Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Sept. 22, 2023
Abstract
In
recent
years,
with
the
improvement
in
living
standards,
incidence
of
diabetes
has
been
increasing
year
by
year.
Diabetic
nephropathy(DN),
as
one
most
common
complications
diabetes,
also
an
incidence.
Some
existing
clinical
studies
and
reviews
have
revealed
a
connection
between
diabetic
nephropathy
gut
microbiota(GM),
but
whether
there
is
causal
relationship
two
still
unclear.
Exploring
microbiota
can
help
disease
screening
provide
new
biomarkers.
This
study
used
two-sample
Mendelian
randomization
analysis,
using
4,111
DN
patients
from
GWAS
database
308,539
control
group
members,
to
attempt
find
categories
among
211
types
that
nephropathy.
Further
heterogeneity
sensitivity
analysis
were
conducted
eliminate
influence
confounding
factors
on
experimental
results.
Ultimately,
15
found
nephropathy,
providing
hints
treatment
directions
for
research.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 1984 - 1984
Published: Feb. 6, 2024
Dermatoses
are
an
increasingly
common
problem,
particularly
in
developed
countries.
The
causes
of
this
phenomenon
include
genetic
factors
and
environmental
elements.
More
more
scientific
reports
suggest
that
the
gut
microbiome,
specifically
its
dysbiosis,
also
plays
important
role
induction
progression
diseases,
including
dermatological
diseases.
microbiome
is
recognised
as
largest
endocrine
organ,
has
a
key
function
maintaining
human
homeostasis.
In
review,
authors
will
take
close
look
at
link
between
gut-skin
axis
pathogenesis
dermatoses
such
atopic
dermatitis,
psoriasis,
alopecia
areata,
acne.
focus
on
probiotics
remodelling
alleviation
dermatoses.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 28, 2024
Disturbed
gut
microbiota
and
associated
metabolic
dysfunction
exist
in
Psoriasis.
Despite
the
growing
use
of
interleukin-17
inhibitor
(anti-IL17)
therapy,
effect
anti-IL17
on
gut/skin
function
is
not
fully
understood
patients
with
Therefore,
we
explored
whether
Psoriasis
alterations
selected
a
study
cohort,
longitudinal
cohort
to
reveal
effects
IL-17A
treatment
In
case-control
study,
14
10
age,
sex
body
mass
index-matched
Healthy
Controls
were
recruited.
Longitudinal
mapping
microbiome
was
performed
using
16S
rRNA
gene
sequencing.
Mouse
models
used
further
validate
interrelationship
between
skin
PICRUST2
applied
predict
bacterial
community.
patients,
dysbiosis
present
increased
heterogeneity:
decreased
Bacteroidota
Firmicutes
as
well
Actinobacteriota
predominating
Escherichia-Shigella
enrichment
reduction
serum
levels
total
bile
acid
markers
Apoptotic
pathways.
After
studies
observed
trend
toward
normal
distribution
modulation
apoptosis-related
Results
from
mouse
model
showed
dysregulation
characterized
by
Staphylococcus
colonization.
The
psoriatic
exhibits
loss
community
stability
pathogen
enrichment.
inhibitors
restore
homeostasis
pathways,
reduce
pro-inflammatory
cytokine
expression,
alleviate
symptoms
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(2), P. 1194 - 1194
Published: Jan. 18, 2024
The
current
understanding
of
atopic
dermatitis
(AD)
seems
to
be
extending
beyond
a
skin-confined
condition
frequently
associated
with
allergic
comorbidities,
as
in
number
epidemiological
studies,
the
prevalence
rate
range
illnesses
has
been
determined
greater
patients
AD,
or
inversely.
In
most
cases,
reasons
for
this
are
vague.
A
subset
these
conditions
gastrointestinal
disorders,
including
food
sensitization
(FS)
and
allergy
(FA),
eosinophilic
esophagitis
(EoE)
(it
is
mixed
background,
both
IgE-dependent
independent),
protein-induced
enterocolitis
syndrome
(FPIES)
exemplifies
an
IgE-independent
allergy),
Crohn's
disease
(CD),
colitis
ulcerosa
(CU),
celiac
disease,
irritable
bowel
(IBS),
gastroesophageal
reflux
(GERD).
review,
we
performed
comprehensive
search
literature
using
PubMed
database.
We
addressed
epidemiology
increased
co-occurrence
diseases
AD
discussed
potential
causes
subject.
Multiple
gastroenterological
comorbidities
appear
more
common
according
our
review.
mechanisms
that
underlie
phenomenon
largely
unknown,
highlighting
need
further
study
field.
Experimental Dermatology,
Journal Year:
2024,
Volume and Issue:
33(12)
Published: Dec. 1, 2024
ABSTRACT
The
human
skin
hosts
an
estimated
1000
bacterial
species
that
are
essential
for
maintaining
health.
Extensive
clinical
and
preclinical
studies
have
established
the
significant
role
of
microbiome
in
dermatological
disorders
such
as
atopic
dermatitis,
psoriasis,
diabetic
foot
ulcers,
hidradenitis
suppurativa
cancers.
In
these
conditions,
is
not
only
altered
but,
some
cases,
implicated
disease
pathophysiology.
Microbiome‐based
therapies
(MBTs)
represent
emerging
category
live
biotherapeutic
products
with
tremendous
potential
a
novel
intervention
platform
diseases.
Beyond
using
wild‐type
strains
native
to
skin,
can
be
enhanced
express
targeted
therapeutic
molecules,
offering
more
tailored
treatment
approaches.
This
review
explores
various
common
disorders,
particular
focus
on
development
MBTs
treating
conditions.
Applied Sciences,
Journal Year:
2023,
Volume and Issue:
13(18), P. 10540 - 10540
Published: Sept. 21, 2023
It
is
acknowledged
that
humans
have
a
diverse
and
abundant
microbial
community
known
as
the
human
microbiome.
Nevertheless,
our
comprehension
of
numerous
functions
these
microorganisms
in
health
still
its
early
stages.
Microorganisms
belonging
to
microbiome
typically
coexist
with
their
host,
but
certain
situations,
they
can
lead
diseases.
They
are
found
several
areas
body
healthy
individuals.
The
highly
diverse,
composition
varies
depending
on
site.
primarily
comprises
bacteria
crucial
for
upholding
state
well-being
equilibrium.
microbiome’s
influence
atopic
dermatitis
development
was,
therefore,
analyzed.
importance
maintaining
balanced
functional
commensal
microbiota,
well
use
prebiotics
probiotics
prevention
treatment
were
also
explored.
skin
association
will
allow
better
understanding
pathogenesis
exploring
new
therapeutic
approaches,
making
an
increasingly
relevant
target.
