The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities DOI Creative Commons
Winnie L. Kan, Claire M. Weekley, Tracy L. Nero

et al.

Immunological Reviews, Journal Year: 2025, Volume and Issue: 329(1)

Published: Jan. 1, 2025

ABSTRACT Cytokines are small proteins that critical for controlling the growth and activity of hematopoietic cells by binding to cell surface receptors transmitting signals across membranes. The β common (βc) cytokine receptor family, consisting granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), interleukin (IL)‐3, IL‐5 receptors, is an architype heterodimeric systems. We now know signaling not always “all or none” phenomenon. Subtle alterations cytokine:receptor complex can result in differential selective underpin a variety diseases including chronic inflammatory conditions cancers. Structural biology techniques, such as X‐ray crystallography cryo‐electron microscopy alongside studies, providing detailed insights into signaling. Recently, we found IL‐3 ternary forms higher‐order assemblies, like those earlier GM‐CSF receptor, demonstrated functionally distinct biological arise from different oligomeric assemblies. As enhance our understanding structural nuances cytokine–receptor interactions, foresee new era theranostics whereby structurally guided mechanism‐based manipulation through rational/targeted protein engineering will harness full potential precision medicine.

Language: Английский

Mouse mesenchymal stem cell-derived exosomal miR-205-5p modulates LPS-induced macrophage polarization and alleviates lung injury by regulating the USP7/FOXM1 axis DOI
Yinglu Feng, Min Tang, Haopeng Li

et al.

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

1
Laminarin Alleviates Acute Lung Injury Induced by LPS Through Inhibition of M1 Macrophage Polarisation DOI Creative Commons
Liming Zeng, Jieyu Zhang,

Rongrong Song

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(5)

Published: March 1, 2025

The lipopolysaccharide-induced acute lung injury (ALI) mouse model is used to simulate human respiratory distress syndrome (ARDS), which has a high mortality rate. An imbalance between M1 and M2 macrophages, characterised by an increase in was observed sepsis-induced ALI. We report that laminarin, active ingredient found algae, exhibits exceptional performance of It ameliorates edema, enhances the survival rate mice reduces levels inflammatory factors TNF-α IL-6. Furthermore, laminarin reduced expression CD86, are markers associated with macrophages. Laminarin treatment secretion IL-6 LPS-stimulated also decreases glucose uptake Transcriptome sequencing reveals genes downregulated macrophages following predominantly enriched HIF-1α signalling pathway. Experimental validation confirms significantly related indicators ROS NLRP3. After using siRNA knock down RAW264.7 cells, inhibitory effect on LPS-induced polarisation abolished. This suggests may potentially inhibit macrophage towards phenotype downregulating signal. In conclusion, data presented our study demonstrate can effectively reduce signalling. makes it novel candidate drug for

Language: Английский

Citations

1
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling DOI
Stephen T. Yeung, Payal Damani‐Yokota, Sara A. Thannickal

et al.

Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

1
Neutrophil extracellular traps and long COVID DOI Creative Commons
Areez Shafqat, Mohamed H. Omer, Ibrahem Albalkhi

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 27, 2023

Post-acute COVID-19 sequelae, commonly known as long COVID, encompasses a range of systemic symptoms experienced by significant number survivors. The underlying pathophysiology COVID has become topic intense research discussion. While chronic inflammation in received considerable attention, the role neutrophils, which are most abundant all immune cells and primary responders to inflammation, been unfortunately overlooked, perhaps due their short lifespan. In this review, we discuss emerging neutrophil extracellular traps (NETs) persistent inflammatory response observed patients. We present early evidence linking persistence NETs pulmonary fibrosis, cardiovascular abnormalities, neurological dysfunction COVID. Several uncertainties require investigation future studies. These include mechanisms SARS-CoV-2 brings about sustained activation phenotypes after infection resolution; whether heterogeneity neutrophils seen acute persists into phase; presence autoantibodies can induce protect them from degradation; exert differential, organ-specific effects; specifically NET components contribute pathologies, such fibrosis; senescent drive formation through pro-inflammatory secretome Answering these questions may pave way for development clinically applicable strategies targeting NETs, providing relief health crisis.

Language: Английский

Citations

23
Vitamin C: Rationale for Its Use in Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS) DOI Creative Commons
Alpha A. Fowler

Antioxidants, Journal Year: 2024, Volume and Issue: 13(1), P. 95 - 95

Published: Jan. 12, 2024

Acute respiratory distress syndrome (ARDS) is a life-threatening event that occurs in patients suffering from bacterial, fungal, or viral sepsis. Research performed over the last five decades showed ARDS consequence of severe unrestrained systemic inflammation, which leads to injury lung's microvasculature and alveolar epithelium. acute hypoxic/hypercapnic failure death significant number hospitalized intensive care units worldwide. Basic clinical research during time since was first described has been unable construct pharmacological agent will combat inflammatory fire leading ARDS. In-depth studies molecular pharmacology vitamin C indicate it can serve as potent anti-inflammatory capable attenuating pathobiological events lead lungs other body organs. This analysis C's role treatment includes focused systematic review literature relevant physiology past performance trials using agent.

