The chronicles of inflammation: uncovering of distinct patterns of NET degradation products DOI Creative Commons
Janina Schoen,

Marco Muñoz-Becerra,

Jasmin Knopf

et al.

Frontiers in Drug Discovery, Journal Year: 2024, Volume and Issue: 4

Published: Sept. 13, 2024

Aims Neutrophils and neutrophil extracellular traps (NETs) play multifaceted roles in inflammatory diseases. If the balance of NET formation clearance is disturbed, they contribute to development pathogenesis a plethora They promote inflammation tissue degradation, occlude vessels ducts. This study focused on presence remnants generated during by nucleases phagocytes. Methods associated parameters serum plasma samples from various pathological conditions were investigated. We performed fluorescence-based assays analyze concentration cell free DNA activity elastase. The citrullinated histone H3, as well elastase- or myeloperoxidase-DNA complexes examined employing enzyme-linked immunosorbent assays. Results analyzed variety conditions: (I) rheumatic autoimmune diseases systemic lupus erythematosus, rheumatoid arthritis, primary Sjögren’s syndrome (II) bowel ulcerative colitis Crohn’s disease (III) hidradenitits suppurativa (IV) viral-induced pathologies Coronavirus 2019 (COVID-19), Post COVID Syndrome (PCS). While most detected all conditions, certain markers displayed disease-specific patterns. compared terms concentration, correlations with each other activity, their impact sample variability. Systemic erythematosus arthritis increased levels DNA, H3 elastase-activity, respectively. Samples patients COVID-19 characterized elevated complexes. Conclusion Different are linked characteristic patterns parameters. These offer insights into aberrant different may represent key targets for treatment development.

Language: Английский

SARS-CoV-2 immunity in animal models DOI Creative Commons
Chen Zhao,

Yaochang Yuan,

Qing‐Tao Hu

et al.

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(2), P. 119 - 133

Published: Jan. 18, 2024

The COVID-19 pandemic, which was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a worldwide health crisis due to its transmissibility. SARS-CoV-2 infection results in illness and can lead significant complications affected individuals. These encompass symptoms such as coughing, distress, fever, infectious shock, distress (ARDS), even multiple-organ failure. Animal models serve crucial tools for investigating pathogenic mechanisms, immune responses, escape antiviral drug development, vaccines against SARS-CoV-2. Currently, various animal infection, nonhuman primates (NHPs), ferrets, hamsters, many different mouse models, have been developed. Each model possesses distinctive features applications. In this review, we elucidate the response elicited patients provide an overview of characteristics mainly used well corresponding responses applications these models. A comparative analysis transcriptomic alterations lungs from revealed that K18-hACE2 mouse-adapted virus exhibited highest similarity with deceased patients. Finally, highlighted current gaps related research between studies clinical investigations, underscoring lingering scientific questions demand further clarification.

Language: Английский

Citations

17
Effect of Public Investment on Health Population: A Review of BRICS Countries DOI Creative Commons

Tanveer Ahmed Shahid,

Saif Ur Rahman,

Salman Masood Sheikh

et al.

iRASD Journal of Economics, Journal Year: 2024, Volume and Issue: 6(1), P. 1 - 9

Published: Feb. 20, 2024

This research aims to investigate the perspectives offered by literature on health population in relation public investment, Foreign Direct Investment, and Economics Policy Uncertainty emerging nations. paper explores summarizes current theoretical empirical studies issue. It begins providing a summary of foreign direct HP BRICS The is identified second way, utilizing conceptual practical knowledge from published works. Furthermore, this clarified methodologies that describes how these strategies function. work advances fields population, economic policy.

Language: Английский

Citations

16
How Neutrophils Shape the Immune Response: Reassessing Their Multifaceted Role in Health and Disease DOI Open Access
Areez Shafqat, Jibran Ahmad Khan,

Aghiad Yahya Alkachem

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17583 - 17583

Published: Dec. 18, 2023

Neutrophils are the most abundant of circulating immune cells and first to be recruited sites inflammation. a heterogeneous group from which derived extracellular traps (NETs), reactive oxygen species, cytokines, chemokines, immunomodulatory factors, alarmins that regulate recruitment phenotypes neutrophils, macrophages, dendritic cells, T B cells. In addition, cytokine-stimulated neutrophils can express class II major histocompatibility complex internal machinery necessary for successful antigen presentation memory CD4+ This may relevant in context vaccine memory. thus emerge as orchestrators responses play key role determining outcome infections, efficacy, chronic diseases like autoimmunity cancer. review aims provide synthesis current evidence regards these functions homeostasis disease.

