Novel insight into the therapeutical potential of flavonoids from traditional Chinese medicine against cerebral ischemia/reperfusion injury

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 29, 2024

Cerebral ischemia/reperfusion injury (CIRI) is a major contributor to poor prognosis of ischemic stroke. Flavonoids are broad family plant polyphenols which abundant in traditional Chinese medicine (TCM) and have beneficial effects on several diseases including Accumulating studies indicated that flavonoids derived from herbal TCM effective alleviating CIRI after stroke vitro or vivo , exhibit favourable therapeutical potential. Herein, we systematically review the classification, metabolic absorption, neuroprotective efficacy, mechanisms against CIRI. The literature suggest exert potential medicinal functions suppressing excitotoxicity, Ca 2+ overloading, oxidative stress, inflammation, thrombin’s cellular toxicity, different types programmed cell deaths, protecting blood-brain barrier, as well promoting neurogenesis recovery stage following Furthermore, identified certain matters should be taken into account future research, proposed difficulties opportunities transforming TCM-derived medications functional foods for treatment prevention Overall, this aim provide novel ideas identification new prospective medication candidates therapeutic strategy

Language: Английский

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Research Progress on Anti-Inflammatory Effects and Related Mechanisms of Astragalin

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4476 - 4476

Published: April 19, 2024

Chronic inflammation is a significant contributor to the development of cancer, cardiovascular disease, diabetes, obesity, autoimmune inflammatory bowel and other illnesses. In academic field, there constant demand for effective methods alleviate inflammation. Astragalin (AST), type flavonoid glycoside that primary component in several widely used traditional Chinese anti-inflammatory medications clinical practice, has garnered attention from numerous experts scholars. This article focuses on effects AST conducts research relevant literature 2003 2023. The findings indicate demonstrates promising potential various models diseases. Specifically, believed possess inhibitory inflammation-related factors protein levels vitro cell models, such as macrophages, microglia, epithelial cells. vivo studies have shown effectively alleviates neuroinflammation brain damage while also exhibiting treating moderate diseases depression stroke; it both large small intestinal Animal experiments further demonstrated exerts therapeutic colitis mice. Molecular biology revealed regulates complex signaling networks, including NF-κB, MAPK, JAK/STAT pathways, etc. conclusion, this review will provide insights references an agent well related drug development.

Language: Английский

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Flavonoid Synthesis Pathway Response to Low-Temperature Stress in a Desert Medicinal Plant, Agriophyllum Squarrosum (Sandrice)

Genes, Journal Year: 2024, Volume and Issue: 15(9), P. 1228 - 1228

Published: Sept. 20, 2024

(L.) Moq. (

Language: Английский

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Astragalin alleviates lipopolysaccharide-induced depressive-like behavior in mice by preserving blood-brain barrier integrity and suppressing neuroinflammation

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: 232, P. 340 - 352

Published: March 13, 2025

Language: Английский

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Astragalin improves cognitive disorder in Alzheimer's disease: Based on network pharmacology and molecular docking simulation

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(8)

Published: Aug. 1, 2024

We investigate the mechanism of action astragalin (AST) in treatment Alzheimer's disease (AD). Network pharmacology was conducted to analyze relationships among AST, AD, and neuroinflammation, The APP/PS1 transgenic mice with AD were used experiments; be specific, influence AST on behavior analyzed by Morris water maze eight-arm radial tests, tissue inflammatory factor levels detected ELISA, pathological changes H&E immunohistochemical staining. Analysis results network suggested that exerted multi-target effect neuroinflammation AD. Through molecular docking dynamics analyses, COX2 might target AST. Moreover, animal experimental demonstrated improved mice, enhanced motor memory abilities, meanwhile, it suppressed expression factors tissues activation microglial cells. this study discovers can suppress cell via improve

Language: Английский

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Ginsenoside Rg3 Restores Mitochondrial Cardiolipin Homeostasis via GRB2 to Prevent Parkinson's Disease

