Inhibition of mast cell activation by Jaranol-targeted Pirin ameliorates allergic responses in mouse allergic rhinitis DOI Creative Commons
Yue Huang, Shuhua Su, Bo Duan

et al.

Open Life Sciences, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Jaranol, a bioactive compound derived from various traditional medicinal herbs, has demonstrated significant anti-inflammatory properties. This study investigates its effects and possible mechanisms underlying role in mast cells, as well ovalbumin (OVA)-induced allergic rhinitis (AR) mice model. Forty were randomly divided into blank, AR, dexamethasone (positive control), Jaranol groups (10 mg/ml), with 10 each group. was found to inhibit nasal mucosal inflammation reduce cell numbers AR models. It also inhibited the secretion of several inflammatory cytokines (IFN-γ, TNF-α, IL-1β, IL-6, MCP-1, CXCR10) proliferation migration. Interestingly, Pirin differentially expressed groups. Further studies indicated that cytokine cells by mediating Moreover, it function suppressing expression. These findings suggest exerts therapeutic inhibiting expression thereby reducing histopathological changes associated AR.

Language: Английский

IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma DOI Creative Commons
Siti Muhamad Nur Husna, Norasnieda Md Shukri,

Noor Suryani Mohd Ashari

et al.

PeerJ, Journal Year: 2022, Volume and Issue: 10, P. e13444 - e13444

Published: May 30, 2022

Allergic rhinitis (AR) is a common disorder of the upper airway, while asthma disease affecting lower airway and both diseases are usually comorbid. Interleukin (IL)-4 IL-13 critical cytokines in induction pathogenic Th2 responses AR asthma. Targeting IL-4/IL-13 axis at various levels its signaling pathway has emerged as promising targeted therapy patient populations. In this review, we discuss biological characteristics IL-4 IL-13, their pathways, therapeutic antibodies against each cytokine well receptors. particular, pleiotropic roles orchestrating patients indicate that dual blockade strategy for diseases.

Language: Английский

Citations

52
Exosomal lncRNA GAS5 promotes M1 macrophage polarization in allergic rhinitis via restraining mTORC1/ULK1/ATG13-mediated autophagy and subsequently activating NF-кB signaling DOI
Xiaoyuan Zhu,

Yudong Sun,

Qianjiang Yu

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 121, P. 110450 - 110450

Published: June 19, 2023

Language: Английский

Citations

17
Phytochemical Composition, Anti-Inflammatory Property, and Anti-Atopic Effect of Chaetomorpha linum Extract DOI Creative Commons
Luisa Frusciante, Michela Geminiani, Alfonso Trezza

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(5), P. 226 - 226

Published: May 17, 2024

Utilizing plant-based resources, particularly their by-products, aligns with sustainability principles and circular bioeconomy, contributing to environmental preservation. The therapeutic potential of plant extracts is garnering increasing interest, this study aimed demonstrate promising outcomes from an extract obtained underutilized waste. Chaetomorpha linum, invasive macroalga found in the Orbetello Lagoon, thrives eutrophic conditions, forming persistent mats covering approximately 400 hectares since 2005. biomass C. linum undergoes mechanical harvesting treated as waste, requiring significant human efforts economic resources—A critical concern for municipalities. Despite posing challenges local ecosystems, identified a natural source bioactive metabolites. Phytochemical characterization revealed lipids, amino acids, other compounds anti-inflammatory activity extract. In vitro assays LPS-stimulated RAW 264.7 TNF-α/IFN-γ-stimulated HaCaT cells showed inhibited reactive oxygen species (ROS), nitric oxide (NO), prostaglandin E2 (PGE2) productions, reduced inducible synthase (iNOS) cyclooxygenase-2 (COX-2) expressions via NF-κB nuclear translocation, cells. It also chemokines (TARC/CCL17, RANTES/CCL5, MCP-1/CCL2, IL-8) cytokine IL-1β production cells, suggesting candidate chronic diseases like atopic dermatitis. Finally, silico studies indicated palmitic acid contributor observed effect. This research not only uncovered untapped but laid foundation its integration into promoting sustainable practices, innovative applications across various industries.

