Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer’s disease

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Feb. 19, 2024

Alzheimer’s disease (AD) is a prevalent neurodegenerative that has become one of the main factors affecting human health. It serious impacts on individuals, families, and society. With development population aging, incidence AD will further increase worldwide. Emerging evidence suggests many physiological metabolic processes, such as lipid metabolism, are implicated in pathogenesis AD. Bile acids, undertakers play an important role occurrence disease. Tauroursodeoxycholic acid, endogenous bile been proven to possess therapeutic effects different diseases, including This review tries find relationship between acid metabolism AD, well explore potential taurocursodeoxycholic for this The mechanisms may include reducing deposition Amyloid-β protein, regulating apoptotic pathways, preventing tau hyperphosphorylation aggregation, protecting neuronal synapses, exhibiting anti-inflammatory properties, improving disorders. objective study shed light use tauroursodeoxycholic preparations prevention treatment with aim identifying effective targets clarifying various involved

Language: Английский

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The effect of eight weeks of aerobic training with vitamin C on some apoptotic markers in the hippocampus tissue of rats with Alzheimer’s disease; an experimental study

Neurological Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: Jan. 4, 2025

Objectives The aim of this study was to investigate the effect eight weeks aerobic training (AT) and vitamin C supplementation (VC) on apoptotic markers in hippocampus tissue AD rats treated with trimethyltin (TMT).

Language: Английский

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Trends and Disparities in Alzheimer’s Disease Mortality in the United States: The Impact of COVID-19

NeuroSci, Journal Year: 2025, Volume and Issue: 6(1), P. 16 - 16

Published: Feb. 14, 2025

Background: Alzheimer's disease (AD) is the fifth leading cause of death for Americans older than 65. Though fluctuations have been noticed over past two decades, mortality patients increased considerably during COVID-19 pandemic. This study aims to explore temporal trends in AD-associated (ADAM) and disparities these trends, we aim discern changes Methods: The CDC WONDER Multiple Cause-of-Death Public Use Records from 1999 2022 were used extract population data on deaths related AD stratify them based age, biological sex, race, ethnicity, place death, census region, state. ICD-10 codes G30.0, G30.1, G30.8, G30.9 identify AD-related mortality. Statistical analysis was performed using Joinpoint Regression Program version 5.0.2. Results: We confirmed an increase rate all races, sexes, places age groups above 65, states/census regions. Interestingly, age-adjusted (AAMR) consistently higher females compared males. Non-Hispanic whites had highest by race ethnicity. At intersection White AAMR with AD. Lastly, noted at hospice facilities as other death. Conclusions: Our findings demonstrate that number due exacerbated recent pandemic disproportionately affected. relating ADAM uncovered this may assist healthcare administrators policymakers their decisions. Additionally, might help initiate larger studies focusing novel risk/prognostic factors

Language: Английский

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Shared genetic architecture of COVID-19 and Alzheimer’s disease

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Oct. 20, 2023

The severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the сoronavirus disease 2019 (COVID-19) have become a global health threat. At height of pandemic, major efforts were focused on reducing COVID-19-associated morbidity mortality. Now is time to study long-term effects particularly cognitive impairment associated with long COVID. In recent years much attention has been paid possible relationship between COVID-19 Alzheimer’s disease, which considered main cause age-related impairment. Genetic predisposition was shown for both disease. However, analysis similarity genetic architecture these diseases usually limited indicating positive correlation them. this review, we described intrinsic linkages pointed out shared susceptibility genes that previously identified in genome-wide association studies highlighted panel SNPs includes candidate risk markers COVID-associated

Language: Английский

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Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer’s Disease

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 788 - 788

Published: June 16, 2024

The COVID-19 pandemic, caused by infection with the SARS-CoV-2 virus, is associated cognitive impairment and Alzheimer’s disease (AD) progression. Once it enters brain, virus stimulates accumulation of amyloids in brain that are highly toxic to neural cells. These may trigger neurological symptoms COVID-19. meningeal lymphatic vessels (MLVs) play an important role removal toxins mediate viral drainage from brain. MLVs considered a promising target prevent COVID-19-exacerbated dementia. However, there limited methods for augmentation MLV function. This review highlights new discoveries field COVID-19-mediated amyloid development strategies stimulate clearance through other pathways. based on innovative treating dysfunction induced infection, including use photobiomodulation, plasmalogens, medicinal herbs, which offer hope addressing challenges posed virus.

Language: Английский

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Vergleich zwischen COVID-19-bedingten und anderen natürlichen Todesfällen während der ersten fünf Pandemiewellen

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, Journal Year: 2024, Volume and Issue: 67(8), P. 939 - 946

Published: July 16, 2024

Older age is a risk factor for fatal course of SARS-CoV‑2 infection, possibly due to comorbidities whose exact role in this context, however, not yet well understood. In paper, the characteristics and persons who had died COVID-19 Bavaria by July 2022 are shown compared with other fatalities during pandemic.

