Treatment of Insomnia With Traditional Chinese Medicine Presents a Promising Prospect DOI
Boyi Zhang, Qianqian Wang, Yuhang Zhang

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

ABSTRACT Insomnia, a prevalent sleep disorder, significantly impacts global health. While Western medications provide temporary relief, their risks of dependency and cognitive impairment have spurred the search for safer alternatives. Traditional Chinese Medicine (TCM) offers promising approach to treating insomnia by focusing on harmonizing balance Yin Yang functions internal organs. This review explores recent research advances in TCM treatment, integrating classical theories with modern scientific understanding key pathological mechanisms, including neurotransmitter regulation (GABA, monoamines), immune‐inflammatory responses, HPA axis, interactions gut microbiota. Growing clinical evidence supports effectiveness prescriptions treatments like acupuncture improving quality, particularly when combined enhance efficacy reduce dependency. However, also has its limitations. Future directions should focus modernizing applications, addressing comorbidities associated insomnia, exploring role microbiota, optimizing medicinal edible homologous products. By traditional knowledge cutting‐edge technologies, holds great potential advancing personalized effective globally.

Language: Английский

Integrated traditional Chinese and Western medicine in the prevention and treatment of non-alcoholic fatty liver disease: future directions and strategies DOI Creative Commons
Xin Ding, Xu He,

Bulang Tang

et al.

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Feb. 3, 2024

Abstract Traditional Chinese medicine (TCM) has been widely used for several centuries metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). At present, NAFLD become the most prevalent form of chronic worldwide and can progress to steatohepatitis (NASH), cirrhosis, even hepatocellular carcinoma. However, there is still a lack effective treatment strategies in Western medicine. The development driven by multiple mechanisms, genetic factors, insulin resistance, lipotoxicity, mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, gut microbiota dysbiosis, adipose tissue dysfunction. Currently, certain drugs, sensitizers, statins, vitamin E, ursodeoxycholic acid betaine, are proven be beneficial clinical NAFLD. Due its complex pathogenesis, personalized that integrates various mechanisms may provide better benefits patients with holistic view syndrome differentiation TCM have advantages treating NAFLD, which similar principles In TCM, primarily classified into five types based on experience. It located closely related spleen kidney functions. due multi-component characteristics traditional medicine, application considerably limited. this review, we summarize advances pathogenesis drawn from both perspectives. We highlight complementary should receive increased attention prevention

Language: Английский

Citations

12
Reduce electrical overload via threaded Chinese acupuncture in nerve electrical therapy DOI Creative Commons
Yupu Liu, Yawei Du, Juan Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 46, P. 476 - 493

Published: Jan. 5, 2025

Language: Английский

Citations

1
Electroacupuncture normalized tumor vasculature by downregulating glyoxalase-1 to polarize tumor-associated macrophage to M1 phenotype in triple-negative breast cancer DOI
Xuewei Qi,

Yanyan Lian,

Zhenjia Fan

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 113988 - 113988

Published: Jan. 7, 2025

Language: Английский

Citations

1
Electroacupuncture combined with trigonelline inhibits pyroptosis in cerebral ischemia-reperfusion by suppressing autophagy via the PI3K/AKT/mTOR signaling pathway DOI Creative Commons

Zhengguo Qiu,

Jianbing Ma, Xiaqing Zhang

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111200 - 111200

Published: Jan. 1, 2025

Electroacupuncture (EA) and trigonelline (TG) have been reported to be beneficial in alleviating cerebral ischemia/reperfusion injury (CIRI). However, the synergistic effects of EA TG CIRI underlying mechanism not demonstrated. Rats were subjected middle artery occlusion (MCAO) surgery reperfusion (MCAO/R) establish a model. Neurological deficit score was evaluated using Garcia's scale. Cerebral infarction rats determined TTC staining. Brain tissue morphology assessed by HE The expression various proteins measured IF assay western blot. or treatment could effectively ameliorate neurological disorders, attenuate reduce neuronal damage brain rats. In addition, suppressed autophagy pyroptosis More importantly, intervention observed ameliorating suppressing pyroptosis, while Rapa, an inducer autophagy, strengthened these MCAO/R-induced Furthermore. Rapa reversed combination with TG-mediated improvement suppression Notably, PI3K/AKT/mTOR pathway inactivated combined enhanced activation pathway. LY294002, inhibitor pathway, stimulated pyroptosis. which dependent on inhibition through signaling

Language: Английский

Citations

1
Evolutionary Pathway of TCM in Allergic Diseases: A Fusion from Ancient Wisdom to Modern Science DOI Creative Commons

Zhili Wang,

Jiawei Ran,

Rui Wang

et al.

Allergy medicine., Journal Year: 2025, Volume and Issue: unknown, P. 100029 - 100029

Published: Feb. 1, 2025

Language: Английский

Citations

1
Immunomodulatory hydrogels for skin wound healing: cellular targets and design strategy DOI

Yinhai He,

Ying Cen,

Meng Tian

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 12(10), P. 2435 - 2458

Published: Dec. 27, 2023

Schematic illustration of roles and targets immunoregulatory cells hydrogel design strategies to promote wound healing.

Language: Английский

Citations

18
Electroacupuncture pretreatment mediates sympathetic nerves to alleviate myocardial ischemia–reperfusion injury via CRH neurons in the paraventricular nucleus of the hypothalamus DOI Creative Commons
Jie Zhou, Bin Zhang, Xiang Zhou

et al.

