Chemical Data Collections, Journal Year: 2025, Volume and Issue: unknown, P. 101184 - 101184
Published: Feb. 1, 2025
Language: Английский
Microorganisms, Journal Year: 2023, Volume and Issue: 11(4), P. 1050 - 1050
Published: April 17, 2023
Antimicrobial resistance (AMR) is one of the Global Health challenges 21st century. The inclusion AMR on global map parallels scientific, technological, and organizational progress healthcare system socioeconomic changes last 100 years. Available knowledge about has mostly come from large institutions in high-income countries scattered studies across various fields, focused patient safety (infectious diseases), transmission pathways pathogen reservoirs (molecular epidemiology), extent problem at a population level (public health), their management cost (health economics), cultural issues (community psychology), events associated with historical periods (history science). However, there little dialogue between aspects that facilitate development, spread, evolution stakeholders (patients, clinicians, public health professionals, scientists, economic sectors, funding agencies). This study consists four complementary sections. first reviews factors have contributed to building current Healthcare system, scientific framework which traditionally been approached such novel approaching fourth globalization scenario. second discusses need reframe contexts. Given implementation policies guidelines are greatly influenced by information surveillance systems, third section, we review
Language: Английский
Citations
91
International Journal of Food Microbiology, Journal Year: 2023, Volume and Issue: 391-393, P. 110148 - 110148
Published: Feb. 24, 2023
Language: Английский
Citations
42
Engineering Science & Technology Journal, Journal Year: 2024, Volume and Issue: 5(3), P. 716 - 727
Published: March 10, 2024
Strategic partnerships in the satellite and telecommunications sectors have become increasingly vital as technological advancements market complexities continue to evolve. This conceptual review delves into significance of data analytics-enabled identification capitalization synergies within these partnerships. The fusion technologies presents unique opportunities for innovation growth, but also challenges that necessitate strategic collaboration. By leveraging analytics, organizations can effectively identify between services, leading enhanced operational efficiencies, expanded service offerings, improved customer experiences. Through a comprehensive analysis available data, companies pinpoint areas overlap complementary strengths, laying foundation mutually beneficial explores multifaceted nature sectors, emphasizing importance aligning capabilities, strategies, regulatory frameworks. It underscores role analytics catalyst informed decision-making, enabling stakeholders anticipate trends, optimize resource allocation, mitigate risks. Furthermore, examines implications emerging such artificial intelligence, machine learning, predictive on partnership dynamics. These tools not only streamline processes empower proactively synergistic adapt evolving dynamics real-time. synthesis theoretical frameworks empirical evidence, this provides insights imperatives guiding formation management sectors. need holistic approach integrates expertise with business acumen compliance unlock full potential collaborations. advocates proactive data-driven identifying capitalizing harnessing power navigate digital ecosystem, drive innovation, achieve sustainable competitive advantage an interconnected world. Keywords: Partnership, Telecommunication, Data Analytics, Capitalization, Enabled Identification, Review.
Language: Английский
Citations
29
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: April 10, 2024
Cancer is a severe disease that results in death all countries of the world. A nano-based drug delivery approach best alternative, directly targeting cancer tumor cells with improved cellular uptake. Different types nanoparticle-based carriers are advanced for treatment cancer, and to increase therapeutic effectiveness safety therapy, many substances have been looked into as carriers. Lipid-based nanoparticles (LBNPs) significantly attracted interest recently. These natural biomolecules alternate other polymers frequently recycled medicine due their amphipathic properties. Lipid typically provide variety benefits, including biocompatibility biodegradability. This review covers different classes LBNPs, characterization synthesis technologies. discusses most significant advancements lipid nanoparticle technology use administration. Moreover, also emphasized applications used types.
Language: Английский
Citations
28
Pathogens, Journal Year: 2024, Volume and Issue: 13(5), P. 393 - 393
Published: May 8, 2024
Medical devices such as venous catheters (VCs) and urinary (UCs) are widely used in the hospital setting. However, implantation of these is often accompanied by complications. About 60 to 70% nosocomial infections (NIs) linked biofilms. The main complication ability microorganisms adhere surfaces form biofilms which protect them help persist host. Indeed, crossing skin barrier, insertion VC inevitably allows flora or accidental environmental contaminants access underlying tissues cause fatal complications like bloodstream (BSIs). In fact, 80,000 central catheters-BSIs (CVC-BSIs)-mainly occur intensive care units (ICUs) with a death rate 12 25%. Similarly, catheter-associated tract (CA-UTIs) most commonlyhospital-acquired (HAIs) worldwide.These represent up 40% NIs.In this review, we present summary biofilm formation steps. We provide an overview two important clinical settings medical devices, namely catheter-asociated (CA-BSIs) (CA-UTIs), highlight also multidrug resistant bacteria implicated infections. Furthermore, draw attention toseveral useful prevention strategies, advanced antimicrobial antifouling approaches developed reduce bacterial colonization on catheter incidence catheter-related
Language: Английский
Citations
24
Pathogens, Journal Year: 2022, Volume and Issue: 11(6), P. 663 - 663
Published: June 8, 2022
Infections caused by bacteria have a major impact on public health-related morbidity and mortality. Despite advances in the prevention treatment of bacterial infections, latter continue to represent significant economic social burden worldwide. The WHO compiled list six highly virulent multidrug-resistant named ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species) responsible for life-threatening diseases. Taken together with Clostridioides difficile, Escherichia coli, Campylobacter spp., (C. jejuni C. coli), Legionella Salmonella Neisseria gonorrhoeae, all these microorganisms are leading causes nosocomial infections. rapid accurate detection pathogens is not only important early initiation appropriate antibiotic therapy, but also resolving outbreaks minimizing subsequent antimicrobial resistance. need ever-improving molecular diagnostic techniques fundamental importance improving epidemiological surveillance In this review, we aim discuss recent use based genomic proteomic approaches diagnosis advantages limitations each considered discussed.
