Assessment and Improvement of Nutritional Knowledge among Hospitalized Cancer Patients: Gaps, Sources, and Educational Strategies DOI Open Access

Qiu Yan

Qeios, Journal Year: 2024, Volume and Issue: unknown

Published: March 18, 2024

This study explores the nutritional knowledge, its acquisition, and assessment among hospitalized cancer patients, revealing significant gaps influence of demographic factors. The research identifies predominance informal unreliable sources for information, such as internet searches peer advice, highlighting inadequacy in patient education provided by healthcare professionals. Additionally, addresses lack validated tools evaluating patients' emphasizing need comprehensive accessible educational resources standardized measurement instruments. findings advocate an integrated approach involving personalized guidance development to improve knowledge health outcomes.

Language: Английский

Single-cell and bulk transcriptome analysis unveils a ligand‒receptor-based signature for prognostication and reveals that TREM1 controls the malignant behaviors of hepatocellular carcinoma DOI Creative Commons

Jie-Min Zhang,

Qian Huang, Yingying Zheng

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Heterogenous cancer-associated fibroblasts related tumor microenvironment marked by CD10/KLF4/TIAM1 were identified in pancreatic adenocarcinoma by integrated transcriptomics DOI Creative Commons

Yu Wan,

Qiong Hu, Kai Sun

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 14, 2025

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by dense and heterogeneous tumor microenvironment (TME) composed of various cancer-associated fibroblasts (CAFs). In this study, we explored the composition proportions CAF subtypes within PDAC TME identified three distinct CAF-related subtypes: iCAF-rich, myCAF-rich, PSC-rich. We observed significant heterogeneity in populations across different patients, which correlated with patient prognosis mechanical fibrotic properties TME. Our analysis revealed that these exhibit gene expression profiles, myCAF-rich subtype showing upregulation hypoxia- glycolysis-related genes, such as LDHA. Furthermore, set survival analyses demonstrated specific harbor unique protective risk factors, were non-overlapping between subtypes. These findings suggest plays critical role progression therapeutic response. By utilizing multiplex immunohistochemistry spatial transcriptomics, also key subpopulations, iCAF_17, iCAF_19, myCAF_12, found to interact closely cells macrophages. chemotherapy-treated myCAFs positioned at boundary, potentially acting barrier invasion. This study provides novel insights into subtypes, offering foundation for future strategies targeting CAFs PDAC.

Language: Английский

Citations

0
Knowledge map of programmed cell death in esophageal cancer: a bibliometric analysis DOI Creative Commons

Rulin Li,

Yanchun Yang,

Yang Gao

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 24, 2025

This study aimed to delineate the evolving knowledge structure of programmed cell death in esophageal cancer and identify key thematic trends, influential collaborations, emerging areas for future research. A bibliometric approach was applied 2677 publications retrieved from Web Science Core Collection (2000-2024). Three complementary tools-CiteSpace, VOSviewer, bibliometrix-were employed visualize co-citation networks, detect citation bursts, map collaborative patterns among authors, institutions, countries. Inclusion criteria focused on articles reviews that addressed conjunction with apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy, or related pathways. Publication outputs grew markedly, reflecting a shift early investigations basic apoptotic mechanisms broader explorations ferroptosis. China led publication volume citations, driven by substantial governmental funding large clinical cohorts. The United States Japan also contributed significantly, forming international research networks spanned Asia Europe. Leading particularly Zhengzhou University, demonstrated extensive collaborations. Journals such as Oncology Letters Reports were prominent outlets new findings, while highly cited references highlighted hypoxia, immune checkpoint blockade, gene-editing strategies. Keyword analyses revealed ascendance immuno-oncology, network pharmacology, translational applications targeting multiple regulated Bibliometric evidence underscores rapid expansion multidisciplinary integrates diverse pathways cancer. Continued leveraging advanced genomics immunologic strategies, are poised accelerate breakthroughs enable more personalized, effective therapies.

Language: Английский

Citations

0
Advances in the study of tertiary lymphoid structures in the immunotherapy of breast cancer DOI Creative Commons
Xin Li, Xu Han,

Ziwei Du

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 2, 2024

Breast cancer, as one of the most common malignancies in women, exhibits complex and heterogeneous pathological characteristics across different subtypes. Triple-negative breast cancer (TNBC) HER2-positive are two highly invasive subtypes within cancer. The stability microbiota is closely intertwined with immune environment, immunotherapy a approach for treating cancer.Tertiary lymphoid structures (TLSs), recently discovered cell aggregates surrounding resemble secondary organs (SLOs) associated prognosis survival some patients, offering new avenues immunotherapy. Machine learning, form artificial intelligence, has increasingly been used detecting biomarkers constructing tumor models. This article systematically reviews latest research progress on TLSs application machine learning detection study prognosis. insights provided contribute valuable perspectives further exploring biological differences among formulating personalized treatment strategies.

