The Covid-19 and TB Syndemic: Differences and Similarities DOI Open Access
Stefan H. E. Kaufmann, Alan Sher, Alex Sigal

et al.

Frontiers research topics, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 1, 2023

it is a pioneering approach to the world of academia, radically improving way scholarly research managed.The grand vision Frontiers where all people have an equal opportunity seek, share and generate knowledge.Frontiers provides immediate permanent online open access its publications, but this alone not enough realize our goals. journal seriesThe series multi-tier interdisciplinary set openaccess, journals, promising paradigm shift from current review, selection dissemination processes in academic publishing.All journals are driven by researchers for researchers; therefore, they constitute service community.At same time, operates on revolutionary invention, tiered publishing system, initially addressing specific communities scholars, gradually climbing up broader public understanding, thus serving interests lay society, too. Dedication qualityEach article landmark highest quality, thanks genuinely collaborative interactions between authors review editors, who include some world's best academicians.Research must be certified peers before entering stream knowledge that may eventually reach -and shape society; only applies most rigorous unbiased reviews.Frontiers revolutionizes freely delivering outstanding research, evaluated with no bias both social point view.By applying advanced information technologies, catapulting into new generation.

Language: Английский

What is the role of microbial biotechnology and genetic engineering in medicine? DOI Creative Commons
Fernando Santos‐Beneit

MicrobiologyOpen, Journal Year: 2024, Volume and Issue: 13(2)

Published: March 31, 2024

Abstract Microbial products are essential for developing various therapeutic agents, including antibiotics, anticancer drugs, vaccines, and enzymes. Genetic engineering techniques, functional genomics, synthetic biology unlock previously uncharacterized natural products. This review highlights major advances in microbial biotechnology, focusing on gene‐based technologies medical applications.

Language: Английский

Citations

13
Perspectives on development and advancement of new tuberculosis vaccines DOI Creative Commons
Christopher da Costa, Christine Stabell Benn, Thomas Nyirenda

et al.

International Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: 141, P. 106987 - 106987

Published: Feb. 26, 2024

Tuberculosis (TB) remains a leading cause of death globally and is estimated to have caused 1.3 million deaths worldwide in 2022. Approximately one quarter the world's population are infected with Mycobacterium tuberculosis, whom up 10% will progress developing active TB disease. Achieving WHO End Strategy targets 95% reduction mortality 90% incidence worldwide, by 2035, daunting task. The continuing spread multi-drug resistant adds another obstacle achieving global control. Larger funding pledges coupled technological advances recently enabled enhancement vaccine development efforts. These yielding pipeline over 17 products currently different stages clinical trials. Emerging promising phase 1 2 trials' results advancement 3 trials necessitated "vaccine preparedness" parallel so that smooth transition from any positive 4 evaluation implementation into policy practice can follow. Promotion human-rights-based approach which recognizes upholds fundamental rights all affected disease, essential ensure universal access quality vaccines regardless their background or personal circumstances.

Language: Английский

Citations

11
Extracellular vesicles versus lipid nanoparticles for the delivery of nucleic acids DOI Creative Commons

Johannes Bader,

Finn Brigger,

Jean‐Christophe Leroux

et al.

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 115461 - 115461

Published: Oct. 1, 2024

Language: Английский

Citations

5
Ecology, global diversity and evolutionary mechanisms in the Mycobacterium tuberculosis complex DOI
Galo A. Goig, Etthel M. Windels, Chloé Loiseau

et al.

Nature Reviews Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Citations

0
Immunogenicity and Protective Efficacy of a Multi-Antigen Mycobacterium tuberculosis Subunit Vaccine in Mice DOI Creative Commons
Annuurun Nisa,

Rachel Pinto,

Warwick J. Britton

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(9), P. 997 - 997

Published: Aug. 30, 2024

There is an urgent need for effective TB vaccine capable of controlling both acute and chronic

Language: Английский

Citations

3
Integrating systemic immune-inflammation index, fibrinogen, and T-SPOT.TB for precision distinction of active pulmonary tuberculosis in the era of mycobacterial disease research DOI Creative Commons
Zhikang Yu,

Zifang Shang,

Qingyan Huang

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: April 25, 2024

The clinical challenge of differentiating suspected tuberculosis with positive T-SPOT.TB results persist. This study aims to investigate the utility Systemic Immune-Inflammation Index (SII), Fibrinogen, and in distinguishing between active pulmonary (PTB) non-tuberculous lung diseases.

