Universal gut microbial relationships in the gut microbiome of wild baboons DOI Creative Commons
Kimberly Roche, Johannes R. Björk, Mauna Dasari

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: May 9, 2023

Ecological relationships between bacteria mediate the services that gut microbiomes provide to their hosts. Knowing overall direction and strength of these is essential learn how ecology scales up affect microbiome assembly, dynamics, host health. However, whether bacterial are generalizable across hosts or personalized individual debated. Here, we apply a robust, multinomial logistic-normal modeling framework extensive time series data (5534 samples from 56 baboon over 13 years) infer thousands correlations in abundance baboons test degree which 'universal'. We also compare patterns two human sets. find that, most weak, negative, universal hosts, such shared correlation dominate host-specific by almost twofold. Further, taxon pairs had inconsistent signs (either positive negative) different always weak within From perspective, with similar taxonomic compositions tended be genetic relatives. Compared humans, universality was infants, stronger than one set adults. Bacterial families showed infants were often baboons. Together, our work contributes new tools for analyzing associations implications personalization, community stability, designing interventions improve health.Communities living guts humans other animals perform as digesting food, degrading toxins, fighting viruses cause disease. These emerge so-called ‘ecological’ species bacteria. One species, example, may break down molecule food into another compound is, turn, digested small can absorb use. The involved process become more less common together host. In situations, some have opposing roles each other, meaning if becomes abundant it reduce level other. not known consistent (i.e., universal) unique (personalized). words, pair increase decrease host, do they same hosts? Microbes swap genes gain traits; harbors distinctive microbes, possible microbial change depending on present specific environment. To investigate, Roche et al. studied feces collected 13-year period. came long-term research project Amboseli, Kenya has been studying population wild continuously since 1971. measured hundreds understand pairs. This revealed connections largely rather baboon. Furthermore, strongest negative Microbial strong effects microbiome’s composition might therefore especially universal. Further analyses measuring babies found Hence, fill ecological primates, perhaps mammals. findings suggest leverage develop therapies diseases associated bacteria, inflammatory bowel disease Clostridium difficile infection.

Language: Английский

Energy crop-based rhizoremediation and lignocellulosic biomass production as sustainable bioeconomy-driven solution for biofuel generation and waste mitigation DOI
Nandita Das, Dinesh Kumar Maheshwari, Piyush Pandey

et al.

Progress in Energy and Combustion Science, Journal Year: 2024, Volume and Issue: 103, P. 101161 - 101161

Published: June 4, 2024

Language: Английский

Citations

7
Unraveling the Role of the Human Gut Microbiome in Health and Diseases DOI Creative Commons
Mohamad Khalil, Agostino Di Ciaula, Laura Mahdi

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2333 - 2333

Published: Nov. 15, 2024

The human gut is a complex ecosystem that supports billions of living species, including bacteria, viruses, archaea, phages, fungi, and unicellular eukaryotes. Bacteria give genes enzymes for microbial host-produced compounds, establishing symbiotic link between the external environment host at both systemic levels. microbiome, which primarily made up commensal critical maintaining healthy host's immune system, aiding digestion, synthesizing essential nutrients, protecting against pathogenic as well influencing endocrine, neural, humoral, immunological functions metabolic pathways. Qualitative, quantitative, and/or topographic shifts can alter resulting in dysbiosis dysfunction, contribute to variety noncommunicable illnesses, hypertension, cardiovascular disease, obesity, diabetes, inflammatory bowel cancer, irritable syndrome. While most evidence date observational does not establish direct causation, ongoing clinical trials advanced genomic techniques are steadily enhancing our understanding these intricate interactions. This review will explore key aspects relationship microbiota, eubiosis, health highlighting emerging strategies microbiome engineering potential therapeutic approaches various conditions.

Language: Английский

Citations

6
Extracellular DNA (eDNA): Neglected and Potential Sources of Antibiotic Resistant Genes (ARGs) in the Aquatic Environments DOI Creative Commons
Periyasamy Sivalingam, John Poté, K. Prabakar

et al.

