Impact of Epstein-Barr Virus Nuclear Antigen 1 on Neuroinflammation in PARK2 Knockout Mice with Mitochondrial Dysfunction DOI Open Access
Davide Cossu, Yuji Tomizawa,

Sachiko Noda

et al.

Published: Aug. 26, 2024

This study aimed to explore the intricate relationship between mitochondrial dysfunction, infections, and neuroinflammation, focusing specifically on impact of pathogenic epitopes Epstein-Barr Virus (EBV) nuclear antigen 1 (EBNA1) in a mouse model dysfunctions. The investigation included female middle-aged PARK2-/- C57BL/6J wild-type mice immunized with EBNA1386-405 or active experimental autoimmune encephalomyelitis (EAE) induction by myelin oligodendrocyte glycoprotein (MOG)35-55 peptide. developed more severe EAE than mice. Following immunization EBNA1386-405, only exhibited symptoms resembling EAE. During acute phase, either MOG35-55 similar infiltration T cells macrophages spinal cord decreased GFAP expression brain. However, -immunized showed significantly increased frequencies CD8a+ CD11c+ B cells, distinct cytokine profiles periphery compared controls. These findings highlight role EBV exacerbating inflammation, particularly context deficiencies.

Language: Английский

Altered metabolism in cancer: insights into energy pathways and therapeutic targets DOI Creative Commons
Muhammad Tufail, Canhua Jiang, Ning Li

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 18, 2024

Language: Английский

Citations

54
Neurodegenerative diseases and catechins: (−)-epigallocatechin-3-gallate is a modulator of chronic neuroinflammation and oxidative stress DOI Creative Commons
Siying Li,

Zaoyi Wang,

Gang Liu

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 1, 2024

Catechins, a class of phytochemicals found in various fruits and tea leaves, have garnered attention for their diverse health-promoting properties, including potential combating neurodegenerative diseases. Among these catechins, (-)-epigallocatechin-3-gallate (EGCG), the most abundant polyphenol green tea, has emerged as promising therapeutic agent due to its potent antioxidant anti-inflammatory effects. Chronic neuroinflammation oxidative stress are key pathological mechanisms diseases such Alzheimer's disease (AD) Parkinson's (PD). EGCG neuroprotective efficacy scavenging free radicals, reducing attenuating neuroinflammatory processes. This review discusses molecular EGCG's anti-oxidative chronic neuroinflammation, emphasizing effects on autoimmune responses, neuroimmune system interactions, focusing related AD PD. By elucidating action impact processes, this underscores intervention AD, PD, possibly other Overall, emerges natural compound stress, offering novel avenues strategies treatment disorders.

Language: Английский

Citations

10
Antimicrobial carbon materials-based quantum dots: From synthesis strategies to antibacterial properties for diagnostic and therapeutic applications in wound healing DOI
Iman Zare,

Shima Zahed Nasab,

Amid Rahi

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216211 - 216211

Published: Sept. 18, 2024

Language: Английский

Citations

7
The Potential of Mitochondrial Therapeutics in the Treatment of Oxidative Stress and Inflammation in Aging DOI
Jitendra Kumar Sinha,

Khanak Jorwal,

Krishna Kumar Singh

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

Language: Английский

Citations

6
The Crucial Role of the Blood–Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications DOI Open Access
Sehwan Kim, Un Ju Jung, Sang Ryong Kim

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 386 - 386

Published: Jan. 9, 2025

The blood-brain barrier (BBB) is a crucial structure that maintains brain homeostasis by regulating the entry of molecules and cells from bloodstream into central nervous system (CNS). Neurodegenerative diseases such as Alzheimer's Parkinson's disease, well ischemic stroke, compromise integrity BBB. This leads to increased permeability infiltration harmful substances, thereby accelerating neurodegeneration. In this review, we explore mechanisms underlying BBB disruption, including oxidative stress, neuroinflammation, vascular dysfunction, loss tight junction integrity, in patients with neurodegenerative diseases. We discuss how breakdown contributes neurotoxicity, abnormal accumulation pathological proteins, all which exacerbate neuronal damage facilitate disease progression. Furthermore, potential therapeutic strategies aimed at preserving or restoring function, anti-inflammatory treatments, antioxidant therapies, approaches enhance integrity. Given role neurodegeneration, maintaining its represents promising approach slow prevent progression

Language: Английский

Citations

0
The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options DOI Creative Commons

Jiayong Yao,

Xiaohong Dai,

Xueping Yv

et al.

