Short-chain fatty acid metabolism and multiple effects on cardiovascular diseases

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 81, P. 101706 - 101706

Published: Aug. 4, 2022

Language: Английский

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SGLT2 inhibitors: role in protective reprogramming of cardiac nutrient transport and metabolism

Nature Reviews Cardiology, Journal Year: 2023, Volume and Issue: 20(7), P. 443 - 462

Published: Jan. 6, 2023

Language: Английский

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The Implication of the Gut Microbiome in Heart Failure

Cells, Journal Year: 2023, Volume and Issue: 12(8), P. 1158 - 1158

Published: April 14, 2023

Heart failure is a worldwide health problem with important consequences for the overall wellbeing of affected individuals as well healthcare system. Over recent decades, numerous pieces evidence have demonstrated that associated gut microbiota represent an component human physiology and metabolic homeostasis, can affect one’s state or disease directly, through their derived metabolites. The advances in microbiome studies shed light on relationship between cardiovascular system, revealing its contribution to development heart failure-associated dysbiosis. HF has been linked dysbiosis, low bacterial diversity, intestinal overgrowth potentially pathogenic bacteria decrease short chain fatty acids-producing bacteria. An increased permeability allowing microbial translocation passage bacterial-derived metabolites into bloodstream progression. A more insightful understanding interactions microbiome, risk factors mandatory optimizing therapeutic strategies based modulation offering individualized treatment. purpose this review summarize available data regarding influence communities HF, order obtain better multi-layered complex relationship.

Language: Английский

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Dysbiosis of the gut microbiome in elderly patients with hepatocellular carcinoma

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: May 13, 2023

Abstract Fecal samples from participants aged 60–80 were collected and sequenced by a high-throughput second-generation sequencer to explore the structural composition of gut microbiota in elderly patients with hepatocellular carcinoma(HCC). Comparison between carcinoma healthy controls, α diversity β statistically different. At genus level, compared normal group, abundance A Blautia , Fusicatenibacter Anaerostipes, Lachnospiraceae_ND3007_group, CAG-56, Eggerthella, Lachnospiraceae_FCS020_group Olsenella decreased significantly LC group. In contrast, Escherichia-Shigella, Fusobacterium, Megasphaera Veillonella, Tyzzerella_4, Prevotella_2 Cronobacter increased significantly. The KEGG COG pathway analyses showed that dysbiosis bacteria primary liver is associated several pathways, including amino acid metabolism, replication repair, nucleotide cell motility, growth death, transcription. Age negatively Bifidobacterium . Lachnospiraceae_ ND3007_ group [Eubacterium]_hallii_group Fuscatenibacter Anaerostipes are correlated ALT, AST GGT levels (p < 0.05), respectively. Alpha-fetoprotein (AFP) positively Erysipelatoclostridium Magasphaera Prevotella 2 Escherichia-Shigella Streptococcus [Eubacterium]_eligens_group random forest model genera Eggerthella demonstrated best predictive capacity. area under Receiver Operating Characteristic Curve 0.791, 0.766 0.730, These data derived first known microbiome study carcinoma. Potentially, specific can be used as characteristic index for screening, diagnosis, prognosis changes even therapeutic clinical target.

Language: Английский

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The Pathophysiological Associations Between Obesity, NAFLD, and Atherosclerotic Cardiovascular Diseases

Hormone and Metabolic Research, Journal Year: 2024, Volume and Issue: 56(10), P. 683 - 696

Published: March 12, 2024

Abstract Obesity, non-alcoholic fatty liver disease (NAFLD), and atherosclerotic cardiovascular diseases are common growing public health concerns. Previous epidemiological studies unfolded the robust correlation between obesity, NAFLD, diseases. Obesity is a well-known risk factor for both of them can markedly increase odds On other hand, significant weight loss achieved by lifestyle modification, bariatric surgery, or medications, such as semaglutide, concomitantly improve NAFLD Therefore, certain pathophysiological links involved in development obesity NAFLD. Moreover, recent indicated that simultaneously targeting several mechanisms tirzepatide retatrutide leads to greater improves complications metabolic syndrome. These findings remind importance mechanistic viewpoint breaking association In this review article, we mainly focus on shared mechanisms, including insulin resistance, dyslipidemia, GLP1 signaling, inflammation, oxidative stress, mitochondrial dysfunction, gut dysbiosis, renin-angiotensin-aldosterone system (RAAS) overactivity, endothelial dysfunction. Most these alterations primarily initiated obesity. The further exacerbates molecular cellular alterations, leading progression final manifestation perturbation. A better insight into makes it feasible develop new multi-target approaches unhinge deleterious chain events linking

Language: Английский

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The Role of Gut Microbiota and the Potential Effects of Probiotics in Heart Failure

