Urobiome of patients with diabetic kidney disease in different stages is revealed by 2bRAD-M DOI Creative Commons
Nan Li, Ying Wang, Haojun Zhang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 10, 2025

Knowledge of the urinary microbiome (urobiome) in diabetic kidney disease (DKD) remains limited. The most commonly used 16S rRNA sequencing technique can only provide bacterial identification at genus level. As a novel technique, 2bRAD for (2bRAD-M) be to identify low-biomass species In this study, we 2bRAD-M compare urobiome composition patients with DKD different stages healthy individuals and those type 2 diabetes mellitus (T2DM), expectation that would find discriminative correlated DKD. Healthy controls, microalbuminuria (DKD1 group) or macroalbuminuria (DKD2 group), T2DM were recruited (n = 20 each group). first-morning urine was collected testing. albumin-to-creatinine ratio (ACR) also measured samples. Serum samples detecting clinical indicators. microbial diversity based on abundance calculated. Differential bacteria groups identified. Besides, correlation between indices analyzed. Urobiome significantly reduced groups. DKD1 group, dominant genus, followed by Pseudomonas_E, whereas DKD2 Pseudomonas_E became Escherichia notably reduced. Both Bifidobacterium Streptococcus, which top genera control substantially decreased included coli Acinetobacter johnsonii, while DKD2, oleovorans, Enterococcus faecalis, Morganella morganii showed strong renal function indicators protein levels. markedly from patients. These findings valuable insights into onset progression DKD, driven changes community structure.

Language: Английский

Gut–X axis DOI Creative Commons
Lin Xu, Yu Zhang, Xueyan Li

et al.

iMeta, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 1, 2025

Abstract Recent advances in understanding the modulatory functions of gut and microbiota on human diseases facilitated our focused attention contribution to pathophysiological alterations many extraintestinal organs, including liver, heart, brain, lungs, kidneys, bone, skin, reproductive, endocrine systems. In this review, we applied “gut–X axis” concept describe linkages between other organs discussed latest findings related axis,” underlying mechanisms potential clinical intervention strategies.

Language: Английский

Citations

2
The roles of gut microbiota and its metabolites in diabetic nephropathy DOI Creative Commons
Hui Zhao,

Cheng-E Yang,

Tian Liu

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: July 27, 2023

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes, which increases the risk renal failure and causes high global disease burden. Due to lack sustainable treatment, DN has become primary cause end-stage worldwide. Gut microbiota its metabolites exert critical regulatory functions in maintaining host health are associated with many pathogenesis aging-related chronic diseases. Currently, theory gut–kidney axis opened novel angle understand relationship between gut multiple kidney In recent years, accumulating evidence revealed that their play an essential role pathophysiologic processes through axis. this review, we summarize current investigations microbial involvement progression DN, further discuss potential microbiota-targeted therapeutic approaches for DN.

Language: Английский

Citations

27
Gut microbiota and its metabolites – molecular mechanisms and management strategies in diabetic kidney disease DOI Creative Commons

Zi‐Hui Mao,

Zhong‐Xiuzi Gao, Dongwei Liu

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 19, 2023

Diabetic kidney disease (DKD) is one of the major microvascular complications diabetes mellitus and also serious risk factors in cardiovascular events, end-stage renal disease, mortality. DKD associated with diversified, compositional, functional alterations gut microbiota. The interaction between microbiota host mainly achieved through metabolites, which are small molecules produced by microbial metabolism from exogenous dietary substrates endogenous compounds. plays a critical role pathogenesis producing multitudinous metabolites. Nevertheless, detailed mechanisms its metabolites involved occurrence development have not been completely elucidated. This review summarizes specific classes microbiota-derived aims to explore molecular pathophysiology progression, recognizes biomarkers for screening, diagnosis, prognosis DKD, as well provides novel therapeutic strategies DKD.

Language: Английский

Citations

25
Composition of gut microbiota and non‐alcoholic fatty liver disease: A systematic review and meta‐analysis DOI
Xin Su, Shiyun Chen,

Jiazi Liu

et al.

