Journal of Personalized Medicine,
Journal Year:
2023,
Volume and Issue:
13(12), P. 1632 - 1632
Published: Nov. 22, 2023
Stem
cells
are
undifferentiated
presenting
extensive
self-renewal
features
and
the
ability
to
differentiate
"in
vitro"
vivo"
into
a
range
of
lineage
cells,
like
chondrogenic,
osteogenic
adipogenic
lineages
when
cultured
in
specific
inducing
media.
Two
major
domains
clinical
applications
stem
thoracic
surgery
have
been
investigated:
regenerative
medicine,
which
is
section
translational
research
tissue
engineering
focusing
on
replacement,
renewal
or
regeneration
tissues
organs
re-establish
damaged
physiologic
functions;
drug
loading
delivery,
representing
new
branch
proposing
as
carriers
provide
selected
districts
with
anti-cancer
agents
for
targeted
treatments.
Respiratory Research,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: April 1, 2024
Abstract
Introduction
EXO-CD24
are
exosomes
genetically
manipulated
to
over-express
Cluster
of
Differentiation
(CD)
24.
It
consists
two
breakthrough
technologies:
CD24,
the
drug,
as
a
novel
immunomodulator
that
is
smarter
than
steroids
without
any
side
effects,
and
ideal
natural
drug
carrier.
Methods
A
randomized,
single
blind,
dose-finding
phase
IIb
trial
in
hospitalized
patients
with
mild
moderate
Coronavirus
disease
2019
(COVID-19)
related
Acute
Respiratory
Distress
Syndrome
(ARDS)
was
carried
out
medical
centers
Athens.
Patients
received
either
10
9
or
exosome
particles
EXO-CD24,
daily,
for
five
consecutive
days
monitored
28
days.
Efficacy
assessed
at
day
7
among
91
who
underwent
randomization.
The
outcome
also
compared
post-hoc
analysis
an
income
control
group
(n
=
202)
fit
inclusion
exclusion
criteria.
Results
mean
age
49.4
(±
13.2)
years
74.4%
were
male.
By
7,
83.7%
showed
improved
respiratory
signs
64%
had
better
oxygen
saturation
(SpO
2
)
(p
<
0.05).
There
significant
reductions
all
inflammatory
markers,
most
notably
C-reactive
protein
(CRP),
lactate
dehydrogenase
(LDH),
ferritin,
fibrinogen
array
cytokines.
Conversely,
levels
anti-inflammatory
cytokine
Interleukin-10
(IL-10)
increased
Of
documented
adverse
events,
none
considered
treatment
related.
No
drug-drug
interactions
noted.
Two
succumbed
COVID-19.
Post-hoc
revealed
exhibited
greater
improvements
clinical
laboratory
outcomes
observational
group.
Conclusions
presents
promising
therapeutic
approach
hyper-inflammatory
state
particular
ARDS.
Its
unique
combination
exosomes,
carrier,
immunomodulator,
coupled
inhalation
administration,
warrants
further
investigation
larger,
international,
quadri-blind
against
placebo.
Extracellular Vesicle,
Journal Year:
2024,
Volume and Issue:
4, P. 100045 - 100045
Published: June 26, 2024
Idiopathic
pulmonary
fibrosis
(IPF)
is
a
lethal
and
chronic
lung
disease
that
occurs
due
to
persistent
epithelial
cell
injury
abnormal
extracellular
matrix
(ECM)
deposition.
Extracellular
vesicles
(EVs)
have
been
proposed
as
potential
therapeutic
option
of
IPF
because
their
functions,
such
anti-inflammation,
anti-fibrosis,
microenvironment
regulation,
tissue
repair.
In
this
study,
we
investigated
the
human
adipose-derived
mesenchymal
stem
(AD-MSC)
EVs
in
model.
AD-MSC
were
isolated
by
multi-filtration
system
based
on
tangential
flow
filtration
(TFF)
characterized
using
transmission
electron
microscopy
(TEM),
dynamic
light
scattering
(DLS),
cytometry
analysis,
zeta
potential,
small
RNA
sequencing.
vitro
analysis
reveals
treatments
inhibited
migration
fibroblasts
myofibroblast
differentiation
through
down
regulation
fibrosis-associated
TGF-β
WNT
signaling.
addition,
inhalation
treatment
significantly
alleviated
bleomycin
(BLM)-induced
fibrosis.
These
results
reveal
are
highly
promising
for
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
19(4), P. 100942 - 100942
Published: July 9, 2024
Asthma
is
a
widespread
public
health
concern,
with
an
increasing
incidence.
Despite
the
implementation
of
current
treatment
strategies,
asthma
control,
particularly
for
severe
cases,
remains
suboptimal.
