Associations between plasma and urinary heavy metal concentrations and the risk of prostate cancer DOI Creative Commons
Donatella Coradduzza, Andrea Sanna, Biagio Di Lorenzo

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 24, 2025

Prostate cancer is a leading cause of morbidity and mortality worldwide, with incidence rates projected to double between 2020 2040. This growing health challenge highlights the need for improved diagnostic strategies risk assessment tools better understand disease etiology progression. Among environmental factors, heavy metals have been implicated in inflammation carcinogenesis, yet their specific role prostate remains insufficiently explored. novel study analyses relationship metal concentrations plasma urine patients benign prostatic hyperplasia, precancerous lesions cancer. In addition evaluating key clinical parameters, including age, total PSA levels, hemoglobin monocyte/lymphocyte ratio, it aims determine whether contribute progression they can serve as potential biomarkers early diagnosis. Our findings reveal significant differences vanadium antimony plasma, suggesting pathophysiology. Notably, lower are associated an increased PC, while significantly higher PL group. Regression analysis further supports association highlighting copper or therapeutic targets health. The also explores impact lead exposure on risk, revealing concentration PC. These underscore complex interaction emphasizing research elucidate underlying mechanisms explore interventions.

Language: Английский

The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm DOI Creative Commons
Thi Thuy Tien Vo, Tzu‐Yu Peng,

Thi Hong Nguyen

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 5, 2024

Abstract Copper is a crucial trace element that plays role in various pathophysiological processes the human body. also acts as transition metal involved redox reactions, contributing to generation of reactive oxygen species (ROS). Under prolonged and increased ROS levels, oxidative stress occurs, which has been implicated different types regulated cell death. The recent discovery cuproptosis, copper-dependent death pathway distinct from other known forms, raised interest researchers field cancer therapy. Herein, present work aims outline current understanding with an emphasis on its anticancer activities through interplay copper-induced stress, thereby providing new ideas for therapeutic approaches targeting modes future.

Language: Английский

Citations

29
Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review DOI Creative Commons

Sara Abdolmaleki,

Alireza Aliabadi, Samad Khaksar

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(4)

Published: April 25, 2024

Abstract Copper is a necessary micronutrient for maintaining the well-being of human body. The biological activity organic ligands, especially their anticancer activity, often enhanced when they coordinate with copper(I) and (II) ions. its compounds are capable inducing tumor cell death through various mechanisms action, including activation apoptosis signaling pathways by reactive oxygen species (ROS), inhibition angiogenesis, induction cuproptosis, paraptosis. Some copper complexes currently being evaluated in clinical trials ability to map hypoxia cancers, locally advanced rectal cancer bulky tumors. Several studies have shown that nanoparticles can be used as effective agents chemodynamic therapy, phototherapy, hyperthermia, immunotherapy. Despite promising copper-based compounds, use subject certain limitations. Elevated concentrations may promote growth, metastasis affecting cellular processes.

Language: Английский

Citations

26
Cuproptosis: Unraveling the Mechanisms of Copper-Induced Cell Death and Its Implication in Cancer Therapy DOI Open Access

Chloe Springer,

Danish Humayun,

Rachid Skouta

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 647 - 647

Published: Feb. 2, 2024

Copper, an essential element for various biological processes, demands precise regulation to avert detrimental health effects and potential cell toxicity. This paper explores the mechanisms of copper-induced death, known as cuproptosis, its disease implications, including cancer therapy. Copper ionophores, such elesclomol disulfiram, increase intracellular copper levels. elevation triggers oxidative stress subsequent offering implications in Additionally, ionophores disrupt mitochondrial respiration protein lipoylation, further contributing toxicity death. Potential targets biomarkers are identified, can be targeted those proteins trigger cuproptosis. The role different cancers is discussed understand therapies using nanomaterials, chelators. Furthermore, explored through diseases Wilson Menkes physiological copper. Exploring cuproptosis presents opportunity improve treatments copper-related disorders cancers, with bring significant advancements modern medicine.

Language: Английский

Citations

25
Interplay of Ferroptosis and Cuproptosis in Cancer: Dissecting Metal-Driven Mechanisms for Therapeutic Potentials DOI Open Access
Jinjiang Wang, Jiaxi Li, Jiao Liu

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 512 - 512

Published: Jan. 24, 2024

Iron (Fe) and copper (Cu), essential transition metals, play pivotal roles in various cellular processes critical to cancer biology, including cell proliferation, mitochondrial respiration, distant metastases, oxidative stress. The emergence of ferroptosis cuproptosis as distinct forms non-apoptotic death has heightened their significance, particularly connection with these metal ions. While initially studied separately, recent evidence underscores the interdependence cuproptosis. Studies reveal a link between accumulation induction. This interconnected relationship presents promising strategy, especially for addressing refractory cancers marked by drug tolerance. Harnessing toxicity iron clinical settings becomes crucial. Simultaneous targeting cuproptosis, exemplified combination sorafenib elesclomol-Cu, represents an intriguing approach. Strategies mitochondria further enhance precision approaches, providing hope improving treatment outcomes drug-resistant cancers. Moreover, chelators copper-lowering agents established therapeutic modalities exhibits synergy that holds promise augmentation anti-tumor efficacy malignancies. review elaborates on complex interplay underlying mechanisms, explores potential druggable targets both research settings.