Language: Английский
Citations
45
Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13
Published: March 17, 2022
Rapid bacterial identification and antimicrobial resistance gene (ARG) detection are crucial for fast optimization of antibiotic treatment, especially septic patients where each hour delayed prescription might have lethal consequences. This work investigates whether the Oxford Nanopore Technology's (ONT) Flongle sequencing platform is suitable real-time directly from blood cultures to identify bacteria detect resistance-encoding genes. For analysis, we used pure four clinical isolates Escherichia coli Klebsiella pneumoniae two samples spiked with either E. or K. that had been cultured overnight. We sequenced both whole genome plasmids isolated these using different kits. Generally, data allow rapid ID resistome based on first 1,000-3,000 generated sequences (10 min 3 h start), albeit ARG variant did not always correspond ONT MinION Illumina sequencing-based data. sufficient 99.9% coverage within at most 20,000 (clinical isolates) 50,000 (positive cultures) generated. The SQK-LSK110 Ligation kit resulted in higher more accurate than SQK-RBK004 Barcode kit.
Language: Английский
Citations
39
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: March 29, 2023
There is a limitation in the range of effectual antibiotics due to Pseudomonas aeruginosa (PA) infection its innate antimicrobial resistance. Researchers have therefore been concentrating their efforts discover advanced and cost effective antibacterial agents among ever-increasing PA bacterial resistance strains. It has discovered that various nanoparticles can be employed as agents. Here, we evaluated properties Zinc Oxide (ZnO NPs), which was biosynthesized, being examined on six hospital strains alongside reference strain (ATCC 27853). A chemical approach applied biosynthesize ZnO NPs from Olea europaea performed, confirmed by using X-ray diffraction Scanning Electron Microscopes. The then examine them against clinically isolated strain. This process tested for results minimum inhibitory concentration (MIC) bactericidal (MBC). Growth, biofilm formation eradication were analyzed. influence differentiating degrees regard Quorom sensing gene expression further examined. exhibited crystalline size diameter (Dc) 40-60 nm both MIC MBC tests revealed positive outcomes concentrations 3 6 mg/ml each strain, respectively. At sub concentration, found significantly inhibit growth all decreases biomass metabolic behavior established biofilms; these varied depending dosage. 900 µg/ml, majority quorum genes reduced, at 300 few impacted. In conclusion, treatment could other antibiotic resistant bacteria approached it uncovered they withhold properties.
Language: Английский
Citations
31
Brazilian Journal of Microbiology, Journal Year: 2024, Volume and Issue: 55(3), P. 2753 - 2766
Published: June 18, 2024
The current burden associated to multidrug resistance, and the emerging superbugs, result in a decreased even loss of antibiotic efficacy, which poses significant challenges treatment infectious diseases. This situation has created high demand for discovery novel antibiotics that are both effective safe. However, while play crucial role preventing treating diseases, they also with adverse effects. emergence multidrug-resistant extensive appearance drug-resistant microorganisms, become one major hurdles healthcare. Addressing this problem will require development at least 20 new by 2060. process designing is time-consuming. To overcome spread microbes infections, constant evaluation innovative methods molecules essential. Research actively exploring alternative strategies, such as combination therapies, drug delivery systems, repurposing existing drugs. In addition, advancements genomic proteomic technologies aiding identification potential targets compounds. review, we explore sources natural from plants, algae other sources, propose bioinspired systems their use an approach promoting responsible mitigate infections.
Language: Английский
Citations
8
Polymers, Journal Year: 2023, Volume and Issue: 15(6), P. 1392 - 1392
Published: March 10, 2023
Antibiotic-resistant bacteria (ARB) is a growing global health threat, leading to the search for alternative strategies combat bacterial infections. Phytochemicals, which are naturally occurring compounds found in plants, have shown potential as antimicrobial agents; however, therapy with these agents has certain limitations. The use of nanotechnology combined antibacterial phytochemicals could help achieve greater capacity against ARB by providing improved mechanical, physicochemical, biopharmaceutical, bioavailability, morphological or release properties. This review aims provide an updated overview current state research on phytochemical-based nanomaterials treatment ARB, special focus polymeric nanofibers and nanoparticles. discusses various types that been incorporated into different nanomaterials, methods used synthesize materials, results studies evaluating their activity. challenges limitations using well future directions this field, also considered here. Overall, highlights promising strategy but stresses need further fully understand mechanisms action optimize clinical settings.
Language: Английский
Citations
22