Language: Английский

Citations

8
Advances in lung ischemia/reperfusion injury: unraveling the role of innate immunity DOI
Qingqing Li, Hanxiang Nie

Inflammation Research, Journal Year: 2024, Volume and Issue: 73(3), P. 393 - 405

Published: Jan. 24, 2024

Language: Английский

Citations

8
A Narrative Review: The Role of NETs in Acute Respiratory Distress Syndrome/Acute Lung Injury DOI Open Access
Xinyu Zhou,

Jiajia Jin,

Tangfeng Lv

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1464 - 1464

Published: Jan. 25, 2024

Nowadays, acute respiratory distress syndrome (ARDS) still has a high mortality rate, and the alleviation treatment of ARDS remains major research focus. There are various causes ARDS, among which pneumonia non-pulmonary sepsis most common. Trauma blood transfusion can also cause ARDS. In aggregation infiltration neutrophils in lungs have great influence on development disease. Neutrophils regulate inflammatory responses through pathways, release neutrophil extracellular traps (NETs) is considered to be one important mechanisms. NETs mainly composed DNA, histones, granuloproteins, all mediate downstream signaling pathways that activate responses, generate immune clots, damage surrounding tissues. At same time, components promote formation NETs, thus forming vicious cycle continuously aggravates progression associated with cytokine storms balance. Since DNA main component DNase I viable drug for removing NETs. Other therapeutic methods inhibit worthy further exploration. This review discusses mechanism Understanding association between may help develop new perspectives

Language: Английский

Citations

7
Immunotherapy strategies and prospects for acute lung injury: Focus on immune cells and cytokines DOI Creative Commons

Wenfang Zhu,

Yiwen Zhang, Ying-Hong Wang

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 22, 2022

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a disastrous condition, which can be caused by wide range of diseases, such as pneumonia, sepsis, traumas, and the most recent, COVID-19. Even though we have gained an improved understanding acute pathogenesis treatment mechanism, there still no effective for syndrome, partly responsible unacceptable mortality rate. In injury, inflammatory storm main pathological feature. More more evidences show that immune cells cytokines secreted play irreplaceable role in injury. Therefore, here mainly reviewed various injury from perspective immunotherapy, elaborated crosstalk cytokines, aiming to provide novel ideas targets

Language: Английский

Citations

26
Nothing but NETs: Cytokine adsorption correlates with lower circulating nucleosomes and is associated with decreased primary graft dysfunction DOI Creative Commons
Sandra Lindstedt, Anna Niroomand,

Margareta Mittendorfer

et al.

The Journal of Heart and Lung Transplantation, Journal Year: 2023, Volume and Issue: 42(10), P. 1358 - 1362

Published: June 20, 2023

Elevated levels of neutrophil extracellular traps (NETs) have been reported in primary graft dysfunction, making methods to reduce or remove them highly valuable. The mechanisms behind dysfunction (PGD) remain rudimentarily understood but its relation higher rates acute and chronic rejection necessitates the development preventative treatments. This case series explores use a cytokine adsorber during lung transplantation with focus reducing circulating nucleosome as measure NETs. Treated patients showed reduced nucleosomes remained free from PGD histopathological signs at 1- 3-month post-transplant. In contrast, without experienced nucleosomes, grades 1 3, rejection. Using may provide systemic inflammatory state lower NETs consequently support acceptance.

Language: Английский

Citations

15
Neutrophil extracellular traps and their implications in airway inflammatory diseases DOI Creative Commons

Nanxia Xuan,

Jie Zhao,

Zhi-Ying Kang

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 12, 2024

Neutrophil extracellular traps (NETs) are essential for immune defense and have been increasingly recognized their role in infection inflammation. In the context of airway inflammatory diseases, there is growing evidence suggesting involvement significance NETs. This review aims to provide an overview formation mechanisms components NETs impact on various including acute lung injury/ARDS, asthma, chronic obstructive pulmonary disease (COPD) cystic fibrosis. By understanding inflammation, we can gain valuable insights into underlying pathogenesis these diseases identify potential targets future therapeutic strategies that either target or modulate harmful effects. Further research warranted elucidate complex interactions between inflammation develop targeted therapies effectively mitigate detrimental effects while preserving beneficial functions host defense.

Language: Английский

Citations

6