Advances in Science, Technology & Innovation/Advances in science, technology & innovation, Journal Year: 2025, Volume and Issue: unknown, P. 211 - 242
Published: Jan. 1, 2025
Language: Английский
World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(16), P. 2452 - 2468
Published: April 24, 2023
Gastric cancer (GC) is defined as the primary epithelial malignancy derived from stomach, and it a complicated heterogeneous disease with multiple risk factors. Despite its overall declining trend of incidence mortality in various countries over past few decades, GC remains fifth most common fourth leading cause cancer-related death globally. Although global burden has shown significant downward trend, severe certain areas, such Asia. ranks third among all types China, accounts for nearly 44.0% 48.6% new cases GC-related deaths world, respectively. The regional differences are obvious, annual increasing rapidly some developing regions. Therefore, early preventive screening strategies urgently needed. clinical efficacies conventional treatments limited, understanding pathogenesis increased demand therapeutic regimens, including immune checkpoint inhibitors, cell immunotherapy vaccines. present review describes epidemiology worldwide, especially summarizes prognostic factors, focuses on novel immunotherapies to develop management patients.
Language: Английский
Citations
177
Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 213, P. 150 - 163
Published: Jan. 6, 2024
Language: Английский
Citations
26
Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 7, 2025
Abstract Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, with limited treatment options in advanced stages. Immunotherapy, particularly immune checkpoint inhibitors (ICIs) targeting PD1/PD-L1, has emerged as promising therapeutic approach. However, significant proportion patients exhibit primary or acquired resistance, limiting the overall efficacy immunotherapy. This review provides comprehensive analysis mechanisms underlying immunotherapy resistance GC, including role tumor microenvironment, dynamic PD-L1 expression, compensatory activation other checkpoints, and genomic instability. Furthermore, explores GC-specific factors such molecular subtypes, unique evasion mechanisms, impact Helicobacter pylori infection. We also discuss emerging strategies to overcome combination therapies, novel immunotherapeutic approaches, personalized based on genomics microenvironment. By highlighting these key areas, this aims inform future research directions clinical practice, ultimately improving outcomes for GC undergoing
Language: Английский
Citations
2
World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(4), P. 286 - 289
Published: Jan. 26, 2024
Gastric cancer, a prevalent malignancy worldwide, ranks sixth in terms of frequency and third fatality, causing over million new cases 769000 annual deaths. Predominant Eastern Europe Asia, risk factors include family medical history, dietary habits, tobacco use, Helicobacter pylori , Epstein-Barr virus infections. Unfortunately, gastric cancer is often diagnosed at an advanced stage, leading to grim prognosis, with 5-year overall survival rate below 5%. Surgical intervention, particularly D2 Lymphadenectomy, the mainstay for early-stage but offers limited success. For cases, National Comprehensive Cancer Network recommends chemotherapy, radiation, targeted therapy. Emerging immunotherapy presents promise, especially unresectable or metastatic strategies like immune checkpoint inhi-bitors, tumor vaccines, adoptive immunotherapy, nonspecific immunomodulators. In this Editorial, regards article “Advances key focus areas immunotherapy: A comprehensive scientometric clinical trial review”, we address advances field its future prospects.
Language: Английский
Citations
14
Cancer Treatment and Research Communications, Journal Year: 2024, Volume and Issue: 41, P. 100845 - 100845
Published: Jan. 1, 2024
Language: Английский
Citations
12
Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 560 - 560
Published: Jan. 28, 2024
Gastric carcinoma, being one of the most prevalent types solid tumors, has emerged as third leading cause death worldwide. The symptoms gastric cancer (GC) are typically complex, which makes early detection challenging. Immune checkpoint inhibition become new standard targeted therapy for advanced or metastatic GC. It is currently explored in various combinations, both with and without chemotherapy, across multiple therapies clinical trials. Immunotherapy can stimulate immune responses GC patients, to destruction cells. Compared traditional therapies, immunotherapy shown strong effectiveness tolerable toxicity levels. Hence, this innovative approach treatment gained popularity. In review, we have outlined recent advancements GC, including inhibitors, vaccines, vascular endothelial growth factor-A chimeric antigen receptor T-cell therapy. Our current emphasis on examining immunotherapies presently employed settings, addressing existing challenges associated these therapeutic approaches, exploring promising strategies overcome their limitations.