Obesity Reviews, Journal Year: 2023, Volume and Issue: 25(1)

Published: Oct. 9, 2023

Summary The present systematic review and meta‐analysis aimed to summarize the associations between gut microbiota composition non‐alcoholic fatty liver disease. To compare differences individuals with or without NAFLD, standardized mean difference 95% confidence interval were computed for each α‐diversity index relative abundance of microbes. β‐diversity indices summarized in a qualitative manner. A total 54 studies 8894 participants included. Overall, patients NAFLD had moderate reduction including Shannon (SMD = −0.36, CI [−0.53, −0.19], p < 0.001) Chao 1 −0.42, [−0.68, −0.17], 0.001), but no significant found Simpson, observed species, phylogenetic diversity, richness, abundance‐based coverage estimator, evenness ( ranged from 0.081 0.953). Over 75% included reported β‐diversity. Although there was substantial interstudy heterogeneity, especially analyses at phylum, class, family levels, majority showed alterations depletion anti‐inflammatory microbes (i.e., Ruminococcaceae Coprococcus ) enrichment proinflammatory Fusobacterium Escherichia NAFLD. Perturbations associated commonly reflected by beneficial species an increase pathogenic species.

Language: Английский

Citations

24
Causal relationship between gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study DOI Creative Commons
Shuxiang Yan, Hua Wang,

Baiyu Feng

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 8, 2024

Objective Emerging evidence has provided compelling linking gut microbiota (GM) and diabetic nephropathy (DN) via the “gut-kidney” axis. But causal relationship between them hasn’t been clarified yet. We perform a Two-Sample Mendelian randomization (MR) analysis to reveal connection with GM development of DN, type 1 diabetes (T1DN), 2 (T2DN), mellitus (T1DM), (T2DM). Methods used summary data from MiBioGen on 211 taxa in 18340 participants. Generalized MR methods were conducted estimate their causality risk T1DN, T2DN, T1DM T2DM FinnGen. To ensure reliability findings, comprehensive set sensitivity analyses confirm resilience consistency results. Results It was showed that Class Verrucomicrobiae [odds ratio (OR) =1.5651, 95%CI:1.1810-2.0742, P FDR=0.0018], Order Verrucomicrobiales (OR=1.5651, 95%CI: 1.1810-2.0742, FDR=0.0018) Family Verrucomicrobiaceae (OR=1.3956, 95%CI:1.0336-1.8844, FDR=0.0296) had significant DN. Our found associations including Verrucomimicrobiae (OR=1.8227, 95% CI: 1.2414-2.6763, PFDR=0.0139), 1.8227-2.6764, PFDR=0.0024), Rhodospirillales (OR=1.8226, 1.2412-2.6763, PFDR=0.0026), Verrucomicroniaceae PFDR=0.0083). The Eubacteriumprotogenes (OR=0.4076, 0.2415-0.6882, PFDR=0.0021) exhibited protection against T1DN. Sensitivity confirmed there no heterogeneity pleiotropy. Conclusions At gene prediction level, we identified specific is causally linked DN both patients. Moreover, distinct microbial changes T1DN differed those seen offering valuable insights into signatures associated subtype nephropathy.

Language: Английский

Citations

11
Clinical Perspectives of Gut Microbiota in Patients with Chronic Kidney Disease and End-Stage Kidney Disease: Where Do We Stand? DOI Creative Commons
Alexandru Cosmin Pantazi, Mustafa Ali Kassim Kassim, Wassan Nori

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2480 - 2480

Published: Sept. 7, 2023

The gut microbiota (GM) plays a vital role in human health, with increasing evidence linking its imbalance to chronic kidney disease and end-stage disease. Although the exact methods underlying kidney-GM crosstalk are not fully understood, interventions targeting GM were made lay three aspects: diagnostic, predictive, therapeutic interventions. While these show promising results reducing uremic toxins inflammation, challenges remain form of patient-specific variability, potential side effects, safety concerns. Our understanding GMs is still evolving, necessitating further research elucidate causal relationship mechanistic interactions. Personalized focusing on specific signatures could enhance patient outcomes. However, comprehensive clinical trials needed validate approaches’ safety, efficacy, feasibility.

