Autoimmune diseases and atherosclerotic cardiovascular disease

Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(11), P. 780 - 807

Published: June 27, 2024

Language: Английский

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Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with risk of rheumatoid arthritis in the U.S. adult population

Environmental Health, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 13, 2024

Abstract Background Per- and polyfluoroalkyl substances (PFAS) are known environmental contaminants with immunosuppressive properties. Their connection to rheumatoid arthritis (RA), a condition influenced by the immune system, is not well studied. This research explores association between PFAS exposure RA prevalence. Methods utilized data from NHANES, encompassing sample of 10,496 adults 2003–2018 cycles, focusing on serum levels several PFAS. The presence was determined based self-reports. study used multivariable logistic regression assess relationship individual risk, adjusting for covariates calculate odds ratios (ORs). combined effects mixtures were evaluated using BKMR, WQS regression, quantile g-computation. Additionally, sex-specific associations explored through stratified analysis. Results Higher PFOA (OR = 0.88, 95% CI: 0.79, 0.98), PFHxS 0.91, 0.83, 1.00), PFNA 0.87, 0.77, PFDA 0.89, 0.81, 0.99) concentration related lower RA. Sex-specific analysis in single chemical models indicated significant inverse only evident females. BKMR did show an obvious pattern estimates across mixture. outcomes sex-stratified g-computation demonstrated that increase mixture associated decreased females (OR: 0.76, 0.62, 0.92). We identified interaction term WQS*sex 100 repeated hold out Notably, higher significantly reduced (mean OR 0.93, 0.98). Conclusions indicates potential various their observed relationships statistically but males. These findings contribute growing body evidence indicating may have effects.

Language: Английский

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The combined impact of neutrophil-percentage-to-albumin ratio and depressive symptoms on mortality in US arthritis patients: insights from NHANES (2005–2018)

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 6, 2025

Background The neutrophil-to-albumin ratio (NPAR) reflects inflammation and nutritional status, while depression significantly impacts survival in chronic disease patients. This study examines the independent combined effects of NPAR depressive symptoms on all-cause cardiovascular mortality arthritis Methods We analyzed a nationally representative sample people with arthritisaged 40 older from NHANES (2005–2018). assessed were measured by PHQ-9. Weighted Cox regression examined joint associations PHQ-9 (CVD) mortality. Results Our analysis indicated that higher levels lower (PHQ-9 < 10) increased CVD risks In this group, hazard (HR) for was 2.087, similarly elevated risk (HR = 2.614), underscoring NPAR’s predictive strength non-depressed individuals. Among those symptoms, still associated mortality, its impact less marked, highlighting need further research into NPAR-depression interaction. Conclusion identifies as key predictor patients, particularly fewer symptoms. predicts value an nutrition biomarker. Integrating clinical practice could enhance individualized assessment intervention

Language: Английский

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A synergistic effect of triptolide and curcumin on rheumatoid arthritis by improving cell proliferation and inducing cell apoptosis via inhibition of the IL-17/NF-κB signaling pathway

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 112953 - 112953

Published: Sept. 2, 2024

Rheumatoid arthritis (RA) is a chronic, progressive, systemic autoimmune disease. While triptolide (TPL) and curcumin (CUR) are known to have multiple beneficial effects on RA, the combined effect of TPL CUR remains unexplored. This study aimed investigate their synergistic cell proliferation apoptosis via IL-17/NF-κB signaling pathway. The collagen-induced (CIA) rat model was established, showing severe joint synovial damage compared normal rats. Treatment with reduced severity RA in CIA alleviated serum inflammatory cytokines, such as rheumatoid factor, IL-17, TNF-α, IL-1β, IL-6. elevated levels IL-17 NF-κB rats were also inhibited, resistant aggravated by CUR. In vitro, improvement induction observed LPS-stimulated MH7A cells treated CUR, associated inhibition Taken together, may involve relieving symptoms, improving excessive proliferation, inducing resistance, inhibiting

Language: Английский

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Effect of trace elements and nutrients on 21 autoimmune diseases: a Mendelian randomization study

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 20, 2025

Background Numerous clinical studies have observed a close relationship between serum trace elements, nutrients, and autoimmune diseases. However, whether there is genetic causal effect diseases remains unclear. Objective This study aims to investigate the effects of elements nutrients on 21 using Mendelian randomization (MR). Methods Single nucleotide polymorphisms for exposure factors (serum vitamins) were obtained from published UK Biobank database genome-wide association (GWAS) public databases. Outcome GWAS data derived FinnGen database. MR was employed explore relationships 9 6 vitamins Causal inference performed inverse variance weighted methods, Egger, median methods. Subsequently, heterogeneity tests, horizontal pleiotropy MR-PRESSO leave-one-out analyses conducted sensitivity analysis evaluate robustness results. Finally, that statistically significant in IVW method had consistent sizes odds ratios across five methods selected as with diabetes its complications. Additionally, multivariable assess combined multiple Results indicated elevated levels element copper associated an increased risk systemic lupus erythematosus (SLE) decreased ulcerative colitis. Carotene found negative adult-onset Still ’ s disease (AOSD). Elevated selenium hyperthyroidism. Calcium showed polyarteritis nodosa. MVMR results demonstrated could independently affect hyperthyroidism, separate copper. Conclusion The findings both univariable support These implications developing targeted prevention treatment strategies

Language: Английский

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Association between colorectal cancer and arthritis among Americans in 2005–2016

