Global Health,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
Background:
The
unprecedented
outbreak
of
the
severe
acute
respiratory
syndrome
coronavirus
2
(SARS‐CoV‐2)
pandemic
has
dramatically
changed
global
approach
to
public
health,
emphasizing
importance
measures
control
and
prevent
infections.
In
response
COVID‐19
crisis,
stringent
hygiene
practices
surface
disinfection
have
become
norm,
with
an
surge
in
use
disinfectants
antiseptics
(DAs).
Main
Text:
While
these
been
crucial
curbing
spread
virus,
emerging
concern
taken
center
stage:
potential
impact
prolonged
widespread
antimicrobial
compounds
products
on
development
antibiotic
resistance.
Antimicrobial
resistance
(AMR)
long
recognized
as
one
most
pressing
health
threats.
Quaternary
ammonium
(QAC)
such
benzalkonium
chloride,
benzethonium
cetylpyridinium
which
are
extensively
used
DAs
formulations,
gained
less
attention
context
AMR.
Conclusion:
A
high
abundance
QACs
was
detected
wastewater,
certain
bacteria
Pseudomonas
aeruginosa,
Acinetobacter
baumannii
,
Enterococcus
species
developed
over
time.
We
analyzed
available
evidence
from
scientific
literature,
examining
presence
concentrations
different
water
sources,
their
mechanisms.
This
review
aimed
shed
light
multifaceted
challenges
that
arise
dual
battle
against
ongoing
fight
PeerJ,
Journal Year:
2025,
Volume and Issue:
13, P. e18986 - e18986
Published: Feb. 24, 2025
Pseudomonas
aeruginosa
continues
to
be
a
significant
contributor
high
morbidity
and
mortality
rates
worldwide,
particularly
due
its
role
in
severe
infections
such
as
hospital-acquired
conditions,
including
ventilator-associated
pneumonia
various
sepsis
syndromes.
The
global
increase
antimicrobial-resistant
(AMR)
P.
strains
has
made
these
more
difficult
treat,
by
limiting
the
effective
drug
options
available.
This
systematic
review
meta-analysis
aim
provide
an
updated
summary
of
prevalence
AMR
over
past
5
years.
A
search
was
performed
across
three
major
electronic
databases—PubMed,
ScienceDirect,
Web
Science—yielding
40
eligible
studies
published
between
2018
2023.
Using
random-effects
model,
our
estimated
that
overall
Asia
Africa
years
22.9%
(95%
CI
[14.4–31.4]).
for
multidrug-resistant
(MDR)
extensively
drug-resistant
(XDR)
were
found
46.0%
[37.1–55.0])
19.6%
[4.3–34.9]),
respectively.
Furthermore,
extended-spectrum
β-lactamase-
metallo-β-lactamase-producing
33.4%
[23.6–43.2])
16.0%
[9.8–22.3]),
Notably,
resistance
β-lactams
used
treating
pseudomonal
alarmingly
high,
with
84.4%
100.0%
cephalosporins,
40%
isolates
showed
penicillins.
Our
analysis
identified
lowest
last-resort
antimicrobials,
0.3%
[0.0–1.3])
polymyxin
B
5.8%
[1.5–10.2])
colistin/polymyxin
E.
low
polymyxins
suggest
antibiotics
remain
against
MDR
.
However,
findings
also
highlight
critical
public
health
threat
posed
,
concerning
β-lactam
antibiotics.
underscores
need
carefully
planned
intervention
strategies,
development
new
address
growing
challenge
resistance.
Developing
robust
antibiotic
treatment
protocols
is
essential
better
management
control
globally.
Therefore,
continued
research
international
collaboration
vital
tackle
this
escalating
challenge.
study
protocol
registered
International
Prospective
Register
Systematic
Reviews
(PROSPERO),
under
registration
number
CRD42023412839.
Antibiotics,
Journal Year:
2025,
Volume and Issue:
14(1), P. 30 - 30
Published: Jan. 3, 2025
Background/Objectives:
Pseudomonas
aeruginosa
rapidly
acquires
antibiotic
resistance
and
demonstrates
increasing
tolerance
to
antiseptics.
