Cannabichromene as a Novel Inhibitor of Th2 Cytokine and JAK/STAT Pathway Activation in Atopic Dermatitis Models DOI Open Access

Ki-Chan Kim,

Ga Hee Jeong, Chul Hwan Bang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13539 - 13539

Published: Dec. 18, 2024

Cannabichromene (CBC) is one of the main cannabinoids found in cannabis plant, and although less well known than tetrahydrocannabinol (THC) cannabidiol (CBD), it gaining attention for its potential therapeutic benefits. To date, CBC’s mechanisms action include anti-inflammatory, analgesic, antidepressant, antimicrobial, neuroprotective, anti-acne effects through TRP channel activation inhibition inflammatory pathways, suggesting that may have treatment skin diseases, such as atopic dermatitis (AD), but exact mechanism remains unclear. Therefore, this study, we investigated CBC on Th2 cytokines along with Janus kinase (JAK)/signal transducer activator transcription (STAT) pathways involved AD pathogenesis. We used a 2,4-Dinitrochlorobenzene (DNCB)-induced BALB/c mouse model to topically administer (0.1 mg/kg or 1 mg/kg). The results showed lesion severity, ear thickness, epithelial thickness dorsal skin, mast cell infiltration were significantly reduced 0.1 CBC-treated group compared DNCB-treated (p < 0.001). In addition, real-time quantitative reverse polymerase chain reaction (qRT-PCR) analysis significant decrease mRNA expression (TSLP, IL-4, IL-13) mediators (IFN-γ, IL-1β, IL-6, IL-17, IL-18, IL-33) 0.05). Western blot also revealed JAK1, JAK2, STAT1, STAT2, STAT3, STAT6 protein These suggest promising candidate demonstrates alleviate symptoms by suppressing immune response.

Language: Английский

The gut microbiome and cross-reactivity of food allergens: current understanding, insights, and future directions DOI Creative Commons

Carolina Taico Oliva,

Ibrahim Musa,

Daniel Kopulos

et al.

Frontiers in Allergy, Journal Year: 2025, Volume and Issue: 5

Published: Jan. 13, 2025

This mini-review examines the emerging role of gut microbiome in influencing food allergen cross-reactivity. It specifically focuses on how microbial diversity, antigens, and metabolites impact IgE-mediated allergic responses. Cross-reactivity occurs when structurally similar antigens trigger hypersensitivities, affecting millions people worldwide. Recent research underscores significance diversity early life for developing immune tolerance. Beneficial strains, such as Lactobacillus Bifidobacterium, play a crucial supporting functions T regulatory cells (Tregs) immunoglobulin A (IgA). Additionally, we discuss metabolites, particularly short-chain fatty acids (SCFAs), which enhance tolerance by promoting Treg differentiation maintaining barrier integrity, thereby reducing entry. However, it is important to note that SCFAs can provoke inflammatory responses under certain conditions, highlighting necessity targeted their dual effects. Dysbiosis-related intestinal permeability, often referred "leaky gut," further worsen Microbial like lipopolysaccharides (LPS) are known influence Th2-dominant

Language: Английский

Citations

1
Topical Anti-Inflammatory Effects of Quercetin Glycosides on Atopic Dermatitis-Like Lesions: Influence of the Glycone Type on Efficacy and Skin Absorption DOI Creative Commons

Shih-Chun Yang,

Zi‐Yu Chang, Chien‐Yu Hsiao

et al.

