Journal of Health Science and Medical Research,
Journal Year:
2024,
Volume and Issue:
unknown, P. 20241056 - 20241056
Published: April 26, 2024
Objective:
Hyperglycemia
promotes
inflammation
through
inducing
the
formation
of
AGE
products,
which
bind
with
receptor
(RAGE)
products
in
cell
membranes,
leading
to
activation
necrosis
factor–kappa
beta
(NF-κB).
This
study
aimed
analyze
effects
tempeh-based
supplement
(TBS)
preparations
γ-amino
butyric
acid
(GABA)
tempeh
against
mRNA
expressions
RAGE
and
NF-κB
on
pancreas
a
type
2
diabetes
mellitus
(DM)
mice
model.
Material
Methods:
research
was
quasi-experiment,
pre
post-tests
control
design
for
blood
glucose
levels;
post-test
only
utilizing
expressions.
A
total
30
male
mice,
8-10
weeks
old,
weighing
20-25
g
were
divided
into
6
treatment
groups:
non-diabetic,
Diabetic,
Diabetic+metformin,
Diabetic+TBS
10
mg/100
BW,
20
40
BW.
STZ
induction
once
day
two
days
preceded
by
NA
create
DM
model;
meanwhile,
TBS
administrated
21
days.Results:
The
mean
difference
fasting
levels
diabetic+TBS
BW
group
highest
when
compared
diabetic
(159.52±1.85)
mg/dL.
One-way
ANOVA
revealed
statistically
significant
differences
levels,
at
various
dosage
group.
Relative
downregulated
Conclusion:
can
decrease
downregulate
relative
mice.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: June 3, 2024
Abstract
Metabolic
syndrome
encompasses
amongst
other
conditions
like
obesity
and
type-2
diabetes
is
associated
with
gut
microbiome
(GM)
dysbiosis.
Fecal
microbiota
transplantation
(FMT)
has
been
explored
to
treat
metabolic
by
restoring
the
GM;
however,
concerns
on
accidentally
transferring
pathogenic
microbes
remain.
As
a
safer
alternative,
fecal
virome
(FVT,
sterile-filtrated
feces)
advantage
over
FMT
in
that
mainly
bacteriophages
are
transferred.
FVT
from
lean
male
donors
have
shown
promise
alleviating
effects
of
high-fat
diet
preclinical
mouse
study.
However,
still
carries
risk
eukaryotic
viral
infections.
To
address
this,
recently
developed
methods
applied
for
removing
or
inactivating
viruses
component
FVT.
Modified
FVTs
compared
unmodified
saline
diet-induced
model
C57BL/6
N
mice.
Contrasted
obese
control,
mice
administered
modified
(nearly
depleted
viruses)
exhibits
enhanced
blood
glucose
clearance
but
not
weight
loss.
The
improves
liver
pathology
reduces
proportions
immune
cells
adipose
tissue
non-uniform
response.
GM
analysis
suggests
bacteriophage-mediated
modulation
influences
outcomes.
Optimizing
these
approaches
could
lead
development
safe
bacteriophage-based
therapies
targeting
through
restoration.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(20), P. 3440 - 3440
Published: Oct. 11, 2024
Background:
More
than
half
of
the
states
in
U.S.
report
that
over
30%
adults
are
obese.
Obesity
increases
risk
many
chronic
diseases,
including
type
2
diabetes,
hypertension,
and
cardiovascular
disease,
can
even
reduce
one’s
lifespan.
Similarly,
prevalence
diabetes
follows
a
comparable
trend.
As
result,
researchers
striving
to
find
solutions
obesity
rates,
with
particular
focus
on
gut
health,
which
has
been
previously
linked
both
diabetes.
Recent
studies
suggest
Akkermansia
muciniphila
(Akk)
may
have
positive
probiotic
effect
preventing
onset
obesity.
Methods:
We
conducted
quantitative
meta-analysis
15
qualified
animal
investigating
effects
Akk
administration
as
probiotic.
Results:
The
statistical
analyses
showed
significantly
reduced
body
weight
gain
by
10.4%
fasting
blood
glucose
21.2%,
while
also
improving
tolerance
22.1%
increasing
insulin
levels
26.9%.
However,
our
analysis
revealed
substantial
heterogeneity
between
control
experimental
groups
across
all
subgroups.
Conclusions:
Overall,
appears
be
effective
at
reducing
diet-induced
Long-term
larger
sample
sizes
needed
confirm
these
beneficial
effects,
current
were
short
duration
(less
20
weeks).
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(11), P. 1386 - 1386
Published: Nov. 14, 2024
Background:
The
gut
microbiota
constitutes
a
complex
microorganism
community
that
harbors
bacteria,
viruses,
fungi,
protozoa,
and
archaea.
human
bacterial
has
been
extensively
proven
to
participate
in
metabolism,
immunity,
nutrient
absorption.
Its
imbalance,
namely
“dysbiosis”,
linked
disordered
metabolism.
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
one
of
the
features
deranged
metabolism
leading
cause
cirrhosis
hepatocellular
carcinoma.
Thus,
there
pathophysiological
link
between
dysbiosis
MASLD.
Aims
Methods:
We
aimed
review
literature
data
on
composition
its
MASLD
describe
concept
“gut–liver
axis”.
Moreover,
we
reviewed
approaches
for
modulation
treatment.
Results:
There
consolidated
evidence
particular
associated
with
stages.
model
explaining
relationship
bidirectional
organization,
physiopathology
Oxidative
stress
keystones
pathophysiology
fibrosis
generation.
promising
efficacy
pre-
probiotics
reversing
patients,
therapeutic
effects.
Few
yet
encouraging
fecal
transplantation
(FMT)
are
available
literature.
Conclusions:
characteristic
key
target
reversal
treatment
via
diet,
pre/probiotics,
FMT
remains
treatment,
prevention,
reversal.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(22), P. 3951 - 3951
Published: Nov. 19, 2024
Type
2
diabetes
(T2D)
is
a
chronic
metabolic
disorder
with
heterogeneous
etiology
encompassing
societal
and
behavioral
risk
factors
in
addition
to
genetic
environmental
susceptibility.
The
cardiovascular
consequences
of
account
for
more
than
two-thirds
mortality
among
people
T2D.
Not
only
does
T2D
shorten
life
expectancy,
but
it
also
lowers
quality
associated
extremely
high
health
expenditures
since
diabetic
complications
raise
both
direct
indirect
healthcare
costs.
An
increasing
body
research
indicates
connection
between
gut
microbial
traits,
as
numerous
alterations
the
intestinal
microorganisms
have
been
noted
pre-diabetic
individuals.
These
include
pro-inflammatory
bacterial
patterns,
increased
permeability,
endotoxemia,
hyperglycemia-favoring
conditions,
such
alteration
glucagon-like
peptide-1
(GLP-1)
secretion.
Restoring
homeostasis
can
be
very
beneficial
preventing
co-treating
improving
antidiabetic
therapy
outcomes.
This
review
summarizes
characteristics
"diabetic"
microbiota
metabolites
produced
by
species
that
worsen
or
ameliorate
progression,
suggesting
microbiota-targeted
strategies
restore
eubiosis
regulate
blood
glucose.
Nutritional
supplementation,
diet,
physical
exercise
are
known
play
important
roles
T2D,
here
their
effects
on
discussed,
non-pharmacological
approaches
greatly
help
management
highlighting
importance
tailoring
treatments
individual
needs.