This
study
evaluated
the
activity
of
eight
antiseptics
against
P.
aeruginosa,
assessed
its
ability
develop
adaptation
these
antiseptics,
and,
for
first
time,
determined
Karpinski
Adaptation
Index
(KAI)
this
bacterium.
Methods:
The
minimal
inhibitory
concentration
(MIC),
susceptibility
antibiotics,
bactericidal
time
according
EN
1040:2005,
potential,
KAI
strains
were
evaluated.
Results:
most
effective
based
on
MIC
activity,
octenidine
dihydrochloride
(OCT;
mean
11.3
±
4.5
µg/mL),
polyhexamethylene
biguanide
(PHMB;
22.6
8.0
chlorhexidine
digluconate
(CHX;
26.6
14.4
µg/mL).
Sodium
hypochlorite
(NaOCl)
ethacridine
lactate
(ET)
showed
moderate
while
boric
acid
(BA),
povidone-iodine
(PVI),
potassium
permanganate
(KMnO4)
exhibited
weakest
activity.
values
NaOCl
(95
15.4
µg/mL)
KMnO4
(>10
mg/mL)
close
or
exceeded
clinical
concentrations
used
in
commercial
products.
OCT,
CHX,
PVI
fastest
effect
within
1
min.
Bactericidal
times
up
15
min
PHMB,
60
ET,
more
than
BA,
NaOCl,
KMnO4.
lowest
values,
indicating
a
low
risk,
observed
OCT
(0.12),
PHMB
(0.19),
BA
(0.19).
Moderate
risk
was
noted
(0.21),
CHX
(0.29),
ET
(0.47).
highest
signifying
very
high
found
(1.0)
(≥1.0).
Conclusions:
Antiseptics
like
partially
can
be
critical
quick
antibacterial
action
infected
wounds,
agents
such
as
might
reserved
cases
where
prolonged
contact
are
possible.
Given
rapid
currently
use,
reconsideration
their
effectiveness
treating
skin
mucous
membrane
infections
is
recommended.
BMC Genomic Data,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: Jan. 22, 2025
Pseudomonas
aeruginosa,
a
Gram-negative
opportunistic
pathogen,
is
frequently
associated
with
multidrug
resistance
and
global
epidemic
outbreaks,
contributing
significantly
to
morbidity
mortality
in
hospitalized
patients.
However,
P.
aeruginosa
belonging
the
sequence
type
(ST)
16
was
rarely
reported.
Here,
this
report
presents
complete
genome
of
YK01,
ST16
isolate
from
patient
keratitis.
The
reference
YK01
expected
provide
valuable
data
for
investigating
its
genomic
population,
enhancing
understanding
genetic
basis
species
complex.
A
6.3
Mb
obtained
by
combining
Illumina
150-bp
short
reads
Nanopore
long
reads.
assembly
fully
chromosomal
size
6,183,266
bp,
presenting
GC
content
66.7%,
plasmid
46,067
59.0%.
Predicted
features
include
5,709
CDS,
12
rRNAs,
63
tRNAs,
4
ncRNAs,
5,788
genes.
To
our
knowledge,
represents
first
ST16,
providing
crucial
information
further
comparative
analysis.
Veterinary Sciences,
Journal Year:
2025,
Volume and Issue:
12(2), P. 157 - 157
Published: Feb. 11, 2025
The
isolation
of
multidrug-resistant
(MDR)
bacteria
from
the
urinary
tracts
pets
is
increasingly
common,
particularly
in
animals
with
concurrent
health
conditions.
Pseudomonas
aeruginosa
(PA)
one
most
significant
antimicrobial-resistant
affecting
cats
and
dogs
within
European
Union
(EU).
This
study
aims
to
review
prevalence
antimicrobial
resistance
patterns
PA
isolated
urine
samples
small
globally.
pathogen
known
for
its
opportunistic
infections
a
concern
veterinary
medicine
due
inherent
multiple
antibiotics
ability
acquire
additional
mechanisms.
seeks
enhance
educational
initiatives
regarding
management
emerging
MDR
bacteria.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
69(3), P. 167 - 179
Published: July 8, 2024
Bacteriophages,
or
phages,
are
microscopic
viruses
that
specifically
infect
and
replicate
within
bacterial
hosts.