Language: Английский

Citations

7
Application of 32 factorial design for loratadine-loaded nanosponge in topical gel formulation: comprehensive in-vitro and ex vivo evaluations DOI Creative Commons
Durgaramani Sivadasan, Krishnaraju Venkatesan, Jamal Moideen Muthu Mohamed

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 16, 2024

Abstract Loratadine (LoR) is a highly lipophilic and practically insoluble in water, hence having low oral bioavailability. As it formulated as topical gel, competitively binds with the receptors, thus reducing side-effects. The objective of this study was to prepare LoR loaded nanosponge (LoR-NS) gel for delivery. Nine different formulations emulsion were prepared by solvent evaporation method polyvinyl alcohol (PVA), ethyl cellulose (EC), dichloromethane (DCM). Based on 3 2 Full Factorial Design (FFD), optimization carried out varying concentration LOR:EC ratio stirring rate. preparations subjected evaluation particle size (PS), vitro release, zeta potential (ZP) entrapment efficiency (EE). results revealed that NS dispersion nanosized sustained release profiles significant PS. optimised formulation incorporated into carbopol 934P hydrogel. then examined surface morphological characterizations using scanning electron microscopy (SEM) which depicted spherical NS. Stability studies, undertaken months at 40 ± °C/75 5% RH, concluded stability formulation. did not cause skin irritation. Therefore, hydrogel proved be promising applicant novel drug delivery system (NDDS) safe, controlled application.

Language: Английский

Citations

6
Current Management of Allergic Rhinitis DOI
Ludger Klimek, Joaquim Mullol, Anne K. Ellis

et al.

The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2024, Volume and Issue: 12(6), P. 1399 - 1412

Published: June 1, 2024

Language: Английский

Citations

6
Nasal Bacteriomes of Patients with Asthma and Allergic Rhinitis Show Unique Composition, Structure, Function and Interactions DOI Creative Commons
Marcos Pérez‐Losada, Eduardo Castro‐Nallar, José Laerte Boechat

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(3), P. 683 - 683

Published: March 7, 2023

Allergic rhinitis and asthma are major public health concerns economic burdens worldwide. However, little is known about nasal bacteriome dysbiosis during allergic rhinitis, alone or associated with comorbidity. To address this knowledge gap we applied 16S rRNA high-throughput sequencing to 347 samples from participants (AS = 12), (AR 53), (ARAS 183) healthy controls (CT 99). One three of the most abundant phyla, five seven dominant genera differed significantly (p < 0.021) between AS, AR ARAS CT groups. All alpha-diversity indices microbial richness evenness changed 0.01) CT, while all beta-diversity structure 0.011) each respiratory disease groups controls. Bacteriomes rhinitic showed 72 differentially expressed 0.05) metabolic pathways related mainly degradation biosynthesis processes. A network analysis bacteriomes depicted more complex webs interactions among their members than those This study demonstrates that nose harbors distinct bacteriotas identifies potential taxonomic functional biomarkers for diagnostics therapeutics in rhinitis.

Language: Английский

Citations

15
Mechanisms and Predictive Biomarkers of Allergen Immunotherapy in the Clinic DOI
Janice A. Layhadi, Anastasia Lalioti, Elizabeth Palmer

et al.

The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2023, Volume and Issue: 12(1), P. 59 - 66

Published: Nov. 22, 2023

Language: Английский

Citations

14
Quercetin a promising functional food additive against allergic Diseases: A comprehensive and mechanistic review DOI Creative Commons
Neshat Najaf Najafi,