Inflammation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Atopic dermatitis (AD) is a multifaceted inflammatory skin condition characterized by the involvement of various cell types, such as keratinocytes, macrophages, neutrophils, and mast cells. Research indicates that flavonoids possess anti-inflammatory properties may be beneficial in management AD. However, investigation glycoside forms for anti-AD therapy limited. We aimed to assess ability quercetin-3-O-glycosides treating AD-like lesions through silico-, cell-, animal-based platforms. The glycosylated flavonols quercitrin, isoquercitrin, rutin were used this study. also tried understand influence glycone type on bioactivity delivery glycosides. glycosides effectively reduced overexpression proinflammatory effectors interleukin (IL)-6, chemokine (C-X-C motif) ligand (CXCL)1, CXCL8, regulated upon activation normal T expressed secreted (RANTES), thymus activation-regulated (TARC) activated keratinocytes. This reduction could due inhibition extracellular signal-regulated kinase (ERK) p38 phosphorylation. Isoquercitrin (but not quercitrin rutin) arrest upregulated IL-6 CCL5 macrophage model. significantly prevented histamine release from RBL-2H3 absorption examination showed greater permeation isoquercitrin than with dual sugar moieties smaller molecular volume higher lipophilicity. deposition was enhanced about 11-fold stripped delipidized skins, which mimicked AD lesions. vivo dinitrochlorobenzene (DNCB)-induced mouse model demonstrated less erosion, scaling, epidermal hyperplasia after topical treatment. concentration cytokines/chemokines lesion decreased isoquercitrin. These effects similar those tacrolimus ointment. immunohistochemistry (IHC) displayed hyperproliferation immune infiltration results indicated quercetin provide an efficient safe way treat inflammation.

Language: Английский

Citations

1
Evaluating Efficacy and Safety of Crisaborole in Managing Childhood Mild to Moderate Atopic Dermatitis: A Systematic Review and Meta-Analysis DOI Creative Commons

Jianhua You,

H Li,

Zhongyun Wang

et al.

British Journal of Hospital Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: Jan. 24, 2025

Aims/Background Atopic dermatitis (AD) is a common chronic inflammatory skin disorder globally. Crisaborole, nonsteroidal topical phosphodiesterase 4 inhibitor (PDE4i), has been utilized in treating AD. Crisaborole regulates the production of cytokines, which are usually overactive among AD patients. Therefore, this study aimed to explore efficacy and safety crisaborole patients aged ≤18 years. Methods A literature search was performed across PubMed, MEDLINE, Embase, Cochrane, Google Scholar. The inclusion criteria involved primary studies evaluating effect dermatitis, articles exploring use below 18 years (>two years), published English between 2000 2022. However, adult patients, those reporting treatments other than crisaborole, before 2000, written languages were excluded from analysis. Furthermore, secondary data sources such as case reports, newspaper articles, magazines, systematic reviews meta-analyses excluded. meta-analysis conducted using RevMan 5.4. risk bias manuscripts assessed Cochrane tool. I-square test statistic used determine heterogeneity, Egger’s evaluate publication bias. Results Ten met eligibility included final Most exhibited low with no Meta-analysis indicated significant difference number attaining Investigator Static Global Assessment (ISGA) success at day 29, significantly higher group vehicle (odds ratio (OR) 1.56, 95% CI 1.24 1.96; I 2 = 77%; p 0.0001). Similarly, pruritus improvement two cohorts indicating heterogeneity (OR 1.70, 1.10 2.63; 91%; 0.02). profiling insignificant, demonstrating statistical treatment-emergent adverse events (TEAEs) groups high 0.53, 0.14 1.98; 99%; 0.35). Conclusion demonstrates substantial mild moderate compared therapies, it reduces signs symptoms disease. well tolerated an acceptable profile

Language: Английский

Citations

0
Atopic dermatitis: a comprehensive updated review of this intriguing disease with futuristic insights DOI Creative Commons
Heidi M. Abdel-Mageed

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

Citations

0
Lifestyle Factors in the Clinical Manifestation and Management of Atopic Dermatitis DOI Open Access

K. H. Lam,

Deepak Agrawal

Archives of Internal Medicine Research, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 1, 2025

Atopic dermatitis (AD), also known as eczema, is an inflammatory dermatologic condition that results in inflamed, itchy skin lesions. The development of this governed by a variety genetic and environmental factors including lifestyle habits. severity atopic has been attributed to be affected various factors, prompting the interest utilizing modifications form treatment for symptoms. Many research studies have conducted investigate effects different such sleep, stress, diet, smoking tobacco use, exposure temperatures humidity levels, skincare cosmetic products on symptoms, how certain habits can modified manage AD conditions. Current demonstrated significant impact some elicit with improving dermatitis, while discussing other require further determine their AD. This review article summarizes findings current literature investigates role exacerbation explores mechanisms which these behaviors trigger

Language: Английский

Citations

0
Development and Characterization of a Vaccinium vitis-idaea Liposomal Gel for the Treatment of Atopic Dermatitis DOI Creative Commons
Zhigang Zhang, Jinhai Huo, Lina Feng

et al.

