Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(4), P. 498 - 498
Published: April 20, 2025
Advanced
glycation
end-products
(AGEs)
cause
blood
vessel
damage
and
induce
diabetic
complications
in
various
organs,
such
as
the
eyes,
kidneys,
nerves,
skin.
As
stress
causes
aesthetic,
physical,
functional
changes
skin,
glycation-targeting
skin
anti-aging
strategies
are
attracting
attention
cosmetology
dermatology.
The
primary
goal
of
this
review
is
to
understand
significance
glycation-induced
aging
examine
therapeutic
potential
strategies.
This
study
covers
experimental
clinical
studies
exploring
interventions
attenuate
aging.
Glycation
decreases
viability
cells
culture
media,
cell-mediated
contraction
collagen
lattices
reconstructed
models,
expression
fibrillin-1
at
dermo-epidermal
junction
explants.
It
also
increases
cross-links
tail
tendon
animals,
prolonging
its
breakdown
time.
However,
these
attenuated
by
several
synthetic
natural
agents.
Animal
have
shown
that
dietary
or
topical
administration
agents
with
antiglycation
antioxidant
activity
can
AGE
levels
(measured
autofluorescence)
parameters
(e.g.,
color,
wrinkles,
elasticity,
hydration,
dermal
density)
induced
chronological
aging,
diabetes,
high-carbohydrate
diets,
ultraviolet
radiation,
oxidative
stress.
Therefore,
accumulating
evidence
supports
supplements
formulations
containing
one
more
may
help
mitigate
AGEs.
Food Frontiers,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 30, 2024
Abstract
The
genus
Primula
holds
great
importance
as
a
source
of
traditional
remedies
in
various
folk
medicine
systems.
In
the
present
study,
we
investigated
chemical
composition
and
biological
properties
different
extracts
(ethyl
acetate,
ethanol,
ethanol/water,
water)
aerial
parts
rhizomes
vulgaris
.
To
determine
profile,
were
analyzed
using
ultrahigh
performance
liquid
chromatography‐high‐resolution
mass
spectrometry
(UHPLC‐HRMS)
technique
flavonoids
major
group
this
profile.
antioxidant
capacity
was
demonstrated
by
vitro
tests
general
ethanol/water
extract
found
to
be
most
potent.
Enzyme
inhibition
studied
against
enzymes
ethanol
more
active
than
others.
assess
anti‐inflammatory
potential
at
molecular
level,
human
dermal
fibroblasts
(HDF)
treated
with
lipopolysaccharide
(LPS).
experiments
showed
that
levels
nuclear
factor
kappa
B
(NFKB),
receptor
for
advanced
glycation
endproducts
(RAGE),
activator
protein‐1
(AP‐1),
interleukin
6
(IL‐6),
17
(IL‐17)
tumor
necrosis
(TNF)‐alpha
significantly
reduced
after
treatment
tested
extracts.
addition,
an
inhibitory
effect
on
collagenase,
elastase,
hyaluronidase,
which
are
involved
inflammatory
process
destabilization
extracellular
matrix
(ECM).
P.
has
been
observed
modulate
metalloproteinase
(MMP)
synthesis
decreasing
concentration
cellular
reactive
oxygen
species
(ROS)
during
LPS‐induced
inflammation.
This
study
also
examined
binding
dynamic
behavior
proteins
associated
skin
infections
ligands
derived
from
Simulations
AutoDock
Vina
V1.1.2
GROMACS
2023.1
isoquercetin
particular
superior
interactions
hyaluronidase.
These
findings
important
development
therapeutic
strategies
health
infection
control.
summary,
can
considered
natural
bioactive
compounds
effective
health‐promoting
applications
nutraceuticals,
pharmaceuticals,
cosmetics
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Oct. 18, 2024
The
most
recognizable
implications
of
tissue
aging
manifest
themselves
on
the
skin.
Skin
laxity,
roughness,
pigmentation
disorders,
age
spots,
wrinkles,
telangiectasia
or
hair
graying
are
symptoms
physiological
aging.
Development
senescent
phenotype
depends
interaction
between
cells
and
remodeling
skin’s
extracellular
matrix
(ECM)
that
contains
collagen
elastic
fiber.
