Journal of Oral and Maxillofacial Pathology,
Journal Year:
2024,
Volume and Issue:
28(4), P. 665 - 671
Published: Oct. 1, 2024
In
recent
years,
Candida
albicans
has
emerged
as
a
significant
opportunistic
pathogen,
causing
various
infections,
particularly
in
immunocompromised
geriatric
individuals.
One
of
the
major
hindrances
managing
infections
lies
its
potential
to
develop
and
survive
biofilms,
which
demonstrate
resistance
conventional
antifungal
therapies,
thereby
complicating
treatment
strategies.
While
clove
oil
shown
promising
results
agent,
specific
anti-biofilm
effects
against
biofilms
remain
relatively
underexplored.
Therefore,
there
is
need
for
comprehensive
review
evaluate
existing
literature
on
properties
mechanisms
action
biofilms.
Such
will
provide
valuable
insights
into
therapeutic
applications
combating
biofilm-associated
infections.
This
enable
us
infer
understand
albicans.
systematic
aims
determine
efficacy
was
registered
'PROSPERO'
(CRD42024524134)
followed
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses
guidelines.
The
searches
used
Google
Scholar,
PubMed,
Science
Direct
databases.
All
original
studies
published
English
from
2004
2023
were
included.
From
37
found
online,
only
four
reviewed.
Results
showed
that
had
activity
when
assessed
Our
provides
oil's
agent
Clove
also
represents
avenue
future
research
development
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 12, 2023
Bacterial
biofilms
can
pose
a
serious
health
risk
to
humans
and
are
less
susceptible
antibiotics
disinfection
than
planktonic
bacteria.
Here,
novel
method
for
biofilm
eradication
based
on
antimicrobial
photodynamic
therapy
utilizing
nanoparticle
in
conjunction
with
BODIPY
derivative
as
photosensitizer
was
developed.
Reactive
oxygen
species
generated
upon
illumination
visible
light
lead
strong,
controllable
persistent
of
both
bacteria
biofilms.
One
the
biggest
challenges
is
penetration
agent
into
its
matrix.
A
biocompatible
hydrophilic
utilized
delivery
system
hydrophobic
dye
enabled
accumulation
within
biofilm.
This
key
feature
delivering
site
action
where
it
activated
resulted
effective
all
tested
3
bacterial
that
commonly
form
clinically
relevant
pathogenic
were
selected:
Escherichia
coli,
Staphylococcus
aureus
Streptococcus
mutans.
The
development
this
tool
takes
promising
step
towards
new
methods
much
needed
treatment
Photodiagnosis and Photodynamic Therapy,
Journal Year:
2024,
Volume and Issue:
49, P. 104296 - 104296
Published: July 28, 2024
Evaluation
of
the
effect
phycocyanin
(PC)
and
toluidine
blue
(TBO)
along
with
sodium
fluoride
varnish
(FV)
or
titanium
tetrafluoride
(TiF4)
under
conditions
antimicrobial
photodynamic
therapy
(PDT)
on
a
dual-species
cariogenic
biofilm
remineralization
process.
After
development
Streptococcus
mutans
Lactobacillus
acidophilus
biofilms
human
enamel
disks,
they
were
divided
into
11
groups
(n
=
9):
Control
(0.9%
saline),
PC,
TBO,
FV,
TiF4
alone,
PC
TBO
in
combination
635
nm
diode
laser
(PDT
treatment),
PC-PDT+
(PC
+
FV
laser),
TBO-PDT+
(TBO
laser).
treatment,
crystal
violet
assay
was
performed
to
determine
reduction
biofilms.
Enamel
changes
analyzed
using
energy
dispersive
X-ray
spectroscopy
(EDX)
field
emission
scanning
electron
microscopy
(FESEM)
for
calcium
phosphorus
(Ca/P)
ratio.
Only
showed
superior
antibiofilm
activity
when
applied.
Furthermore,
highest
Ca/P
ratio
found
after
treatment
surfaces
TiF4-TBO-PDT+.
The
FESEM
images
that
disks
treated
plus
TBO-mediated
PDT
exhibited
surface
coating.
However,
PC-mediated
cannot
repair
demineralized
enamel.
These
data
suggest
TBO-PDT
can
effectively
reduce
significantly
remineralize
opening
new
avenues
caries
prevention.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(9), P. 1232 - 1232
Published: Sept. 18, 2024
Objectives:
The
aim
of
this
study
is
to
investigate
the
antimicrobial
efficacy
photodynamic
therapy
(PDT)
using
natural
photosensitizers
(curcumin,
riboflavin,
and
phycocyanin)
light-emitting
diode
(LED)
irradiation
against
multispecies
biofilms
in
an
acrylic
denture
base
model.
Materials
Methods:
Forty-five
specimens
were
fabricated
heat-curing
resin.
then
infected
with
a
mixed
culture
bacterial
fungal
species
(including
Streptococcus
mutans,
sanguinis,
Candida
albicans,
glabrata)
for
4
days.
discs
divided
into
nine
groups,
each
group
containing
five
discs:
control,
0.2%
chlorhexidine,
5.25%
sodium
hypochlorite,
curcumin,
phycocyanin
alone
or
along
LED.
