Copper metabolism in cell death and autophagy

Autophagy, Journal Year: 2023, Volume and Issue: 19(8), P. 2175 - 2195

Published: April 14, 2023

Copper is an essential trace element in biological systems, maintaining the activity of enzymes and function transcription factors. However, at high concentrations, copper ions show increased toxicity by inducing regulated cell death, such as apoptosis, paraptosis, pyroptosis, ferroptosis, cuproptosis. Furthermore, can trigger macroautophagy/autophagy, a lysosome-dependent degradation pathway that plays dual role regulating survival or death fate cells under various stress conditions. Pathologically, impaired metabolism due to environmental genetic causes implicated variety human diseases, rare Wilson disease common cancers. Therapeutically, copper-based compounds are potential chemotherapeutic agents be used alone combination with other drugs approaches treat cancer. Here, we review progress made understanding metabolic processes their impact on regulation autophagy. This knowledge may help design future clinical tools improve cancer diagnosis treatment.

Language: Английский

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Selective Targeting of Cancer Cells by Copper Ionophores: An Overview

Frontiers in Molecular Biosciences, Journal Year: 2022, Volume and Issue: 9

Published: March 4, 2022

Conventional cancer therapies suffer from severe off-target effects because most of them target critical facets cells that are generally shared by all rapidly proliferating cells. The development new therapeutic agents should aim to increase selectivity and therefore reduce side effects. In addition, these overcome cell resistance stem Some copper ionophores have shown promise in this direction thanks an intrinsic preferentially inducing cuproptosis compared normal Here, Cu discussed with a focus on towards the mechanisms responsible for selectivity. proposed strategies, further improve targeting ionophores, also reported.

Language: Английский

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Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapies

Cancer Letters, Journal Year: 2023, Volume and Issue: 561, P. 216157 - 216157

Published: April 1, 2023

Language: Английский

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Copper in cancer: from limiting nutrient to therapeutic target

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: June 23, 2023

As an essential nutrient, copper’s redox properties are both beneficial and toxic to cells. Therefore, leveraging the characteristics of copper-dependent diseases or using copper toxicity treat copper-sensitive may offer new strategies for specific disease treatments. In particular, concentration is typically higher in cancer cells, making a critical limiting nutrient cell growth proliferation. Hence, intervening metabolism cells become potential tumor treatment strategy, directly impacting metastasis. this review, we discuss body summarize research progress on role promoting inducing programmed death Additionally, elucidate copper-related drugs treatment, intending provide perspectives treatment.

Language: Английский

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Leveraging disulfiram to treat cancer: Mechanisms of action, delivery strategies, and treatment regimens

Biomaterials, Journal Year: 2021, Volume and Issue: 281, P. 121335 - 121335

Published: Dec. 28, 2021

Language: Английский

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Emerging roles of cystathionine β-synthase in various forms of cancer

Redox Biology, Journal Year: 2022, Volume and Issue: 53, P. 102331 - 102331

Published: May 10, 2022

The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is markedly increased in many forms cancer, including colorectal, ovarian, lung, breast and kidney, while other cancers (liver cancer glioma) it becomes downregulated. According to clinical database data high-CBS-expressor (e.g. colon or ovarian cancer), high CBS typically predicts lower survival, low-CBS-expressor liver low associated with survival. In high-CBS expressing tumor cells, CBS, its product hydrogen sulfide (H2S) serves as a bioenergetic, proliferative, cytoprotective stemness factor; also supports angiogenesis epithelial-to-mesenchymal transition microenvironment. current article reviews various tumor-cell-supporting roles CBS/H2S axis expressor overviews anticancer effects silencing pharmacological inhibition models vitro vivo; outlines potential approaches for biomarker identification, support future targeted therapies based on inhibition.

Language: Английский

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Metal-organic frameworks (MOFs) as biomolecules drug delivery systems for anticancer purposes

European Journal of Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 244, P. 114801 - 114801

Published: Oct. 4, 2022

Language: Английский

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Advances in thiosemicarbazone metal complexes as anti-lung cancer agents

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 27, 2022

The great success of cisplatin as a chemotherapeutic agent considerably increased research efforts in inorganic biochemistry to identify more metallic drugs having the potential treating lung cancer. Metal coordination centres, which exhibit wide range numbers and geometries, various oxidised reduced states inherent ligand properties offer pharmaceutical chemists plethora drug structures. Owing presence C=N C=S bonds thiosemicarbazone Schiff base, N S atoms its hybrid orbital has lone pair electrons, can generate metal complexes with different stabilities most elements under certain conditions. Such ligands play key roles treatment anti-lung Research regarding cancer advanced considerably, but there remain several challenges. In this review, we discuss base drugs, their anti-cancer activities likely action mechanisms involving recent families copper, nickel, platinum, ruthenium other complexes.

Language: Английский

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DDTC-Cu(I) based metal-organic framework (MOF) for targeted melanoma therapy by inducing SLC7A11/GPX4-mediated ferroptosis

Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 225, P. 113253 - 113253

Published: March 7, 2023

Language: Английский

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Hyperbaric Oxygen Boosts Antitumor Efficacy of Copper-Diethyldithiocarbamate Nanoparticles against Pancreatic Ductal Adenocarcinoma by Regulating Cancer Stem Cell Metabolism

Research, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

Cuproptosis-based cancer nanomedicine has received widespread attention recently. However, cuproptosis against pancreatic ductal adenocarcinoma (PDAC) is severely limited by stem cells (CSCs), which reside in the hypoxic stroma and adopt glycolysis metabolism accordingly to resist cuproptosis-induced mitochondria damage. Here, we leverage hyperbaric oxygen (HBO) regulate CSC overcoming tumor hypoxia augment elimination efficacy of polydopamine hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanoparticles (CuET@PH NPs). Mechanistically, while HBO CuET@PH NPs inhibit oxidative phosphorylation, respectively, combination potently suppresses energy CSCs, thereby achieving robust inhibition PDAC elongating mice survival importantly. This study reveals novel insights into effects on suggests that with holds significant clinical translation potential for patients.

Language: Английский

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