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 4, 2025

Intracerebral hemorrhage (ICH) is a non traumatic that occurs in certain part of the brain. It usually leads to brain cell damage. According large number experimental research, oxidative stress an important pathophysiological processes cerebral hemorrhage. In this paper, we aim determine how changes biomarkers indicate damage degree hemorrhage, and explore summarize potential treatments or interventions. We found patients with are characterized by increased levels markers, such as total malondialdehyde (MDA), F2 isoprostaglandin, hydroxynonenal, myeloperoxidase protein hydroxyl. Therefore, caused ICH on these markers can be used evaluate diagnose ICH, predict its prognosis, guide preventive treatment turn antioxidant based new alternative.

Language: Английский

Citations

0
Integrated proteomics reveals enrichment of oxidative stress and inflammatory proteins in the urine and stone matrix of calcium oxalate stone formers DOI
Suttipong Suttapitugsakul,

Supatcha Sassanarakkit,

Paleerath Peerapen

et al.

Urolithiasis, Journal Year: 2025, Volume and Issue: 53(1)

Published: Feb. 6, 2025

Language: Английский

Citations

0
Dihydroartemisinin inhibits the development of autoimmune thyroiditis by modulating oxidative stress and immune imbalance DOI Creative Commons

Shuangjie Zhu,

Yiping Cui,

Huizheng Hu

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: 231, P. 57 - 67

Published: Feb. 21, 2025

Language: Английский

Citations

0
Updating on the Dual Role of Salivary Gland Epithelial Cell (SGEC) in Sjögren’s Disease DOI Creative Commons

Wen Zhu,

Yun Lu,

Yifan Zhu

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 3039 - 3053

Published: Feb. 28, 2025

Sjögren's disease, an autoimmune inflammatory currently lacks effective treatment options. The salivary gland, a crucial exocrine organ responsible for saliva production and local immune responses on mucous membranes, is frequently impaired in individuals with disease. Restoring gland function poses significant challenge researchers. Salivary epithelial cells, recognized as pivotal components of the have been increasingly implicated key initiators inflammation exhibit innate cell-like properties. On whole, SGEC plays protective role physiological state, can also participate persistence initiating factor pathological state. In review, we explore interplay between Ca+, endoplasmic reticulum (ER), mitochondrial homeostasis imbalance cells. Additionally, provide overview current literature research advancements related to Pattern Recognition Receptors (PRRs), programmed cell death, posttranslational modification (PTM), oral microecology, etc. specifically focusing their implications Given cells onset based may potential alleviate condition by addressing response glands.

Language: Английский

Citations

0
Biodegradation of Hexagonal Boron Nitride Nanomaterials by Neutrophils DOI

Zhuomiao Liu,

Jian Zhao,

Liyun Yin

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

The biodegradation of hexagonal boron nitride (h-BN) nanomaterials by neutrophils was investigated. After incubation for 36 h, h-BN nanosheets are taken up neutrophils, and their structure is highly disrupted, as observed via high-resolution transmission electron microscopy (HR-TEM) confocal Raman imaging. Among the three degradation pathways, release neutrophil extracellular traps from dominant, with myeloperoxidase (MPO) playing an important role. Molecular dynamics simulations show that MPO spontaneously attach onto surface, leverage active sites to form favorable contacts initiate degradation. Hypochlorite produced responsible With assistance hypochlorite, B–O N–O bonds formed on h-BN, along B–N bond breakage ionic nitrogen based byproduct identification first-principle calculations. Additionally, significantly degraded into small pieces, particle concentration a size 0–100 nm increases 58.7% after Following degradation, induce significant hemolysis red blood cells, exhibit higher cytotoxicity against epithelial cells. Our findings highlight importance considering its safe application, demonstrate actual risk in biological natural environments.

Language: Английский

Citations

0