Language: Английский

Citations

28
Neutrophil Activity and Extracellular Matrix Degradation: Drivers of Lung Tissue Destruction in Fatal COVID-19 Cases and Implications for Long COVID DOI Creative Commons

Teluguakula Narasaraju,

Indira Neeli, Sheila Criswell

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(2), P. 236 - 236

Published: Feb. 17, 2024

Pulmonary fibrosis, severe alveolitis, and the inability to restore alveolar epithelial architecture are primary causes of respiratory failure in fatal COVID-19 cases. However, factors contributing abnormal fibrosis critically ill patients remain unclear. This study analyzed histopathology lung specimens from eight six non-COVID-19 postmortems. We assessed distribution changes extracellular matrix (ECM) proteins, including elastin collagen, alveoli through morphometric analyses. Our findings reveal significant degradation fibers along thin walls parenchyma, a process that precedes onset interstitial collagen deposition widespread intra-alveolar fibrosis. Lungs with collapsed organized fibrotic regions showed extensive fragmentation fibers, accompanied by cell death. Immunoblotting autopsy tissue extracts confirmed degradation. Importantly, we found loss was strongly correlated induction neutrophil elastase (NE), potent protease degrades ECM. affirms critical role neutrophils enzymes pathogenesis COVID-19. Consistently, observed increased staining for peptidyl arginine deiminase, marker trap release, myeloperoxidase, an enzyme-generating reactive oxygen radical, indicating active involvement pathology. These place at center impaired function argue elastolysis alveolitis trigger ECM repair this has implications complications, long COVID other chronic inflammatory disorders.

Language: Английский

Citations

5
A single-cell RNA sequencing dataset of peripheral blood cells in long COVID patients on herbal therapy DOI Creative Commons
Karolina Hanna Prazanowska, Tae-Hun Kim, Jung Won Kang

et al.

Scientific Data, Journal Year: 2025, Volume and Issue: 12(1)

Published: Jan. 30, 2025

Language: Английский

Citations

0
NETosis: A Key Player in Autoimmunity, COVID-19, and Long COVID DOI Creative Commons
Diana M. Monsalve, Yeny Acosta‐Ampudia, Nicolás Guerrero Acosta

et al.

Journal of Translational Autoimmunity, Journal Year: 2025, Volume and Issue: 10, P. 100280 - 100280

Published: Feb. 21, 2025

Language: Английский

Citations

0
Lipid nanoparticles target neutrophils to reduce SARS-CoV-2-induced lung injury and inflammation DOI

Ha Eun Shin,

Stefanos Giannakopoulos, Joo Dong Park

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113736 - 113736

Published: April 1, 2025

Language: Английский

Citations

0
Nets in fibrosis: Bridging innate immunity and tissue remodeling DOI
Xueni Ma,

LI Ji-pin,

Muyang Li

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 137, P. 112516 - 112516

Published: June 20, 2024

Language: Английский

Citations

3
A Significance of Endothelial Dysfunction in Long COVID-19 for The Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease DOI Open Access
Hidekatsu Yanai,

Hiroki Adachi,

Mariko Hakoshima

et al.

Published: June 21, 2024

Various symptoms have been reported to persist beyond acute phase of severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which is referred as long disease 19 (long COVID-19). Over 65 million individuals suffer from COVID-19. However, the causes COVID-19 largely unknown. Since are observed throughout body, vascular endothelial dysfunction may be a strong candidate induce The angioten-sin-converting enzyme (ACE2), entry receptor SARS-CoV-2, ubiquitously expressed in cells. We previously found that risk factors for athero-sclerotic cardiovascular (ASCVD) and history ASCVD can COVID-19, suggesting contribution pre-existing Here, we show significant association with development biomarkers patients also crucial players ASCVD. consider influence on chronic kidney (CKD) Furthermore, suggest therapeutic interventions by considering treatment tar-gets Such prevent pandemic CKD post era.

Language: Английский

Citations

2
The Significance of Endothelial Dysfunction in Long COVID-19 for the Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease DOI Creative Commons
Hidekatsu Yanai,

Hiroki Adachi,

Mariko Hakoshima

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 965 - 965

Published: Aug. 8, 2024

Various symptoms have been reported to persist beyond the acute phase of severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which is referred as long disease 19 (long COVID-19). Over 65 million individuals suffer from COVID-19. However, causes COVID-19 are largely unknown. Since observed throughout body, vascular endothelial dysfunction a strong candidate explaining induction The angiotensin-converting enzyme (ACE2), entry receptor for SARS-CoV-2, ubiquitously expressed in cells. We previously found that risk factors atherosclerotic cardiovascular (ASCVD) and history ASCVD raise COVID-19, suggesting contribution pre-existing Here, we show significant association with development biomarkers patients also crucial players ASCVD. consider influence on chronic kidney (CKD) Future assessments outcomes resulting therapeutic interventions improve function may imply significance

Language: Английский

Citations

1