Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 22, 2024
is an opportunistic pathogen commonly found in the normal flora of gastrointestinal tract. While it typically remains benign, can lead to severe healthcare-associated infections, particularly among immunocompromised individuals and those long-term care settings. This study aimed investigate epidemiology antibiotic resistance patterns
Language: Английский
Microbiological Research, Journal Year: 2024, Volume and Issue: 287, P. 127837 - 127837
Published: July 18, 2024
Language: Английский
Citations
13
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(9), P. 1206 - 1206
Published: Sept. 12, 2024
The rise of antibiotic resistance and the dwindling antimicrobial pipeline have emerged as significant threats to public health. emergence carbapenem-resistant
Language: Английский
Citations
9
Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107399 - 107399
Published: Feb. 1, 2025
Language: Английский
Citations
1
Vaccines, Journal Year: 2025, Volume and Issue: 13(3), P. 303 - 303
Published: March 11, 2025
Background: Klebsiella pneumoniae infections pose a great burden worldwide, causing high morbidity and mortality, which are worsened by the increase in multidrug-resistant strains. New therapeutic/prophylactic strategies urgently needed to overcome antibiotic resistance reduce health economic impacts of diseases caused this pathogen. Fimbriae important virulence factors involved biofilm formation adhesion host cells. Their exposed location, conservation among clinical isolates adjuvant properties make them interesting candidates for inclusion protein-based vaccines. Therefore, present work investigated immunological potential type 1 3 fimbriae subunits murine model K. lung infection. Methods: MrkA FimA were produced as recombinant proteins E. coli, purified used immunize mice subcutaneously. The immune responses characterized protection against pneumonia was evaluated after intranasal challenge. Results: Subcutaneous immunization with induced IgG1 production; antibodies efficiently recognized native at bacterial surface, promoted C3 deposition reduced vitro. Mice vaccinated co-administered loads lungs challenge, less inflammation tissue damage. Conclusion: results suggest that both contribute infection, inducing bind bacteria favoring Complement clearance host, while inhibiting formation.
Language: Английский
Citations
1
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Klebsiella pneumoniae is a gram-negative bacterium naturally found in the gastrointestinal and oropharyngeal tracts but can become an opportunistic pathogen, causing severe healthcare-associated infections, especially immunocompromised patients. This study aimed to investigate epidemiology antibiotic resistance patterns of K. infections among female patients long-term care hospital Riyadh, Saudi Arabia. A cross-sectional retrospective examined microbial cultures 27 with confirmed positive who were admitted Riyadh. Demographic information, addition culture sites susceptibility tests, was collected. The associations between patient characteristics investigated, focusing on prevalence carbapenem-resistant Enterobacterales (CRE) production extended-spectrum beta-lactamases (ESBL). total 51.9% (n = 14) CRE isolates reported, indicating substantial resistance. Patients bedsores exhibited lower infection proportion (18.5%) compared those without (33.3%), no statistically significant difference (p 0.888). Older age (>50 years) demonstrated higher (29.6%) younger (22.2%), statistical significance 0.351). Further, all reported widespread use Foley catheters, tracheostomy or stay duration did not significantly correlate patterns. Notably, imipenem highest rate (66.7%), whereas cotrimoxazole (51.9%) ampicillin (33.3%) high highlights increasing ESBL-producing patients, underscoring need for enhanced control strategies antimicrobial stewardship programs mitigate spread multidrug-resistant (MDR) pathogens. Targeted interventions, particularly high-risk are essential reducing settings. Future research should include larger cohorts further gender-based differences
Language: Английский
Citations
0
Tissue and Cell, Journal Year: 2025, Volume and Issue: unknown, P. 102865 - 102865
Published: March 1, 2025
Language: Английский
Citations
0
Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123531 - 123531
Published: March 1, 2025
Citations
0
Future Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13
Published: March 26, 2025
Multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKP) combines high pathogenicity with multidrug resistance to become a new superbug. MDR-hvKP reports continue emerge, shattering the perception that K. (hvKP) strains are antibiotic sensitive. Patients infected have been reported in Asia, particularly China. Although hvKP can acquire drug genes, seems be more easily transformed from classical (cKP), which has strong gene uptake ability. To better understand biology of MDR-hvKP, this review discusses virulence factors, mechanisms, formation pathways, and identification MDR-hvKP. Given their destructive transmissible potential, continued surveillance these organisms enhanced control measures should prioritized.
Language: Английский
Citations
0
Journal of Applied Mathematics, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Nosocomial infections, such as those caused by carbapenem‐resistant Klebsiella pneumoniae (CRKP) transmitted into hospitals, worsen patient outcomes, strain healthcare infrastructure, increase treatment costs, prolong hospital stays, and complicate medical due to their high level of antibiotic resistance. Taking account these detrimental aspects, this study deals with a dynamic system nonlinear differential equations maintenance preventive strategies, applying combination therapy has been considered prevent CRKP transmission reduce resistance while accounting for two populations. The analytical analysis includes positivity, boundedness, existence unique solution, stability at equilibrium points, reproduction number ( R 0 ), sensitivity, convergence state variables. And, the numerical simulations were performed using fourth‐order Runge–Kutta method. We find that proper implementation hygiene practices among hospitalized patients consistent use personal protective equipment (PPE) workers play an important role in preventing hospitals. Additionally, approach reduces Consequently, improves safety ensures healthier environment minimizing spread infectious agents reducing risks nosocomial infections.
Language: Английский
Citations
0
Antibiotics, Journal Year: 2024, Volume and Issue: 13(9), P. 844 - 844
Published: Sept. 5, 2024
Flavonoids are secondary metabolites that exhibit remarkable biological activities, including antimicrobial properties against
Language: Английский
Citations
3