Language: Английский
Citations
11
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Feb. 26, 2024
Gastric cancer (GC) remains one of the most life-threatening disease worldwide with poor prognosis because absence effective treatment and delay in diagnosis. Due to diagnosis, a large proportion GC patients are diagnosed as advanced GC, extreme short lifespan. In past few years, some pivotal progress novel therapies was proposed, conducted into clinical researches practice. this study, we summarized development several immunotherapy or targeted modalities for including immune checkpoint inhibitors, anti-angiogenic therapy vaccines. Additionally, advantage potential weakness each these therapeutic methods also listed. Finally, discussed promising research direction treatment, limitation basic combination therapy.
Language: Английский
Citations
9
Cancers, Journal Year: 2024, Volume and Issue: 16(19), P. 3323 - 3323
Published: Sept. 28, 2024
Gastric cancer (GC) is the second most common cause of cancer-related death worldwide and a serious public health concern. This high rate mostly caused by late-stage diagnoses, which lead to poor treatment outcomes. Radiation immunotherapy targeted therapies are becoming increasingly popular in GC treatment, addition surgery systemic chemotherapy. In this review, we have focused on both vitro vivo research, presents summary recent developments for gastric cancer. We explore therapy approaches, including integrin receptors, HER2, Claudin 18, glutathione-responsive systems. For instance, targeting receptors such as αvβ3 αvβ5 integrins shown promise enhancing diagnostic precision efficacy. Furthermore, nanotechnology provides novel approaches drug delivery imaging. These include nanoplatforms cyclic RGD peptide-conjugated nanoparticles. strategies seek reduce toxicity while increasing specificity To sum up, review addresses significance personalized medicine advancements cancer-targeted therapies. It explores potential methods prognosis future.
Language: Английский
Citations
9
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 24, 2025
Background Long non-coding RNAs (lncRNAs) in extracellular vesicles (EVs) have been confirmed as effective non-invasive biomarkers for multiple diseases. However, their expression and clinical value gastric cancer (GC) remain poorly understood. Materials methods Serum EV RNA was extracted from four patients with GC healthy controls, followed by high-throughput sequencing. LncRNAs were further validated training validation sets using quantitative real-time reverse transcription polymerase chain reaction. Results A total of 37,684 lncRNAs obtained, 10 selected based on the criteria ( P < 0.05 |log 2 FoldChange| ≥1). lncRNA RMRP, RPPH1, linc-ROR significantly higher than those chronic gastritis, atypical hyperplasia, or control (all 0.05). Three also correlated tumor diameter, lymphatic metastasis, distal TNM stage The area under curve (AUC) values 0.727, 0.774, 0.811, respectively. Corresponding sensitivity specificity 63.4% 85.4%, 50.7% 89.6%, 78.5% 66.7%. combination these three carcinoembryonic antigen (CEA) yielded an AUC 0.909, a 83.3% each. Furthermore, high RMRP levels associated worse disease-free survival overall (OS). Univariate multivariate Cox regression analyses that only independent prognostic factor GC. Finally, lncRNA-miRNA-mRNA network showed predicted to interact 15 miRNAs 69 mRNAs. In addition, immune cell infiltration, including neutrophils, central memory CD4 T cells, macrophage, natural kill cells. Conclusion are prospective biomarker infiltration It provides foundation development serum EV-targeted novel immunotherapy targets
Language: Английский
Citations
1
Human Vaccines & Immunotherapeutics, Journal Year: 2023, Volume and Issue: 19(1)
Published: Jan. 2, 2023
Gastric cancer (GC) is one of the most common malignancies. Immunotherapy becomes an indispensable part GC. This study conducts bibliometric analysis immunotherapy for GC to clarify research status and identify potential new directions. VOS viewer CiteSpace visualization software were used demonstrate collaborations correlations. A total 1141 English publications from 2012 2022 included. The number increased year by year. mainly China (n = 579, 50.70%), followed United States. Fudan University published 48, 4.21%). Frontiers in Oncology Journal Clinical ranked first cited co-cited journals, respectively. Kim Kyoung-Mee on 14). clustering timeline view references show hotspot transformation Initially, hot topic was "cytokine-induced killer cells" "myeloid-derived suppressor cells." In recent years, focus has turned "targeted therapy." "CAR-T" become hottest topic, entered precision therapy phase. Screening patients who can benefit key improving prognosis. combination with other treatment options, such as chemotherapy targeted therapy, currently research. Chimeric antigen receptor T cell will be further studied future.Bibliometrics main tools current spots. gastric cancer. cells play important role
Language: Английский
Citations
18