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: Feb. 17, 2025

In this study, a liposomal gel with anti-inflammatory, antibacterial, and antioxidant effects improving atopic dermatitis (AD) was prepared using Vaccinium vitis-idaea polyphenol as the main active ingredient, which is safe, effective, of stable quality has anti-inflammatory antimicrobial effects. The extract from obtained through ultrasonic extraction subsequently purified macroporous resin. A liposome incorporating formulated poloxamer 188 407 base materials. gel's physical characteristics, including appearance, vesicle size, zeta potential, were systematically characterized. Furthermore, its antioxidant, anti-aging, anti-AD assessed both ex vivo in studies. After process optimization, yield 4.33%; encapsulation rate 90.45%. by optimal had potential -33.67 mV, particle size 119 nm, PDI 0.147, showed good stability under conditions 60 °C, 75% relative humidity, light intensity 4500 ± 500 Lux. results vitro studies that polyphenols have antibacterial effects, safe for skin application, effectively reduces dandruff erythema, degree keratinization, congestion inflammatory infiltration local tissues well increasing content collagen fibers tissues, promotes restoration structural integrity skin, reducing factors TNF-α, IL-4. By expression level IL-4, IL-13, MDA, SOD, diversity bacterial flora AD it can play role anti-bacterial, improve symptoms AD. present study demonstrated an ameliorating effect on

Language: Английский

Citations

0
Subcutaneous Injection and Brush Application of Ovalbumin–Aluminum Salt Solution Induces Dermatitis-like Changes in Mice DOI Open Access
Gabriel Siquier-Dameto, Ainhoa Iguaran-Pérez,

Javier Gimeno-Beltrán

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1701 - 1701

Published: March 3, 2025

Background: Intraperitoneal sensitization combined with topical and/or epicutaneous treatment using an ovalbumin (OVA)–aluminum salt solution (OVA-AL) represents a model for inducing atopic dermatitis (AD). However, the combination of subcutaneous and cutaneous application OVA-AL via brush has not been explored as method AD. Methods: Adult mice were subcutaneously injected following on days 0, 7, 14 treated to dorsal skin fortnightly until 35 49. Concomitant alloknesis changes assessed. Mice Balb/c ICR-CD1 strains day 35, only strain continuing Control animals received saline. At 49 days, was harvested processed histological analysis. Results: developed dry skin, no scratching or alloknesis. Histological examination revealed increase in mast cells collagen deposition. Conclusions: Dermatitis-like symptoms observed this administration method.

Language: Английский

Citations

0
Dermatological diseases predisposing to the development of otitis externa (literature review) DOI
А. С. Дворников, T. A. Gaydina, Kriukov Ai

et al.

Russian Bulletin of Otorhinolaryngology, Journal Year: 2025, Volume and Issue: 90(1), P. 50 - 50

Published: March 18, 2025

Otitis externa is the most common diagnosis in practice of an otorhinolaryngologist. Definitions term are not precise at moment, and a universal generally accepted classification has been developed. In separate nosological group, otitis can be distinguished from background dermatological diseases. These patients need interdisciplinary approach, joint supervision otorhinolaryngologists dermatovenerologists to increase effectiveness treatment minimize risks chronic otitis. Severe complications obstructive keratosis, fibrous atresia, persistent conductive hearing loss. Diagnostic algorithms therapeutic strategies for should include search therapy disease. At tactics managing suffering on diseases continues

Language: Английский

Citations

0
Association between fine particulate matter (PM2.5) and atopic dermatitis—a systematic review DOI Creative Commons

Noah Weslock,

Delaney T. Drew,

Deepak Kumar Palanichami

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 24, 2025

Language: Английский

Citations

0
Topical administration of coumarin derivatives alleviates skin inflammatory symptoms in atopic dermatitis model DOI
Goeun Han,

Bon‐Hee Gu,

Sun Young Park

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 118004 - 118004

Published: March 31, 2025

Language: Английский

Citations

0