Infection and Drug Resistance,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 7515 - 7545
Published: Dec. 1, 2023
Abstract:
Antimicrobial
resistance,
referring
to
microorganisms'
capability
subsist
and
proliferate
even
when
there
are
antimicrobials
is
a
foremost
threat
public
health
globally.
The
appearance
of
antimicrobial
resistance
can
be
ascribed
anthropological,
animal,
environmental
factors.
Human-related
causes
include
overuse
misuse
in
medicine,
antibiotic-containing
cosmetics
biocides
utilization,
inadequate
sanitation
hygiene
settings.
Prophylactic
therapeutic
overuse,
using
as
feed
additives,
microbes
resistant
antibiotics
genes
animal
excreta,
residue
found
animal-origin
food
excreta
animals
related
contributive
factors
for
the
antibiotic
emergence
spread.
Environmental
including
naturally
existing
genes,
improper
disposal
unused
antimicrobials,
contamination
from
waste
settings,
farms,
pharmaceutical
industries,
use
agricultural
chemicals
facilitatet
its
Wildlife
has
plausible
role
Adopting
one-health
approach
involving
properly
humans,
improving
spaces
implementing
coordinated
governmental
regulations
crucial
combating
resistance.
Collaborative
cooperative
involvement
stakeholders
public,
veterinary
ecological
sectors
circumvent
problem
effectively.
Keywords:
one
health,
gene,
environment,
wildlife
Agriculture Communications,
Journal Year:
2024,
Volume and Issue:
2(1), P. 100027 - 100027
Published: Feb. 3, 2024
The
pervasive
use
of
antibiotics
in
agriculture
and
animal
husbandry
has
raised
a
significant
concern—residual
antibiotic
contamination
food,
which
contributes
to
the
natural
evolution
resistance
pathogenic
microbial
strains.
emergence
communities
poses
global
threat
food
safety
security.
Recently,
situation
been
exacerbated
by
discovery
novel
strains
resistant
bacteria
(ARB)
plant-
animal-derived
foods.
These
microbes
can
enter
human
body
through
direct
contact
with
affected
animals
or
consumption
contaminated
In
this
review,
we
explore
prevalence
contaminants
at
various
locations
around
world,
delve
into
molecular
mechanisms
behind
acquisition
antimicrobial
resistance,
examine
current
strategies
employed
mitigate
spread
pathogens,
discuss
emerging
technologies
aimed
halting
trend
that
projects
10
million
annual
deaths
2050
as
result
ARB
agriculture.
Genetic
processes,
including
mutations,
efflux
pump
activity,
horizontal
gene
transfer,
play
crucial
roles
widespread
distribution
community.
Effectively
addressing
requires
development
methodologies
rapidly
detect
supply
chain.
Therefore,
several
established
rapid
diagnostic
techniques
such
Quick,
Easy,
Cheap,
Effective,
Rugged,
Safe
(QuEChERS)
methodology,
aptasensors,
fluorescence-based
Metal
Organic
Frameworks.
Additionally,
innovative
fight
nano-antibiotics,
antibiotics,
synthetic
biology,
bacteriophages,
predator
bacteria.
Here,
propose
omics
biochar
potential
tools
for
combating
ARB.
We
anticipate
review
article
will
serve
valuable
resource
future
research,
particularly
designed
not
only
suppress
activities
genes
but
also
potentially
reverse
are
already
communities.
iScience,
Journal Year:
2023,
Volume and Issue:
26(12), P. 108373 - 108373
Published: Nov. 1, 2023
Reactive
oxygen
species
(ROS)
produced
as
a
secondary
effect
of
bactericidal
antibiotics
are
hypothesized
to
play
role
in
killing
bacteria.
If
correct,
ROS
may
development
de
novo
resistance.
Here
we
report
that
single-gene
knockout
strains
with
reduced
scavenging
exhibited
enhanced
accumulation
and
more
rapid
acquisition
resistance
when
exposed
sublethal
levels
antibiotics.
Consistent
this
observation,
the
scavenger
thiourea
medium
decelerated
development.
Thiourea
downregulated
transcriptional
level
error-prone
DNA
polymerase
glycosylase
MutM,
which
counters
incorporation
8-hydroxy-2'-deoxyguanosine
(8-HOdG)
genome.
