Exploring the Wound Healing Potential of Hispidin DOI Open Access
Yi-Shan Liu,

Mei-Chou Lai,

Tang-Yao Hong

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3161 - 3161

Published: Sept. 19, 2024

Background: Hispidin, a polyphenol component mainly derived from the medicinal mushroom species Phellinus and Inonotus, shows promise for biomedical applications, yet its potential in wound healing remains largely unexplored. This research investigates effects of hispidin through vitro vivo experiments, while also evaluating antimicrobial properties safety profile. Methods: In scratch assays were conducted to evaluate impact on migration NIH-3T3 cells. The was assessed rats using excision wounds, dead space linear incisions, treated with various topical ointments including simple ointment, 2.5% (w/w) 5% 0.2% nitrofurazone administered at 0.2 g daily 14 days. Results: Hispidin demonstrated particularly effective against Staphylococcus epidermidis. enhanced cell viability, promoted closure assays, correlating increased levels FGF21, TGF-β1, EGF, VEGF. models, ointment improved contraction, epithelialization, tissue regeneration, fibroblast activity, angiogenesis. granulation reduced pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) lipid peroxidation, increasing anti-inflammatory (IL-10) antioxidant activities (SOD, GPx, CAT), along connective markers like hydroxyproline, hexosamine, hexuronic acid. breaking strength incision models. Acute dermal toxicity studies indicated no adverse 2000 mg/kg. Conclusions: These findings highlight hispidin’s care, demonstrating antimicrobial, regenerative, properties.

Language: Английский

Opportunities and challenges of nanomaterials in wound healing: Advances, mechanisms, and perspectives DOI
Wentao Fu,

Shengbo Sun,

Yuhao Cheng

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153640 - 153640

Published: July 1, 2024

Language: Английский

Citations

25
Functional hydrogel-based wound dressings: A review on biocompatibility and therapeutic efficacy DOI Creative Commons
Simran Nasra, Milonee Patel, Haly Shukla

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 334, P. 122232 - 122232

Published: Oct. 31, 2023

Chronic wounds, burns, and surgical incisions represent critical healthcare challenges that significantly impact patient quality of life strain resources. In response to these pressing needs, the field wound healing has witnessed a radical advancement with emergence functional hydrogel-based dressings. This review article underscores severity importance this transformative study in domain healing. The hydrogel matrix offers moist supportive environment facilitates cellular migration, proliferation, tissue regeneration, vital for efficient closure. Their conformable nature ensures comfort, reducing pain uneasiness during dressing changes, particularly chronic wounds where frequent interventions are required. Beyond their structural merits, dressings possess capability incorporating bioactive molecules such as growth factors antimicrobial agents. targeted sustained delivery therapeutics directly site, addressing multifactorial enhancing trajectory. integration advanced nanotechnology propelled design enhanced mechanical strength controlled drug release profiles, amplifying therapeutic potential. conclusion, significance lies its ability revolutionize practices positively lives countless individuals suffering from burns. As technology gains momentum, it holds promise major burden worldwide, thus heralding new era care management.

Language: Английский

Citations

35
Fabrication of gelatin coated polycaprolactone nanofiber scaffolds co-loaded with luliconazole and naringenin for treatment of Candida infected diabetic wounds DOI

Manjit Manjit,

K. T. Nivas Kumar, Manish Kumar

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129621 - 129621

Published: Jan. 25, 2024

Language: Английский

Citations

11
Bacterial Species Involved in Venous Leg Ulcer Infections and Their Sensitivity to Antibiotherapy—An Alarm Signal Regarding the Seriousness of Chronic Venous Insufficiency C6 Stage and Its Need for Prompt Treatment DOI Creative Commons
Sergiu-Ciprian Matei, Cristina-Stefania Dumitru,

Ayman M. FAKHRY

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(3), P. 472 - 472

Published: Feb. 26, 2024

Venous leg ulcers (VLUs) are a common chronic wound condition susceptible to infection by various bacterial species. Understanding presence and antibiotic sensitivity is crucial for effective treatment. Methodsː Medical records of 60 patients diagnosed with the C6 venous insufficiency stage were analyzed retrospectively. The divided into an active recurrent VLU group (33 cases) first-onset (27 cases). Bacterial identification, sensitivity, laboratory markers assessed. Resultsː

Language: Английский

Citations

9
Antibacterial hydrogel: The sniper of chronic wounds DOI Creative Commons
Shengtai Bian, Huijun Ye, Pan Wang

et al.

BMEMat, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract Chronic wounds are that difficult to heal or do not follow the normal healing process. These include pressure ulcers, diabetic venous and arterial incomplete ulcers. Unlike acute wounds, chronic often even heal. Its pathogenesis involves many factors; bacterial infection is main cause of wound. With increase in population aging, incidence has become a critical issue current medical health field. Management faced with problems long treatment time, difficulty, high cost, repeated attacks disability rate, which seriously threaten patients' ability take care themselves life heavy burden individuals, families society. Over past few years, development antibacterial hydrogels for infections received lot attention. Since only have mechanical properties hydrogels, biocompatibility adjustable functional structure, but also excellent properties, they may be an ideal dressing solve problem wound healing. This article introduces types their characteristics, challenges treating wounds. It classifies antimicrobial based on modes further discusses advancements smart along benefits obstacles using explores directions management.