Language: Английский

Citations

21
Association of the gut microbiome with kidney function and damage in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) DOI Creative Commons
Brandilyn A. Peters, Qibin Qi, Mykhaylo Usyk

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: March 7, 2023

Background The gut microbiome is altered in chronic kidney disease (CKD), potentially contributing to CKD progression and co-morbidities, but population-based studies of the across a wide range function damage are lacking.Methods In Hispanic Community Health Study/Study Latinos, was assessed by shotgun sequencing stool (n = 2,438; 292 with suspected CKD). We examined cross-sectional associations estimated glomerular filtration rate (eGFR), urinary albumin:creatinine (UAC) ratio, features. Kidney trait-related features were interrogated for correlation serum metabolites 700), microbiome-related trait prospective analysis 3,635).Results Higher eGFR associated overall composition, greater abundance species from Prevotella, Faecalibacterium, Roseburia, Eubacterium, microbial functions related synthesis long-chain fatty acids carbamoyl-phosphate. UAC ratio lower diversity composition only participants without diabetes. Microbiome better health many (e.g., higher indolepropionate, beta-cryptoxanthin; imidazole propionate, deoxycholic acids, p-cresol glucuronide). Imidazole acid metabolites, glucuronide reductions and/or increases over ~6 y.Conclusions significant correlate microbiome, while relationship depends on diabetes status. Gut may contribute progression.

Language: Английский

Citations

17
Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota DOI Creative Commons
Xiaqing Wu, Lei Zhao,

Yanlong Zhao

et al.

Pharmaceutical Biology, Journal Year: 2024, Volume and Issue: 62(1), P. 423 - 435

Published: May 17, 2024

Context Diabetic kidney disease (DKD) affects nearly 40% of diabetic patients, often leading to end-stage renal that requires replacement therapies, such as dialysis and transplantation. The gut microbiota, an integral aspect human evolution, plays a crucial role in this condition. Traditional Chinese medicine (TCM) has shown promising outcomes ameliorating DKD by addressing the microbiota.

Language: Английский

Citations

8
Iridoids modulate inflammation in diabetic kidney disease: A review DOI

Tongyi Zhou,

Na Tian,

Liu Li

et al.

Journal of Integrative Medicine, Journal Year: 2024, Volume and Issue: 22(3), P. 210 - 222

Published: March 28, 2024

Language: Английский

Citations

6
A systematic review and meta-analysis of gut microbiota in diabetic kidney disease: Comparisons with diabetes mellitus, non-diabetic kidney disease, and healthy individuals DOI Creative Commons
Shisheng Han, Min Chen, Cheng Pei

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 20, 2022

Gut microbiota has been reported to play an important role in diabetic kidney disease (DKD), however, the alterations of gut bacteria have not determined.Studies comparing differences microbiome between patients with DKD and non-DKD individuals using high-throughput sequencing technology, were systematically searched reviewed. Outcomes set as bacterial diversity, microbial composition, correlation clinical parameters DKD. Qualitative data summarized compared through a funnel R script, quantitative estimated by meta-analysis.A total 15 studies 1640 participants included, comparisons conducted DKD, diabetes mellitus (DM), non-diabetic (NDKD), healthy controls. There no significant α-diversity DM, NDKD, lower richness was found Different compositions subjects. The phylum Actinobacteria be enriched At genus level, we enrichment Hungatella, Bilophila, Escherichia showed abundances Faecalibacterium those NDKD. genera Butyricicoccus, Faecalibacterium, Lachnospira depleted controls, whereas Escherichia, lactobacillus significantly enriched. Ruminococcus torques group demonstrated inversely correlated glomerular filtration rate DKD.Gut characterized Hungatella depletion butyrate-producing bacteria, which might associated occurrence development Further are still needed validate these findings, due substantial heterogeneity.https://www.crd.york.ac.uk/prospero/, identifier CRD42022340870.

Language: Английский

Citations

27