Antimicrobial Responses to Bacterial Metabolic Activity and Biofilm Formation Studied Using Microbial Fuel Cell-Based Biosensors DOI Creative Commons

Wenguo Wu,

Hoàng Thị Kim Hồng, Jia Horng Lin

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(12), P. 606 - 606

Published: Dec. 11, 2024

Simultaneous monitoring of antimicrobial responses to bacterial metabolic activity and biofilm formation is critical for efficient screening new anti-biofilm drugs. A microbial fuel cell-based biosensor using

Language: Английский

Copper-based nanomaterials for the treatment of bacteria-infected wounds: material classification, strategies and mechanisms DOI
Wenqi Wang, Peng Gao,

Hengshuo Gui

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216205 - 216205

Published: Sept. 11, 2024

Language: Английский

Citations

18
Novel silver nanoparticle-based biomaterials for combating Klebsiella pneumoniae biofilms DOI Creative Commons

Eslam Elashkar,

Rihaf Alfaraj, Ola M. El‐Borady

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

Klebsiella pneumoniae is a significant nosocomial pathogen that has developed resistance to multiple antibiotics, often forming biofilms enhance its virulence. This study investigated the efficacy of novel nanoformulation, AgNPs@chitosan-NaF, in combating K. biofilms. Antimicrobial susceptibility testing was performed assess antibiotic profile isolates. The antibiofilm activity AgNPs@chitosan-NaF evaluated using crystal violet staining and scanning electron microscopy. underlying mechanisms action were through gene expression analysis. majority isolates exhibited high levels multidrug resistance. demonstrated superior biofilm inhibition compared AgNPs@chitosan, significantly reducing biomass disrupting architecture at MICs ranging from 0.125 1 μg/mL. Mechanistic studies revealed nanoformulation downregulated key biofilm-associated genes, including treC, fimA, mrkA, ecpA. While concentration-dependent cytotoxic effect on both normal cancer cell lines, minimal cytotoxicity observed concentrations below 31.25 highlights synergistic silver nanoparticles, chitosan, sodium fluoride emerges as promising therapeutic strategy address challenge multidrug-resistant bacterial infections.

Language: Английский

Citations

2
Bacteriocin Isolated from Ralstonia mannitolilytica and Bacteriocin-Capped Silver Nanoparticles: Comparative Effects on Biofilm Formation and LuxS Gene’s Expressions by Proteus mirabilis as an Approach to Counter MDR Catheter Infection DOI
Mais E. Ahmed,

Ahmed N. Aljarbou,

Hamdoon A. Mohammed

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107558 - 107558

Published: April 1, 2025

Language: Английский

Citations

1
Prevention and potential remedies for antibiotic resistance: current research and future prospects DOI Creative Commons

Rabiya Tabbassum Khan,

Vanshika Sharma,

Sofia Sharief Khan

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 3, 2024

The increasing threat of antibiotic resistance and shrinking treatment options for infections have pushed mankind into a difficult position. looming the return pre-antibiotic era has caused sense urgency to protect conserve potency therapy. One perverse effects is dissemination its causative agents from non-clinically important strains clinically vice versa. popular saying "Prevention better than cure" appropriate tackling resistance. On one hand, new effective antibiotics are required; on other measures use antibiotics, along with increased awareness in general public related use, essential. Awareness, especially resistance, dissemination, potential threats, can help greatly controlling abuse containment Antibiotic drugs' effectiveness be enhanced by producing novel analogs or adding adjuvants current antibiotics. Combinatorial therapy proven successful treating multidrug-resistant (MDR) bacterial infections. This review aims highlight global situation discuss methods used monitor, prevent, inhibit, reverse mechanisms fight against

Language: Английский

Citations

8
Nanoparticle-driven aquaculture: transforming disease management and boosting sustainable fish farming practices DOI
Esraa A. Abdelkarim, Tamer Elsamahy, Rasha M. El Bayomi

et al.

Aquaculture International, Journal Year: 2025, Volume and Issue: 33(4)

Published: April 23, 2025

Language: Английский

Citations

1
Anti-microbial, anti-biofilm, and efflux pump inhibitory effects of ellagic acid–bonded magnetic nanoparticles against Escherichia coli isolates DOI

Fatemeh Norouzalinia,

Leila Asadpour, Masoud Mokhtary

et al.

International Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 6, 2024

Language: Английский

Citations

3
Alleviation of mycobacterial infection by impairing motility and biofilm formation via natural and synthetic molecules DOI Creative Commons

Abirami Karthikeyan,

Nazia Tabassum, Geum-Jae Jeong

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(4)

Published: March 28, 2025

Language: Английский

Citations

0
Silver Nanoparticles Functionalized with Polymeric Substances to Reduce the Growth of Planktonic and Biofilm Opportunistic Pathogens DOI Open Access
Mădălina Preda, Alina Maria Holban, Beatrice Bălăceanu-Gurău

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3930 - 3930

Published: April 22, 2025

The global rise in antimicrobial resistance, particularly among ESKAPE pathogens, has intensified the demand for alternative therapeutic strategies. Silver nanoparticles (AgNPs) have exhibited broad-spectrum activity and represent a promising approach to combat multidrug-resistant infections. This study aimed synthesize functionalize AgNPs using various polymeric agents—ethylene glycol (EG), polyethylene (PEG), polyvinylpyrrolidone (PVP), their combinations—and evaluate antibiofilm efficacy against clinically relevant bacterial strains. were synthesized via chemical reduction functionalized as Ag@EG, Ag@PEG, Ag@EG/PVP, Ag@PEG/PVP. A total of 68 clinical isolates—including Staphylococcus aureus, epidermidis, lugdunensis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa—were tested. Antimicrobial susceptibility was assessed disc diffusion broth microdilution assays, while evaluated crystal violet method. Among all tested formulations, Ag@EG/PVP highest activity, with notably low minimum inhibitory concentrations (MIC50) biofilm eradication (MBEC50) Ps. aeruginosa K. pneumoniae. In contrast, PEG or EG alone showed limited efficacy. Biofilm-forming isolates, spp., required higher inhibition. These results highlight critical role functionalization modulating properties AgNPs, demonstrating potent both planktonic biofilm-associated bacteria. Overall, this supports further developing AgNPs-based formulations adjuncts alternatives conventional antibiotics, managing biofilm-related Future research should focus on formulation optimization, safety assessment, translational potential.

Language: Английский

Citations

0
Exploring the antivirulence mechanisms of ZnO-PEG-quercetin nanoparticles: Biofilm disruption, attenuation of virulent factors, and cell invasion suppression against pathogenic Pseudomonas aeruginosa DOI

Fatemeh Esnaashari,

Ghazaleh Nikzad,

Hossein Zahmatkesh

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 161, P. 108527 - 108527

Published: April 26, 2025

Language: Английский

Citations

0
Evaluation of antimicrobial effect ZnO nanoparticles and Clove extract against Pseudomonas aeruginosa isolated from clinical samples DOI Creative Commons

Fatemah HajiSadeghi,

Ali Sobhani‐Nasab, Somaye Rashki

et al.

The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100363 - 100363

Published: April 1, 2025

Language: Английский

Citations

0