Hydrogel systems for spatiotemporal controlled delivery of immunomodulators: engineering the tumor immune microenvironment for enhanced cancer immunotherapy DOI Creative Commons
Yanting Liu, Fang Liu, Yan Zeng

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 13, 2024

Tumor immunotherapy, modulating innate and adaptive immunity, has become an important therapeutic strategy. However, the tumor immune microenvironment’s (TIME) complexity heterogeneity challenge immunotherapy. Hydrogel is a hydrophilic three-dimensional (3D) mesh structure with good biocompatibility drug release control, which widely used in delivery, agriculture, industry, etc. Hydrogels loaded cells, cytokines, checkpoint inhibitors, anti-tumor drugs can achieve targeted delivery ultimately activate response TIME. In this review, we will summarize components of TIME their effects, emerging immunomodulatory agents, characteristics functions hydrogels, how hydrogels regulate cells

Language: Английский

Enhanced Antitumor Efficacy of STING Agonist MSA-2 by Lipid Nanoparticles Delivering Circular IL-23 mRNA and Platinum-Modified MSA-2 Combination DOI Creative Commons
He Tian,

Yating Li,

Weiqi Li

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101446 - 101446

Published: Jan. 5, 2025

A next-generation STING agonist MSA-2 is a promising tumor immunotherapy strategy. However, the methods for improving anti-tumor efficacy of are lot effort. We have demonstrated antitumor effect platinum-modified (MSA-2-Pt) was better than MSA-2. Here, we combined lipid nanoparticles delivering circular IL-23 mRNA (LNP@cIL-23) and MSA-2-Pt strategy, which showed good efficacy. Firstly, synthesized new series ionizable phospholipids formulated optimized an LNP36 mRNA. Then, combination LNP36@cIL-23 induced cell death immune activation in with single i.t. injection. Finally, significantly decreased melanoma B16F10 prolonged survival, demonstrating significant effects. This finding provides avenues strategies immunotherapy.

Language: Английский

Citations

1
cGAS/STING signaling pathway in gynecological malignancies: From molecular mechanisms to therapeutic values DOI Creative Commons
Danyang Zhang, Bingxue Zhang

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 30, 2025

Gynecological cancers, including cervical, ovarian, and endometrial malignancies, remain a significant global health burden, exacerbated by disparities in access to preventive measures such as HPV vaccination routine screening. The cGAS/STING signaling pathway, pivotal mechanism innate immunity, detects cytosolic DNA from pathogens or cellular damage, triggering immune responses via type I interferons inflammatory cytokines. This pathway’s dual role gynecological either promoting antitumor immunity facilitating tumor evasion, makes it compelling target for innovative therapies. article outlines cGAS/STING’s influence on microenvironments, surveillance, inflammation, with emphasis molecular mechanisms driving cancer progression. It explores interactions between damage response pathways modulation, highlighting the impact of activation suppression cancers. therapeutic potential STING agonists, PARP inhibitors, targeted immunotherapies is reviewed, demonstrating how these approaches can boost responses, counteract chemotherapy resistance, improve patient outcomes. study also discusses strategies leveraging enhance efficacy address tumor-mediated suppression, providing insights into future directions personalized treatments.

Language: Английский

Citations

1
The silent spread: exploring diverse metastatic pathways in high-grade serous ovarian cancer DOI Creative Commons
Mengqi Deng,

Ruiye Yang,

Junyi Jiang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 5, 2025

High-grade serous ovarian cancer (HGSOC) is a highly aggressive and deadly gynecological cancer, with metastasis being key factor in its poor prognosis. Historically, HGSOC was thought to spread primarily through the peritoneal cavity, but recent research has revealed additional routes of metastasis, including blood lymphatic systems. This review discusses complex processes focusing on immune suppression, stromal reprogramming, role circulating tumor cells blood-based spread. We also explore clinical significance particularly impact patient outcomes. Gaining insight into molecular genetic drivers, such as BRCA mutations interactions within microenvironment, essential for developing targeted treatments. Future studies should aim enhance experimental models, identify early detection markers, investigate novel therapeutic approaches effectively address improve survival.

