing to their unique advantages, such biocompatibility, immune tolerability, and target specificity. Various engineering strategies been implemented harness these innate qualities, with a focus on enhancing the pharmacokinetic pharmacodynamic properties of exosomes via payload loading surface for active targeting. This concise review outlines challenges in development carriers offers insights into effective clinical translation. We also highlight preclinical studies that successfully employed anti-inflammatory suggest future directions exosome therapeutics. These advancements underscore potential integrating exosome-based therapies practice, heralding promise medical interventions.

Language: Английский

Citations

9
Unravelling the therapeutic properties of aptamer-modified exosome nanocomposite DOI

Simran Makkar,

Niket Rana, Nitesh Priyadarshi

et al.

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 103517 - 103517

Published: April 1, 2025

Language: Английский

Citations

1
Patient-Derived Exosomes as siRNA Carriers in Ovarian Cancer Treatment DOI Open Access

Aasa Shimizu,

Kenjiro Sawada, Masaki Kobayashi

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(8), P. 1482 - 1482

Published: April 12, 2024

RNA interference is a powerful gene-silencing tool with potential clinical applications. However, its therapeutic use challenging because suitable carriers are unavailable. Exosomes stable small endogenous vesicles that can transport functional molecules to target cells, making them ideal interfering (siRNA) carriers. Herein, we elucidated the of patient-derived exosomes as an siRNA carrier for ovarian cancer (OC) treatment. The were extracted from culture medium primary fibroblasts collected omentum patients OC during surgery. MET proto-oncogene, receptor tyrosine kinase (MET) was selected gene silencing, c-Met siRNAs synthesized and loaded into (Met-siExosomes) via electroporation, treatment effect Met-siExosomes assessed in vitro vivo. downregulated protein levels inhibited cell proliferation, migration, invasion. In xenograft experiments using SKOV3-13 ES-2 selectively peritoneally disseminated tumors. Intraperitoneal suppressed downstream targets cells prolonged mouse survival. successfully delivered intraperitoneally As routinely undergo omentectomy abundant be easily omentum, may represent promising treat OC.

Language: Английский

Citations

8
Standardized Reporting of Research on Exosomes to Ensure Rigor and Reproducibility DOI
Anita Yadav, Yi Xuan, Chandan K. Sen

et al.

Advances in Wound Care, Journal Year: 2024, Volume and Issue: 13(11), P. 584 - 599

Published: June 18, 2024

Significance: The study of extracellular vesicles (EV), especially exosomes, has unlocked new avenues in understanding cellular communication and potential therapeutic avenues. Recent Advances: Advancements EV research have shown significant contributions from the International Society for Extracellular Vesicles (ISEV), establishing methodological standards. evolution MISEV guidelines 2014 to 2023 reflects enhanced rigor reproducibility. launch EV-TRACK platform promotes uniformity reproducibility by providing a centralized repository data sharing standardization practices. Furthermore, databases like EVpedia ExoCarta facilitated collaboration within scientific community. Concurrently, exosome-based therapies emerged as forefront area regenerative medicine targeted drug delivery, showcasing exosomes promoting tissue regeneration. Critical Issues: Despite advancements, field grapples with challenges such vesicular heterogeneity, isolation complexity, standardization. These issues impact clinical applications. inconsistency exosomal preparations trials poses efficacy safety. Future Directions: review outlines critical areas future research, including need technological innovation characterization, establishment standardized protocols, deeper exosome biology. also highlights reassess guidelines, develop characterization technologies, establish protocols overcome current limitations. Emphasis is placed on interdisciplinary address complexities biology, improve trial design, ultimately realize exosome's diagnostic potential. Continued evaluation rigorous validation are essential successful integration.

Language: Английский

Citations

8
Extracellular vesicles biogenesis, isolation, manipulation and genetic engineering for potential in vitro and in vivo therapeutics: An overview DOI Creative Commons
Nastaran Hadizadeh,

Diba Bagheri,

Mehdi Shamsara

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10

Published: Nov. 4, 2022

The main goals of medicine consist early detection and effective treatment different diseases. In this regard, the rise exosomes as carriers natural biomarkers has recently attracted a lot attention managed to shed more light on future disease diagnosis methods. Here, exosome biogenesis, its role biomarker in metabolic disorders, recent advances state-of-art technologies for isolation will be reviewed along with research directions challenges regarding manipulation genetic engineering potential vitro vivo approaches.

Language: Английский

Citations

24
Role of exosomes in non-small cell lung cancer and EGFR-mutated lung cancer DOI Creative Commons
Dingyu Rao, Defa Huang,

Mao-Yan Si

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 12, 2023

As an important mediator of information transfer between cells, exosomes play a unique role in regulating tumor growth, supporting vascular proliferation, invasion, and metastasis. Exosomes are widely present various body fluids, therefore they can be used as potential tool for non-invasive liquid biopsy. The study reviews the biopsy, microenvironment formation, epithelial-mesenchymal transition non-small cell lung cancer (NSCLC). By targeting epidermal growth factor receptor (EGFR) therapy first-line treatment patients with NSCLC, this also briefly describes occurrence EGRF+ their contents detection therapeutic targets EGFR-mutated cancer.

Language: Английский

Citations

16
Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology DOI Creative Commons

Rupal Dhariwal,

Mukul Jain, Y. Mir

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

Neurodegenerative diseases, characterized by progressive neuronal loss and cognitive impairments, pose a significant global health challenge. This study explores the potential of nanotherapeutics as promising approach to enhance drug delivery across physiological barriers, particularly blood–brain barrier (BBB) blood-cerebrospinal fluid (B-CSFB). By employing nanoparticles, this research aims address critical challenges in diagnosis treatment conditions such Alzheimer’s, Parkinson’s, Huntington’s diseases. The multifactorial nature these disorders necessitates innovative solutions that leverage nanomedicine improve solubility, circulation time, targeted while minimizing off-target effects. findings underscore importance advancing applications develop effective therapeutic strategies can alleviate burden neurodegenerative diseases on individuals healthcare systems.

Language: Английский

Citations

0