Medicina, Journal Year: 2024, Volume and Issue: 60(2), P. 271 - 271

Published: Feb. 4, 2024

Heart failure (HF) remains a significant global health challenge, affecting millions of individuals worldwide and posing substantial burden on healthcare systems. HF is syndrome intricate pathophysiology, involving systemic inflammation, oxidative stress, metabolic perturbations, maladaptive structural changes in the heart. It influenced by complex interactions between cardiac function, physiology, environmental factors. Among these factors, gut microbiota has emerged as novel intriguing player landscape pathophysiology. The microbiota, beyond its role digestion nutrient absorption, impacts immune responses, processes, and, suggested evidence literature, development progression HF. There bidirectional communication heart, often known gut–heart axis, through which microbiota-derived metabolites, signals, microbial products exert profound effects cardiovascular health. This review aims to provide comprehensive overview relationship Additionally, we explore potential using probiotics therapeutic strategy modulate microbiota’s composition attenuate adverse observed Conventional approaches targeting hemodynamic neurohormonal dysregulation have substantially improved management HF, but emerging research exploring implications harnessing for innovative treatment.

Language: Английский

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Unravelling the Gut Microbiome Role in Cardiovascular Disease: A Systematic Review and a Meta-Analysis

Biomolecules, Journal Year: 2024, Volume and Issue: 14(6), P. 731 - 731

Published: June 20, 2024

A notable shift in understanding the human microbiome's influence on cardiovascular disease (CVD) is underway, although causal association remains elusive. systematic review and meta-analysis were conducted to synthesise current knowledge microbial taxonomy metabolite variations between healthy controls (HCs) those with CVD. An extensive search encompassing three databases identified 67 relevant studies (2012-2023) covering CVD pathologies from 4707 reports. Metagenomic metabolomic data, both qualitative quantitative, obtained. Analysis revealed substantial variability alpha beta diversities. Moreover, specific changes bacterial populations shown, including increased

Language: Английский

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Characteristics of the fecal microbiome and metabolome in older patients with heart failure and sarcopenia

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 24, 2023

Background Increasing evidence supports that gut microbiota plays an important role in the development of cardiovascular diseases. The prevalence sarcopenia is increasing patients with heart failure. Muscle wasting independent predictor death failure patients. Aims In this study, we aimed to explore characteristics and metabolites or without sarcopenia. Methods Fecal samples 33 sarcopenia, 29 15 controls were collected. intestinal was analyzed using 16S rRNA sequencing detected gas chromatography-mass spectrometry method. Results There significant differences overall microbial community structure diversity between control However, no clear clustering observed Several bacterial, particularly Nocardiaceae , Pseudonocardiaceae, Alphaproteobacteria Slackia significantly enriched while Synergistetes more abundant Isobutyric acid, isovaleric valeric acid lower than but lacked significance. Conclusions This study demonstrates there are individuals Modulating may be a new target for prevention treatment

Language: Английский

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Gut Microbiota and Derived Short-Chain Fatty Acids Are Linked to Evolution of Heart Failure Patients

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 13892 - 13892

Published: Sept. 9, 2023

There is a lack of direct evidence regarding gut microbiota dysbiosis and changes in short-chain fatty acids (SCFAs) heart failure (HF) patients. We sought to assess any association between composition, SCFA production, clinical parameters, the inflammatory profile cohort newly diagnosed HF In this longitudinal prospective study, we enrolled eighteen At admission after 12 months, blood samples were collected for assessment proinflammatory cytokines, monocyte populations, endothelial dysfunction, stool analysis composition quantification SCFAs. Twelve months initial episode, patients demonstrated improved parameters reduced state dysfunction. This favorable evolution was associated with reversal dysbiosis, consisting increment health-related bacteria, such as genus Bifidobacterium, levels SCFAs, mainly butyrate. Furthermore, there decrease abundance pathogenic bacteria. vitro, fecal follow-up exhibited lower inflammation than at admission. conclusion, progression episode linked increased particularly Whether restoring butyrate or promoting growth butyrate-producing bacteria could serve complementary treatment these deserves further studies.

Language: Английский

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The Role of Gut Microbiota and Its Metabolites in Patients with Heart Failure

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 894 - 894

Published: April 18, 2024

Heart failure (HF) is a significant health concern; early detection and prevention are crucial. Recent studies suggest that the gut microbiota its metabolites may influence HF development risk factors. We explored this relationship by examining changes in composition metabolite levels patients. patients often exhibit decreased alpha beta diversity compared to controls, suggesting lower bacterial richness community variation. Changes specific phyla were observed, with decreases Firmicutes (e.g., Ruminococcus) Bacteroidetes Prevotella) increases Proteobacteria Escherichia, Shigella, Klebsiella) Actinobacteria. Gut-microbiota-related have been identified, potentially affecting various body systems, including cardiovascular system. Among these short-chain fatty acids (SCFAs), betaine, trimethylamine N-oxide (TMAO), phenylalanine, tryptophan–kynurenine, phenylacetylgutamine (PAGIn). Although SCFAs positively affect our organisms, observed experience decline bacteria responsible for producing chemical compounds. There indications of possible links between TMAO, PAGIn, heart failure. TMAO particular, show promise as potential prognostic However, their clinical significance has not yet thoroughly evaluated requires further investigation.

Language: Английский

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