Their
unique
ability
to
target
control
populations
makes
them
valuable
tools
with
applications
ranging
from
human
medicine
agriculture
environmental
management
biotechnology.
In
this
comprehensive
review,
we
explore
the
diverse
promising
medical
non-medical
of
bacteriophages,
highlighting
their
pivotal
role
across
various
niches.
From
safeguarding
food
production
through
pathogen
innovative
utilization
in
wastewater
treatment,
bacteriophages
prove
be
versatile
agents.
To
achieve
phages
on
a
larger
scale,
it
is
necessary
make
legal
framework
more
suitable
flexible,
create
special
approval
programs
(e.g.,
for
novel
antimicrobial
drugs),
promote
targeted
research
development
activities
phages.
Additionally,
intensive
exchange
between
academia,
industry,
regulatory
authorities,
stakeholders
health
system
should
pursued.
Marine Drugs,
Journal Year:
2025,
Volume and Issue:
23(1), P. 43 - 43
Published: Jan. 16, 2025
The
rise
in
multidrug-resistant
(MDR)
bacteria
has
prompted
extensive
research
into
antibacterial
compounds,
as
these
resistant
strains
compromise
current
treatments.
This
resistance
leads
to
prolonged
hospitalization,
increased
mortality
rates,
and
higher
healthcare
costs.
To
address
this
challenge,
the
pharmaceutical
industry
is
increasingly
exploring
natural
products,
particularly
those
of
marine
origin,
promising
candidates
for
antimicrobial
drugs.
Marine
sponges,
particular,
are
interest
because
their
production
secondary
metabolites
(SM),
which
serve
chemical
defenses
against
predators
pathogens.
These
exhibit
a
wide
range
therapeutic
properties,
including
activity.
systematic
review
examines
recent
advancements
identifying
new
sponge-derived
compounds
with
activity,
specifically
targeting
Pseudomonas
aeruginosa,
prevalent
Gram-negative
pathogen
highest
incidence
rates
clinical
settings.
selection
criteria
focused
on
reported
Minimum
Inhibitory
Concentration
(MIC)
values.
identified
SM
include
alkaloids,
sesterterpenoids,
nitrogenous
diterpene,
bromotyrosine-derived
derivatives.
structural
features
active
selected
may
provide
foundational
framework
developing
new,
highly
bioactive
agents.
Infectious Medicine,
Journal Year:
2025,
Volume and Issue:
4(1), P. 100168 - 100168
Published: Feb. 6, 2025
Phages,
including
the
viruses
that
lyse
bacterial
pathogens,
offer
unique
therapeutic
advantages,
their
capacity
to
antibiotic-resistant
bacteria
and
disrupt
biofilms
without
harming
host
microbiota.
The
lack
of
new
effective
antibiotics
growing
limitations
existing
have
refocused
attention
on
phage
therapy
as
an
option
in
complex
clinical
cases
such
burn
wounds,
cystic
fibrosis,
pneumonia.
This
review
describes
preclinical
studies
which
has
been
both
human
veterinary
medicine,
agricultural
context.
In
addition,
critical
challenges,
narrow
range
bacteriophages,
possibility
resistance,
regulatory
constraints
widespread
use
therapy,
are
addressed.
Future
directions
include
optimizing
through
strategies
ranging
from
cocktails
broadening
genetic
modification,
using
phages
vaccines
or
biocontrol
agents.
future,
if
can
be
efficiently
delivered,
maintained
a
stable
state,
phage-antibiotic
synergy
achieved,
will
much
needed
treatment
options.
However,
successful
implementation
within
current
standards
practice
also
require
considerable
development
infrastructure
greater
public
acceptance.
closing,
this
highlights
promise
backup
substitute
for
antibiotics.
It
proposes
role
significant
adjunct
to,
even
replacement
for,
treating
multidrug-resistant
infections.