Language: Английский

Citations

1
In-vivo and in-vitro wound healing and tissue repair effect of Trametes versicolor polysaccharide extract DOI Creative Commons
Seyedeh Kiana Teymoorian, Hoda Nouri, Hamid Moghimi

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 15, 2024

Abstract Regarding different medical benefits of fungi, using the mushroom extracts as wound-healing agents is gaining popularity. This study, evaluated wound healing characteristics Trametes versicolor . Anti-oxidant activity addressed by employing DPPH (2,2-diphenyl-1-picrylhydrazyl) assay resulting 53.7% inhibitory effect. Besides, for anti-microbial ability determination, MIC (Minimum Inhibitory Concentration) extract measured which Escherichia coli growth was inhibited at 1.1 mg/ml, and Staphylococcus aureus did not grow 4.38 mg/ml extract. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method indicated dose dependence with 63 ± 3% 28 viability 1250 μg/ml 156.25 extract, higher concentration caused cell viability. outcome gene expression analysis determined that overall FGF2 (Fibroblast Growth Factor 2), IL-1β (Interleukin-1β), TGF-β1 (Transforming Factor-β1) 4 times 48 h than 24 in treated cells, suggesting a stimulating effect on growth. An in-vivo animal model suggested enhanced process after treatment 0.01 g Furthermore, number fibroblasts, epidermal thickness, collagen fiber respectively 2, 3, threefold mice when compared to untreated mice. wounds showed 100% 60% within 14 days. results this research show promise fungus-based treatments, may help tissue regeneration cutaneous wounds.

Language: Английский

Citations

7
Advancing Diabetic Wound Care: The Role of Copper-containing Hydrogels DOI Creative Commons

Mohammad Ebrahim Astaneh,

Narges Fereydouni

Heliyon, Journal Year: 2024, Volume and Issue: 10(20), P. e38481 - e38481

Published: Sept. 26, 2024

Language: Английский

Citations

6
Electrospun Nanofibers Loaded with Marigold Extract Based on PVP/HPβCD and PCL/PVP Scaffolds for Wound Healing Applications DOI Open Access
Magdalena Paczkowska-Walendowska, Natalia Rosiak, Tomasz Plech

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(8), P. 1736 - 1736

Published: April 10, 2024

Marigold flower is a traditionally used plant material topically applied on the skin due to its anti-inflammatory properties and antibacterial activity. This potential of action justifies implementation marigold extract in nanofiber scaffolds based poly-vinylpyrrolidone/hydroxypropyl-β-cyclodextrin (PVP/HPβCD) polycaprolactone/polyvinylpyrrolidone (PCL/PVP) obtained by electrospinning for wound treatment. Using SEM, morphology electrospun showed fiber diameter range 298-527 nm, with uniform bead-free appearance. ATR-FTIR spectroscopy confirmed presence extracts nanofibrous scaffolds. The composition nanofibers can control release; case PVP/HPβCD, immediate release 80% chlorogenic acid (an analytical functional marker extract) was achieved within 30 min, while PCL/PVP, controlled 24 h (70% acid). All systems weak activity against wound-infecting bacteria Staphylococcus aureus (MIC 100 mg/mL), Pseudomonas aeruginosa 200 mg/mL) yeasts Candida albicans mg/mL). Analysis effect different scaffold compositions electrofibers that those PCL/PVP had better healing potential. scratch closed after 36 h, compared 48 required PVP/HPβCD. Overall, study shows loaded classic have best as dressing materials because their ability selectively modulate inflammation (via inhibition hyaluronidase enzyme) supportive antimicrobial properties, thereby aiding early stages repair.

Language: Английский

Citations

4
Direct metagenomics investigation of non-surgical hard-to-heal wounds: a review DOI Creative Commons
Madjid Morsli, Florian Salipante, Chloé Magnan

et al.

Annals of Clinical Microbiology and Antimicrobials, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 3, 2024

Abstract Background Non-surgical chronic wounds, including diabetes-related foot diseases (DRFD), pressure injuries (PIs) and venous leg ulcers (VLU), are common hard-to-heal wounds. Wound evolution partly depends on microbial colonisation or infection, which is often confused by clinicians, thereby hampering proper management. Current routine microbiology investigation of these wounds based in vitro culture, focusing only a limited panel the most frequently isolated bacteria, leaving large part wound microbiome undocumented. Methods A literature search was conducted original studies published through October 2022 reporting metagenomic next generation sequencing (mNGS) samples. Studies were eligible for inclusion if they applied 16 S rRNA metagenomics shotgun analysis diagnosis. Case reports, prospective, retrospective included. However, review articles, animal studies, model optimisation, benchmarking, treatment optimisation non-clinical excluded. Articles identified PubMed, Google Scholar, Web Science, Microsoft Academic, Crossref Semantic Scholar databases. Results Of 3,202 articles found initial search, 2,336 removed after deduplication 834 following title abstract screening. further 14 full text reading, with 18 finally Data provided 3,628 patients, 1,535 DRFDs, 956 VLUs, 791 PIs, 164 genera 116 species using mNGS approaches. high diversity observed depending geographical location evolution. Clinically infected diverse, possibly due to widespread pathogenic bacteria from body environmental microbiota. data presence virus (EBV) fungi ( Candida Aspergillus species), as well Staphylococcus Pseudomonas bacteriophages. Conclusion This study highlighted benefit time-effective pathogen genome detection. Despite majority included investigating rDNA, ignoring viral, fungal parasite colonisation, detected number studies. Such technology could be implemented microbiota post-treatment surveillance.

Language: Английский

Citations

4
Nanoformulations for dismantling fungal biofilms: The latest arsenals of antifungal therapy DOI
Payal Gupta,

Krishna Mohan Poluri,

Shweta Tripathi

et al.

Molecular Aspects of Medicine, Journal Year: 2024, Volume and Issue: 98, P. 101290 - 101290

Published: June 29, 2024

Language: Английский

Citations

4