Language: Английский

Citations

2
Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches DOI Creative Commons
Débora L. Campos, Christian S. Carnero Canales, Fernanda Manaia Demarqui

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 11, 2024

Tuberculosis remains a serious global health threat, exacerbated by the rise of resistant strains. This study investigates potential two benzofuroxan ( Bfx ) derivatives, 5n and 5b, as targeted treatments for MDR-TB using in silico , vitro vivo methodologies. In analyses showed that compounds have significant activity against Mtb H37Rv, with standing out MIC 90 0.09 ± 0.04 μM. Additionally, their efficacy MDR pre-XDR strains was superior compared to commercial drugs. These narrow spectrum mycobacteria, which helps avoid dysbiosis gut microbiota, they also exhibit high selectivity low toxicity. Synergism studies indicate derivatives could be combined rifampicin enhance treatment reduce its duration. Scanning electron microscopy revealed severe damage morphology following 5n, showing distortions bacillary structures. Whole-genome sequencing 5n-resistant isolate suggests resistance mechanisms mediated Rv1855c gene, supported studies. compound reduced pulmonary load 3.0 log 10 CFU/mL, demonstrating superiority over rifampicin, achieved reduction 1.23 CFU/mL. conclusion, especially effectively address infections caused suggesting solid foundation future therapeutic developments MDR-TB.

Language: Английский

Citations

1
The Role of Proline-Proline-Glutamic Acid (PPE) Proteins in Mycobacterium tuberculosis Virulence: Mechanistic Insights and Therapeutic Implications DOI Open Access

Ajibola Ilesanmi,

Oluwasanmi M Odeniran,

Lenora Tatsipie

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 9, 2024

For decades, tuberculosis (TB), caused by Mycobacterium (MTB), has remained a global health challenge. Central to this issue are the proline-proline-glutamic acid (PPE) proteins, which play pivotal role in pathogenesis and persistence of MTB. This article explores molecular mechanisms PPE proteins their roles facilitating MTB’s evasion host’s immune system while enhancing virulence transmission. Focusing on structural functional aspects review provides detailed analysis antigenic variation, crucial mechanism allowing MTB elude detection. It also probes genetic diversity these complex interactions with host immunity, offering insights into challenges they pose for therapeutic development. delves potential targeting novel strategies, discussing prospects drug vaccine The evidence reviewed underscores pressing need innovative approaches combat TB, especially face increasing resistance. Ultimately, highlights untapped revolutionizing TB treatment, paving way breakthroughs

Language: Английский

Citations

0
Cystatin F Depletion in Mycobacterium tuberculosis-Infected Macrophages Improves Cathepsin C/Granzyme B-driven Cytotoxic Effects on HIV-Infected Cells during Coinfection. DOI Open Access
Manoj Mandal, David Pires, Marta Calado

et al.

Published: March 28, 2024

Cystatin F (CstF) is a protease inhibitor of cysteine cathepsins, including those involved in acti-vating the perforin/granzyme cytotoxic pathways. It targeted to endolysosomal pathway but can also be secreted extracellular milieu or endocytosed by bystander cells. CtsF was shown significantly increased tuberculous pleurisy, and during HIV coinfection, pleural fluids display high viral loads. In human macrophages, we revealed strong upregulation CstF infection with Mycobacterium tuberculosis (Mtb). manipulation using RNA si-lencing led proteolytic activity lysosomal improving Mtb intracellular killing. Here, investigate impact depletion coinfection Mtb-infected mac-rophages lymphocytes infected HIV. Our results indicate that decreasing released phagocytes impacts major pro-granzyme convertase cathepsin C immune Consequently, an observed increase granzyme B apoptotic effects leads significant re-duction replication HIV-infected lymphocytes. Overall, our mecha-nism Mtb/HIV evasion mediated pathogen killing driven ax-is CstF/ catC/granzymes contributing this syndemic interaction. Ultimately, knowledge crucial for developing new therapeutic approaches control both pathogens based on manipulating CstF.

Language: Английский

Citations

0
Enhanced Glycosylation Caused by Overexpression of Rv1002c in a Recombinant BCG Promotes Immune Response and Protects against Mycobacterium tuberculosis Infection DOI Creative Commons
Shufeng Weng, Qingchun Li, Tianran Zhang

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(6), P. 622 - 622

Published: June 4, 2024

Tuberculosis (TB) is a major global health threat despite its virtual elimination in developed countries. Issues such as drug accessibility, emergence of multidrug-resistant strains, and limitations the current BCG vaccine highlight urgent need for more effective TB control measures. This study constructed strains overexpressing Rv1002c found that rBCG-Rv1002c strain secreted glycosylated proteins, significantly enhancing macrophage activation immune protection against Mycobacterium tuberculosis (M. tb). These results indicate overexpression promotes elevated levels O-glycosylation bacteriophages, their phagocytic antigenic presentation functions. Moreover, upregulated regulatory molecules on surface, activated NF-κB pathway, facilitated release large amounts NO H2O2, thereby bacterial control. In mice, immunization induced greater innate adaptive responses, including increased production multifunctional long-term memory T cells. Furthermore, rBCG-Rv1002c-immunized mice exhibited reduced lung load histological damage upon M. tb infection. result shows it has potential to be an excellent candidate preventive TB.

Language: Английский

Citations

0