Extracellular vesicles in the treatment of oxidative stress injury: global research status and trends DOI Creative Commons
Wenwen Zhang, Bin Gan, Tingyu Wang

et al.

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 10

Published: Feb. 15, 2024

Objective: The aim of this study was to conduct a bibliometric analysis the literature on “Extracellular Vesicles in Treatment Oxidative Stress Injury” and reveal its current status, hot spots trends. Methods: relevant obtained from Web Science Core Collection (WoSCC) 29 April 2023. We performed clustering partnership authors, institutions, countries, references keywords through CiteSpace software online platform mapped knowledge maps. Results: A total 1,321 publications were included analysis, with number field increasing year by year. These 944 “articles” 377 “reviews”. maximum published China is 512, highly cited United States 20. Based CiteSpace, country collaboration network map shows close stable among high-productivity countries. WoSCC, there are 1706 research institutions 119 elite which Kaohsing Chang Gung Men Hosp has most extensive influence. Studies related have been 548 journals. show main areas breakthroughs. area found be as follows: exosome(s), extracellular vesicle(s), oxidative stress, inflammation, mesenchymal stem cells, apoptosis, microRNA (miRNA), mitochondria, biomarker, autophagy, angiogenesis Alzheimer’s disease. Analysis showed that “mesenchymal cells”, “microRNA”, “autophagy”, “histology” “therapeutic” emerged explosive keywords. Conclusion: This first use visual data mining assess Injury”. history, status direction provide theoretical basis for scientific research.

Language: Английский

The changes of digestive system inflammatory, oxidative stress, and histopathology factors following oral mesenchymal stem cells administration in rats with traumatic brain injury DOI Creative Commons

Masoud Eslami,

Alireza Raji-Amirhasani, Mohammad Khaksari

et al.

BMC Neuroscience, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 6, 2025

Mucous mesenchymal stem cells can migrate to damaged areas, and their use is proposed as a new approach treating diseases. The present study aimed investigate the effect of oral (OMSCs) on inflammatory, oxidative stress, histopathological indices in tissues stomach, intestine, colon after traumatic brain injury (TBI). Adult male rats were randomly divided into four groups: Sham, TBI, Vehicle (Veh), Stem cell (SC). Intravenous injection OMSCs was performed at 1 24 h injury. small evaluated 48 After IL-1β IL-6 levels increased IL-10 decreased colon, but administration OMSCS prevented these changes large extent. Oxidative stress (MDA, PC, TAC, SOD, CAT) showed an increase less severe OMSC group. TBI improved outcome colon. Administration suffering from improve which shows beneficial using TBI.

Language: Английский

Citations

0
Therapeutic Approaches and Potential Mechanisms of Small Extracellular Vesicles in Treating Vascular Dementia DOI Creative Commons

Yujie Yang,

Chunchu Deng,

Fatima Aldali

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 409 - 409

Published: March 11, 2025

Small extracellular vesicles (sEVs), including exosomes as a subtype, with diameter typically less than 200 nm and originating from the endosomal system, are capable of transporting diverse array bioactive molecules, proteins, nucleic acids, lipids, thereby facilitating intercellular communication modulating cellular functions. Vascular dementia (VaD) represents form cognitive impairment attributed to cerebrovascular disease, characterized by complex multifaceted pathophysiological mechanism. Currently, therapeutic approach VaD predominantly emphasizes symptom management, no specific pharmacological treatment exists cure condition. Recent investigations have illuminated significant role sEVs in pathogenesis vascular dementia. This review seeks provide comprehensive analysis characteristics functions sEVs, particular focus on their involvement its underlying mechanisms. The objective is advance understanding interplays between dementia, offering novel insights for future research strategies.

Language: Английский

Citations

0
Trans-anethole enhances mesenchymal stem cell derived exosomes function to inhibit H2O2-induced rheumatoid arthritis-like inflammation in HIG-82 synovial cells DOI

Tai-Lung Huang,

Yuchun Chang, Wei-Wen Kuo

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 28, 2025

Language: Английский

Citations

0
Utilizing Extracellular Vesicles from Phaeodactylum tricornutum as a Novel Approach for Protecting the Skin from Oxidative Damage DOI
Ran Xu, Ying Lü, Luyun Cai