The
8-HOdG
significantly
increased
following
incubation
but
decreased
after
treatment
thiourea.
These
observations
suggest
E.
coli
stimulate
resistance,
providing
mechanistic
basis
for
hormetic
responses
induced
by
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
Antimicrobial
resistance
(AMR)
poses
a
critical
global
public
health
challenge.
This
study
investigates
the
microbiome
of
Brassica
oleracea
var.
acephala
(kale)
to
evaluate
role
food
production
systems,
particularly
plant-derived
foods,
in
AMR
dissemination.
Using
16S
rRNA
gene
sequencing
and
metagenomic
shotgun
sequencing,
we
analyzed
microbial
diversity
antimicrobial
genes
(ARGs)
kale
samples.
Results
showed
significant
regional
differences
microbiota
composition
ARG
distribution,
with
traditional
fertilizer
use
linked
higher
prevalence
coliform
bacteria
compared
farms
using
other
fertilization
methods.
Additionally,
confirmed
transfer
potential
by
Klebsiella
pneumoniae
within
populations.
Storage
conditions
notably
affected
dynamics,
temperatures
promoting
K.
growth
washed
These
findings
revealed
importance
research
foods
highlight
need
for
improved
agricultural
practices
mitigate
risks
associated
high
abundance
bacteria.
Microbiology,
Journal Year:
2023,
Volume and Issue:
169(7)
Published: July 28, 2023
Plasmids,
extrachromosomal
DNA
molecules
commonly
found
in
bacterial
and
archaeal
cells,
play
an
important
role
genetics
evolution.
Our
understanding
of
plasmid
biology
has
been
furthered
greatly
by
the
development
mathematical
models,
there
are
many
questions
about
plasmids
that
models
would
be
useful
answering.
In
this
review,
we
present
introductory,
yet
comprehensive,
overview
suitable
for
modellers
unfamiliar
with
who
want
to
get
up
speed
begin
working
on
plasmid-related
models.
addition
reviewing
diversity
genes
they
carry,
their
key
physiological
functions,
interactions
between
host,
also
highlight
selected
topics
may
particular
interest
areas
where
is
a
need
theoretical
development.
The
world
holds
great
variety
subjects
will
biologists,
introducing
new
subject
help
expand
existing
body
theory.
British Journal of Biomedical Science,
Journal Year:
2024,
Volume and Issue:
81
Published: Aug. 7, 2024
The
global
issue
of
antimicrobial
resistance
poses
significant
challenges
to
public
health.
World
Health
Organization
(WHO)
has
highlighted
it
as
a
major
health
threat,
causing
an
estimated
700,000
deaths
worldwide.
Understanding
the
multifaceted
nature
antibiotic
is
crucial
for
developing
effective
strategies.
Several
physiological
and
biochemical
mechanisms
are
involved
in
development
resistance.
Bacterial
cells
may
escape
bactericidal
actions
drugs
by
entering
physiologically
dormant
state
known
bacterial
persistence.
Recent
findings
this
field
suggest
that
persistence
can
be
one
main
sources
chronic
infections.
tolerance
developed
persister
could
tolerate
high
levels
antibiotics
give
rise
offspring.
These
offspring
attributed
mechanisms,
especially
This
review
attempts
shed
light
on
persister-induced
current
therapeutic
Antibiotics,
Journal Year:
2023,
Volume and Issue:
12(2), P. 195 - 195
Published: Jan. 17, 2023
Infections
led
by
Acinetobacter
baumannii
strains
are
of
great
concern
in
healthcare
environments
due
to
the
strong
ability
bacteria
spread
through
different
apparatuses
and
develop
drug
resistance.
Severe
diseases
can
be
caused
A.
critically
ill
patients,
but
its
biological
process
mechanism
not
well
understood.
Secretion
systems
have
recently
been
demonstrated
involved
pathogenic
process,
five
types
secretion
out
currently
known
six
from
Gram-negative
found
baumannii.
They
promote
fitness
pathogenesis
releasing
a
variety
effectors.
Additionally,
antibiotic
resistance
is
related
some
systems.
In
this
review,
we
describe
genetic
structural
compositions
that
exist
Acinetobacter.
addition,
function
molecular
each
system
summarized
explain
how
they
enable
these
critical
pathogens
overcome
eukaryotic
hosts
prokaryotic
competitors
cause
diseases.