Language: Английский

Citations

24
AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer DOI Creative Commons
Zicheng Sun,

Hua‐Zhen Xu,

Guan-Ming Lu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract Cuproptosis, a recently defined copper‐dependent cell death pathway, remains largely unexplored in tumor therapies, particularly breast cancer. This study demonstrates that triple‐negative cancer (TNBC) bears relatively elevated copper levels and exhibits resistance to cuproptosis. Mechanistically, activates the AKT signaling which inhibits ferredoxin‐1 (FDX1), key regulator of AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis aerobic respiration but also promotes glycolysis. Consequently, combination AKT1 inhibitors ionophores synergistically alleviate TNBC tumorigenesis both vitro vivo. In summary, findings reveal crucial mechanism underlying suggest potential therapeutic approach for TNBC.

Language: Английский

Citations

2
Dying to survive: harnessing inflammatory cell death for better immunotherapy DOI
Long Cheng, Yibo Wang, Ying Zhang

et al.

Trends in cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

2
The Importance of Being Casiopeina as Polypharmacologycal Profile (Mixed Chelate–Copper (II) Complexes and Their In Vitro and In Vivo Activities) DOI Creative Commons
Zenayda Aguilar-Jiménez, Adrián Espinoza-Guillén, Karen Reséndiz-Acevedo

et al.

Inorganics, Journal Year: 2023, Volume and Issue: 11(10), P. 394 - 394

Published: Oct. 7, 2023

In this review, we present a timeline that shows the origin of mixed chelate copper (II) complexes, registered as Mark Title Casiopeínas®, first compounds proposed anticancer drugs in 1988 and 1992. late twentieth century, use essential metals agents was not even considered, except for their antifungal or antibacterial effects; also, copper, gold salts, used arthritis problems. The to diminish secondary toxic effects Cisplatin our driving force: find less more economical under rational design metal complexes. Due chemical properties, were choice continue drug development. order ideas, designs chelate–copper complexes (Casiopeínas, (Cas) homoleptic heteroleptic, depending on nature ligand) synthesized fully characterized. search new, effective, drugs, Casiopeína® emerged family approximately 100 from coordinated Cu(II) with proven antineoplastic potential through cytotoxic action. Cas have general formula [Cu(N–N)(N–O)]NO3 [Cu(N–N)(O–O)]NO3, where N–N is an aromatic substituted diimine (1,10-phenanthroline 2,2′-bipyridine), oxygen donor (O–O) acetylacetonate salicylaldehyde. Lately, some similar been developed by other research groups considering hypothesis after Casiopeína’s discoveries had published, described herein. As example translational medicine criteria, covered each step established normative process development, consequently, one molecules (Casiopeína III ia (CasIIIia)) has reached clinical phase I. For these compounds, activities, such antibacterial, antiparasitic antiviral, discovered.

Language: Английский

Citations

23
Current Trends on the Involvement of Zinc, Copper, and Selenium in the Process of Hepatocarcinogenesis DOI Open Access
Takashi Himoto, Tsutomu Masaki

Nutrients, Journal Year: 2024, Volume and Issue: 16(4), P. 472 - 472

Published: Feb. 6, 2024

Numerous nutritional factors increase the risk of hepatocellular carcinoma (HCC) development. The dysregulation zinc, copper, and selenium homeostasis is associated with occurrence HCC. impairment these essential trace elements results in oxidative stress, DNA damage, cell cycle progression, angiogenesis, finally leading to hepatocarcinogenesis. These can affect microenvironment carrier proteins for zinc copper selenium-containing enzymes play important roles prevention or progression enhance alleviate chemosensitivity anticancer agents patients may other each other. Novel types death including ferropotosis cupropotosis are also Therapeutic strategies HCC that target have been developed vitro vivo studies. use zinc-, copper- selenium-nanoparticles has considered as novel therapeutic indicate become promising targets clinical application an urgent unmet requirement. This review article highlights correlation between development summarizes current trends on pathogenesis

Language: Английский

Citations

15
Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases DOI
Zhibo Yang,

Ridong Feng,

Zhao Hai

et al.

APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(9-10), P. 1330 - 1360

Published: July 16, 2024

Language: Английский

Citations

12
Heavy metals and prostate cancer: a new study with new findings DOI Creative Commons
Donatella Coradduzza, Antonella Congiargiu, Andrea Sanna

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract Heavy metals influence the development of several health conditions, including inflammation and cancer. This study investigates relationship between heavy metal concentrations in plasma urine, presence benign prostatic hyperplasia (BPH), precancerous lesions (PL), prostate cancer (PC). The age, total PSA levels, hemoglobin concentrations, monocyte-to-lymphocyte ratio (MLR) is also analyzed across three groups: BPH, PL, PC. Our findings reveal significant differences vanadium antimony plasma, suggesting a potential role disease pathophysiology. Notably, lower are associated with an increased risk PC, while significantly higher PL group. Regression analysis further supports association highlighting copper as biomarkers or therapeutic targets for health. explores impact lead exposure on risk, revealing urine concentration These underscore complex interaction emphasizing need research to elucidate underlying mechanisms explore interventions.

Language: Английский

Citations

1