Plasma Amino Acids and Acylcarnitines Are Associated with the Female but Not Male Adolescent Swimmer’s Performance: An Integration between Mass Spectrometry and Complex Network Approaches DOI Creative Commons

Flávio Marcio Macedo Mendes,

Pedro Henrique Godoy Sanches, Alex Silva

et al.

Biology, Journal Year: 2022, Volume and Issue: 11(12), P. 1734 - 1734

Published: Nov. 29, 2022

The main aim of this study was to compare the performance over different distances, critical velocity (CV), and plasma acylcarnitines/amino acids male female adolescent swimmers. Moreover, we applied complex network approach identify which molecules are associated with athletes’ performances. On first day under a controlled environment, blood samples were collected after 12 h overnight fasting. Performance trials (100, 200, 400, 800-m) randomly performed in subsequent four days swimming pool, CV determined by linear distance versus time mathematical function. Metabolomic analyses carried out on triple quadrupole mass spectrometer performing electrospray ionization positive mode. No difference observed between Except for 200-m (p = 0.08), tyrosine positively significantly times during (100-m, p 0.04; 400-m, 800-m, 0.02), inversely 0.02). showed that glycine (0.406), glutamine (0.400), arginine (0.335), free carnitine (0.355), tryptophan (0.289), histidine (0.271) most influential nodes reach tyrosine. These results revealed thread must be explored further randomized/controlled designs, improving knowledge surrounding nutrition

Language: Английский

The transition from genomics to phenomics in personalized population health DOI
James T. Yurkovich, Simon J. Evans, Noa Rappaport

et al.

Nature Reviews Genetics, Journal Year: 2023, Volume and Issue: 25(4), P. 286 - 302

Published: Dec. 13, 2023

Language: Английский

Citations

22
Digital Literacy 5.0 to Enhance Multicultural Education DOI Creative Commons
Dito Anurogo, Hardin La Ramba,

Nabila Diyana Putri

et al.

Multicultural Islamic Education Review, Journal Year: 2023, Volume and Issue: 1(2), P. 109 - 179

Published: Dec. 8, 2023

In Digital Literacy 5.0, the intersectionality of digital competence across various domains marks a paradigm shift from traditional siloed approaches to more integrated and holistic framework. This article explores pervasive influence literacy diverse fields including health, medicine, nutrition, medical tourism, economy, biomedical sciences, bioinformatics, telemedicine, telehealth, artificial intelligence (AI), vascular surgery. Emphasizing necessity not just as skill for tool utilization but cornerstone understanding leveraging potential technologies, this comprehensive exploration underscores critical role in enhancing patient outcomes, driving economic growth, spurring innovation, revolutionizing healthcare surgical practices. Through multidisciplinary lens, elucidates indispensability technologically interconnected era, highlighting its implications policy, educational paradigms, future technological advancements.

Language: Английский

Citations

20
Dynamic transcriptomic responses to divergent acute exercise stimuli in young adults DOI
Kaleen M. Lavin, Zachary Graham, Jeremy S. McAdam

et al.

Physiological Genomics, Journal Year: 2023, Volume and Issue: 55(4), P. 194 - 212

Published: March 20, 2023

We examined small and long transcriptomics in skeletal muscle serum-derived extracellular vesicles before after a single exposure to traditional combined exercise (TRAD) high-intensity tactical training (HITT). Across 40 young adults, we found more consistent protein-coding gene responses TRAD, whereas HITT elicited differential expression of microRNA enriched brain regions. Follow-up analysis revealed relationships temporal dynamics across transcript networks, highlighting potential avenues for research into mechanisms response adaptation.

Language: Английский

Citations

14
Microalgae and exercise: from molecular mechanisms and brain health to clinical perspectives in the context of 3P medicine DOI
Xuenong Bo

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

Citations

0
Novel possibilities of acceleration time series for performance and acute fatigue assessment in uphill trail running DOI
Lluc Montull, Sergi Matas, Albert Canton

et al.

Sports Biomechanics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: April 10, 2025

The potential for assessing performance and acute fatigue in uphill trail running (UTR) through acceleration time series remains underexplored. For this purpose, time-variability of body covariation among limb were studied UTR. Twenty competitive young runners participated a simulation UTR test covering distance 4758 meters, with total elevation gain 575 meters an average slope 13.6%. Four sections clear differences identified. Detrended Fluctuation Analysis upper back Principal Component wrists ankle performed the whole each section.The outcomes correlated standardized effect size was used to compare sections. main findings suggest that (a) higher showed less persistence fluctuations greater interlimb diversity, (b) steepest parts, particularly final effortful section, increased some lost covariation.In conclusion, coordination analyses seem be sensitive UTR, which opens further possibilities providing more integrative, dynamic, practical assessment tools.

Language: Английский

Citations

0
Predicting Injuries in Elite Female Football Players With Global-Positioning-System and Multiomics Data DOI Creative Commons
Juan R. González, Alejandro Cáceres, Eva Ferrer

et al.