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: March 6, 2024

Abstract Background Myocardial ischemia–reperfusion can further exacerbate myocardial injury and increase the risk of death. Our previous research found that paraventricular nucleus (PVN) hypothalamus plays a crucial role in improvement (MIRI) by electroacupuncture (EA) pretreatment, but its mechanism action is still unclear. CRH neurons exhibit periodic concentrated expression PVN, needed to determine whether they are involved MIRI EA pretreatment. Meanwhile, numerous studies have shown changes sympathetic nervous system innervation activity associated with many heart diseases. This study aims investigate pretreatment improves through mediated PVN neurons. Methods Integrated use fiber-optic recording, chemical genetics other methods detect relevant indicators: ECG signals were acquired Powerlab standard II leads, LabChart 8 calculated rate, ST-segment offset, rate variability (HRV); Left ventricular ejection fraction (LVEF), left short-axis shortening (LVFS), end-systolic internal diameter (LVIDs) interventricular septal thickness (IVSs) measured echocardiography; infarct area (IA) at (AAR) Evans-TTC staining. Pathological cardiomyocytes observed HE staining; Changes neuronal recorded photometry; Sympathetic nerve discharges for vivo electrophysiology; NE TH protein was assayed Western blot. Results data indicated effectively alleviate MIRI. we model, number co labeled c-Fos rat brain increased, frequency discharge increased. could reverse this change. In addition, results inhibiting has similar protective effect on as activation counteract effect. Conclusion inhibit improve nerve, which offers fresh perspectives application acupuncture management cardiovascular disease.

Language: Английский

Citations

6
Relation extraction using large language models: a case study on acupuncture point locations DOI
Yiming Li, Xueqing Peng, Jianfu Li

et al.

Journal of the American Medical Informatics Association, Journal Year: 2024, Volume and Issue: 31(11), P. 2622 - 2631

Published: Aug. 29, 2024

Abstract Objective In acupuncture therapy, the accurate location of acupoints is essential for its effectiveness. The advanced language understanding capabilities large models (LLMs) like Generative Pre-trained Transformers (GPTs) and Llama present a significant opportunity extracting relations related to acupoint locations from textual knowledge sources. This study aims explore performance LLMs in acupoint-related assess impact fine-tuning on GPT’s performance. Materials Methods We utilized World Health Organization Standard Acupuncture Point Locations Western Pacific Region (WHO Standard) as our corpus, which consists descriptions 361 acupoints. Five types (“direction_of”, “distance_of”, “part_of”, “near_acupoint”, “located_near”) (n = 3174) between were annotated. Four compared: pre-trained GPT-3.5, fine-tuned GPT-4, well pretrained 3. Performance metrics included micro-average exact match precision, recall, F1 scores. Results Our results demonstrate that GPT-3.5 consistently outperformed other scores across all relation types. Overall, it achieved highest score 0.92. Discussion superior model, shown by scores, underscores importance domain-specific enhancing extraction acupuncture-related tasks. light findings this study, offers valuable insights into leveraging developing clinical decision support creating educational modules acupuncture. Conclusion effectiveness GPT locations, with implications accurately modeling promoting standard implementation training practice. also contribute advancing informatics applications traditional complementary medicine, showcasing potential natural processing.

Language: Английский

Citations

6
Non-Pharmacological Interventions for Pain Management in Hemodialysis: A Narrative Review DOI Open Access
Mustafa Ali Kassim Kassim, Alexandru Cosmin Pantazi, Wassan Nori

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(16), P. 5390 - 5390

Published: Aug. 19, 2023

This narrative review aims to summarize non-pharmacological interventions for pain management in hemodialysis patients, assessing their potential benefits and limitations enhancing patient well-being quality of life. We reviewed the current literature on five primary interventions: acupuncture, cognitive behavioral therapy, relaxation techniques, virtual reality, alternative methods such as transcutaneous electrical nerve stimulation, music aromatherapy. analyzed evidence regarding effectiveness, feasibility, optimal implementation strategies. The existing supports these managing improving patients. However, further high-quality research is needed confirm establish best practices, assess long-term impact outcomes. Non-pharmacological hold promise Additional required optimize validate contributing comprehensive strategies this vulnerable population.

Language: Английский

Citations

15
Treatment of Allergic Rhinitis with Acupuncture Based on Pathophysiological DOI Creative Commons

Boyang Dong,

Bingquan Li,

Liangzhen Xie

et al.

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 2741 - 2756

Published: June 1, 2024

Allergic rhinitis is a prevalent allergic diseases and has profound impact on physical well-being. In recent years, more people have changed to diseases, such as rhinitis, asthma, dermatitis so on. the incidence of covering all ages. The common clinical treatment are drugs immunotherapy, but these therapies certain limitations. Therefore, an effective economical for AR urgently needed. Acupuncture widely used in various effect acupuncture (AR) significant, mechanism also hot spot. one traditional methods Chinese medicine, which achieves therapeutic by pressing needle or other means at specific location skin produce special sensation. Among them, acupuncture, popular method, attracted attention. this review, we provide overview current understanding AR, well studies investigating efficacy safety AR.

Language: Английский

Citations

5