Macrophages and Gut Barrier Function: Guardians of Gastrointestinal Health in Post-Inflammatory and Post-Infection Responses

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9422 - 9422

Published: Aug. 30, 2024

The gut barrier is essential for protection against pathogens and maintaining homeostasis. Macrophages are key players in the immune system, indispensable intestinal health, contribute to defense repair mechanisms. Understanding multifaceted roles of macrophages can provide critical insights into restoring gastrointestinal (GI) health. This review explores role function their contribution post-inflammatory post-infectious responses gut. significantly integrity through epithelial repair, modulation, interactions with microbiota. They demonstrate active plasticity by switching phenotypes resolve inflammation, facilitate tissue regulate microbial populations following an infection or inflammation. In addition, tissue-resident (M2) infiltration (M1) convert each other problems such as IBS IBD via major signaling pathways mediated NF-κB, JAK/STAT, PI3K/AKT, MAPK, Toll-like receptors, specific microRNAs miR-155, miR-29, miR-146a, miR-199, which may be good targets new therapeutic approaches. Future research should focus on elucidating detailed molecular mechanisms developing personalized approaches fully harness potential maintain restore permeability

Language: Английский

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Mutations, inflammation and phenotype of myeloproliferative neoplasms

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: May 22, 2023

Knowledge on the myeloproliferative neoplasms (MPNs) – polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF) has accumulated since discovery of JAK/STAT-activating mutations associated with MPNs: JAK2 V617F, observed in PV, ET and PMF; MPL CALR mutations, found PMF. The intriguing lack disease specificity these chronic inflammation MPNs, triggered a quest for finding what precisely determines that MPN patients develop or PMF phenoptype. mechanisms action MPN-driving concomitant ( ASXL1, DNMT3A, TET2 , others), have been extensively studied, as well role played by inflammation, several pathogenic models proposed. In parallel, different types drugs tested MPNs (JAK inhibitors, interferons, hydroxyurea, anagrelide, azacytidine, combinations those), some acting both inflammation. Yet remain incurable diseases. This review aims to present current, detailed knowledge specifically may pave way development novel, curative therapies.

Language: Английский

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Possible Mechanisms of Dark Tea in Cancer Prevention and Management: A Comprehensive Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(18), P. 3903 - 3903

Published: Sept. 7, 2023

Tea is one of the most popular drinks in world. Dark tea a kind post-fermented with unique sensory characteristics that produced by special fermentation microorganisms. It contains many bioactive substances, such as polyphenols, theabrownin, polysaccharides, etc., which have been reported to be beneficial human health. This paper reviewed latest research on dark tea’s potential preventing and managing cancer, mechanisms mainly involved anti-oxidation, anti-inflammation, inhibiting cancer cell proliferation, inducing apoptosis, tumor metastasis, regulating intestinal flora. The purpose this review accumulate evidence anti-cancer effects tea, corresponding limitations for prevention management, future prospects, demanding questions about possible contributions an adjuvant.

Language: Английский

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Hyaluronic Acid Viscosupplement Modulates Inflammatory Mediators in Chondrocyte and Macrophage Coculture via MAPK and NF-κB Signaling Pathways

ACS Omega, Journal Year: 2024, Volume and Issue: 9(19), P. 21467 - 21483

Published: May 1, 2024

Osteoarthritis (OA) is a chronic musculoskeletal disorder characterized by cartilage degeneration and synovial inflammation. Paracrine interactions between chondrocytes macrophages play an essential role in the onset progression of OA. In this study, replicating inflammatory response during OA pathogenesis, were treated with interleukin-1β (IL-1β), lipopolysaccharide interferon-γ. addition, coculture system was developed to simulate biological situation joint. we examined impact hyaluronic acid (HA) viscosupplement, particularly Hyruan Plus, on macrophages. Notably, viscosupplement has demonstrated promising outcomes reducing inflammation; however, underlying mechanism action remains elusive. The attenuated inflammation, showing inhibitory effect nitric oxide production, downregulating proinflammatory cytokines such as matrix metalloproteinases (MMP13 MMP3), upregulating expression levels type II collagen aggrecan chondrocytes. HA also reduced level IL-1β, TNF-α, IL-6 macrophages, exerted overall protective partially suppressing MAPK pathway p65/NF-κB signaling Therefore, shows potential for treating arthritic joints.