Pathogens, Journal Year: 2020, Volume and Issue: 9(11), P. 874 - 874

Published: Oct. 23, 2020

Over the past decades, rising antibiotic resistance bacteria (ARB) are continuing to emerge as a global threat due potential public health risk. Rapidly evolving and its persistence in environment, have underpinned need for more studies identify possible sources limit spread. In this context, not commonly studied neglected genetic material called extracellular DNA (eDNA) is gaining increased attention it can be one of significant drivers transmission ARGS (eARGs) via horizontal gene transfer (HGT) competent environmental diverse antibiotic-resistance genes (ARGs) environment. Consequently, review highlights that address occurrence eDNA encoding eARGs impact on resistome. review, we also brief recent dedicated technological advancements accelerating extraction efficiency treatment technologies reducing focuses ecological

Language: Английский

Citations

49
Skin Microbiome Analysis for Forensic Human Identification: What Do We Know So Far? DOI Creative Commons
Pamela Tozzo, Gabriella D’Angiolella, Paola Brun

et al.

Microorganisms, Journal Year: 2020, Volume and Issue: 8(6), P. 873 - 873

Published: June 9, 2020

Microbiome research is a highly transdisciplinary field with wide range of applications and methods for studying it, involving different computational approaches models. The fact that people host radically microbiota highlights forensic perspectives in understanding what leads to this variation regulates order effectively use microbes as evidence. This narrative review provides an overview some the main scientific works so far produced, focusing on potentiality using skin microbiome profiling human identification forensics. was performed following Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. examined literature clearly ascertains microbial communities, although personalized, vary systematically across body sites time, intrapersonal differences over time smaller than interpersonal ones, showing such high degree spatial temporal variability nature can constitute itself important parameter useful distinguishing individuals from one another. Even making effort organically synthesize all results achieved until now, it quite evident these are still pieces puzzle, which not yet complete.

Language: Английский

Citations

45
Universal gut microbial relationships in the gut microbiome of wild baboons DOI Creative Commons
Kimberly Roche, Johannes R. Björk, Mauna Dasari

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: May 9, 2023

Ecological relationships between bacteria mediate the services that gut microbiomes provide to their hosts. Knowing overall direction and strength of these is essential learn how ecology scales up affect microbiome assembly, dynamics, host health. However, whether bacterial are generalizable across hosts or personalized individual debated. Here, we apply a robust, multinomial logistic-normal modeling framework extensive time series data (5534 samples from 56 baboon over 13 years) infer thousands correlations in abundance baboons test degree which 'universal'. We also compare patterns two human sets. find that, most weak, negative, universal hosts, such shared correlation dominate host-specific by almost twofold. Further, taxon pairs had inconsistent signs (either positive negative) different always weak within From perspective, with similar taxonomic compositions tended be genetic relatives. Compared humans, universality was infants, stronger than one set adults. Bacterial families showed infants were often baboons. Together, our work contributes new tools for analyzing associations implications personalization, community stability, designing interventions improve health.Communities living guts humans other animals perform as digesting food, degrading toxins, fighting viruses cause disease. These emerge so-called ‘ecological’ species bacteria. One species, example, may break down molecule food into another compound is, turn, digested small can absorb use. The involved process become more less common together host. In situations, some have opposing roles each other, meaning if becomes abundant it reduce level other. not known consistent (i.e., universal) unique (personalized). words, pair increase decrease host, do they same hosts? Microbes swap genes gain traits; harbors distinctive microbes, possible microbial change depending on present specific environment. To investigate, Roche et al. studied feces collected 13-year period. came long-term research project Amboseli, Kenya has been studying population wild continuously since 1971. measured hundreds understand pairs. This revealed connections largely rather baboon. Furthermore, strongest negative Microbial strong effects microbiome’s composition might therefore especially universal. Further analyses measuring babies found Hence, fill ecological primates, perhaps mammals. findings suggest leverage develop therapies diseases associated bacteria, inflammatory bowel disease Clostridium difficile infection.

Language: Английский

Citations

16