Language: Английский

Citations

3
Predicting mitophagy-related genes and unveiling liver endothelial cell heterogeneity in hepatic ischemia-reperfusion injury DOI Creative Commons

Bochen Pan,

Xuan Ma,

Shihuan Zhou

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 17, 2024

Hepatic Ischemia-Reperfusion Injury (HIRI) is a major complication in liver transplants and surgeries, significantly affecting postoperative outcomes. The role of mitophagy, essential for removing dysfunctional mitochondria maintaining cellular balance, remains unclear HIRI.

Language: Английский

Citations

3
Lights and Shadows of Cytokines in Age‐Related Eye Diseases: A Narrative Literature Review DOI Open Access

Yuyu Xue,

Lu Ye,

Chan Huang

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(1)

Published: Jan. 1, 2025

ABSTRACT The eye is considered to be an immune‐privileged region. However, several parts of the have distinct mechanisms for delivering immune cells injury sites or even in response aging. Although these responses are intended protective, visual acuity can compromised by release pro‐inflammatory cytokines cells, which induce chronic inflammation and fibrosis. Age‐related diseases (AREDs) primary cause vision impairment (VI) elderly, with a poor comprehension their pathophysiology. affect both anterior posterior segments, resulting diminished quality life risk irreversible blindness. Immune system dysregulation upregulation been linked AREDs, underscoring need comprehend inflammation's impact on ocular disorders enhance patient symptom management. In this framework, PubMed database was searched using medical subject headings (MeSH) terms “Age‐related diseases,” “dry syndrome,” “glaucoma,” “cataract,” “diabetic retinopathy,” “inflammation,” “interleukin,” “cytokine” aim overview role AREDs discuss potential therapeutic approaches.

Language: Английский

Citations

0
Human platelet lysate: a potential therapeutic for intracerebral hemorrhage DOI Creative Commons

Dachang Qiu,

Lin Wang, Lanlan Wang

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 15, 2025

Intracerebral hemorrhage (ICH) is a major public health challenge worldwide, and associated with elevated rates of mortality, disability, morbidity, especially in low- middle-income nations. However, our knowledge the detailed molecular processes involved ICH remains insufficient, particularly those secondary injury stage, resulting lack effective treatments for ICH. Human platelet lysates (HPL) are abundant bioactive factors, numerous studies have demonstrated their beneficial effects on neurological diseases, including anti-neuroinflammatory ability, anti-oxidant effects, maintenance blood-brain barrier integrity, promotion neurogenesis. In this review, we thoroughly explore potential HPL treating from three critical perspectives: rationale selecting as treatment ICH, mechanisms through which contributes to management, additional measures necessary We elucidate role platelets pathophysiology highlight limitations current options advancements preclinical research application disorders. Furthermore, historical developments preparation methods field biomedicine discussed. Additionally, summarize molecules present therapeutic Finally, outline issues that must be addressed regarding utilizing modality

Language: Английский

Citations

0
Review of: "The Application and Pathway Regulation of Traditional Chinese Medicine in Lung Cancer Treatment: An Exploratory Review" DOI Creative Commons
Palmiro Poltronieri

Published: March 8, 2024

Language: Английский

Citations

1
The impact of Sangju Qingjie Decoction on the pulmonary microbiota in the prevention and treatment of chronic obstructive pulmonary disease DOI Creative Commons

Zheng Liu,

Ying Huang, Chao Hu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: April 30, 2024

Objective Exploring the effect of SJQJD on pulmonary microbiota chronic obstructive disease (COPD) rats through 16S ribosomal RNA (rRNA) sequencing. Methods A COPD rat model was constructed smoking and lipopolysaccharide (LPS) stimulation, efficacy evaluated by hematoxylin eosin (H&E) staining Enzyme-Linked Immunosorbnent Assay (ELISA). The alveolar lavage fluid subjected to rRNA diversity lung composition community structure analyzed differential were screened. Additionally, machine learning algorithms used for screening biomarkers each group microbiota. Results could improve inflammatory response in rats. 16s sequencing analysis showed that significantly abundance bacterial communities Through methods, potential microbial identified as Mycoplasmataceae , Bacillaceae Lachnospiraceae . Conclusion tissue morphology local rats, its may be related

Language: Английский

Citations

1
Spatial transcriptomics: a new frontier in accurate localization of breast cancer diagnosis and treatment DOI Creative Commons
Yang Zhang,

Shuhua Gong,

Xiaofei Liu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 8, 2024

Breast cancer is one of the most prevalent cancers in women globally. Its treatment and prognosis are significantly influenced by tumor microenvironment heterogeneity. Precision therapy enhances efficacy, reduces unwanted side effects, maximizes patients’ survival duration while improving their quality life. Spatial transcriptomics significant importance for precise breast cancer, playing a critical role revealing internal structural differences tumors composition microenvironment. It offers novel perspective studying spatial structure cell interactions within tumors, facilitating more effective personalized treatments cancer. This article will summarize latest findings diagnosis from transcriptomics, focusing on revelation microenvironment, identification new therapeutic targets, enhancement disease diagnostic accuracy, comprehension progression metastasis, assessment drug responses, creation high-resolution maps cells, representation heterogeneity, support clinical decision-making, particularly elucidating immunotherapy correlation with outcomes.

Language: Английский

Citations

1