Aging
changes
occur
due
to
combination
both
endogenous
(gene
mutation,
cellular
metabolism
hormonal
agents)
exogenous
factors
(ultraviolet
light,
environmental
pollutants,
unsuitable
diet).
However,
overproduction
mitochondrial
reactive
oxygen
species
(ROS)
is
a
key
factor
driving
senescence.
theories
have
disclosed
range
diverse
molecular
mechanisms
associated
with
senescence
body.
Theories
best
supported
by
evidence
include
protein
glycation,
oxidative
stress,
telomere
shortening,
cell
cycle
arrest,
limited
number
divisions.
Accumulation
ECM
damage
suggested
be
in
skin
Every
indicates
functional
morphological
change
may
used
as
biomarker
Senescence-associated
β
-galactosidase
(SA-β-gal),
inhibitors
(p16INK4a,
p21CIP1,
p27,
p53),
DNA
segments
chromatin
alterations
reinforcing
(DNA-SCARS),
senescence-associated
heterochromatin
foci
(SAHF),
shortening
telomeres
downregulation
lamina
B1
constitute
just
an
example
biomarkers
known
so
far.
also
assessed
non-invasively
through
measuring
fluorescence
advanced
glycation
end-products
(AGEs).
This
review
summarizes
recent
knowledge
pathogenesis
clinical
conditions
well
Pharmacology & Therapeutics,
Journal Year:
2024,
Volume and Issue:
260, P. 108681 - 108681
Published: June 17, 2024
Our
skin
protects
us
from
external
threats
including
ultraviolet
radiation,
pathogens
and
chemicals,
prevents
excessive
trans-epidermal
water
loss.
These
varied
activities
are
reliant
on
a
vast
array
of
lipids,
many
which
unique
to
skin,
that
support
physical,
microbiological
immunological
barriers.
The
cutaneous
physical
barrier
is
dependent
specific
lipid
matrix
surrounds
terminally-differentiated
keratinocytes
in
the
stratum
corneum.
Sebum-
keratinocyte-derived
lipids
cover
skin's
surface
regulate
microbiota.
Meanwhile,
signal
between
resident
infiltrating
immune
cells,
driving
inflammation
its
resolution
response
other
threats.
Lipids
particular
importance
include
ceramides,
crucial
for
corneum
formation
therefore
functionality,
fatty
acids,
contribute
acidic
pH
microbiota,
as
well
matrix,
bioactive
metabolites
these
involved
cell
signalling,
inflammation,
numerous
processes.
diverse
complex
maintain
homeostasis
healthy
implicated
diseases,
unrelated
systemic
conditions
with
manifestations,
processes
such
ageing.
also
gut-skin
axis,
signalling
two
sites.
Therefore,
provide
valuable
resource
exploration
processes,
local
disease
development
progression,
accessible
biomarker
discovery
disease,
an
opportunity
fully
understand
relationship
host
Investigation
could
diagnostic
prognostic
biomarkers,
help
identify
new
targets
interventions.
Development
improvement
existing
vitro
silico
approaches
explore
lipidome,
advances
lipidomics
technologies,
will
facilitate
ongoing
progress
research.
Life,
Journal Year:
2023,
Volume and Issue:
13(2), P. 256 - 256
Published: Jan. 17, 2023
Advanced
glycation
end
products
(AGEs)
represent
an
endogenously
produced
or
exogenously
derived
group
of
compounds
from
nonenzymatic
glycation.
Recent
experimental
studies
are
suggesting
that
AGEs
could
play
important
role
in
the
skin's
quality
and
its
aging
process.
Hence,
aim
this
study
was
to
clinically
evaluate
skin
parameters
across
different
age
groups
general
population.
The
included
237
participants.
Melanin,
erythema,
hydration,
friction
transepidermal
water
loss
(TEWL)
were
evaluated
using
noninvasive
probes,
while
a
autofluorescence
reader.
There
significant
positive
correlation
between
amount
melanin
(p
<
0.001),
erythema
0.001)
TEWL
there
negative
hydration
0.001).
After
dividing
sample
into
three
depending
on
their
age,
all
groups,
count
Multiple
linear
regression
analysis
showed
level
as
dependent
variable
retained
association
with
=
0.005)
predictors.
Moreover,
0.017)
These
outcomes
imply
be
linked
complex
physiology
Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
31(1)
Published: Jan. 18, 2025
Diabetic
chronic
foot
ulcers
pose
a
significant
therapeutic
challenge
around
the
world,
resulting
in
adverse
effects
and
complications
patients.