Recent
research
has
revealed
encouraging
prospects
extracellular
vesicles
(EVs)
secreted
by
mesenchymal
stem
cells
(MSCs)
as
viable
therapeutic
option
alleviating
symptoms.
Therefore,
present
review
aims
to
provide
overview
progress
and
mechanisms
using
MSC-derived
EVs
(MSC-EVs)
treatment.
Additionally,
different
administration
approaches
their
impacts
on
biodistribution
curative
outcomes
are
summarized.
Notably,
potential
benefits
nebulized
inhalation
MSC-EVs
addressed.
Also,
possibilities
challenges
in
clinics
highlighted.
Overall,
this
intended
give
new
insight
into
utilization
biological
drug
Journal of Inflammation Research,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 9041 - 9058
Published: Nov. 1, 2024
Lung
diseases
are
associated
with
high
morbidity
and
mortality
rates,
thereby
jeopardizing
human
health
imposing
a
great
burden
on
society.
Currently,
lung
mainly
treated
medications,
oxygen
therapy
mechanical
ventilation,
but
these
approaches
unable
to
effectively
reduce
the
rate.
Therefore,
transplantation
remains
ultimate
treatment
for
various
chronic
diseases,
this
is
also
hindered
by
limited
availability
of
sources,
immature
technology
low
survival
rate
after
transplantation.
With
constant
changes
in
environment,
pathogens,
type
amount
harmful
substances
prevalence
respiratory
there
an
urgent
need
identify
alternative
methods.
Research
stem
cell
has
been
very
successful
recent
years,
mesenchymal
cells
(MSCs),
together
their
secretory
bodies,
play
significant
therapeutic
role.
Extracellular
vesicles
MSCs
(MSC-EVs)
major
components
paracrine
secretion
MSCs,
including
exosomes,
microvesicles,
apoptotic
among
which
exosomes
most
typical.
MSC-EVs
believed
be
present
tissues
body
where
they
can
carry
proteins,
DNA,
RNA
biologically
active
factors,
just
name
few.
They
transmit
biological
signals
participate
different
activities,
maintenance
homeostasis
within
tissue.
Several
studies
have
further
demonstrated
that
generated
extracellular
important
role
diseases.
In
paper,
origin,
properties
roles
reviewed,
mechanisms
limitations
current
options
Chronic
Obstructive
Pulmonary
Disease,
asthma,
infectious
disease,
cancer,
pulmonary
fibrosis,
arterial
hypertension,
acute
injury/
distress
syndrome
discussed
(Figure
1).
addition,
possible
future
research
directions
view
providing
new
ideas
Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ),
Journal Year:
2024,
Volume and Issue:
7(1), P. 144 - 152
Published: Aug. 17, 2024
Background:
The
remarkably
low
delivery
efficiency
and
lack
of
specificity
anticancer
medicines
constrain
systemic
chemotherapy
due
to
its
inadequate
therapeutic
effectiveness
significant
toxic
side
effects.
Objective:
To
evaluate
the
feasibility
protein
nanoparticles
made
from
sericin
loaded
with
paclitaxel
as
a
carrier
for
pulmonary
lung
cancer
treatment.
Methods:
Self-assembled
poloxamer
407
were
prepared
by
desolvation
method
physicochemical,
in
vitro
vivo
characteristics
investigated.
Results:
PTX-loaded
successfully
exhibited
particle
size
(145.0
nm),
high
entrapment
paclitaxel,
spherical
shape
confirmed
TEM.
demonstrated
prolonged
cytotoxicity
on
A549
cells
comparison
conventional
solution.
Once
transformed
into
aerosol
form,
significantly
extended
duration
lungs
slowed
down
elimination
compared
standard
medication
(Taxol®).
animal
group
treated
these
did
not
exhibit
any
notable
histopathological
findings
when
control
group.
Conclusions:
Aerosolized
can
improve
lungs,
leading
improved
lower
frequency
administration.
They
also
show
promise
treating
cancer.
Journal of Personalized Medicine,
Journal Year:
2023,
Volume and Issue:
13(12), P. 1632 - 1632
Published: Nov. 22, 2023
Stem
cells
are
undifferentiated
presenting
extensive
self-renewal
features
and
the
ability
to
differentiate
"in
vitro"
vivo"
into
a
range
of
lineage
cells,
like
chondrogenic,
osteogenic
adipogenic
lineages
when
cultured
in
specific
inducing
media.
Two
major
domains
clinical
applications
stem
thoracic
surgery
have
been
investigated:
regenerative
medicine,
which
is
section
translational
research
tissue
engineering
focusing
on
replacement,
renewal
or
regeneration
tissues
organs
re-establish
damaged
physiologic
functions;
drug
loading
delivery,
representing
new
branch
proposing
as
carriers
provide
selected
districts
with
anti-cancer
agents
for
targeted
treatments.
