Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis

Cellular and Molecular Immunology, Journal Year: 2023, Volume and Issue: 20(12), P. 1513 - 1526

Published: Nov. 27, 2023

Language: Английский

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The Z-nucleic acid sensor ZBP1 in health and disease

The Journal of Experimental Medicine, Journal Year: 2023, Volume and Issue: 220(8)

Published: July 14, 2023

Nucleic acid sensing is a central process in the immune system, with far-reaching roles antiviral defense, autoinflammation, and cancer. Z-DNA binding protein 1 (ZBP1) sensor for double-stranded DNA RNA helices unusual left-handed Z conformation termed Z-RNA. Recent research established ZBP1 as key upstream regulator of cell death proinflammatory signaling. Recognition Z-DNA/RNA by promotes host resistance to viral infection but can also drive detrimental autoinflammation. Additionally, has interesting cancer other disease settings emerging an attractive target therapy.

Language: Английский

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The crucial regulatory role of type I interferon in inflammatory diseases

Cell & Bioscience, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 20, 2023

Type I interferon (IFN-I) plays crucial roles in the regulation of inflammation and it is associated with various inflammatory diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), periodontitis, impacting people's health quality life. It well-established that IFN-Is affect immune responses factors by regulating some signaling. However, currently, there no comprehensive overview regulatory role IFN-I distinctive pathways as well diseases. This review aims to provide a narrative involvement different signaling pathways, mainly mediating related key specific targets cascades influence progression As such, we suggested induce through stimulation certain which displays possible efficient treatment methods provides reference for precise control

Language: Английский

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Inflammasome diversity: exploring novel frontiers in the innate immune response

Trends in Immunology, Journal Year: 2024, Volume and Issue: 45(4), P. 248 - 258

Published: March 21, 2024

Language: Английский

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Cell death shapes cancer immunity: spotlighting PANoptosis

Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)

Published: June 15, 2024

Abstract PANoptosis represents a novel type of programmed cell death (PCD) with distinctive features that incorporate elements pyroptosis, apoptosis, and necroptosis. is governed by newly discovered cytoplasmic multimeric protein complex known as the PANoptosome. Unlike each these PCD types individually, still in early stages research warrants further exploration its specific regulatory mechanisms primary targets. In this review, we provide brief overview conceptual framework molecular components PANoptosis. addition, highlight recent advances understanding therapeutic applications By elucidating crosstalk between apoptosis necroptosis summarizing functional consequences special focus on tumor immune microenvironment, review aims to theoretical basis for potential application cancer therapy.

Language: Английский

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Interference without interferon: interferon-independent induction of interferon-stimulated genes and its role in cellular innate immunity

mBio, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

ABSTRACT Interferons (IFNs) are multifaceted proteins that play pivotal roles in orchestrating robust antiviral immune responses and modulating the intricate landscape of host immunity. The major signaling pathway activated by IFNs is JAK/STAT (Janus kinase/signal transducer activator transcription) pathway, which leads to transcription a battery genes, collectively known as IFN-stimulated genes (ISGs). While well-established role coordinating innate response against viral infections widely acknowledged, recent years have provided more distinct comprehension functional significance attributed non-canonical, IFN-independent induction ISGs. In this review, we summarize non-conventional pathways ISG induction. These alternative offer new avenues for developing strategies or immunomodulation various diseases.

Language: Английский

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Bimetallic peroxide nanoparticles induce PANoptosis by disrupting ion homeostasis for enhanced immunotherapy

Science Advances, Journal Year: 2024, Volume and Issue: 10(45)

Published: Nov. 8, 2024

PANoptosis has recently emerged as a potential approach to improve the immune microenvironment. However, current methods for inducing are limited. Herein, through biological screening, rational use of nutrient metal ions Cu

Language: Английский

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Korean Red ginseng enhances ZBP1-mediated cell death to suppress viral protein expression in host defense against Influenza A virus

The Journal of Microbiology, Journal Year: 2025, Volume and Issue: 63(1), P. e:2409007 - e:2409007

Published: Jan. 24, 2025

Language: Английский

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Innate Immune Sensors and Cell Death—Frontiers Coordinating Homeostasis, Immunity, and Inflammation in Skin

Viruses, Journal Year: 2025, Volume and Issue: 17(2), P. 241 - 241

Published: Feb. 10, 2025

The skin provides a life-sustaining interface between the body and external environment. A dynamic communication among immune non-immune cells in is essential to ensure homeostasis. Dysregulated cellular can lead manifestation of inflammatory conditions. In this review, we will focus on following two key frontiers skin: innate sensors cell death, as well their crosstalk context homeostasis inflammation. This review highlight recent advancements mechanisms how these pathways integrate signals orchestrate immunity, focusing diseases infections mice humans.

Language: Английский

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Ischemia-reperfusion injury induces ZBP1-dependent PANoptosis in endothelial cells

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167782 - 167782

Published: March 1, 2025

Language: Английский

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