Advances in Clinical Medicine, Journal Year: 2023, Volume and Issue: 13(07), P. 11741 - 11749
Published: Jan. 1, 2023
Language: Английский
Burns & Trauma, Journal Year: 2024, Volume and Issue: 12
Published: Jan. 1, 2024
Abstract Diabetic foot ulcer (DFU), characterized by high recurrence rate, amputations and mortality, poses a significant challenge in diabetes management. The complex pathology involves dysregulated glucose homeostasis leading to systemic local microenvironmental complications, including peripheral neuropathy, micro- macro-angiopathy, recurrent infection, persistent inflammation re-epithelialization. Novel approaches accelerate DFU healing are actively pursued, with focus on utilizing exosomes. Exosomes natural nanovesicles mediating cellular communication containing diverse functional molecular cargos, DNA, mRNA, microRNA (miRNA), lncRNA, proteins, lipids metabolites. While some exosomes show promise modulating function promoting healing, their efficacy is limited low yield, impurities, loading content inadequate targeting. Engineering enhance curative activity represents potentially more efficient approach for DFUs. This could facilitate focused repair regeneration of nerves, blood vessels soft tissue after development. review provides an overview pathogenesis, strategies exosome engineering the targeted therapeutic application engineered addressing critical pathological changes associated
Language: Английский
Citations
8
Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e28086 - e28086
Published: March 1, 2024
Wound healing is an intricate and fine regulatory process. In diabetic patients, advanced glycation end products (AGEs), excessive reactive oxygen species (ROS), biofilm formation, persistent inflammation, angiogenesis regression contribute to delayed wound healing. Epigenetics, the fast-moving science in 21st century, has been up date associated with repair. this review, we go over functions of epigenetics repair retrospect, covering transcriptional posttranscriptional regulation. Among these, found that histone modification widely involved inflammation by affecting macrophages endothelial cells. DNA methylation factors regulation but also affects differentiation phenotype cells hyperglycemia. addition, noncodingRNA RNA were generalized. The future prospects for epigenetic applications are discussed end. conclusion, study suggests integral mechanism
Language: Английский
Citations
7
ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(5), P. 2725 - 2741
Published: April 17, 2024
Amidst the present healthcare issues, diabetes is unique as an emerging class of affliction with chronicity in a majority population. To check and control its effects, there have been huge turnover constant development management strategies, though bigger part health care area involved achieving related issues such effect on wound healing many works reached certain successful outcomes, still lack managing it, maximum yet to be attained. Studying pathophysiology involvement various treatment options, tissue engineering, application hydrogels, drug delivery methods, enhancing angiogenesis, are at constantly developing stages either direct or indirect. In this review, we gathered wide field information different new therapeutic methods targets for scientific community, paving way toward more settled ideas research advances cure diabetic wounds manage their outcomes.
Language: Английский
Citations
7
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 6411 - 6423
Published: Nov. 1, 2023
Abstract: Skin photoaging is a complex biological process characterized by the accumulation of oxidative damage and structural changes in skin, resulting from chronic exposure to ultraviolet (UV) radiation. Despite growing demand for effective treatments, current therapeutic options skin remain limited. However, emerging research has highlighted potential extracellular vesicles (EVs), including exosomes, micro-vesicles, apoptotic bodies liposomes, as promising agents rejuvenation. EVs are involved intercellular communication can deliver bioactive molecules, proteins, nucleic acids, lipids, recipient cells, thereby influencing various cellular processes. This comprehensive review aims summarize progress application treatment photoaging, their isolation characterization methods, roles homeostasis, clinical applications photoaging. Additionally, challenges future directions EVs-based therapies rejuvenation discussed. Keywords: vesicles, stem
Language: Английский
Citations
14
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4357 - 4375
Published: May 1, 2024
Abstract: Wound healing is a sophisticated and orderly process of cellular interactions in which the body restores tissue architecture functionality following injury. Healing chronic diabetic wounds difficult due to impaired blood circulation, reduced immune response, disrupted repair mechanisms, are often associated with diabetes. Stem cell-derived extracellular vesicles (SC-EVs) hold regenerative potential, encapsulating diverse cargo proteins, RNAs, cytokines, presenting safe, bioactivity, less ethical issues than other treatments. SC-EVs orchestrate multiple processes by modulating communication, increasing angiogenesis, promoting recruitment differentiation progenitor cells, thereby potentiating reparative milieu for wound healing. Therefore, this review investigated effects mechanisms EVs from various stem cells healing, as well their limitations challenges. Continued exploration has potential revolutionize care. Keywords: diabetes, EVs, ncRNAs, regeneration
