The significant mechanism and treatments of cell death in heatstroke

APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(7-8), P. 967 - 980

Published: June 17, 2024

Language: Английский

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Exploration and breakthrough in the mode of chondrocyte death - A potential new mechanism for osteoarthritis

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 115990 - 115990

Published: Dec. 6, 2023

Osteoarthritis (OA) is a frequent chronic joint disease in orthopedics that effects individuals and society significantly. Obesity, aging, genetic susceptibility, misalignment are all known risk factors for OA, but its pathomechanism still poorly understood. Researches have revealed OA much complex process related to inflammation, metabolic chondrocyte death. It can affect parts of the characterized by causing death extracellular matrix descent. Previously, was thought develop from excessive mechanical loading leading destruction articular cartilage. Since some programmed cell deaths share pattern destruction, it likely also involves Even though apoptosis pyroptosis been investigated clarifing solely conventional pathways insufficient understand pathophysiology osteoarthritis. With more researches, has discovered osteoarthritis other new processes, including PANoptosis, ferroptosis, senescence, strongly associated. Among these, PANoptosis combines key traits pyroptosis, apoptosis, necrotic into highly coordinated dynamically balanced inflammatory mechanism. Furthermore, we think PANopotosis might obstruct necroptosis senescence. Therefore, order offer direction therapeutic treatment, evaluate development research on multiple chondrocytes OA.

Language: Английский

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PANoptosis in cancer, the triangle of cell death

Cancer Medicine, Journal Year: 2023, Volume and Issue: 12(24), P. 22206 - 22223

Published: Dec. 1, 2023

Abstract Background PANoptosis is a novel form of programmed cell death (PCD) found in 2019 that regulated by the PANoptosome. combines essential features pyroptosis, apoptosis, and necroptosis, forming “death triangle” cells. While necroptosis have been extensively studied for their roles human inflammatory diseases many other clinical conditions, historically they were considered as independent processes. However, emerging evidence indicates these PCDs exhibit cross talk interactions, resulting development concept PANoptosis. Methods In this review, we offer concise summary fundamental mechanisms necroptosis. We subsequently introduce notion detail assembly mechanism PANoptosome complex which responsible inducing death. also describe some regulatory networks Results now has associated with various including cancer. Although exact function each tumor not fully understood, it represents prospective avenue cancer therapy, offering promise advancements therapy. Conclusions future, in‐depth study will continue to help us understanding processes underlying provide scientific support research.

Language: Английский

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Induction mechanisms of autophagy and endoplasmic reticulum stress in intestinal ischemia-reperfusion injury, inflammatory bowel disease, and colorectal cancer

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 115984 - 115984

Published: Dec. 8, 2023

In recent years, the incidence of intestinal ischemia-reperfusion injury (II/RI), inflammatory bowel disease (IBD), and colorectal cancer (CRC) has been gradually increasing, posing significant threats to human health. Autophagy endoplasmic reticulum stress (ERS) play important roles in II/RI. Damage caused by ischemia cellular can activate ERS, which turn initiates autophagy clear damaged organelles abnormal proteins, thereby alleviating ERS maintaining environment. IBD, chronic inflammation damages tissues activates ERS. is initiated upregulating ATG genes downregulating factors that inhibit autophagy, clearing organelles, bacteria. Simultaneously, persistent stimulation also trigger leading protein imbalance folding ER lumen. The activation maintain homeostasis initiating process, reducing responses cell apoptosis intestine. CRC, excessive proliferation synthesis lead increased regulated signaling pathways such as IRE1α PERK, initiate proteins negative effects It be seen a crucial regulatory role development diseases. Therefore, progress targeted therapy for diseases based on provides novel strategies managing this paper, we review advances regulation diseases, emphasizing potential molecular mechanisms therapeutic applications.

Language: Английский

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Construction of disulfidptosis-related lncRNA signature for predicting the prognosis and immune escape in colon adenocarcinoma

BMC Gastroenterology, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 10, 2023

Colon adenocarcinoma (COAD) is one of the most frequent types cancer worldwide. Disulfidptosis has been identified as a new mode cell death recently. The goal this study was to explore possibility connection between disulfidptosis and COAD. RNA sequencing data from COAD patients were retrieved Cancer Genome Atlas (TCGA) database for investigation. R software various methods used identify disulfidptosis-related lncRNAs (DRLs) in COAD, prognostic model created based on 6 DRLs (AP003555.1, AL683813.1, SNHG7, ZEB1-AS1, AC074212.1, RPL37A-DT). demonstrated good accuracy predicting prognosis patients, according receiver operating characteristic (ROC) curve Concordance index (C-index) analyses. Gene Ontology (GO) enrichment analysis Kyoto Encyclopedia Genes Genomes (KEGG) revealed significant differences biological functions signaling pathways involved differential genes risk subgroups, including protein - DNA complex subunit organization, Hippo pathway, Wnt pathway. TIDE done groupings study, it found that high-risk group had more immune escape potential less probable react immunotherapy. Real-time quantitative pcr (qRT-PCR) relatively high expression colon lines. In summary, possible novel molecular therapy targets This be tool forecasting clinical practice, well providing insights function mechanism process.

Language: Английский

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