Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(25)

Published: April 13, 2023

Diabetic wounds are characterized by drug-resistant bacterial infections, biofilm formation, impaired angiogenesis and perfusion, oxidative damage to the microenvironment. Given their complex nature, diabetic remain a major challenge in clinical practice. Reactive oxygen species (ROS), which have been shown trigger hyperinflammation excessive cellular apoptosis, play pivotal role pathogenesis of wounds. ROS-scavenging nanosystems recently emerged as smart multifunctional nanomedicines with broad synergistic applicability. The documented anti-inflammatory pro-angiogenic ability treatments predestines these promising options for treatment Yet, this context, therapeutic applicability efficacy be elucidated. Herein, ROS is deciphered, properties strengths capacity summarized. In addition, current challenges such potential future directions discussed through clinical-translational lens.

Language: Английский

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CGRP sensory neurons promote tissue healing via neutrophils and macrophages

Nature, Journal Year: 2024, Volume and Issue: 628(8008), P. 604 - 611

Published: March 27, 2024

Abstract The immune system has a critical role in orchestrating tissue healing. As result, regenerative strategies that control components have proved effective 1,2 . This is particularly relevant when dysregulation results from conditions such as diabetes or advanced age impairs healing following injury 2,3 Nociceptive sensory neurons crucial immunoregulators and exert both protective harmful effects depending on the context 4–12 However, how neuro–immune interactions affect repair regeneration acute unclear. Here we show ablation of Na V 1.8 nociceptor skin wound muscle after injury. Nociceptor endings grow into injured tissues signal to cells through neuropeptide calcitonin gene-related peptide (CGRP) during process. CGRP acts via receptor activity-modifying protein 1 (RAMP1) neutrophils, monocytes macrophages inhibit recruitment, accelerate death, enhance efferocytosis polarize towards pro-repair phenotype. neutrophils are mediated thrombospondin-1 release its subsequent autocrine and/or paracrine effects. In mice without nociceptors diabetic with peripheral neuropathies, delivery an engineered version accelerated promoted regeneration. Harnessing potential treat non-healing which dysregulated impair

Language: Английский

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Stimuli-responsive polysaccharide-based smart hydrogels for diabetic wound healing: Design aspects, preparation methods and regulatory perspectives

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 324, P. 121537 - 121537

Published: Nov. 2, 2023

Language: Английский

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Phytoconstituents as modulators of NF-κB signalling: Investigating therapeutic potential for diabetic wound healing

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117058 - 117058

Published: July 4, 2024

The NF-κB pathway plays a pivotal role in impeding the diabetic wound healing process, contributing to prolonged inflammation, diminished angiogenesis, and reduced proliferation. In contrast modern synthetic therapies, naturally occurring phytoconstituents are well-studied inhibitors of that now attracting increased attention context because lower toxicity, better safety efficacy, cost-effectiveness. This study explores recent research on phytoconstituent-based therapies delve into their action mechanisms targeting potential for assisting effective wounds. For this purpose, we have carried out surveys literature analyzed studies from prominent databases such as Science Direct, Scopus, PubMed, Google Scholar, EMBASE, Web Science. classification various categorie as: alkaloids, triterpenoids, phenolics, polyphenols, flavonoids, monoterpene glycosides, naphthoquinones tocopherols. Noteworthy phytoconstituents, including Neferine, Plumbagin, Boswellic acid, Genistein, Luteolin, Kirenol, Rutin, Vicenin-2, Gamma-tocopherol, Icariin, Resveratrol, Mangiferin, Betulinic Berberine, Syringic Gallocatechin, Curcumin, Loureirin-A, Loureirin-B, Lupeol, Paeoniflorin, Puerarin emerge these promising agents through inhibition pathway. Extensive has revealed how they modulate signalling pathways, NF-κB, demonstrate development therapeutic assist chronic

Language: Английский

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Exosomal miRNA-26b-5p from PRP suppresses NETs by targeting MMP-8 to promote diabetic wound healing

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 372, P. 221 - 233

Published: June 23, 2024

Language: Английский

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Recent progress in nanozymes for the treatment of diabetic wounds

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(29), P. 6746 - 6761

Published: Jan. 1, 2023

The slow healing of diabetic wounds has seriously affected human health. Meanwhile, the open are susceptible to bacterial infection. Clinical therapeutic methods such as antibiotic therapy, insulin treatment, and surgical debridement have made great achievements in treatment wounds. However, drug-resistant bacteria will develop after long-term use antibiotics, resulting decreased efficacy. To improve effect, increasing drug concentration is a common strategy clinical practice, but it also brings serious side effects. In addition, hyperglycemia control or can easily bring negative effects patients, hypoglycemia damage normal tissue. Therefore, essential novel strategies effectively promote wound healing. recent years, nanozyme-based systems received extensive attention because they possess advantages nanomaterials natural enzymes. For example, nanozymes small size high surface area volume ratio, which enhance tissue penetration increase reactive active sites. Moreover, compared with enzymes, more stable catalytic activity, lower production cost, stronger operability. this review, we first reviewed basic characteristics then elaborated on mechanism action principle different types from three aspects: controlling infection, hyperglycemia, relieving inflammation. Finally, challenges, prospects future implementation for outlined.