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

Oxidative stress is a principal factor contributing to skin damage induced by deleterious stimuli, including ultraviolet (UV) radiation. Microalgae-derived extracellular vesicles (EVs), particularly those from Phaeodactylum tricornutum (PTEV), are gaining recognition as potential therapeutic avenue for restoring homeostasis, owing their scalable production and multifaceted biological activities. This study evaluates the effects of PTEV on oxidative in H2O2-stimulated HaCaT cells UV-exposed KM mouse models, based extraction characterization PTEV. Subsequently, injury model H2O2 acute photodamage mice UV were established. The results show that exhibit time-dependent uptake PTEV, confirming nontoxic has intercellular cross-boundary regulation. Treatment with can enhance vitality cells, reduce intracellular ROS levels, increase antioxidant enzyme activity cells. Further evaluation revealed inhibit UV-induced thickening epidermis degradation collagen fibers suppressing overexpression matrix metalloproteinase (MMP-3) UV. It enhances expression type I (COL1A1) increases enzymes, well overall capacity tissues. Additionally, reduces malondialdehyde levels lowers inflammatory factors TNF-α IL-6, thereby protecting barrier function photodamage. Continuous offers promising applications strategies.

Language: Английский

Citations

0
3-methyladenine ameliorates acute lung injury by inhibiting oxidative damage and apoptosis DOI Creative Commons

Xiong Lei,

Xiling Liu, Jia Yu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33996 - e33996

Published: July 1, 2024

Acute lung injury (ALI) is a condition characterized by inflammation and oxidative damage. 3-methyladenine (3-MA) has great potential for regulating apoptosis, but its regulatory role in ALI unknown.

Language: Английский

Citations

3
Emerging Landscape of Mesenchymal Stem Cell Senescence Mechanisms and Implications on Therapeutic Strategies DOI
Jing Wang, Muqing Zhang, Hu Wang

et al.

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(8), P. 2306 - 2325

Published: July 17, 2024

Mesenchymal stem cells (MSCs) hold significant promise for regenerative medicine and tissue engineering due to their unique multipotent differentiation ability immunomodulatory properties. MSC therapy is widely discussed utilized in clinical treatment. However, during both vitro expansion vivo transplantation, MSCs are prone senescence, an irreversible growth arrest characterized by morphological, gene expression, functional changes genomic regulation. The microenvironment surrounding plays a crucial role modulating senescence phenotype, influenced factors such as hypoxia, inflammation, aging status. Numerous strategies targeting have been developed, including senolytics senomorphic agents, antioxidant exosome therapies, mitochondrial transfer, niche modulation. Novel approaches addressing replicative also emerged. This paper comprehensively reviews the current molecular manifestations of addresses environmental impact on highlights potential therapeutic mitigate MSC-based therapies. These insights aim enhance efficacy understanding

Language: Английский

Citations

3
Engineering durable antioxidative nanoreactors as synthetic organelles for autoregulatory cellular protection against oxidative stress DOI

Panyue Wen,

Anjaneyulu Dirisala,

Haocheng Guo

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113683 - 113683

Published: April 1, 2025

Language: Английский

Citations

0
The supportive role of stem cells-derived exosomes in the embryo implantation process by regulating oxidative stress DOI
Rezvan Asgari,

Sahar Rashidi,

Bijan Soleymani

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 188, P. 118171 - 118171

Published: May 23, 2025

Language: Английский

Citations

0
Mesenchymal stem cells and their extracellular vesicles in bone and joint diseases: targeting the NLRP3 inflammasome DOI

Shuangshuang Xu,

Ying Zhang,

Zejun Zheng

et al.

Human Cell, Journal Year: 2024, Volume and Issue: 37(5), P. 1276 - 1289

Published: July 10, 2024

Language: Английский

Citations

2
Antioxidant Potential of Exosomes in Animal Nutrition DOI Creative Commons
Hengyu Jin, Jianxin Liu, Diming Wang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 964 - 964

Published: Aug. 8, 2024

This review delves into the advantages of exosomes as novel antioxidants in animal nutrition and their potential for regulating oxidative stress. Although traditional nutritional approaches promote stress defense systems mammalian animals, several issues remain to be solved, such low bioavailability, targeted tissue efficiency, high-dose by-effect. As an important candidate offering regulation opportunities concerned with cellular communication, disease prevention, physiology multiple biological systems, mediating redox status has not been well described. A previously reported relationship between system circulating suggested a fundamental both regulator biomarker system. Herein, we effects on animals application nutrition. Then, highlight regulators due higher bioavailability physiological heterogeneity-targeted properties, providing theoretical foundation feed industry application. Therefore, have shown great field They can overcome limitations terms dosage side effects, which will provide unprecedented management may become major breakthrough

Language: Английский

Citations

2