D-mannose
is
enriched
cirtus
peel
exerts
beneficial
among
various
diseases,
especially
against
inflammation-related
disorders.
Here,
we
examined
potential
effect
of
during
wound
healing
process
streptozotocin
(STZ)-induced
diabetes
mice
vivo
by
culturing
keratinocytes
under
high
glucose
condition
vitro.
The
skin
lesion
was
recorded
photos
evaluated
histochemical
staining.
What's
more,
advanced
glycation
end
products
(AGEs)
concentration
blood
quantified.
Apoptotic
cells
were
assessed
flow
cytometry
Western
blotting.
Inflammatory
cytokines
cellular
differential
gene
expression
levels
measured
real-time
PCR.
AMPK/Nrf2/HO-1
signaling-related
molecules
determined
We
first
found
that
topical
supplementation
remarkably
improved
mice.
Furthermore,
both
vitro
experiments
demonstrated
reduced
AGEs
generation.
Mechanistically,
inhibited
AGEs,
then
upregulated
signaling
context
to
maintain
keratinocyte
normal
functions,
which
positively
influenced
macrophage
fibroblast
accelerate
diabetic
healing.
Noteworthily,
these
protective
abolished
pretreatment
with
inhibitors
or
AMPK.
As
far
as
know,
this
study
exploring
role
on
via
supplementation.
find
protects
from
stimulation
inhibition
formation
well
orchestrates
inflammatory
microenvironment
wounded
skin,
suggesting
its
therapy
promote
refractory
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 169 - 169
Published: Jan. 23, 2025
Accumulating
evidence
suggests
that
overt
hypothyroidism
is
associated
with
accelerated
atherosclerosis,
thereby
increasing
the
risk
for
major
cardiovascular
events.
The
present
study
aimed
to
investigate
associations
between
serum
catestatin
levels
and
advanced
glycation
end-products
(AGEs),
indicators
of
vascular
health,
in
individuals
Hashimoto’s
thyroiditis
compared
healthy
controls.
A
total
100
female
patients
age-matched
controls
were
included
study.
Serum
(10.2
(6.5–15.8)
vs.
6.4
(4.1–9.3)
ng/mL,
p
<
0.001)
tissue
AGEs
(2.21
±
0.55
ng/mL
1.89
0.56,
both
significantly
higher
group
positive
correlation
was
observed
overall
population
(r
=
0.489,
within
0.457,
0.001).
Additionally,
weak
correlations
noted
high-sensitivity
C-reactive
protein,
as
well
anti-thyroid
peroxidase
antibodies
0.277,
0.005
r
0.229,
0.024,
respectively).
All
these
confirmed
through
multivariate
analyses.
analysis
indicates
might
be
implicated
consequences
thyroiditis.
However,
future
research
should
focus
on
longitudinal
studies
explore
if
causal
relationship
exists.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(2), P. 212 - 212
Published: Feb. 13, 2025
Methylglyoxal
(MGO),
a
by-product
of
glycolysis,
plays
significant
role
in
cellular
metabolism,
particularly
under
stress
conditions.
However,
MGO
is
potent
glycotoxin,
and
its
accumulation
has
been
linked
to
the
development
several
pathological
conditions
due
oxidative
stress,
including
diabetes
mellitus
neurodegenerative
diseases.
This
paper
focuses
on
biochemical
mechanisms
by
which
contributes
through
formation
advanced
glycation
end
products
(AGEs),
interactions
with
antioxidant
systems,
involvement
chronic
diseases
like
diabetes,
neurodegeneration,
cardiovascular
disorders.
exerts
effects
multiple
signaling
pathways,
NF-κB,
MAPK,
Nrf2,
induce
stress.
Additionally,
triggers
apoptosis
primarily
via
intrinsic
extrinsic
while
endoplasmic
reticulum
(ER)
mediated
PERK-eIF2α
IRE1-JNK
signaling.
Moreover,
activation
inflammatory
RAGE
crucial
pathogenesis
these
study
points
out
connection
between
carbonyl
increased
formation,
it
should
be
an
incentive
search
for
marker
that
could
have
prognostic
significance
or
targeted
therapeutic
intervention
various