Language: Английский
Citations
6
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13
Published: Jan. 20, 2025
Skin photoaging, primarily caused by chronic ultraviolet (UV) exposure, leads to the degradation of extracellular matrix components, increased oxidative stress, and diminished cellular repair capacity, contributing visible signs aging such as wrinkles, pigmentation, loss skin elasticity. In recent years, exosomes, small vesicles involved in intercellular communication, have emerged a promising therapeutic tool rejuvenation management photoaging. Exosomes derived from various cell types, including mesenchymal stem cells (MSCs), keratinocytes, fibroblasts, carry bioactive molecules proteins, lipids, RNAs, growth factors that can modulate homeostasis, promote collagen synthesis, enhance mechanisms. This review aims explore molecular mechanisms which exosomes influence their potential applications regenerative dermatology, challenges associated with clinical translation. Furthermore, we discuss future prospects exosome-based therapies development novel anti-aging treatments, emphasizing safety, efficacy, delivery systems.
Language: Английский
Citations
0
Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Extracellular vesicles (EVs) are heterogeneous membranous structures released by various cell types, including large vesicles, microvesicles (MVs), and exosomes. These play crucial roles in intercellular communication within interstitial fluids involved numerous physiological pathological processes. This review aims to examine the regulatory of EVs pregnancy complications, focusing on their involvement gestational diabetes mellitus (GDM), preeclampsia (PE), preterm birth (PTB). Placenta- embryo-derived have gained significant attention for biological due effects inflammation, immune response immunomodulation. Recent research highlights importance embryonic development gestation. During pregnancy, several functioned complex endocrine regulation complications that can affect both mother fetus, with long-term cardiovascular metabolic risks. discusses current evidence how modulate outcomes explores pathology GDM, PE, PTB. In spite difficulties relating these findings pathogenesis insufficient clinical practice, potential impact specific proteins miRNAs transported is noteworthy emergence complications. Future should continue explore interactions mediated develop novel diagnostic therapeutic strategies pregnancy-related disorders.
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 409 - 409
Published: March 11, 2025
Small extracellular vesicles (sEVs), including exosomes as a subtype, with diameter typically less than 200 nm and originating from the endosomal system, are capable of transporting diverse array bioactive molecules, proteins, nucleic acids, lipids, thereby facilitating intercellular communication modulating cellular functions. Vascular dementia (VaD) represents form cognitive impairment attributed to cerebrovascular disease, characterized by complex multifaceted pathophysiological mechanism. Currently, therapeutic approach VaD predominantly emphasizes symptom management, no specific pharmacological treatment exists cure condition. Recent investigations have illuminated significant role sEVs in pathogenesis vascular dementia. This review seeks provide comprehensive analysis characteristics functions sEVs, particular focus on their involvement its underlying mechanisms. The objective is advance understanding interplays between dementia, offering novel insights for future research strategies.
Language: Английский
Citations
0
Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 5837 - 5857
Published: May 1, 2025
Diabetic foot ulcers (DFU) represent one of the most common side effects diabetes, significantly impacting patients' quality life and imposing considerable financial burdens on families society at large. Despite advancements in therapies targeting lower limb revascularization various medications dressings, outcomes for patients with severe lesions remain limited. A recent breakthrough DFU treatment stems from development mesenchymal stem cells (MSCs). MSCs have shown promising results treating diseases skin wounds due to their ability multidirectional differentiation immunomodulation. Recent studies highlight that primarily repair tissue through paracrine activities, exosomes playing a crucial role as main biologically active components. These transport proteins, mRNA, DNA, other substances, facilitating immunomodulation, antioxidant effects, angiogenesis promotion, endothelial cell migration proliferation, collagen remodeling. Mesenchymal cell-derived (MSC-Exo) not only deliver comparable therapeutic but also mitigate adverse reactions like immune rejection associated transplantation. This article provides an overview pathophysiology explores mechanisms research progress MSC-Exo therapy.
Language: Английский
Citations
0