Language: Английский

Citations

0
Mendelian randomization reveals immune cell composition as a key determinant of cervical cancer prognosis DOI Creative Commons

Yangyang Chen,

D. Zhong

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 29, 2025

Language: Английский

Citations

0
cGAS/STING signalling pathway in senescence and oncogenesis DOI
Le Yu, Pengda Liu

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 106-107, P. 87 - 102

Published: Aug. 31, 2024

Language: Английский

Citations

3
Microwave ablation combined with α-PD-L1 enhances abscopal effect and promotes CTL activation and intratumoral homing by a cytokine network involving IFN-γ and CXCL9 DOI
Fuqi Ma, Xiayi Miao,

Yuhua Lin

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114498 - 114498

Published: March 17, 2025

Language: Английский

Citations

0
The cGAS-STING pathway and female reproductive system diseases DOI Creative Commons

Ruijie Li,

Hengwei Liu,

Yi Liu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 9, 2024

The cGAS-STING pathway has become a crucial role in the detection of cytosolic DNA and initiation immune responses. not only mediates protective defense against various DNA-containing pathogens but also detects tumor-derived to generate intrinsic anti-tumor immunity. However, abnormal activation by self-DNA can lead autoimmune diseases inflammatory disorders. This article reviews mechanisms functions pathway, as well latest research progress female reproductive-related diseases. We focus on regulatory roles this common reproductive disorders, discuss clinical potential biomarkers therapeutic agents for diseases, controversies, technical issues, biological knowledge gaps that need be resolved. Furthermore, we provide new ideas treatment prevention these

Language: Английский

Citations

1
Bidirectional regulation of the cGAS-STING pathway in the immunosuppressive tumor microenvironment and its association with immunotherapy DOI Creative Commons
Yurui Zhang, Yudi Wang,

Peizheng Mu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 11, 2024

Adaptive anti-tumor immunity is currently dependent on the natural immune system of body. The emergence tumor immunotherapy has improved prognosis and prolonged survival cycle patients. Current mainstream immunotherapies, including checkpoint blockade, chimeric antigen receptor T-cell immunotherapy, monoclonal antibody therapy, are linked to immunity. cGAS-STING pathway an important signaling that plays role in fighting against invasion foreign pathogens maintaining homeostasis organism. Increasing evidence suggests a key immunity, combination STING-related agonists can significantly enhance efficacy reduce immunotherapeutic resistance. However, double-edged sword, its activation immunosuppression. Immunosuppressive cells, M2 macrophages, MDSC, regulatory T microenvironment play crucial escape, thereby affecting effect. bi-directionally regulate this group immunosuppressive targeting affect function providing new ideas for immunotherapy. In study, we summarize immunological elaborate escape mediated by microenvironment. Finally, approaches related explore ways improve them, guidelines further clinical services.

Language: Английский

Citations

1
Hydrogel systems for spatiotemporal controlled delivery of immunomodulators: engineering the tumor immune microenvironment for enhanced cancer immunotherapy DOI Creative Commons
Yanting Liu, Fang Liu, Yan Zeng

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 13, 2024

Tumor immunotherapy, modulating innate and adaptive immunity, has become an important therapeutic strategy. However, the tumor immune microenvironment’s (TIME) complexity heterogeneity challenge immunotherapy. Hydrogel is a hydrophilic three-dimensional (3D) mesh structure with good biocompatibility drug release control, which widely used in delivery, agriculture, industry, etc. Hydrogels loaded cells, cytokines, checkpoint inhibitors, anti-tumor drugs can achieve targeted delivery ultimately activate response TIME. In this review, we will summarize components of TIME their effects, emerging immunomodulatory agents, characteristics functions hydrogels, how hydrogels regulate cells

Language: Английский

Citations

1