Language: Английский

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Polarization of M2 Tumor-associated Macrophages (TAMs) in Cancer Immunotherapy

Critical Reviews™ in Oncogenesis, Journal Year: 2024, Volume and Issue: 29(4), P. 75 - 95

Published: Jan. 1, 2024

We have witnessed in the last decade new milestones treatment of various resistant cancers with immunotherapeutic modalities. These advances resulted significant objective durable clinical responses a subset cancer patients. findings strongly suggested that immunotherapy should be considered for all subsets Accordingly, mechanisms underlying resistance to must explored and develop means target these factors. One pivotal tumor microenvironment (TME) is high infiltration tumor-associated macrophages (TAMs) are highly immunosuppressive responsible, large part, immune evasion. Thus, approaches been investigated TAMs restore anti-tumor response. approach polarize M2 TAMS M1 phenotype participates activation In this review, we discuss differential properties phenotypes, molecular signaling pathways participate polarization, used polarization into phenotype. include inhibitors histone deacetylases, PI3K inhibitors, STAT3 TLR agonists, metabolic reprogramming. Clearly, due distinct features their heterogeneities, single outlined above might only effective against some not others. addition, targeting by itself may efficacious unless combination other therapeutic

Language: Английский

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Anti-Inflammatory Activities of Yataprasen Thai Traditional Formulary and Its Active Compounds, Beta-Amyrin and Stigmasterol, in RAW264.7 and THP-1 Cells

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1018 - 1018

Published: Aug. 1, 2024

Yataprasen (YTPS) remedy formulary, a national Thai traditional medicine comprises 13 herbal plants. It has been extensively prescribed to relieve osteoarthritis and musculoskeletal pain in the healthcare system. The aim of this study was investigate antioxidant anti-inflammatory properties bioactive compounds (β-amyrin stigmasterol) YTPS formulary ethanolic extract, along with its composition. extract contains 70.30 nM β-amyrin 605.76 stigmasterol. exhibited ABTS DPPH free radical scavenging activity, IC

Language: Английский

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Shaping the immune landscape: Multidimensional environmental stimuli refine macrophage polarization and foster revolutionary approaches in tissue regeneration

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37192 - e37192

Published: Aug. 30, 2024

In immunology, the role of macrophages extends far beyond their traditional classification as mere phagocytes; they emerge pivotal architects immune response, with function being significantly influenced by multidimensional environmental stimuli. This review investigates nuanced mechanisms which diverse external signals ranging from chemical cues to physical stress orchestrate macrophage polarization, a process that is crucial for modulation responses. By transitioning between pro-inflammatory (M1) and anti-inflammatory (M2) states, exhibit remarkable plasticity, enabling them adapt influence surroundings effectively. The exploration polarization provides compelling narrative on how these cells can be manipulated foster an environment conducive tissue repair regeneration. Highlighting cutting-edge research, this presents innovative strategies leverage dynamic interplay environment, proposing novel therapeutic avenues harness potential in regenerative medicine. Moreover, critically evaluates current challenges future prospects translating macrophage-centered laboratory clinical applications.

Language: Английский

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Wei-fu-chun tablet halted gastric intestinal metaplasia and dysplasia associated with inflammation by regulating the NF-κB pathway

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 318, P. 117020 - 117020

Published: Aug. 9, 2023

Language: Английский

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FKBP5 regulates trophoblast-macrophage crosstalk in recurrent spontaneous abortion through PI3K/AKT and NF-κB signaling pathways

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 209, P. 55 - 69

Published: Oct. 10, 2023

Language: Английский

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Nerve Growth Factor and Autoimmune Diseases

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(11), P. 8950 - 8973

Published: Nov. 10, 2023

NGF plays a crucial immunomodulatory role and increased levels are found in numerous tissues during autoimmune states. directly modulates innate adaptive immune responses of B T cells causes the release neuropeptides neurotransmitters controlling system activation inflamed tissues. Evidence suggests that is involved pathogenesis diseases including thyroiditis, chronic arthritis, multiple sclerosis, systemic lupus erythematosus, mastocytosis, granulomatous disease. Furthermore, as have been linked to disease severity, it could be considered an optimal early biomarker identify therapeutic approach efficacy. In conclusion, by gaining insights into how these molecules function which they interact with, future studies can devise targeted therapies address various neurological, immunological, other disorders more effectively. This knowledge may pave way for innovative treatments based on manipulation aimed at improving quality life individuals affected involving neurotrophins.

Language: Английский

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