Negin Armide,

Abolfazl Akbari

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 116, P. 106152 - 106152

Published: April 5, 2024

The crucial roles of innate and acquired immunity in the pathogenesis allergic diseases have been well highlighted based on molecular mechanisms. Thus, modulation unregulated unabated inflammatory responses is a therapeutic strategy diseases. One most important natural compounds with high immune anti-inflammation potency quercetin, found various fruits vegetables, namely onions, shallots, apples, berry crops. Therefore, this study, we reviewed influences quercetin against conditions, including asthma, rhinitis, atopic dermatitis, conjunctivitis, anaphylaxis. Scientific databases, PubMed, Scopus, Web Sciences, EMBASE, were searched English until March 2024. Quercetin's beneficial effects attributed to its anti-cancer, anti-viral, anti-oxidant, anti-inflammatory activities, also decrease pro-inflammatory cytokines, leukotrienes production, inhibition histamine release, suppression interleukin IL-4 production. It can reduce production antigen-specific IgE antibodies improve Th1/Th2 balance. These qualities be used as treat According findings these investigations, may influence allergy illnesses.

Language: Английский

Citations

5
Airborne indoor allergen serine proteases and their contribution to sensitisation and activation of innate immunity in allergic airway disease DOI Creative Commons
Xuan Ouyang, James Reihill, Lisa Douglas

et al.

European Respiratory Review, Journal Year: 2024, Volume and Issue: 33(172), P. 230126 - 230126

Published: April 24, 2024

Common airborne allergens (pollen, animal dander and those from fungi insects) are the main triggers of type I allergic disorder in respiratory system associated with rhinitis, asthma, as well immunoglobulin E (IgE)-mediated bronchopulmonary aspergillosis. These promote IgE crosslinking, vasodilation, infiltration inflammatory cells, mucosal barrier dysfunction, extracellular matrix deposition smooth muscle spasm, which collectively cause remodelling airways. Fungus insect (house dust mite cockroaches) indoor particularly rich proteases. Indeed, more than 40 different types aeroallergen proteases, have both IgE-neutralising tissue-destructive activities, been documented Allergen Nomenclature database. Of all inhaled protease allergens, 85% classed serine activities include trypsin-like, chymotrypsin-like collagenolytic In this article, we review compare allergenicity proteolytic effect allergen proteases listed MEROPS databases highlight their contribution to sensitisation, disruption epithelial activation innate immunity airways disease. The utility small-molecule inhibitors a potential treatment strategy for disease will also be discussed.

Language: Английский

Citations

5
Immunomodulatory effect of PLGA-encapsulated mesenchymal stem cells-derived exosomes for the treatment of allergic rhinitis DOI Creative Commons
Khawar Ali Shahzad, Zhao Wang, Xuran Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 8, 2024

Introduction Allergic rhinitis (AR) is an upper airway inflammatory disease of the nasal mucosa. Conventional treatments such as symptomatic pharmacotherapy and allergen-specific immunotherapy have considerable limitations drawbacks. As emerging therapy with regenerative potential immunomodulatory effect, mesenchymal stem cell-derived exosomes (MSC-Exos) recently been trialed for treatment various autoimmune diseases. Methods In order to achieve sustained protected release MSC-Exos intranasal administration, we fabricated Poly(lactic-co-glycolic acid) (PLGA) micro nanoparticles-encapsulated (PLGA-Exos) using mechanical double emulsion local AR. Preclinical in vivo imaging, ELISA, qPCR, flow cytometry, immunohistochemical staining, multiomics sequencing were used phenotypic mechanistic evaluation therapeutic effect PLGA-Exos vitro . Results The results showed that our PLGA platform could efficiently encapsulate a manner. At protein level, upregulated IL-2, IL-10 IFN-γ, downregulated IL-4, IL-17 antigen-specific IgE ovalbumin (OVA)-induced AR mice. cellular reduced Th2 cells, increased Tregs, reestablished Th1/Th2 balance. tissue significantly attenuated infiltration immune cells (e.g., eosinophils goblet cells) Finally, analysis discovered several signaling cascades, e.g., peroxisome proliferator-activated receptor (PPAR) pathway glycolysis pathway, might mechanistically support PLGA-Exos. Discussion For first time, present biomaterial-facilitated delivery system novel promising strategy treatment.

Language: Английский

Citations

5