International Journal of Sports Physiology and Performance, Journal Year: 2024, Volume and Issue: 19(7), P. 661 - 669

Published: May 16, 2024

Injury prevention is a crucial aspect of sports, particularly in high-performance settings such as elite female football. This study aimed to develop an injury prediction model that incorporates clinical, Global-Positioning-System (GPS), and multiomics (genomics metabolomics) data better understand the factors associated with football players.

Language: Английский

Citations

3
Presenting a sham treatment as personalised increases the placebo effect in a randomised controlled trial DOI Creative Commons
Dasha A. Sandra, Jay A. Olson, Ellen J. Langer

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: July 5, 2023

Background: Tailoring interventions to patient subgroups can improve intervention outcomes for various conditions. However, it is unclear how much of this improvement due the pharmacological personalisation versus non-specific effects contextual factors involved in tailoring process, such as therapeutic interaction. Here, we tested whether presenting a (placebo) analgesia machine personalised would its effectiveness. Methods: We recruited 102 adults two samples ( N 1 =17, 2 = 85) receive painful heat stimulations on their forearm. During half stimulations, purportedly delivered an electric current reduce pain. The participants were either told that was genetics and physiology, or effective reducing pain generally. Results: Participants reported more relief intensity than control group both feasibility study (standardised β =−0.50 [–1.08, 0.08]) pre-registered double-blind confirmatory =−0.20 [–0.36, –0.04]). found similar unpleasantness, several personality traits moderated results. Conclusions: present some first evidence framing sham treatment increases Our findings could potentially methodology precision medicine research inform practice. Funding: This funded by Social Science Humanities Research Council (93188) Genome Québec (95747).

Language: Английский

Citations

8
Sportomics suggests that albuminuria is a sensitive biomarker of hydration in cross combat DOI Creative Commons
Luís Carlos Oliveira Gonçalves,

Aníbal Monteiro de Magalhães Neto,

Adriana Bassini

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: May 17, 2022

Abstract We have been using sportomics to understand hypermetabolic stress. Cross Combat (CCombat) has recently initiated as a high-intensity functional training method inspired by CrossFit. used CCombat session induce metabolic stress and evaluated its effects on hydration kidney function. Blood samples were collected from 16 elite-level professional male athletes engaged in sessions over 96-h protocol. myoglobin increased ~ 3.5-fold (119 ± 21 369 62 nmol/L; p = .001) response the protocol, returning pre-exercise level within 48 h. Furthermore, d -dimer levels 6.5 0.6 79.4 21.3 μmol/L ( < exercise decreasing during recovery with high variability among studied athletes. Albuminemia creatininemia 10% cystatin C 240% (1.7 0.1 5.7 0.5 mg/L; .001; effect size 2.4) measured albuminuria (HuA) assess permeability albumin caused exercise. HuA 16-fold (0.16 0.03 2.47 0.41 μmol/L; 1.4) exercise, dropping reaching basal Here, we suggest that microalbuminuria can be an early, sensitive, easy, inexpensive biomarker evaluate status changes intensive chronic impairment renal

Language: Английский

Citations

13
From Microcosm to Macrocosm: The -Omics, Multiomics, and Sportomics Approaches in Exercise and Sports DOI
Renan Muniz‐Santos,

Alexandre Magno-França,

Igor Jurišica

et al.

OMICS A Journal of Integrative Biology, Journal Year: 2023, Volume and Issue: 27(11), P. 499 - 518

Published: Nov. 1, 2023

This article explores the progressive integration of -omics methods, including genomics, metabolomics, and proteomics, into sports research, highlighting development concept "sportomics." We discuss how sportomics can be used to comprehend multilevel metabolism during exercise in real-life conditions faced by athletes, enabling potential personalized interventions improve performance recovery reduce injuries, all with a minimally invasive approach reduced time. Sportomics may also support highly investigations, implementation

Language: Английский

Citations

7
Blood Metabolomics Analysis Identifies Differential Serum Metabolites in Elite and Sub-elite Swimmers DOI Creative Commons
Ming Cai, Chao Wu, Jing Chen

et al.

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: May 5, 2022

Objective: Metabolites in body fluids, such as lactate, glucose, and creatinine, have been measured by conventional methods to evaluate physical function performance or athletic status. The objectives of the current study were explore novel metabolite biomarkers professional swimmers with different competition levels using nuclear magnetic resonance (NMR) metabolomics, try establish a model identify status predict competitive potential. Methods: Serum samples collected from 103 elite 84 sub-elite level Chinese swimmers, profiled NMR analysis. Results: Out thirty-six serum metabolites profiled, ten associated (with p < 0.05). When compared had higher high-density lipoprotein (HDL), unsaturated fatty acid, lactic methanol. Elite lower isoleucine, 3-hydroxybutyric acetoacetate, glutamine, glycine, α-glucose. A four metabolites, including HDL, methanol, α-glucose, was established adjusting covariates. area under curve (AUC) best 0.904 (95% CI: 0.862-0.947), sensitivity specificity 75.5 90.2%, respectively. Conclusion: We identified differentially expressed between differences could result genetic sports two cohorts. has successfully differentiated levels.

Language: Английский

Citations

11