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 24, 2025

Colorectal cancer (CRC) ranks among the most prevalent cancers globally. Some studies have found that arthritis could reduce risk of CRC through inflammatory immune mediation. However, there been no reports on whether is related to CRC. Therefore, correlation between and was investigated provide some theoretical support for understanding prevention diagnosis This study utilized data from National Health Nutrition Examination Survey (NHANES) investigate relationship Americans. A total 300,106 adults participated in study, a questionnaire survey, they were categorized into control group group. In this considered exposure variable, 17 covariates included. The variables then revealed baseline characteristic analysis, association stratified analysis. predictive efficiency assessed using receiver operating curve (ROC) Finally, nomogram created evaluate capacity. 297,681 subjects 2,425 within survey. Significant disparities observed two groups all except drink poverty income ratio (PIR). Three models demonstrated clear (model 1: odds (OR) = 3.57, 95% confidence interval (CI) 2.5–5.1, P 0.00000000025; model 2: OR 1.71, CI 1.15–2.53, 0.008; 3: 1.56, 1.03–2.38, 0.0369), indicating effect not significantly confounded by other across three models. Stratified analysis showed positively associated with CRC, area under (AUC) 0.818, more effective prognosis decision calibration indicated effectively predict had strong occurrence providing ideas strategies its early detection.

Language: Английский

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Association between body roundness index and rheumatoid arthritis: a cross-sectional study based on NHANES

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Background The Body Roundness Index (BRI) has been identified as a potentially superior measure of body fat distribution such mass index (BMI) and waist circumference (WC). However, its relationship with rheumatoid arthritis (RA) yet to be thoroughly investigated. This study examines the association between BRI RA risk using data from National Health Nutrition Examination Survey (NHANES). Methods analysis included 28,559 adults, excluding those missing values for or status. was calculated height WC measurements, while self-reported by participants. Multivariate logistic regression utilized assess RA, controlling sociodemographic variables pertinent comorbid conditions. Receiver operating characteristic (ROC) curves area under curve (AUC) were employed predictive accuracy BRI, BMI, concerning RA. Results An elevated demonstrated notable correlation heightened With each unit increase in there corresponding 10% likelihood after complete adjustment (OR: 1.10, 95% CI: 1.08–1.12, P < 0.001). A clear dose-response among quartiles, where individuals highest quartile exhibited 76% increased 1.76, 1.50–2.07, Subgroup indicated more pronounced participants exhibiting hyperlipidemia (P interaction = 0.012). Threshold revealed value 4.61 critical inflection point, beyond which correlated 12% 1.12, ROC that AUC 0.637 predicting risk, surpassing at 0.622 BMI 0.594. Conclusions serves strong indicator demonstrating enhanced when contrasted conventional metrics like WC. results indicate may function valuable instrument assessing especially hyperlipidemia.

Language: Английский

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Biomaterials for Modulating the Immune Microenvironment in Rheumatoid Arthritis

BME Frontiers, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 1, 2025

Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by joint swelling and bone destruction. Despite an incomplete understanding of its genesis, RA tightly linked to the intricate immunological milieu, involving disruptions in molecular signaling imbalance between innate adaptive immune systems. With advancements biomaterials science, role treatment has evolved from mere drug delivery systems therapeutic microenvironment modulators, providing drug-independent strategies for RA. In this review, we will delve into RA, focusing on contributions immunity, damage-associated patterns (DAMPs), cytokines, pathways disease’s pathogenesis inflammation. We provide detailed analysis applications novel nonpharmaceutical treatment, categorized 3 key mechanisms: biofactor pathway regulation, endogenous gas adjustment, cell modulation. The composition, form, principles, efficacy these be explored. thorough discussion topics offer fresh viewpoint guide future research directions.

Language: Английский

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Time-restricted feeding alleviates arthritis symptoms augmented by high-fat diet

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 13, 2025

Rheumatoid arthritis (RA) affects approximately 1% of the global population. Its hallmark symptoms include severe pain and joint stiffness, which significantly diminish life quality. RA’s development is influenced by multiple factors including unhealthy lifestyle habits. Calorie-rich diets, particularly those high in fat resulting obesity, are associated with RA exacerbate its symptoms. Consequently, dietary modifications recommended as a complementary treatment. However, adherence often low due to restrictive changes required nutrient composition or caloric intake. Our previous findings indicate that time-restricted feeding (TRF) benefits leukocyte rhythm mitigates autoimmune responses. In this study we explored impact TRF on severity K/BxN serum-transfer (STA) mice subjected high-fat diet. Three schedules were implemented: control (Ctrl) constant access standard chow, diet group (HF) ad libitum food access, (HF-TRF) 10-hour window during active phase. After four weeks conditioning, STA was induced. Although macroscopic markers inflammation did not differ between Ctrl HF groups, histological analysis revealed increased mice, expanded edema, pannus formation, bone erosion, elevated synovial neutrophil infiltration serum leptin levels. Importantly, all these inflammatory reduced HF-TRF group, along IL-1β monocyte/macrophage counts. results can severity, potentially serving preventive method sustainable therapeutic support for management.

Language: Английский

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Association of visceral fat metabolism score with risk of rheumatoid arthritis in US adults

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 20, 2025

Background The Visceral Adiposity Index (METS-VF) has emerged as a novel obesity assessment metric. However, research exploring the relationship between METS-VF and rheumatoid arthritis (RA) remains limited. objective of this investigation was to examine correlation prevalence RA METS-VF. Methods NHANES data collected 2011 2018 were used in investigation. To determine association RA, logistic regression analysis used. Sensitivity subgroup done test how reliable results were. Finally, predictive power BMI, waist circumference, for compared using ROC curve analysis. Results This had 8,626 individuals total. findings showed that those without persons with condition noticeably greater levels. significantly positively correlated, according (OR = 1.50, 95% CI 1.12–2.00). sensitivity analyses agreed primary conclusions. indicated possessed superior ability predict BMI circumference. Conclusion study indicates elevated levels are correlated an increased risk US population. Monitoring metric might aid early detection high-risk patients.

Language: Английский

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