Food Research International, Journal Year: 2024, Volume and Issue: 200, P. 115436 - 115436
Published: Nov. 30, 2024
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117302 - 117302
Published: Aug. 19, 2024
Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis, is a complex disorder with an unknown cause. However, the dysbiosis of gut microbiome has been found to play role in IBD etiology, exacerbated immune responses defective intestinal barrier integrity. The can also be potential biomarker for several diseases, IBD. Currently, conventional treatments targeting pro-inflammatory cytokines pathways IBD-associated do not yield effective results. Other therapies that directly target dysbiotic outcomes are emerging. We review health its as diagnostic, prognostic, therapeutic This explores emerging advancements microbiome-associated alterations IBD, such nanoparticle or encapsulation delivery, fecal microbiota transplantation, nutritional therapies, microbiome/probiotic engineering, phage therapy, mesenchymal stem cells (MSCs), proteins, herbal formulas.
Language: Английский
Citations
16
Gastrointestinal Disorders, Journal Year: 2024, Volume and Issue: 6(2), P. 368 - 379
Published: March 28, 2024
The enteric nervous system (ENS), consisting of neurons and glial cells, is situated along the gastrointestinal (GI) tract’s wall plays a crucial role in coordinating digestive processes. Recent research suggests that optimal functioning GI relies on intricate connections between ENS, intestinal epithelium, immune system, microbiome, central (CNS). Inflammatory bowel disease (IBD) encompasses group chronic inflammatory disorders, such as Crohn’s (CD) ulcerative colitis (UC), characterized by recurring inflammation damage to tract. This review explores emerging dynamic field IBD sheds light potential ENS alterations both etiology management IBD. Specifically, we delve into IBD-induced cell (EGC) activation its implications for persistent gliosis, elucidating how this disrupts function through gut–brain axis (GBA). Additionally, examine IBD-associated alterations, focusing EGC senescence acquisition senescence-associated secretory phenotype (SASP). We highlight pivotal these changes recurrence Finally, discuss therapeutic interventions involving senotherapeutic agents, providing insights avenues managing targeting ENS-related mechanisms. approach might represent alternative advance treatment multifaceted disease.
Language: Английский
Citations
5
Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104897 - 104897
Published: Feb. 1, 2025
Language: Английский
Citations
0
Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)
Published: March 5, 2025
Neuroendocrine neoplasms (NENs) comprise a group of rare tumors originating from neuroendocrine cells, which are present in both endocrine glands and scattered throughout the body. Due to their scarcity absence specific markers, diagnosing NENs remains complex challenge. Therefore, new biomarkers required, ideally, easy-to-obtain blood samples. A panel soluble immune checkpoints (sPD-L1, sPD-L2, sPD-1, sCD25, sTIM3, sLAG3, Galectin-9, sCD27, sB7.2 sSIGLEC5) cytokines (IL4, IL6, IP10 MCP1) was quantified cohort 139 NENs, including 29 pituitary 46 pheochromocytomas paragangliomas, 67 gastroenteropancreatic pulmonary (GEPP) as well 64 healthy volunteers (HVs). The potential these circulating immunological parameters distinguish HVs, differentiate among various subtypes, predict prognosis evaluated using mathematical regression models. These factors-based models generated scores that were by Receiver Operating Characteristic (ROC) Area Under Curve (AUC) analyses. Correlations between clinical data performed. From analyses, minimal signature emerged, comprising five shared factors across models: Galectin-9. This refined evaluated, validated, checked for specificity against non-neuroendocrine tumors, demonstrating its clinically relevant tool identifying distinct NENs. Most analyzed showed expression patterns different Scores based on signatures identified with high efficiency, showing AUCs ranging 0.948 0.993 depending comparison, accuracies 92.52% 95.74%. illustrated biological features similarity divergence gastrointestinal correlated features. Furthermore, demonstrated strong performance distinguishing metastatic exitus GEPP achieving sensitivities specificities 80.95% 88.89%. Additionally, an easy-to-implement successfully all AUC values exceeding 0.900, 84.11% 93.12%, internally validated discovery validation randomization strategy. findings highlight effectiveness accurately differentiating analysis presents promising liquid biopsy approach delivering critical insights diagnosis. study serves proof-of-concept innovative holds transform management malignancies, providing non-invasive effective method early detection disease monitoring.