Language: Английский

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Pathogenesis, Animal Models, and Drug Discovery of Alzheimer’s Disease

Journal of Alzheimer s Disease, Journal Year: 2023, Volume and Issue: 94(4), P. 1265 - 1301

Published: July 7, 2023

Alzheimer’s disease (AD), the most common cause of dementia, is a chronic neurodegenerative induced by multiple factors. The high incidence and aging global population make it growing health concern with huge implications for individuals society. clinical manifestations are progressive cognitive dysfunction lack behavioral ability, which not only seriously affect quality life elderly, but also bring heavy burden to family Unfortunately, almost all drugs targeting classical pathogenesis have achieved satisfactory effects in past two decades. Therefore, present review provides more novel ideas on complex pathophysiological mechanisms AD, including variety possible that been proposed recent years. It will be helpful find out key target effect pathway potential prevention treatment AD. In addition, animal models AD research outlined we examine their prospect future. Finally, Phase I, II, III, IV randomized trials or market were searched online databases (Drug Bank Online 5.0, U.S. National Library Medicine, Alzforum). this may provide useful information development new AD-based drugs.

Language: Английский

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Human-derived air–liquid interface cultures decipher Alzheimer’s disease–SARS-CoV-2 crosstalk in the olfactory mucosa

Journal of Neuroinflammation, Journal Year: 2023, Volume and Issue: 20(1)

Published: Dec. 14, 2023

Abstract Background The neurological effects of the coronavirus disease 2019 (COVID-19) raise concerns about potential long-term consequences, such as an increased risk Alzheimer's (AD). Neuroinflammation and other AD-associated pathologies are also suggested to increase serious SARS-CoV-2 infection. Anosmia is a common symptom reported in COVID-19 early AD. olfactory mucosa (OM) important for perception smell proposed site viral entry brain. However, little known infection at OM individuals with Methods To address this gap, we established 3D vitro model from primary cells derived cognitively healthy AD individuals. We cultured air–liquid interface (ALI) study under controlled experimental conditions. Primary ALI expressed angiotensin-converting enzyme 2 (ACE-2), neuropilin-1 (NRP-1), several receptor were highly vulnerable Infection was determined by secreted RNA content confirmed nucleocapsid protein (NP) infected immunocytochemistry. Differential responses individuals-derived sequencing. Results indicate that donors do not differ susceptibility wild-type virus. transcriptomic signatures distinct. Specifically, patients virus showed levels oxidative stress, desensitized inflammation immune responses, alterations genes associated olfaction. These results imply may be greater experiencing severe outcomes infection, potentially driven pre-existing neuroinflammation. Conclusions sheds light on interplay between pathology Altered contribute unique symptoms more course, notable involvement Furthermore, research emphasizes need targeted interventions enhance crucial better comprehend relationship AD, COVID-19, anosmia. It highlights importance ongoing develop effective treatments those high Graphical

Language: Английский

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Uncovering the Correlation between COVID-19 and Neurodegenerative Processes: Toward a New Approach Based on EEG Entropic Analysis

Bioengineering, Journal Year: 2023, Volume and Issue: 10(4), P. 435 - 435

Published: March 29, 2023

COVID-19 is an ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Although it primarily attacks tract, inflammation can also affect central nervous system (CNS), leading to chemo-sensory deficits such as anosmia and serious cognitive problems. Recent studies have shown a connection between neurodegenerative diseases, particularly Alzheimer's disease (AD). In fact, AD appears exhibit neurological mechanisms of protein interactions similar those that occur during COVID-19. Starting from these considerations, this perspective paper outlines new approach based on analysis complexity brain signals identify quantify common features disorders. Considering relation olfactory deficits, AD, COVID-19, we present experimental design involving tasks using multiscale fuzzy entropy (MFE) for electroencephalographic (EEG) signal analysis. Additionally, open challenges future perspectives. More specifically, are related lack clinical standards regarding EEG public data be exploited in phase. Furthermore, integration with machine learning still requires further investigation.

Language: Английский

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Impairment of brain function in a mouse model of Alzheimer's disease during the pre-depositing phase: The role of α7 nicotinic acetylcholine receptors

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117255 - 117255

Published: Aug. 7, 2024

Alzheimer's disease (AD) is an age-dependent incurable neurodegenerative disorder accompanied by neuroinflammation, amyloid accumulation, and memory impairment. It begins decades before the first clinical symptoms appear, identifying early biomarkers key for developing disease-modifying therapies. We show now in a mouse model of AD that any deposition brains 1.5-month-old mice contain increased levels pro-inflammatory cytokines IL-1β IL-6, decreased nicotinic acetylcholine receptors (nAChRs) brain mitochondria amounts α7 nAChR-bound Aβ

Language: Английский

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