Microbiological Research, Journal Year: 2024, Volume and Issue: 289, P. 127914 - 127914
Published: Sept. 24, 2024
Language: Английский
Medicine in Microecology, Journal Year: 2024, Volume and Issue: 22, P. 100111 - 100111
Published: Aug. 25, 2024
Probiotics are microbes associated with a wide range of health benefits and modulate gut flora by releasing effector molecules. The efficacy probiotics at various stages cancer treatment has been well demonstrated. can increase the potency cancer-based immunotherapy, which be administered before, during, or post-phase therapy. consumption among patients minimize detrimental effects chemotherapy act as potential tool for Genetically engineered express specific antigens that combat deadly pathogens. These essential features utilized in other applications. This review aims to provide updated information on mechanism action their applications Moreover, few significant like; antioxidative therapy, biotechnology-based improvement, developing potent probiotic strains effective also discussed.
Language: Английский
Citations
5
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 29, 2025
Overproduction of reactive oxygen species (ROS), elevated synovial inflammation, hyperplasia and fibrosis are the main characteristic microenvironment in rheumatoid arthritis (RA). Macrophages fibroblast-like synoviocytes (FLSs) play crucial roles progression RA. Hence, synergistic combination ROS scavenging, macrophage polarization from pro-inflammatory M1 phenotype towards M2 anti-inflammatory phenotype, restoring homeostasis FLSs will provide a promising therapeutic strategy for In this study, we successfully synthesized metformin-derived carbon dots (MCDs), investigated antirheumatic effect vivo vitro. Designed MCDs could target inflamed cells accumulate at inflammatory joints collagen-induced (CIA) rats. investigation suggested that reduced inflammation hyperplasia, ultimately prevented cartilage destruction, bone erosion, CIA addition, eliminated cellular macrophages RA through enzyme-like catalytic activity as well inhibiting NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome signaling pathway, effectively polarizing them into to realize effect. Furthermore, inhibit proliferation, migration, FLSs. Mechanistically, restored while reducing level by blocking IL-6/gp130 pathway. Combined with preferable biocompatibility, offer prospective treatment approach
Language: Английский
Citations
0
Food Research International, Journal Year: 2025, Volume and Issue: 209, P. 116183 - 116183
Published: March 14, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9026 - 9026
Published: Aug. 20, 2024
Colorectal cancer (CRC) continues to be a significant contributor global morbidity and mortality. Emerging evidence indicates that disturbances in gut microbial composition, the formation of reactive oxygen species (ROS), resulting inflammation can lead DNA damage, driving pathogenesis progression CRC. Notably, bacterial metabolites either protect against or contribute oxidative stress by modulating activity antioxidant enzymes influencing signaling pathways govern ROS-induced inflammation. Additionally, microbiota byproducts, when supplemented through probiotics, affect tumor microenvironments enhance treatment efficacy selectively mediate destruction CRC cells. This review aims discuss mechanisms which taxonomical shifts related such as short-chain fatty acids, secondary bile trimethylamine-N-oxide influence ROS concentrations safeguard promote onset inflammation-mediated we focus on role probiotic ROS-mediated both status inflammation, Nrf2-Keap1, NF-κB, NLRP3 mitigate carcinogenesis. Overall, deeper understanding may aid delaying preventing offer new avenues for adjunct, CRC-specific therapeutic interventions immunotherapy.
Language: Английский
Citations
3
Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3706 - 3706
Published: Oct. 30, 2024
: This review investigates the impact of bioactive molecules produced by probiotics on child health, focusing their roles in modulating gut microbiota, enhancing immune function, and supporting overall development. Key metabolites, including short-chain fatty acids (SCFAs), bacteriocins, exopolysaccharides (EPSs), vitamins, gamma-aminobutyric acid (GABA), are highlighted for ability to maintain regulate inflammation, support neurodevelopment.
Language: Английский
Citations
3
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 347, P. 122660 - 122660
Published: Aug. 26, 2024
Bifidobacteria, which are increasingly linked to health benefits the host, produce structurally complex exopolysaccharides considered be effector molecules responsible for effects. It is currently not clear how bacterial growth conditions, and especially carbon source, affect structural composition of EPS. Here we present our investigations into impact addition 2'-fucosyllactose (2'-FL) galactooligosaccharides (GOS), non-digestible carbohydrates added infant formula, as sole source during B. adolescentis infantis. Intriguingly, produced EPS with larger molecular weights in presence GOS or a mixture GOS/2'-FL. infantis showed increased levels 2'-FL, also an α-1,4-glucan polymer, whose amount was when grown on GOS. These findings highlight species-specific effects conditions structures.
Language: Английский
Citations
1
Microbiological Research, Journal Year: 2024, Volume and Issue: 289, P. 127914 - 127914
Published: Sept. 24, 2024
Language: Английский
Citations
1