Language: Английский
Citations
0
Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23
Published: March 6, 2025
Studies have indicated that milk extracellular vesicles (EVs) are resistant to both the enzymatic activity of digestive enzymes and acidic conditions common in gastrointestinal tract. Thus, intestinal tract efficiently absorbs uses these EVs. There is mounting evidence recent years microRNAs (miRNAs) found EVs derived from essential for prebiotic effect through target gene regulation. In this paper, we summarized sources, biosynthetic processes, cargos, factors affecting milk-derived Furthermore, with particular attention potential communication mechanism cell receptors, including recognizing binding surface receptor cells, internalization uptake, cargos acting on cells. Especially, also explored role several aspects health, such as immunological homeostasis, barrier, injury, inflammatory bowel disease, necrotizing enterocolitis, malignancy, harm other organs connected intestine. We expected use or miRNAs new dietary additives functional regulatory factors. future, will gain more knowledge about substantial impact human intestines health-related matters.
Language: Английский
Citations
0
Antibiotics, Journal Year: 2025, Volume and Issue: 14(4), P. 371 - 371
Published: April 3, 2025
The human gut microbiota—an intricate and dynamic ecosystem—plays a pivotal role in metabolic regulation, immune modulation, the maintenance of intestinal barrier integrity. Although antibiotic therapy is indispensable for managing bacterial infections, it profoundly disrupts microbial communities. Such dysbiosis typified by diminished diversity shifts community structure, especially among beneficial genera (e.g., Bifidobacterium Eubacterium), fosters antibiotic-resistant strains horizontal transfer resistance genes. These alterations compromise colonization resistance, increase permeability, amplify susceptibility to opportunistic pathogens like Clostridioides difficile. Beyond gastrointestinal disorders, emerging evidence associates with systemic conditions, including chronic inflammation, syndrome, neurodegenerative diseases, underscoring relevance microbiota–gut–brain axis. recovery pre-existing communities post-antibiotic highly variable, influenced drug spectrum, dosage, treatment duration. Innovative interventions—such as fecal microbiota transplantation (FMT), probiotics, synbiotics, precision microbiome therapeutics—have shown promise counteracting mitigating its adverse effects. therapies align closely stewardship programs aimed at minimizing unnecessary use preserve curtail spread multidrug-resistant organisms. This review emphasizes pressing need microbiota-centered strategies optimize administration, promote long-term health resilience, alleviate disease burden associated antibiotic-induced dysbiosis.
Language: Английский
Citations
0
Precision Clinical Medicine, Journal Year: 2024, Volume and Issue: 7(3)
Published: July 24, 2024
Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, and its pathogenesis believed to be associated with an imbalance between commensal organisms intestinal immune system. This significantly influenced by microbiota metabolites plays critical role in maintaining mucosal homeostasis. However, disturbances cause dysregulated responses consequently induce inflammation. Recent studies have illustrated roles IBD underscored potential precision diagnosis therapy. work summarises recent progress this field particularly focuses on application diagnosis, prognosis assessment, treatment effectiveness evaluation, therapeutic management IBD.
Language: Английский
Citations
3
Cells, Journal Year: 2023, Volume and Issue: 13(1), P. 90 - 90
Published: Dec. 31, 2023
Patients affected by inflammatory bowel diseases (IBD) can nowadays benefit from a growing number of pharmacological options. However, in moderate-to-severe cases, the therapeutic response is still far optimal, and treatment changes optimizations are often required. Thus, researchers this field strongly engaged studies aiming to identify new potential targets. Extracellular vesicles (EVs) tiny subcellular bodies with phospholipid bilayer envelope containing bioactive molecules, which released different cells involved intercellular communication. Recent pre-clinical data show their emerging role pathogenesis IBD. In our review, we summarize current evidence about function EVs as active agents ulcerative colitis Crohn’s disease, analyzing properties derived cellular sources mechanisms through they may improve intestinal inflammation.
Language: Английский
Citations
6
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 71 - 95
Published: Jan. 1, 2024
Language: Английский
Citations
0
Revue Francophone des Laboratoires, Journal Year: 2024, Volume and Issue: 2024(562), P. 58 - 64
Published: May 1, 2024
Citations
0