Advanced Science, Journal Year: 2024, Volume and Issue: 11(39)

Published: Aug. 19, 2024

Abstract Regulating cardiolipin to maintain mitochondrial homeostasis is a promising strategy for addressing Parkinson's disease (PD). Through comprehensive screening and validation process involving multiple models, ginsenoside Rg3 (Rg3) as compound capable of enhancing levels identified. This augmentation in fosters by bolstering unfolded protein response, promoting mitophagy, oxidative phosphorylation. Consequently, this cascade enhances the survival tyrosine hydroxylase positive (TH + ) dopaminergic neurons, leading an amelioration motor performance within PD mouse models. Using limited proteolysis–small‐molecule mapping combined with molecular docking analysis, it has confirmed Growth Factor Receptor‐Bound Protein 2 (GRB2) target Rg3. Furthermore, these investigations reveal that facilitates interaction between GRB2 TRKA (Neurotrophic Tyrosine Kinase, Receptor, Type 1), thus promotes EVI1 (Ecotropic Virus Integration Site 1 Homolog) phosphorylation ERK, subsequently increases CRLS1 (Cardiolipin Synthase 1) gene expression boosts synthesis. The absence or significantly attenuates beneficial effects on symptoms. Finally, Tenofovir Disoproxil Fumarate (TDF) also binding further identified compounds, TDF, exhibit potential prevention reinstating homeostasis.

Language: Английский

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An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Nuclear factor-κB (NF-κB) cell signaling pathway is essential for the progression and development of numerous human disorders, including cancer. NF-κB regulates a wide range physiological processes, such as survival, growth, migration. Deregulated NF-kB resulted in unregulated proliferation, viability, movement, invasion, thus promoting tumor development. Recent findings have increasingly shown that plant derived phytochemicals inhibit potential to be employed cancer therapeutics. Flavonoids are group polyphenolic natural compounds present various plants their fruits, vegetables, leaves. These medicinal properties owing antioxidant, anti-inflammatory, antiviral, antitumor characteristics. The main mechanism by which these flavonoids exhibit anticancer via potent antioxidative immunomodulatory actions. Current research reports demonstrated exhibited effects suppressing signaling. Based on facts, we comprehensively outlined role processes progression, drug resistance, angiogenesis metastasis. In addition these, also summarize specifically targeting types cancers.

Language: Английский

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Natural products target pyroptosis for ameliorating neuroinflammation: A novel antidepressant strategy

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156394 - 156394

Published: Jan. 14, 2025

Language: Английский

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Astragalin inhibits neuronal excitability and activates neuronal autophagy in the ACC and LH of CFA mice to alleviate inflammatory pain and pain-related emotions

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114115 - 114115

Published: Jan. 21, 2025

Language: Английский

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Lipopolysaccharide-Induced Inflammatory Response and Its Prominent Suppression by Paspalum thunbergii Extract

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1611 - 1611

Published: Feb. 13, 2025

The extract of Paspalum thunbergii, a native perennial herb in Korea belonging to the rice family, was investigated for its anti-inflammatory activity and underlying mechanisms driving effects. Fifteen chemical components P. thunbergii extract, including rosmarinic acid isoquercitrin, were identified using LC-MS. showed antioxidative through DPPH ABTS cation radical scavenging activity. significantly inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production macrophage RAW 264.7 cells. expression lipopolysaccharide-induced iNOS COX-2, which are inflammation-related enzymes. To explore mechanism, levels signal proteins related MAPK, NF-κB, JAK/STAT, Wnt/β-catenin signaling measured. As result, p-p38, p-JNK increased by LPS Additionally, it decreased LPS-induced p-IKKβ p-NF-κB p65 prevented migration into nucleus caused LPS. Notably, p-JAK1, p-STAT3, Wnt 3α, β-catenin, p-GSK-3β protein expressions also inhibited. Therefore, prominent may be via pathway.

Language: Английский

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