Language: Английский

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Immunomodulatory Nanosystems: Advanced Delivery Tools for Treating Chronic Wounds

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

The increasingly aging society led to a rise in the prevalence of chronic wounds (CWs), posing significant burden public health on global scale. One key features CWs is presence maladjusted immune microenvironment characterized by persistent and excessive (hyper)inflammation. A variety immunomodulatory therapies have been proposed address this condition. Yet, date, current delivery systems for therapy remain inadequate lack efficiency. This highlights need new therapeutic systems, such as nanosystems, manage pathological inflammatory imbalance and, ultimately, improve treatment outcomes CWs. While plethora nanosystems modifying shown promising effects, literature intersection remains relatively scarce. Therefore, review aims provide comprehensive overview pathogenesis characteristics CWs, discuss important advancements our understanding CW healing, delineate versatility applicability nanosystems-based management In addition, we herein also shed light main challenges future perspectives rapidly evolving research field.

Language: Английский

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Galangin: A food‐derived flavonoid with therapeutic potential against a wide spectrum of diseases

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(12), P. 5700 - 5723

Published: Sept. 25, 2023

Abstract Galangin is an important flavonoid with natural activity, that abundant in galangal and propolis. Currently, various biological activities of galangin have been disclosed, including anti‐inflammation, antibacterial effect, anti‐oxidative stress aging, anti‐fibrosis, antihypertensive effect. Based on the above bioactivities, more attention has paid to role neurodegenerative diseases, rheumatoid arthritis, osteoarthritis, osteoporosis, skin cancer. In this paper, sources, pharmacokinetics, therapeutic potential against diseases were systematically reviewed by collecting summarizing relevant literature. addition, molecular mechanism new preparation treatment related are also discussed, broaden application prospect provide reference for its clinical application. Furthermore, it should be noted current toxicity studies insufficient, evidence needed support possibility as a functional food.

Language: Английский

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Astragalin: a food-origin flavonoid with therapeutic effect for multiple diseases

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 18, 2023

Naturally occurring flavonoids have long been utilized as essential templates for the development of novel drugs and critical ingredients functional foods. Astragalin (AG) is a natural flavonoid that can be isolated from variety familiar edible plants, such seeds green tea, Morus alba L., Cuscuta chinensis. It noteworthy AG has wide range pharmacological activities possesses therapeutic effects against diseases, covering cancers, osteoarthritis, osteoporosis, ulcerative colitis, mastitis, obesity, diabetes mellitus, diabetic complications, ischemia/reperfusion injury, neuropathy, respiratory reproductive system diseases. This article reviewed source pharmacokinetics systematically summarized potential mechanisms in treating diverse diseases order to promote food, doing so providing references its clinical application disease therapy.

Language: Английский

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A novel diabetic foot ulcer diagnostic model: identification and analysis of genes related to glutamine metabolism and immune infiltration

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Jan. 30, 2024

Abstract Background Diabetic foot ulcer (DFU) is one of the most common and severe complications diabetes, with vascular changes, neuropathy, infections being primary pathological mechanisms. Glutamine (Gln) metabolism has been found to play a crucial role in diabetes complications. This study aims identify validate potential Gln biomarkers associated DFU through bioinformatics machine learning analysis. Methods We downloaded two microarray datasets related patients from Gene Expression Omnibus (GEO) database, namely GSE134431, GSE68183, GSE80178. From GSE134431 dataset, we obtained differentially expressed Gln-metabolism genes (deGlnMRGs) between normal controls. analyzed correlation deGlnMRGs immune cell infiltration status. also explored relationship GlnMRGs molecular clusters Notably, WGCNA (DEGs) within specific clusters. Additionally, conducted GSVA annotate enriched genes. Subsequently, constructed screened best model. Finally, validated predictions' accuracy using nomogram, calibration curves, decision curve analysis (DCA), GSE80178 dataset. Results In both control groups, confirmed presence an activated response. 20 deGlnMRGs, including CTPS1, NAGS, SLC7A11, GGT1, GCLM, RIMKLA, ARG2, ASL, ASNS, ASNSD1, PPAT, GLS2, GLUD1, MECP2, ASS1, PRODH, CTPS2, ALDH5A1, DGLUCY, SLC25A12. Furthermore, were identified DFU. Immune indicated heterogeneity these established Support Vector Machine (SVM) model based on 5 (R3HCC1, ZNF562, MFN1, DRAM1, PTGDS), which exhibited excellent performance external validation datasetGSE134431, (AUC = 0.929). Conclusion five DFU, revealing novel therapeutic targets for immune-inflammatory cells plays progression

Language: Английский

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