After
treatment,
number
colony-forming
units
(CFUs)
per
milliliter
was
counted.
In
addition,
extent
biofilm
degradation
assessed
crystal
violet
staining
method
scanning
electron
microscopy.
Results:
All
experimental
groups
exhibited
significant
reduction
colony
numbers
both
compared
control
(p
<
0.001).
PDT
statistically
counts
bacteria
fungi
photosensitizer-only
groups.
Conclusions:
results
vitro
show
that
LED
devices
can
effectively
reduce
viability
eradicate
microorganisms
responsible
causing
infections.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(14), P. 4212 - 4212
Published: July 19, 2024
Objectives:
Photochemical
systems
are
frequently
recommended
as
an
adjuvant
treatment
option
in
peri-implantitis
therapy.
The
aim
of
the
present
study
was
to
evaluate
efficacy
these
options,
well
a
novel
curcumin-based
option,
biofilm
model
on
implants.
Methods:
Eighty
dental
implants
were
inoculated
with
artificial
periodontal
pathogens
and
placed
peri-implant
pocket
models.
following
groups
analyzed:
I,
photodynamic
therapy
(PDT);
II,
PDT
dye;
III,
curcumin/DMSO
+
laser;
IV,
only;
V,
dimethyl
sulfoxide
(DMSO)
VI,
photothermal
(PTT);
VII,
PTT
VIII,
control.
After
treatment,
remaining
bacterial
loads
assessed
microbiologically
using
quantitative
real-time
polymerase
chain
reaction
analysis.
Results:
PDT,
PTT,
DMSO
methods
associated
statistically
significant
(p
<
0.05)
improvements
germ
reduction
comparison
other
untreated
control
group.
mean
percentage
reductions
follows:
I
(PDT)
93.9%,
II
(PDT
dye)
62.9%,
III
(curcumin/DMSO
laser)
74.8%,
IV
only)
67.9%,
V
89.4%,
VI
(PTT)
86.8%,
VII
(PTT
66.3%.
Conclusions:
commercially
available
largest
periopathogenic
bacteria
implant
surfaces.
However,
activation
laser
light
at
suitable
wavelength
is
necessary
achieve
bactericidal
effects.
use
curcumin
photosensitizer
for
445
nm
irradiation
did
not
lead
any
improvement
antibacterial
rinsing
solution
alone.
BMC Oral Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: March 7, 2024
This
study
was
conducted
to
investigate
the
efficiency
of
periodontal
ligament
(PDL)
stem
cell-derived
exosome-loaded
Emodin
(Emo@PDL-Exo)
in
antimicrobial
photodynamic
therapy
(aPDT)
on
Streptococcus
mutans
and
Lactobacillus
acidophilus
as
cariogenic
bacteria.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 17, 2024
Abstract
Antimicrobial
photodynamic
therapy
(aPDT)
has
been
suggested
as
a
complementary
approach
to
endodontic
treatment
it
promoted
greater
microbial
reduction.
This
case
report
describes
the
effectiveness
of
aPDT
in
bacterial
reduction
and
clinical
management
lower
molar
presenting
previous
poorly
conducted
treatment,
post-treatment
apical
periodontitis
coronal-root
perforation.
A
20-year-old
female
patient
with
radiographic
evidence
perforation
was
submitted
retreatment.
In
addition
procedures,
0.05%
methylene
blue
used
3-minutes
irradiation
period.
Ga-Al-Ar
diode
laser
attached
an
optical
fiber
diameter
365
μm
applied
by
using
90
s
time,
100
mW
power
9
J
energy.
conclusion,
associated
performed
technological
devices
represents
positive
impact
periapical
tissues
healing
teeth
furcation
Journal of lasers in medical sciences,
Journal Year:
2024,
Volume and Issue:
15, P. e58 - e58
Published: Nov. 26, 2024
Introduction:
Nowadays,
antimicrobial
photodynamic
therapy
(aPDT)
has
been
introduced
as
one
of
the
minimally
invasive
methods
for
disinfection
surfaces
dental
implants.
Being
derived
from
seaweed,
Chlorella
used
a
photosensitizer
in
this
study.
This
study
aimed
to
investigate
impacts
aPDT
with
on
rate
reduction
Streptococcus
salivarius
vitro.
Methods:
The
minimum
inhibitory
concentration
Chlorella,
sublethal
exposure
660
nm
diode
laser
irradiation,
and
dose
utilizing
against
S.
were
determined.
Finally,
CFU/mL
value
each
plate
was
calculated.
Then,
Tukey
HSD
one-way
ANOVA
tests
utilized
comparison
number
colonies
after
interventions.
Results:
A
250
µg/mL
at
an
irradiation
time
3
minutes,
identified
salivarius.
In
contrast,
application
4
minutes
combination
final
500
µg/mL,
demonstrated
significantly
greater
efficacy
reducing
compared
other
experimental
groups
(P<0.001).
Conclusion:
mediated
(660
nm,
minutes)
significant
effect
count.
